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Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

heme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei224Substrate1 Publication1
Metal bindingi457Iron (heme axial ligand)1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS06721-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-211981. Xenobiotics.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP04798.

Chemistry databases

SwissLipidsiSLP:000001329.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Cytochrome P450 form 6
Cytochrome P450-C
Cytochrome P450-P1
Gene namesi
Name:CYP1A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:2595. CYP1A1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1543.
OpenTargetsiENSG00000140465.
PharmGKBiPA27092.

Chemistry databases

ChEMBLiCHEMBL2231.
DrugBankiDB00316. Acetaminophen.
DB00518. Albendazole.
DB01118. Amiodarone.
DB00381. Amlodipine.
DB00613. Amodiaquine.
DB01169. Arsenic trioxide.
DB00972. Azelastine.
DB06770. Benzyl alcohol.
DB01393. Bezafibrate.
DB00188. Bortezomib.
DB00201. Caffeine.
DB01136. Carvedilol.
DB00608. Chloroquine.
DB00356. Chlorzoxazone.
DB00169. Cholecalciferol.
DB00568. Cinnarizine.
DB01407. Clenbuterol.
DB01013. Clobetasol propionate.
DB00636. Clofibrate.
DB00882. Clomifene.
DB00575. Clonidine.
DB00363. Clozapine.
DB00851. Dacarbazine.
DB06292. Dapagliflozin.
DB01254. Dasatinib.
DB00694. Daunorubicin.
DB04840. Debrisoquin.
DB01234. Dexamethasone.
DB00633. Dexmedetomidine.
DB00586. Diclofenac.
DB00804. Dicyclomine.
DB00470. Dronabinol.
DB00530. Erlotinib.
DB00783. Estradiol.
DB00655. Estrone.
DB00898. Ethanol.
DB04841. Flunarizine.
DB00693. Fluorescein.
DB00499. Flutamide.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB00317. Gefitinib.
DB00889. Granisetron.
DB00502. Haloperidol.
DB01064. Isoprenaline.
DB01167. Itraconazole.
DB01026. Ketoconazole.
DB00448. Lansoprazole.
DB04871. Lorcaserin.
DB00643. Mebendazole.
DB01065. Melatonin.
DB00170. Menadione.
DB00553. Methoxsalen.
DB00184. Nicotine.
DB01115. Nifedipine.
DB00325. Nitroprusside.
DB01059. Norfloxacin.
DB00338. Omeprazole.
DB01092. Ouabain.
DB00526. Oxaliplatin.
DB00738. Pentamidine.
DB01174. Phenobarbital.
DB00457. Prazosin.
DB01087. Primaquine.
DB00396. Progesterone.
DB00818. Propofol.
DB00571. Propranolol.
DB00165. Pyridoxine.
DB00908. Quinidine.
DB00468. Quinine.
DB01129. Rabeprazole.
DB00740. Riluzole.
DB08931. Riociguat.
DB06176. Romidepsin.
DB00203. Sildenafil.
DB00428. Streptozocin.
DB00605. Sulindac.
DB00675. Tamoxifen.
DB00624. Testosterone.
DB01041. Thalidomide.
DB00277. Theophylline.
DB00730. Thiabendazole.
DB00208. Ticlopidine.
DB00539. Toremifene.
DB00755. Tretinoin.
DB00162. Vitamin A.
DB00682. Warfarin.
GuidetoPHARMACOLOGYi1318.

Polymorphism and mutation databases

BioMutaiCYP1A1.
DMDMi117139.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516271 – 512Cytochrome P450 1A1Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67O-linked (GlcNAc)By similarity1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP04798.
PaxDbiP04798.
PeptideAtlasiP04798.
PRIDEiP04798.

PTM databases

iPTMnetiP04798.
PhosphoSitePlusiP04798.

Expressioni

Tissue specificityi

Lung, lymphocytes and placenta.

Inductioni

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Gene expression databases

BgeeiENSG00000140465.
CleanExiHS_CYP1A1.
ExpressionAtlasiP04798. baseline and differential.
GenevisibleiP04798. HS.

Organism-specific databases

HPAiCAB018654.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CMTM5Q96DZ93EBI-10194262,EBI-2548702

Protein-protein interaction databases

BioGridi107923. 70 interactors.
IntActiP04798. 1 interactor.
STRINGi9606.ENSP00000369050.

Chemistry databases

BindingDBiP04798.

Structurei

Secondary structure

1512
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni47 – 49Combined sources3
Helixi52 – 55Combined sources4
Helixi59 – 70Combined sources12
Beta strandi72 – 78Combined sources7
Beta strandi81 – 86Combined sources6
Helixi89 – 96Combined sources8
Turni97 – 99Combined sources3
Helixi100 – 103Combined sources4
Helixi110 – 114Combined sources5
Helixi116 – 118Combined sources3
Turni121 – 123Combined sources3
Helixi129 – 145Combined sources17
Helixi158 – 179Combined sources22
Helixi186 – 203Combined sources18
Helixi212 – 218Combined sources7
Beta strandi219 – 221Combined sources3
Helixi224 – 228Combined sources5
Helixi233 – 235Combined sources3
Helixi238 – 242Combined sources5
Helixi246 – 271Combined sources26
Helixi281 – 292Combined sources12
Beta strandi296 – 298Combined sources3
Beta strandi300 – 302Combined sources3
Helixi304 – 308Combined sources5
Helixi310 – 334Combined sources25
Helixi337 – 350Combined sources14
Helixi359 – 364Combined sources6
Helixi366 – 379Combined sources14
Beta strandi394 – 396Combined sources3
Beta strandi399 – 401Combined sources3
Beta strandi406 – 410Combined sources5
Helixi411 – 415Combined sources5
Turni418 – 420Combined sources3
Helixi429 – 432Combined sources4
Beta strandi435 – 437Combined sources3
Helixi441 – 444Combined sources4
Helixi453 – 455Combined sources3
Helixi460 – 477Combined sources18
Beta strandi478 – 481Combined sources4
Beta strandi495 – 497Combined sources3
Beta strandi506 – 510Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I8VX-ray2.60A/B/C/D35-512[»]
ProteinModelPortaliP04798.
SMRiP04798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP04798.
KOiK07408.
OMAiRYDHNHQ.
OrthoDBiEOG091G0BT8.
PhylomeDBiP04798.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P04798-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG
60 70 80 90 100
HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG
110 120 130 140 150
DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD
160 170 180 190 200
PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA
210 220 230 240 250
ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA
260 270 280 290 300
FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV
310 320 330 340 350
QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV
360 370 380 390 400
IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY
410 420 430 440 450
IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFLTPDGAID KVLSEKVIIF
460 470 480 490 500
GMGKRKCIGE TIARWEVFLF LAILLQRVEF SVPLGVKVDM TPIYGLTMKH
510
ACCEHFQMQL RS
Length:512
Mass (Da):58,165
Last modified:April 1, 1988 - v1
Checksum:i3C62366044148EFD
GO
Isoform 2 (identifier: P04798-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-189: Y → T
     190-512: Missing.

Note: No experimental confirmation available.
Show »
Length:189
Mass (Da):20,788
Checksum:i6F774C4E9FC85427
GO
Isoform 3 (identifier: P04798-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-261: Missing.
     419-512: Missing.

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):18,441
Checksum:iD0AE3E0EEA55B854
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26I → M in AAA52139 (PubMed:3838385).Curated1
Sequence conflicti235D → E in AAA52139 (PubMed:3838385).Curated1
Sequence conflicti381F → L in CAA26458 (PubMed:2989797).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02319445G → D.3 PublicationsCorresponds to variant rs4646422dbSNPEnsembl.1
Natural variantiVAR_03381766M → V.Corresponds to variant rs35035798dbSNPEnsembl.1
Natural variantiVAR_02319578I → T.2 PublicationsCorresponds to variant rs17861094dbSNPEnsembl.1
Natural variantiVAR_02470693R → W.1 PublicationCorresponds to variant rs2229150dbSNPEnsembl.1
Natural variantiVAR_024707173T → R.1 PublicationCorresponds to variant rs28399427dbSNPEnsembl.1
Natural variantiVAR_009280279R → W.1 PublicationCorresponds to variant rs34260157dbSNPEnsembl.1
Natural variantiVAR_020122286I → T.Corresponds to variant rs4987133dbSNPEnsembl.1
Natural variantiVAR_016937331M → I in allele CYP1A1*6. 1 PublicationCorresponds to variant rs56313657dbSNPEnsembl.1
Natural variantiVAR_016938448I → N in allele CYP1A1*8. 1 PublicationCorresponds to variant rs72547509dbSNPEnsembl.1
Natural variantiVAR_008342461T → N in allele CYP1A1*4. 3 PublicationsCorresponds to variant rs1799814dbSNPEnsembl.1
Natural variantiVAR_001243462I → V in allele CYP1A1*2B and allele CYP1A1*2C. 2 PublicationsCorresponds to variant rs1048943dbSNPEnsembl.1
Natural variantiVAR_016939464R → C in allele CYP1A1*9. 1 PublicationCorresponds to variant rs41279188dbSNPEnsembl.1
Natural variantiVAR_016940464R → S in allele CYP1A1*5. 1 PublicationCorresponds to variant rs41279188dbSNPEnsembl.1
Natural variantiVAR_033818470F → V.Corresponds to variant rs36121583dbSNPEnsembl.1
Natural variantiVAR_016941477R → W in allele CYP1A1*10. 2 PublicationsCorresponds to variant rs56240201dbSNPEnsembl.1
Natural variantiVAR_024708482V → M.1 PublicationCorresponds to variant rs28399429dbSNPEnsembl.1
Natural variantiVAR_016942492P → R in allele CYP1A1*11. 2 PublicationsCorresponds to variant rs28399430dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0533631 – 261Missing in isoform 3. 1 PublicationAdd BLAST261
Alternative sequenceiVSP_053364189Y → T in isoform 2. 1 Publication1
Alternative sequenceiVSP_053365190 – 512Missing in isoform 2. 1 PublicationAdd BLAST323
Alternative sequenceiVSP_053366419 – 512Missing in isoform 3. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02612 Genomic DNA. Translation: CAA26458.1.
K03191 mRNA. Translation: AAA52139.1.
X04300 Genomic DNA. Translation: CAA27843.1.
AF253322 Genomic DNA. Translation: AAK25727.1.
AM233518 mRNA. Translation: CAJ80721.1.
AM233519 mRNA. Translation: CAJ80722.1.
AM233520 mRNA. Translation: CAJ80723.1.
AK223113 mRNA. Translation: BAD96833.1.
AC091230 Genomic DNA. No translation available.
BC023019 mRNA. Translation: AAH23019.1.
M12079 mRNA. Translation: AAA52152.1.
AF040259 mRNA. Translation: AAD10199.1.
CCDSiCCDS10268.1. [P04798-1]
PIRiA24797. O4HU6.
RefSeqiNP_000490.1. NM_000499.4. [P04798-1]
NP_001306145.1. NM_001319216.1.
NP_001306146.1. NM_001319217.1. [P04798-1]
UniGeneiHs.72912.

Genome annotation databases

EnsembliENST00000379727; ENSP00000369050; ENSG00000140465. [P04798-1]
ENST00000395048; ENSP00000378488; ENSG00000140465. [P04798-1]
ENST00000562201; ENSP00000455340; ENSG00000140465. [P04798-2]
ENST00000564596; ENSP00000457668; ENSG00000140465. [P04798-3]
ENST00000567032; ENSP00000456585; ENSG00000140465. [P04798-1]
ENST00000569630; ENSP00000455051; ENSG00000140465. [P04798-2]
GeneIDi1543.
KEGGihsa:1543.
UCSCiuc002ayp.4. human. [P04798-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP1A1 alleles

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

CYP1A1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02612 Genomic DNA. Translation: CAA26458.1.
K03191 mRNA. Translation: AAA52139.1.
X04300 Genomic DNA. Translation: CAA27843.1.
AF253322 Genomic DNA. Translation: AAK25727.1.
AM233518 mRNA. Translation: CAJ80721.1.
AM233519 mRNA. Translation: CAJ80722.1.
AM233520 mRNA. Translation: CAJ80723.1.
AK223113 mRNA. Translation: BAD96833.1.
AC091230 Genomic DNA. No translation available.
BC023019 mRNA. Translation: AAH23019.1.
M12079 mRNA. Translation: AAA52152.1.
AF040259 mRNA. Translation: AAD10199.1.
CCDSiCCDS10268.1. [P04798-1]
PIRiA24797. O4HU6.
RefSeqiNP_000490.1. NM_000499.4. [P04798-1]
NP_001306145.1. NM_001319216.1.
NP_001306146.1. NM_001319217.1. [P04798-1]
UniGeneiHs.72912.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I8VX-ray2.60A/B/C/D35-512[»]
ProteinModelPortaliP04798.
SMRiP04798.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107923. 70 interactors.
IntActiP04798. 1 interactor.
STRINGi9606.ENSP00000369050.

Chemistry databases

BindingDBiP04798.
ChEMBLiCHEMBL2231.
DrugBankiDB00316. Acetaminophen.
DB00518. Albendazole.
DB01118. Amiodarone.
DB00381. Amlodipine.
DB00613. Amodiaquine.
DB01169. Arsenic trioxide.
DB00972. Azelastine.
DB06770. Benzyl alcohol.
DB01393. Bezafibrate.
DB00188. Bortezomib.
DB00201. Caffeine.
DB01136. Carvedilol.
DB00608. Chloroquine.
DB00356. Chlorzoxazone.
DB00169. Cholecalciferol.
DB00568. Cinnarizine.
DB01407. Clenbuterol.
DB01013. Clobetasol propionate.
DB00636. Clofibrate.
DB00882. Clomifene.
DB00575. Clonidine.
DB00363. Clozapine.
DB00851. Dacarbazine.
DB06292. Dapagliflozin.
DB01254. Dasatinib.
DB00694. Daunorubicin.
DB04840. Debrisoquin.
DB01234. Dexamethasone.
DB00633. Dexmedetomidine.
DB00586. Diclofenac.
DB00804. Dicyclomine.
DB00470. Dronabinol.
DB00530. Erlotinib.
DB00783. Estradiol.
DB00655. Estrone.
DB00898. Ethanol.
DB04841. Flunarizine.
DB00693. Fluorescein.
DB00499. Flutamide.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB00317. Gefitinib.
DB00889. Granisetron.
DB00502. Haloperidol.
DB01064. Isoprenaline.
DB01167. Itraconazole.
DB01026. Ketoconazole.
DB00448. Lansoprazole.
DB04871. Lorcaserin.
DB00643. Mebendazole.
DB01065. Melatonin.
DB00170. Menadione.
DB00553. Methoxsalen.
DB00184. Nicotine.
DB01115. Nifedipine.
DB00325. Nitroprusside.
DB01059. Norfloxacin.
DB00338. Omeprazole.
DB01092. Ouabain.
DB00526. Oxaliplatin.
DB00738. Pentamidine.
DB01174. Phenobarbital.
DB00457. Prazosin.
DB01087. Primaquine.
DB00396. Progesterone.
DB00818. Propofol.
DB00571. Propranolol.
DB00165. Pyridoxine.
DB00908. Quinidine.
DB00468. Quinine.
DB01129. Rabeprazole.
DB00740. Riluzole.
DB08931. Riociguat.
DB06176. Romidepsin.
DB00203. Sildenafil.
DB00428. Streptozocin.
DB00605. Sulindac.
DB00675. Tamoxifen.
DB00624. Testosterone.
DB01041. Thalidomide.
DB00277. Theophylline.
DB00730. Thiabendazole.
DB00208. Ticlopidine.
DB00539. Toremifene.
DB00755. Tretinoin.
DB00162. Vitamin A.
DB00682. Warfarin.
GuidetoPHARMACOLOGYi1318.
SwissLipidsiSLP:000001329.

PTM databases

iPTMnetiP04798.
PhosphoSitePlusiP04798.

Polymorphism and mutation databases

BioMutaiCYP1A1.
DMDMi117139.

Proteomic databases

MaxQBiP04798.
PaxDbiP04798.
PeptideAtlasiP04798.
PRIDEiP04798.

Protocols and materials databases

DNASUi1543.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379727; ENSP00000369050; ENSG00000140465. [P04798-1]
ENST00000395048; ENSP00000378488; ENSG00000140465. [P04798-1]
ENST00000562201; ENSP00000455340; ENSG00000140465. [P04798-2]
ENST00000564596; ENSP00000457668; ENSG00000140465. [P04798-3]
ENST00000567032; ENSP00000456585; ENSG00000140465. [P04798-1]
ENST00000569630; ENSP00000455051; ENSG00000140465. [P04798-2]
GeneIDi1543.
KEGGihsa:1543.
UCSCiuc002ayp.4. human. [P04798-1]

Organism-specific databases

CTDi1543.
DisGeNETi1543.
GeneCardsiCYP1A1.
HGNCiHGNC:2595. CYP1A1.
HPAiCAB018654.
MIMi108330. gene.
neXtProtiNX_P04798.
OpenTargetsiENSG00000140465.
PharmGKBiPA27092.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP04798.
KOiK07408.
OMAiRYDHNHQ.
OrthoDBiEOG091G0BT8.
PhylomeDBiP04798.
TreeFamiTF105095.

Enzyme and pathway databases

BioCyciZFISH:HS06721-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-211981. Xenobiotics.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP04798.

Miscellaneous databases

ChiTaRSiCYP1A1. human.
GeneWikiiCytochrome_P450,_family_1,_member_A1.
GenomeRNAii1543.
PROiP04798.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140465.
CleanExiHS_CYP1A1.
ExpressionAtlasiP04798. baseline and differential.
GenevisibleiP04798. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP1A1_HUMAN
AccessioniPrimary (citable) accession number: P04798
Secondary accession number(s): A4F3V9, A4F3W0, Q53G18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 192 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.