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P04774

- SCN1A_RAT

UniProt

P04774 - SCN1A_RAT

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Protein
Sodium channel protein type 1 subunit alpha
Gene
Scn1a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. sodium ion binding Source: RGD
  2. voltage-gated sodium channel activity Source: RGD

GO - Biological processi

  1. membrane depolarization during action potential Source: RefGenome
  2. neuronal action potential Source: RGD
  3. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 1 subunit alpha
Alternative name(s):
Sodium channel protein brain I subunit alpha
Sodium channel protein type I subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.1
Gene namesi
Name:Scn1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi69364. Scn1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 123123Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei124 – 14724Helical; Name=S1 of repeat I
Add
BLAST
Topological domaini148 – 1558Extracellular Reviewed prediction
Transmembranei156 – 17520Helical; Name=S2 of repeat I
Add
BLAST
Topological domaini176 – 18813Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei189 – 20719Helical; Name=S3 of repeat I
Add
BLAST
Topological domaini208 – 2136Extracellular Reviewed prediction
Transmembranei214 – 23320Helical; Voltage-sensor; Name=S4 of repeat I
Add
BLAST
Topological domaini234 – 24916Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei250 – 27324Helical; Name=S5 of repeat I
Add
BLAST
Topological domaini274 – 399126Extracellular Reviewed prediction
Add
BLAST
Transmembranei400 – 42526Helical; Name=S6 of repeat I
Add
BLAST
Topological domaini426 – 762337Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei763 – 78725Helical; Name=S1 of repeat II
Add
BLAST
Topological domaini788 – 79811Extracellular Reviewed prediction
Add
BLAST
Transmembranei799 – 82224Helical; Name=S2 of repeat II
Add
BLAST
Topological domaini823 – 8308Cytoplasmic Reviewed prediction
Transmembranei831 – 85020Helical; Name=S3 of repeat II
Add
BLAST
Topological domaini851 – 8566Extracellular Reviewed prediction
Transmembranei857 – 87620Helical; Voltage-sensor; Name=S4 of repeat II
Add
BLAST
Topological domaini877 – 89216Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei893 – 91321Helical; Name=S5 of repeat II
Add
BLAST
Topological domaini914 – 96653Extracellular Reviewed prediction
Add
BLAST
Transmembranei967 – 99226Helical; Name=S6 of repeat II
Add
BLAST
Topological domaini993 – 1213221Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1214 – 123724Helical; Name=S1 of repeat III
Add
BLAST
Topological domaini1238 – 125013Extracellular Reviewed prediction
Add
BLAST
Transmembranei1251 – 127626Helical; Name=S2 of repeat III
Add
BLAST
Topological domaini1277 – 12826Cytoplasmic Reviewed prediction
Transmembranei1283 – 130422Helical; Name=S3 of repeat III
Add
BLAST
Topological domaini1305 – 13084Extracellular Reviewed prediction
Transmembranei1309 – 133022Helical; Voltage-sensor; Name=S4 of repeat III
Add
BLAST
Topological domaini1331 – 134919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1350 – 137728Helical; Name=S5 of repeat III
Add
BLAST
Topological domaini1378 – 145679Extracellular Reviewed prediction
Add
BLAST
Transmembranei1457 – 148327Helical; Name=S6 of repeat III
Add
BLAST
Topological domaini1484 – 153653Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1537 – 156024Helical; Name=S1 of repeat IV
Add
BLAST
Topological domaini1561 – 157111Extracellular Reviewed prediction
Add
BLAST
Transmembranei1572 – 159524Helical; Name=S2 of repeat IV
Add
BLAST
Topological domaini1596 – 16016Cytoplasmic Reviewed prediction
Transmembranei1602 – 162524Helical; Name=S3 of repeat IV
Add
BLAST
Topological domaini1626 – 163510Extracellular Reviewed prediction
Transmembranei1636 – 165722Helical; Voltage-sensor; Name=S4 of repeat IV
Add
BLAST
Topological domaini1658 – 167215Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1673 – 169523Helical; Name=S5 of repeat IV
Add
BLAST
Topological domaini1696 – 176166Extracellular Reviewed prediction
Add
BLAST
Transmembranei1762 – 178625Helical; Name=S6 of repeat IV
Add
BLAST
Topological domaini1787 – 2009223Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Z disc Source: BHF-UCL
  2. plasma membrane Source: RGD
  3. voltage-gated sodium channel complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20092009Sodium channel protein type 1 subunit alpha
PRO_0000048490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi211 – 2111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi284 – 2841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi295 – 2951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi306 – 3061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi338 – 3381N-linked (GlcNAc...) Reviewed prediction
Modified residuei470 – 4701Phosphoserine1 Publication
Modified residuei551 – 5511Phosphoserine1 Publication
Modified residuei607 – 6071Phosphoserine1 Publication
Glycosylationi1378 – 13781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1392 – 13921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1403 – 14031N-linked (GlcNAc...) Reviewed prediction
Modified residuei1516 – 15161Phosphoserine; by PKC By similarity

Post-translational modificationi

Phosphorylation at Ser-1516 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP04774.
PRIDEiP04774.

Expressioni

Gene expression databases

GenevestigatoriP04774.

Interactioni

Subunit structurei

The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with FGF13; may regulate SCN1A activity By similarity.

Protein-protein interaction databases

BioGridi249530. 1 interaction.
STRINGi10116.ENSRNOP00000051071.

Structurei

3D structure databases

ProteinModelPortaliP04774.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati110 – 454345I
Add
BLAST
Repeati750 – 1022273II
Add
BLAST
Repeati1200 – 1514315III
Add
BLAST
Repeati1523 – 1821299IV
Add
BLAST
Domaini1915 – 194430IQ
Add
BLAST

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04833.
PhylomeDBiP04774.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008051. Na_channel_a1su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
PR01664. NACHANNEL1.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04774-1 [UniParc]FASTAAdd to Basket

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MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK     50
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF 100
RFSATSALYI LTPFNPLRKI AIKILVHSLF SMLIMCTILT NCVFMTMSNP 150
PDWTKNVEYT FTGIYTFESL IKIIARGFCL EDFTFLRDPW NWLDFTVITF 200
AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV 250
MILTVFCLSV FALIGLQLFM GNLRNKCVQW PPTNASLEEH SIEKNVTTDY 300
NGTLVNETVF EFDWKSYIQD SRYHYFLEGV LDALLCGNSS DAGQCPEGYM 350
CVKAGRNPNY GYTSFDTFSW AFLSLFRLMT QDFWENLYQL TLRAAGKTYM 400
IFFVLVIFLG SFYLINLILA VVAMAYEEQN QATLEEAEQK EAEFQQMLEQ 450
LKKQQEAAQQ AAAATASEHS REPSAAGRLS DSSSEASKLS SKSAKERRNR 500
RKKRKQKEQS GGEEKDDDEF HKSESEDSIR RKGFRFSIEG NRLTYEKRYS 550
SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF ADDEHSTFED 600
NESRRDSLFV PRRHGERRNS NLSQTSRSSR MLAGLPANGK MHSTVDCNGV 650
VSLVGGPSVP TSPVGQLLPE VIIDKPATDD NGTTTETEMR KRRSSSFHVS 700
MDFLEDPSQR QRAMSIASIL TNTVEELEES RQKCPPCWYK FSNIFLIWDC 750
SPYWLKVKHI VNLVVMDPFV DLAITICIVL NTLFMAMEHY PMTEHFNHVL 800
TVGNLVFTGI FTAEMFLKII AMDPYYYFQE GWNIFDGFIV TLSLVELGLA 850
NVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII 900
VFIFAVVGMQ LFGKSYKDCV CKIATDCKLP RWHMNDFFHS FLIVFRVLCG 950
EWIETMWDCM EVAGQAMCLT VFMMVMVIRN LVVLNLFLAL LLSSFSADNL 1000
AATDDDNEMN NLQIAVDRMH KGVAYVKRKI YEFIQQSFVR KQKILDEIKP 1050
LDDLNNRKDN CTSNHTTEIG KDLDCLKDVN GTTSGIGTGS SVEKYIIDES 1100
DYMSFINNPS LTVTVPIAVG ESDFENLNTE DFSSESDLEE SKEKLNESSS 1150
SSEGSTVDIG APAEEQPVME PEETLEPEAC FTEGCVQRFK CCQISVEEGR 1200
GKQWWNLRRT CFRIVEHNWF ETFIVFMILL SSGALAFEDI YIDQRKTIKT 1250
MLEYADKVFT YIFILEMLLK WVAYGYQTYF TNAWCWLDFL IVDVSLVSLT 1300
ANALGYSELG AIKSLRTLRA LRPLRALSRF EGMRVVVNAL LGAIPSIMNV 1350
LLVCLIFWLI FSIMGVNLFA GKFYHCVNTT TGDTFEITEV NNHSDCLKLI 1400
ERNETARWKN VKVNFDNVGF GYLSLLQVAT FKGWMDIMYA AVDSRNVELQ 1450
PKYEESLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM 1500
TEEQKKYYNA MKKLGSKKPQ KPIPRPGNKF QGMVFDFVTR QVFDISIMIL 1550
ICLNMVTMMV ETDDQSDYVT SILSRINLVF IVLFTGECVL KLISLRHYYF 1600
TIGWNIFDFV VVILSIVGMF LAELIEKYFV SPTLFRVIRL ARIGRILRLI 1650
KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKREVG 1700
IDDMFNFETF GNSMICLFQI TTSAGWDGLL APILNSKPPD CDPNKVNPGS 1750
SVKGDCGNPS VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL 1800
SEDDFEMFYE VWEKFDPDAT QFMEFEKLSQ FAAALEPPLN LPQPNKLQLI 1850
AMDLPMVSGD RIHCLDILFA FTKRVLGESG EMDALRIQME ERFMASNPSK 1900
VSYQPITTTL KRKQEEVSAV IIQRAYRRHL LKRTVKQASF TYNKNKLKGG 1950
ANLLVKEDMI IDRINENSIT EKTDLTMSTA ACPPSYDRVT KPIVEKHEQE 2000
GKDEKAKGK 2009
Length:2,009
Mass (Da):228,770
Last modified:August 13, 1987 - v1
Checksum:i6808466F6368373B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03638 mRNA. Translation: CAA27286.1.
M22253 mRNA. Translation: AAA79965.1.
PIRiA25019.
RefSeqiNP_110502.1. NM_030875.1.
UniGeneiRn.32079.

Genome annotation databases

GeneIDi81574.
KEGGirno:81574.
UCSCiRGD:69364. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03638 mRNA. Translation: CAA27286.1 .
M22253 mRNA. Translation: AAA79965.1 .
PIRi A25019.
RefSeqi NP_110502.1. NM_030875.1.
UniGenei Rn.32079.

3D structure databases

ProteinModelPortali P04774.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249530. 1 interaction.
STRINGi 10116.ENSRNOP00000051071.

Chemistry

BindingDBi P04774.
ChEMBLi CHEMBL4906.
GuidetoPHARMACOLOGYi 578.

Proteomic databases

PaxDbi P04774.
PRIDEi P04774.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81574.
KEGGi rno:81574.
UCSCi RGD:69364. rat.

Organism-specific databases

CTDi 6323.
RGDi 69364. Scn1a.

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231755.
HOVERGENi HBG053100.
KOi K04833.
PhylomeDBi P04774.

Miscellaneous databases

NextBioi 615093.
PROi P04774.

Gene expression databases

Genevestigatori P04774.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR008051. Na_channel_a1su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
PR01664. NACHANNEL1.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Existence of distinct sodium channel messenger RNAs in rat brain."
    Noda M., Ikeda T., Kayano T., Suzuki H., Takeshima H., Kurasaki M., Takahashi H., Numa S.
    Nature 320:188-192(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and function of sodium channel."
    Noda M., Numa S.
    J. Recept. Res. 7:467-497(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAs."
    Sarao R., Gupta S.K., Auld V.J., Dunn R.J.
    Nucleic Acids Res. 19:5673-5679(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 177-253.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "Multisite phosphorylation of voltage-gated sodium channel alpha subunits from rat brain."
    Berendt F.J., Park K.S., Trimmer J.S.
    J. Proteome Res. 9:1976-1984(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-470; SER-551 AND SER-607.

Entry informationi

Entry nameiSCN1A_RAT
AccessioniPrimary (citable) accession number: P04774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 11, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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