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P04798

- CP1A1_HUMAN

UniProt

P04798 - CP1A1_HUMAN

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Protein

Cytochrome P450 1A1

Gene
CYP1A1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241Substrate
Metal bindingi457 – 4571Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. demethylase activity Source: Ensembl
  3. flavonoid 3'-monooxygenase activity Source: Ensembl
  4. heme binding Source: InterPro
  5. iron ion binding Source: InterPro
  6. oxidoreductase activity Source: BHF-UCL
  7. oxidoreductase activity, acting on diphenols and related substances as donors Source: Ensembl
  8. oxygen binding Source: ProtInc
  9. steroid hydroxylase activity Source: Ensembl
  10. vitamin D 24-hydroxylase activity Source: BHF-UCL

GO - Biological processi

  1. 9-cis-retinoic acid biosynthetic process Source: Ensembl
  2. aging Source: Ensembl
  3. amine metabolic process Source: Ensembl
  4. arachidonic acid metabolic process Source: Reactome
  5. camera-type eye development Source: Ensembl
  6. cell proliferation Source: Ensembl
  7. cellular lipid metabolic process Source: Reactome
  8. cellular response to organic cyclic compound Source: MGI
  9. coumarin metabolic process Source: Ensembl
  10. dibenzo-p-dioxin catabolic process Source: Ensembl
  11. digestive tract development Source: Ensembl
  12. drug metabolic process Source: BHF-UCL
  13. embryo development ending in birth or egg hatching Source: Ensembl
  14. epoxygenase P450 pathway Source: Reactome
  15. flavonoid metabolic process Source: Ensembl
  16. hepatocyte differentiation Source: Ensembl
  17. hydrogen peroxide biosynthetic process Source: Ensembl
  18. insecticide metabolic process Source: Ensembl
  19. maternal process involved in parturition Source: Ensembl
  20. omega-hydroxylase P450 pathway Source: Reactome
  21. oxidation-reduction process Source: BHF-UCL
  22. porphyrin-containing compound metabolic process Source: Ensembl
  23. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  24. response to antibiotic Source: Ensembl
  25. response to arsenic-containing substance Source: Ensembl
  26. response to drug Source: Ensembl
  27. response to food Source: Ensembl
  28. response to herbicide Source: Ensembl
  29. response to hyperoxia Source: Ensembl
  30. response to hypoxia Source: Ensembl
  31. response to iron(III) ion Source: Ensembl
  32. response to lipopolysaccharide Source: Ensembl
  33. response to nematode Source: Ensembl
  34. response to virus Source: Ensembl
  35. response to vitamin A Source: Ensembl
  36. response to wounding Source: Ensembl
  37. small molecule metabolic process Source: Reactome
  38. vitamin D metabolic process Source: BHF-UCL
  39. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.
REACT_13543. Xenobiotics.
REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
SABIO-RKP04798.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Cytochrome P450 form 6
Cytochrome P450-C
Cytochrome P450-P1
Gene namesi
Name:CYP1A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:2595. CYP1A1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Cytochrome P450 1A1PRO_0000051627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671O-linked (GlcNAc) By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP04798.
PaxDbiP04798.
PRIDEiP04798.

PTM databases

PhosphoSiteiP04798.

Expressioni

Tissue specificityi

Lung, lymphocytes and placenta.

Inductioni

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Gene expression databases

ArrayExpressiP04798.
BgeeiP04798.
CleanExiHS_CYP1A1.
GenevestigatoriP04798.

Organism-specific databases

HPAiCAB018654.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369050.

Structurei

Secondary structure

1
512
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni47 – 493
Helixi52 – 554
Helixi59 – 7012
Beta strandi72 – 787
Beta strandi81 – 866
Helixi89 – 968
Turni97 – 993
Helixi100 – 1034
Helixi110 – 1145
Helixi116 – 1183
Turni121 – 1233
Helixi129 – 14517
Helixi158 – 17922
Helixi186 – 20318
Helixi212 – 2187
Beta strandi219 – 2213
Helixi224 – 2285
Helixi233 – 2353
Helixi238 – 2425
Helixi246 – 27126
Helixi281 – 29212
Beta strandi296 – 2983
Beta strandi300 – 3023
Helixi304 – 3085
Helixi310 – 33425
Helixi337 – 35014
Helixi359 – 3646
Helixi366 – 37914
Beta strandi394 – 3963
Beta strandi399 – 4013
Beta strandi406 – 4105
Helixi411 – 4155
Turni418 – 4203
Helixi429 – 4324
Beta strandi435 – 4373
Helixi441 – 4444
Helixi453 – 4553
Helixi460 – 47718
Beta strandi478 – 4814
Beta strandi495 – 4973
Beta strandi506 – 5105

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I8VX-ray2.60A/B/C/D35-512[»]
ProteinModelPortaliP04798.
SMRiP04798. Positions 36-512.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP04798.
KOiK07408.
OMAiHLPYMEA.
OrthoDBiEOG7RBZ85.
PhylomeDBiP04798.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P04798-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG    50
HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG 100
DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD 150
PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA 200
ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA 250
FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV 300
QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV 350
IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY 400
IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFLTPDGAID KVLSEKVIIF 450
GMGKRKCIGE TIARWEVFLF LAILLQRVEF SVPLGVKVDM TPIYGLTMKH 500
ACCEHFQMQL RS 512
Length:512
Mass (Da):58,165
Last modified:April 1, 1988 - v1
Checksum:i3C62366044148EFD
GO
Isoform 2 (identifier: P04798-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-189: Y → T
     190-512: Missing.

Note: No experimental confirmation available.

Show »
Length:189
Mass (Da):20,788
Checksum:i6F774C4E9FC85427
GO
Isoform 3 (identifier: P04798-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-261: Missing.
     419-512: Missing.

Note: No experimental confirmation available.

Show »
Length:157
Mass (Da):18,441
Checksum:iD0AE3E0EEA55B854
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451G → D.3 Publications
Corresponds to variant rs4646422 [ dbSNP | Ensembl ].
VAR_023194
Natural varianti66 – 661M → V.
Corresponds to variant rs35035798 [ dbSNP | Ensembl ].
VAR_033817
Natural varianti78 – 781I → T.2 Publications
Corresponds to variant rs17861094 [ dbSNP | Ensembl ].
VAR_023195
Natural varianti93 – 931R → W.1 Publication
Corresponds to variant rs2229150 [ dbSNP | Ensembl ].
VAR_024706
Natural varianti173 – 1731T → R.1 Publication
Corresponds to variant rs28399427 [ dbSNP | Ensembl ].
VAR_024707
Natural varianti279 – 2791R → W.1 Publication
Corresponds to variant rs34260157 [ dbSNP | Ensembl ].
VAR_009280
Natural varianti286 – 2861I → T.
Corresponds to variant rs4987133 [ dbSNP | Ensembl ].
VAR_020122
Natural varianti331 – 3311M → I in allele CYP1A1*6. 1 Publication
Corresponds to variant rs56313657 [ dbSNP | Ensembl ].
VAR_016937
Natural varianti448 – 4481I → N in allele CYP1A1*8. 1 Publication
VAR_016938
Natural varianti461 – 4611T → N in allele CYP1A1*4. 3 Publications
Corresponds to variant rs1799814 [ dbSNP | Ensembl ].
VAR_008342
Natural varianti462 – 4621I → V in allele CYP1A1*2B and allele CYP1A1*2C. 2 Publications
Corresponds to variant rs1048943 [ dbSNP | Ensembl ].
VAR_001243
Natural varianti464 – 4641R → C in allele CYP1A1*9. 1 Publication
VAR_016939
Natural varianti464 – 4641R → S in allele CYP1A1*5. 1 Publication
Corresponds to variant rs41279188 [ dbSNP | Ensembl ].
VAR_016940
Natural varianti470 – 4701F → V.
Corresponds to variant rs36121583 [ dbSNP | Ensembl ].
VAR_033818
Natural varianti477 – 4771R → W in allele CYP1A1*10. 2 Publications
Corresponds to variant rs56240201 [ dbSNP | Ensembl ].
VAR_016941
Natural varianti482 – 4821V → M.1 Publication
Corresponds to variant rs28399429 [ dbSNP | Ensembl ].
VAR_024708
Natural varianti492 – 4921P → R in allele CYP1A1*11. 2 Publications
Corresponds to variant rs28399430 [ dbSNP | Ensembl ].
VAR_016942

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 261261Missing in isoform 3. VSP_053363Add
BLAST
Alternative sequencei189 – 1891Y → T in isoform 2. VSP_053364
Alternative sequencei190 – 512323Missing in isoform 2. VSP_053365Add
BLAST
Alternative sequencei419 – 51294Missing in isoform 3. VSP_053366Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261I → M in AAA52139. 1 Publication
Sequence conflicti235 – 2351D → E in AAA52139. 1 Publication
Sequence conflicti381 – 3811F → L in CAA26458. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02612 Genomic DNA. Translation: CAA26458.1.
K03191 mRNA. Translation: AAA52139.1.
X04300 Genomic DNA. Translation: CAA27843.1.
AF253322 Genomic DNA. Translation: AAK25727.1.
AM233518 mRNA. Translation: CAJ80721.1.
AM233519 mRNA. Translation: CAJ80722.1.
AM233520 mRNA. Translation: CAJ80723.1.
AK223113 mRNA. Translation: BAD96833.1.
AC091230 Genomic DNA. No translation available.
BC023019 mRNA. Translation: AAH23019.1.
M12079 mRNA. Translation: AAA52152.1.
AF040259 mRNA. Translation: AAD10199.1.
CCDSiCCDS10268.1. [P04798-1]
PIRiA24797. O4HU6.
RefSeqiNP_000490.1. NM_000499.3. [P04798-1]
XP_005254242.1. XM_005254185.1. [P04798-1]
UniGeneiHs.72912.

Genome annotation databases

EnsembliENST00000379727; ENSP00000369050; ENSG00000140465. [P04798-1]
ENST00000395048; ENSP00000378488; ENSG00000140465. [P04798-1]
ENST00000562201; ENSP00000455340; ENSG00000140465. [P04798-2]
ENST00000564596; ENSP00000457668; ENSG00000140465. [P04798-3]
ENST00000567032; ENSP00000456585; ENSG00000140465. [P04798-1]
ENST00000569630; ENSP00000455051; ENSG00000140465. [P04798-2]
GeneIDi1543.
KEGGihsa:1543.
UCSCiuc002ayp.4. human. [P04798-1]

Polymorphism databases

DMDMi117139.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP1A1 alleles

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

CYP1A1 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02612 Genomic DNA. Translation: CAA26458.1 .
K03191 mRNA. Translation: AAA52139.1 .
X04300 Genomic DNA. Translation: CAA27843.1 .
AF253322 Genomic DNA. Translation: AAK25727.1 .
AM233518 mRNA. Translation: CAJ80721.1 .
AM233519 mRNA. Translation: CAJ80722.1 .
AM233520 mRNA. Translation: CAJ80723.1 .
AK223113 mRNA. Translation: BAD96833.1 .
AC091230 Genomic DNA. No translation available.
BC023019 mRNA. Translation: AAH23019.1 .
M12079 mRNA. Translation: AAA52152.1 .
AF040259 mRNA. Translation: AAD10199.1 .
CCDSi CCDS10268.1. [P04798-1 ]
PIRi A24797. O4HU6.
RefSeqi NP_000490.1. NM_000499.3. [P04798-1 ]
XP_005254242.1. XM_005254185.1. [P04798-1 ]
UniGenei Hs.72912.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I8V X-ray 2.60 A/B/C/D 35-512 [» ]
ProteinModelPortali P04798.
SMRi P04798. Positions 36-512.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000369050.

Chemistry

BindingDBi P04798.
ChEMBLi CHEMBL2231.
DrugBanki DB01169. Arsenic trioxide.
DB00865. Benzphetamine.
DB00290. Bleomycin.
DB00356. Chlorzoxazone.
DB00851. Dacarbazine.
DB00970. Dactinomycin.
DB00736. Esomeprazole.
DB00655. Estrone.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB01404. Ginseng.
DB00889. Granisetron.
DB01026. Ketoconazole.
DB00170. Menadione.
DB00466. Picrotoxin.
DB01087. Primaquine.
DB00908. Quinidine.
DB00468. Quinine.
DB00730. Thiabendazole.

PTM databases

PhosphoSitei P04798.

Polymorphism databases

DMDMi 117139.

Proteomic databases

MaxQBi P04798.
PaxDbi P04798.
PRIDEi P04798.

Protocols and materials databases

DNASUi 1543.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379727 ; ENSP00000369050 ; ENSG00000140465 . [P04798-1 ]
ENST00000395048 ; ENSP00000378488 ; ENSG00000140465 . [P04798-1 ]
ENST00000562201 ; ENSP00000455340 ; ENSG00000140465 . [P04798-2 ]
ENST00000564596 ; ENSP00000457668 ; ENSG00000140465 . [P04798-3 ]
ENST00000567032 ; ENSP00000456585 ; ENSG00000140465 . [P04798-1 ]
ENST00000569630 ; ENSP00000455051 ; ENSG00000140465 . [P04798-2 ]
GeneIDi 1543.
KEGGi hsa:1543.
UCSCi uc002ayp.4. human. [P04798-1 ]

Organism-specific databases

CTDi 1543.
GeneCardsi GC15M075011.
HGNCi HGNC:2595. CYP1A1.
HPAi CAB018654.
MIMi 108330. gene.
neXtProti NX_P04798.
PharmGKBi PA27092.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi P04798.
KOi K07408.
OMAi HLPYMEA.
OrthoDBi EOG7RBZ85.
PhylomeDBi P04798.
TreeFami TF105095.

Enzyme and pathway databases

Reactomei REACT_116145. PPARA activates gene expression.
REACT_13543. Xenobiotics.
REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
SABIO-RK P04798.

Miscellaneous databases

ChiTaRSi CYP1A1. human.
GeneWikii Cytochrome_P450,_family_1,_member_A1.
GenomeRNAii 1543.
NextBioi 35461723.
PROi P04798.
SOURCEi Search...

Gene expression databases

ArrayExpressi P04798.
Bgeei P04798.
CleanExi HS_CYP1A1.
Genevestigatori P04798.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism."
    Jaiswal A.K., Gonzales F.J., Nebert D.W.
    Nucleic Acids Res. 13:4503-4520(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence."
    Jaiswal A.K., Gonzalez F.J., Nebert D.W.
    Science 228:80-83(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Structure and drug inducibility of the human cytochrome P-450c gene."
    Kawajiri K., Watanabe J., Gotoh O., Tagashira Y., Sogawa K., Fujii-Kuriyama Y.
    Eur. J. Biochem. 159:219-225(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  4. "Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation."
    Corchero J., Pimprale S., Kimura S., Gonzalez F.J.
    Pharmacogenetics 11:1-6(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Cloning and sequencing of new alternative splicing variants of human CYP1A1 gene."
    Graebsch C., Bauer M.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
    Tissue: Blood.
  6. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-45.
  7. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix.
  9. "Identification of cytochrome P450 1A1 in human brain."
    Yun C.H., Park H.J., Kim S.J., Kim H.K.
    Biochem. Biophys. Res. Commun. 243:808-810(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 282-425 (ISOFORM 1).
    Tissue: Brain.
  10. "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6."
    Quattrochi L.C., Okino S.T., Pendurthi U.R., Tukey R.H.
    DNA 4:395-400(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 295-484 (ISOFORM 1).
  11. "Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism."
    Walsh A.A., Szklarz G.D., Scott E.E.
    J. Biol. Chem. 288:12932-12943(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 35-512 IN COMPLEX WITH HEME AND INHIBITOR ALPHA-NAPHTOFLAVONE, COFACTOR.
  12. "Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene."
    Hayashi S., Watanabe J., Nakachi K., Kawajiri K.
    J. Biochem. 110:407-411(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT VAL-462.
  13. "A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility."
    Cascorbi I., Brockmoller J., Roots I.
    Cancer Res. 56:4965-4969(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-461.
  14. "Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms."
    Smart J., Daly A.K.
    Pharmacogenetics 10:11-24(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TRP-279.
  15. "Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population."
    Chevalier D., Allorge D., Lo-Guidice J.-M., Cauffiez C., Lhermitte M., Lafitte J.-J., Broly F.
    Hum. Mutat. 17:355-355(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ILE-331 AND SER-464.
  16. Cited for: VARIANTS ASN-448; CYS-464; TRP-477 AND ARG-492.
  17. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
    Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
    Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASP-45; THR-78; TRP-93; ARG-173; ASN-461; MET-482 AND ARG-492.
  18. "Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus."
    Jiang Z., Dalton T.P., Jin L., Wang B., Tsuneoka Y., Shertzer H.G., Deka R., Nebert D.W.
    Hum. Mutat. 25:196-206(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASP-45; THR-78; ASN-461 AND VAL-462.
  19. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-477.

Entry informationi

Entry nameiCP1A1_HUMAN
AccessioniPrimary (citable) accession number: P04798
Secondary accession number(s): A4F3V9, A4F3W0, Q53G18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: April 1, 1988
Last modified: September 3, 2014
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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