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P04798

- CP1A1_HUMAN

UniProt

P04798 - CP1A1_HUMAN

Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 170 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei224 – 2241Substrate
    Metal bindingi457 – 4571Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. demethylase activity Source: Ensembl
    3. flavonoid 3'-monooxygenase activity Source: Ensembl
    4. heme binding Source: InterPro
    5. iron ion binding Source: InterPro
    6. oxidoreductase activity Source: BHF-UCL
    7. oxidoreductase activity, acting on diphenols and related substances as donors Source: Ensembl
    8. oxygen binding Source: ProtInc
    9. steroid hydroxylase activity Source: Ensembl
    10. vitamin D 24-hydroxylase activity Source: BHF-UCL

    GO - Biological processi

    1. 9-cis-retinoic acid biosynthetic process Source: Ensembl
    2. aging Source: Ensembl
    3. amine metabolic process Source: Ensembl
    4. arachidonic acid metabolic process Source: Reactome
    5. camera-type eye development Source: Ensembl
    6. cell proliferation Source: Ensembl
    7. cellular lipid metabolic process Source: Reactome
    8. cellular response to organic cyclic compound Source: MGI
    9. coumarin metabolic process Source: Ensembl
    10. dibenzo-p-dioxin catabolic process Source: Ensembl
    11. digestive tract development Source: Ensembl
    12. drug metabolic process Source: BHF-UCL
    13. embryo development ending in birth or egg hatching Source: Ensembl
    14. epoxygenase P450 pathway Source: Reactome
    15. flavonoid metabolic process Source: Ensembl
    16. hepatocyte differentiation Source: Ensembl
    17. hydrogen peroxide biosynthetic process Source: Ensembl
    18. insecticide metabolic process Source: Ensembl
    19. maternal process involved in parturition Source: Ensembl
    20. omega-hydroxylase P450 pathway Source: Reactome
    21. oxidation-reduction process Source: BHF-UCL
    22. porphyrin-containing compound metabolic process Source: Ensembl
    23. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    24. response to antibiotic Source: Ensembl
    25. response to arsenic-containing substance Source: Ensembl
    26. response to drug Source: Ensembl
    27. response to food Source: Ensembl
    28. response to herbicide Source: Ensembl
    29. response to hyperoxia Source: Ensembl
    30. response to hypoxia Source: Ensembl
    31. response to iron(III) ion Source: Ensembl
    32. response to lipopolysaccharide Source: Ensembl
    33. response to nematode Source: Ensembl
    34. response to virus Source: Ensembl
    35. response to vitamin A Source: Ensembl
    36. response to wounding Source: Ensembl
    37. small molecule metabolic process Source: Reactome
    38. vitamin D metabolic process Source: BHF-UCL
    39. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_13543. Xenobiotics.
    REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    SABIO-RKP04798.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Cytochrome P450 form 6
    Cytochrome P450-C
    Cytochrome P450-P1
    Gene namesi
    Name:CYP1A1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:2595. CYP1A1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27092.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Cytochrome P450 1A1PRO_0000051627Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP04798.
    PaxDbiP04798.
    PRIDEiP04798.

    PTM databases

    PhosphoSiteiP04798.

    Expressioni

    Tissue specificityi

    Lung, lymphocytes and placenta.

    Inductioni

    By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

    Gene expression databases

    ArrayExpressiP04798.
    BgeeiP04798.
    CleanExiHS_CYP1A1.
    GenevestigatoriP04798.

    Organism-specific databases

    HPAiCAB018654.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000369050.

    Structurei

    Secondary structure

    1
    512
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni47 – 493
    Helixi52 – 554
    Helixi59 – 7012
    Beta strandi72 – 787
    Beta strandi81 – 866
    Helixi89 – 968
    Turni97 – 993
    Helixi100 – 1034
    Helixi110 – 1145
    Helixi116 – 1183
    Turni121 – 1233
    Helixi129 – 14517
    Helixi158 – 17922
    Helixi186 – 20318
    Helixi212 – 2187
    Beta strandi219 – 2213
    Helixi224 – 2285
    Helixi233 – 2353
    Helixi238 – 2425
    Helixi246 – 27126
    Helixi281 – 29212
    Beta strandi296 – 2983
    Beta strandi300 – 3023
    Helixi304 – 3085
    Helixi310 – 33425
    Helixi337 – 35014
    Helixi359 – 3646
    Helixi366 – 37914
    Beta strandi394 – 3963
    Beta strandi399 – 4013
    Beta strandi406 – 4105
    Helixi411 – 4155
    Turni418 – 4203
    Helixi429 – 4324
    Beta strandi435 – 4373
    Helixi441 – 4444
    Helixi453 – 4553
    Helixi460 – 47718
    Beta strandi478 – 4814
    Beta strandi495 – 4973
    Beta strandi506 – 5105

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I8VX-ray2.60A/B/C/D35-512[»]
    ProteinModelPortaliP04798.
    SMRiP04798. Positions 36-512.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    InParanoidiP04798.
    KOiK07408.
    OMAiHLPYMEA.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP04798.
    TreeFamiTF105095.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P04798-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG    50
    HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG 100
    DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD 150
    PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA 200
    ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA 250
    FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV 300
    QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV 350
    IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY 400
    IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFLTPDGAID KVLSEKVIIF 450
    GMGKRKCIGE TIARWEVFLF LAILLQRVEF SVPLGVKVDM TPIYGLTMKH 500
    ACCEHFQMQL RS 512
    Length:512
    Mass (Da):58,165
    Last modified:April 1, 1988 - v1
    Checksum:i3C62366044148EFD
    GO
    Isoform 2 (identifier: P04798-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         189-189: Y → T
         190-512: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:189
    Mass (Da):20,788
    Checksum:i6F774C4E9FC85427
    GO
    Isoform 3 (identifier: P04798-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-261: Missing.
         419-512: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:157
    Mass (Da):18,441
    Checksum:iD0AE3E0EEA55B854
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261I → M in AAA52139. (PubMed:3838385)Curated
    Sequence conflicti235 – 2351D → E in AAA52139. (PubMed:3838385)Curated
    Sequence conflicti381 – 3811F → L in CAA26458. (PubMed:2989797)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451G → D.3 Publications
    Corresponds to variant rs4646422 [ dbSNP | Ensembl ].
    VAR_023194
    Natural varianti66 – 661M → V.
    Corresponds to variant rs35035798 [ dbSNP | Ensembl ].
    VAR_033817
    Natural varianti78 – 781I → T.2 Publications
    Corresponds to variant rs17861094 [ dbSNP | Ensembl ].
    VAR_023195
    Natural varianti93 – 931R → W.1 Publication
    Corresponds to variant rs2229150 [ dbSNP | Ensembl ].
    VAR_024706
    Natural varianti173 – 1731T → R.1 Publication
    Corresponds to variant rs28399427 [ dbSNP | Ensembl ].
    VAR_024707
    Natural varianti279 – 2791R → W.1 Publication
    Corresponds to variant rs34260157 [ dbSNP | Ensembl ].
    VAR_009280
    Natural varianti286 – 2861I → T.
    Corresponds to variant rs4987133 [ dbSNP | Ensembl ].
    VAR_020122
    Natural varianti331 – 3311M → I in allele CYP1A1*6. 1 Publication
    Corresponds to variant rs56313657 [ dbSNP | Ensembl ].
    VAR_016937
    Natural varianti448 – 4481I → N in allele CYP1A1*8. 1 Publication
    VAR_016938
    Natural varianti461 – 4611T → N in allele CYP1A1*4. 3 Publications
    Corresponds to variant rs1799814 [ dbSNP | Ensembl ].
    VAR_008342
    Natural varianti462 – 4621I → V in allele CYP1A1*2B and allele CYP1A1*2C. 2 Publications
    Corresponds to variant rs1048943 [ dbSNP | Ensembl ].
    VAR_001243
    Natural varianti464 – 4641R → C in allele CYP1A1*9. 1 Publication
    VAR_016939
    Natural varianti464 – 4641R → S in allele CYP1A1*5. 1 Publication
    Corresponds to variant rs41279188 [ dbSNP | Ensembl ].
    VAR_016940
    Natural varianti470 – 4701F → V.
    Corresponds to variant rs36121583 [ dbSNP | Ensembl ].
    VAR_033818
    Natural varianti477 – 4771R → W in allele CYP1A1*10. 2 Publications
    Corresponds to variant rs56240201 [ dbSNP | Ensembl ].
    VAR_016941
    Natural varianti482 – 4821V → M.1 Publication
    Corresponds to variant rs28399429 [ dbSNP | Ensembl ].
    VAR_024708
    Natural varianti492 – 4921P → R in allele CYP1A1*11. 2 Publications
    Corresponds to variant rs28399430 [ dbSNP | Ensembl ].
    VAR_016942

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 261261Missing in isoform 3. 1 PublicationVSP_053363Add
    BLAST
    Alternative sequencei189 – 1891Y → T in isoform 2. 1 PublicationVSP_053364
    Alternative sequencei190 – 512323Missing in isoform 2. 1 PublicationVSP_053365Add
    BLAST
    Alternative sequencei419 – 51294Missing in isoform 3. 1 PublicationVSP_053366Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02612 Genomic DNA. Translation: CAA26458.1.
    K03191 mRNA. Translation: AAA52139.1.
    X04300 Genomic DNA. Translation: CAA27843.1.
    AF253322 Genomic DNA. Translation: AAK25727.1.
    AM233518 mRNA. Translation: CAJ80721.1.
    AM233519 mRNA. Translation: CAJ80722.1.
    AM233520 mRNA. Translation: CAJ80723.1.
    AK223113 mRNA. Translation: BAD96833.1.
    AC091230 Genomic DNA. No translation available.
    BC023019 mRNA. Translation: AAH23019.1.
    M12079 mRNA. Translation: AAA52152.1.
    AF040259 mRNA. Translation: AAD10199.1.
    CCDSiCCDS10268.1. [P04798-1]
    PIRiA24797. O4HU6.
    RefSeqiNP_000490.1. NM_000499.3. [P04798-1]
    XP_005254242.1. XM_005254185.1. [P04798-1]
    UniGeneiHs.72912.

    Genome annotation databases

    EnsembliENST00000379727; ENSP00000369050; ENSG00000140465. [P04798-1]
    ENST00000395048; ENSP00000378488; ENSG00000140465. [P04798-1]
    ENST00000562201; ENSP00000455340; ENSG00000140465. [P04798-2]
    ENST00000564596; ENSP00000457668; ENSG00000140465. [P04798-3]
    ENST00000567032; ENSP00000456585; ENSG00000140465. [P04798-1]
    ENST00000569630; ENSP00000455051; ENSG00000140465. [P04798-2]
    GeneIDi1543.
    KEGGihsa:1543.
    UCSCiuc002ayp.4. human. [P04798-1]

    Polymorphism databases

    DMDMi117139.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Cytochrome P450 Allele Nomenclature Committee

    CYP1A1 alleles

    SHMPD

    The Singapore human mutation and polymorphism database

    Wikipedia

    CYP1A1 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02612 Genomic DNA. Translation: CAA26458.1 .
    K03191 mRNA. Translation: AAA52139.1 .
    X04300 Genomic DNA. Translation: CAA27843.1 .
    AF253322 Genomic DNA. Translation: AAK25727.1 .
    AM233518 mRNA. Translation: CAJ80721.1 .
    AM233519 mRNA. Translation: CAJ80722.1 .
    AM233520 mRNA. Translation: CAJ80723.1 .
    AK223113 mRNA. Translation: BAD96833.1 .
    AC091230 Genomic DNA. No translation available.
    BC023019 mRNA. Translation: AAH23019.1 .
    M12079 mRNA. Translation: AAA52152.1 .
    AF040259 mRNA. Translation: AAD10199.1 .
    CCDSi CCDS10268.1. [P04798-1 ]
    PIRi A24797. O4HU6.
    RefSeqi NP_000490.1. NM_000499.3. [P04798-1 ]
    XP_005254242.1. XM_005254185.1. [P04798-1 ]
    UniGenei Hs.72912.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I8V X-ray 2.60 A/B/C/D 35-512 [» ]
    ProteinModelPortali P04798.
    SMRi P04798. Positions 36-512.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000369050.

    Chemistry

    BindingDBi P04798.
    ChEMBLi CHEMBL2231.
    DrugBanki DB01169. Arsenic trioxide.
    DB00865. Benzphetamine.
    DB00290. Bleomycin.
    DB00356. Chlorzoxazone.
    DB00851. Dacarbazine.
    DB00970. Dactinomycin.
    DB00736. Esomeprazole.
    DB00655. Estrone.
    DB01095. Fluvastatin.
    DB00176. Fluvoxamine.
    DB01404. Ginseng.
    DB00889. Granisetron.
    DB01026. Ketoconazole.
    DB00170. Menadione.
    DB00466. Picrotoxin.
    DB01087. Primaquine.
    DB00908. Quinidine.
    DB00468. Quinine.
    DB00730. Thiabendazole.

    PTM databases

    PhosphoSitei P04798.

    Polymorphism databases

    DMDMi 117139.

    Proteomic databases

    MaxQBi P04798.
    PaxDbi P04798.
    PRIDEi P04798.

    Protocols and materials databases

    DNASUi 1543.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379727 ; ENSP00000369050 ; ENSG00000140465 . [P04798-1 ]
    ENST00000395048 ; ENSP00000378488 ; ENSG00000140465 . [P04798-1 ]
    ENST00000562201 ; ENSP00000455340 ; ENSG00000140465 . [P04798-2 ]
    ENST00000564596 ; ENSP00000457668 ; ENSG00000140465 . [P04798-3 ]
    ENST00000567032 ; ENSP00000456585 ; ENSG00000140465 . [P04798-1 ]
    ENST00000569630 ; ENSP00000455051 ; ENSG00000140465 . [P04798-2 ]
    GeneIDi 1543.
    KEGGi hsa:1543.
    UCSCi uc002ayp.4. human. [P04798-1 ]

    Organism-specific databases

    CTDi 1543.
    GeneCardsi GC15M075011.
    HGNCi HGNC:2595. CYP1A1.
    HPAi CAB018654.
    MIMi 108330. gene.
    neXtProti NX_P04798.
    PharmGKBi PA27092.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    InParanoidi P04798.
    KOi K07408.
    OMAi HLPYMEA.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P04798.
    TreeFami TF105095.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_13543. Xenobiotics.
    REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    SABIO-RK P04798.

    Miscellaneous databases

    ChiTaRSi CYP1A1. human.
    GeneWikii Cytochrome_P450,_family_1,_member_A1.
    GenomeRNAii 1543.
    NextBioi 35461723.
    PROi P04798.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P04798.
    Bgeei P04798.
    CleanExi HS_CYP1A1.
    Genevestigatori P04798.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism."
      Jaiswal A.K., Gonzales F.J., Nebert D.W.
      Nucleic Acids Res. 13:4503-4520(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence."
      Jaiswal A.K., Gonzalez F.J., Nebert D.W.
      Science 228:80-83(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Structure and drug inducibility of the human cytochrome P-450c gene."
      Kawajiri K., Watanabe J., Gotoh O., Tagashira Y., Sogawa K., Fujii-Kuriyama Y.
      Eur. J. Biochem. 159:219-225(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    4. "Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation."
      Corchero J., Pimprale S., Kimura S., Gonzalez F.J.
      Pharmacogenetics 11:1-6(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Cloning and sequencing of new alternative splicing variants of human CYP1A1 gene."
      Graebsch C., Bauer M.
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
      Tissue: Blood.
    6. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-45.
    7. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix.
    9. "Identification of cytochrome P450 1A1 in human brain."
      Yun C.H., Park H.J., Kim S.J., Kim H.K.
      Biochem. Biophys. Res. Commun. 243:808-810(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 282-425 (ISOFORM 1).
      Tissue: Brain.
    10. "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6."
      Quattrochi L.C., Okino S.T., Pendurthi U.R., Tukey R.H.
      DNA 4:395-400(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 295-484 (ISOFORM 1).
    11. "Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism."
      Walsh A.A., Szklarz G.D., Scott E.E.
      J. Biol. Chem. 288:12932-12943(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 35-512 IN COMPLEX WITH HEME AND INHIBITOR ALPHA-NAPHTOFLAVONE, COFACTOR.
    12. "Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene."
      Hayashi S., Watanabe J., Nakachi K., Kawajiri K.
      J. Biochem. 110:407-411(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT VAL-462.
    13. "A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility."
      Cascorbi I., Brockmoller J., Roots I.
      Cancer Res. 56:4965-4969(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ASN-461.
    14. "Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms."
      Smart J., Daly A.K.
      Pharmacogenetics 10:11-24(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT TRP-279.
    15. "Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population."
      Chevalier D., Allorge D., Lo-Guidice J.-M., Cauffiez C., Lhermitte M., Lafitte J.-J., Broly F.
      Hum. Mutat. 17:355-355(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ILE-331 AND SER-464.
    16. Cited for: VARIANTS ASN-448; CYS-464; TRP-477 AND ARG-492.
    17. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
      Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
      Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ASP-45; THR-78; TRP-93; ARG-173; ASN-461; MET-482 AND ARG-492.
    18. "Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus."
      Jiang Z., Dalton T.P., Jin L., Wang B., Tsuneoka Y., Shertzer H.G., Deka R., Nebert D.W.
      Hum. Mutat. 25:196-206(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ASP-45; THR-78; ASN-461 AND VAL-462.
    19. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-477.

    Entry informationi

    Entry nameiCP1A1_HUMAN
    AccessioniPrimary (citable) accession number: P04798
    Secondary accession number(s): A4F3V9, A4F3W0, Q53G18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 170 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3