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P04772

- GLNA2_BRADU

UniProt

P04772 - GLNA2_BRADU

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Protein

Glutamine synthetase 2

Gene

glnII

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Nitrogen fixation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-4195-MONOMER.
RETL1328306-WGS:GSTH-3150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase 2 (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase II
Glutamine synthetase II
Short name:
GSII
Gene namesi
Name:glnII
Ordered Locus Names:blr4169
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Glutamine synthetase 2PRO_0000153220Add
BLAST

Interactioni

Subunit structurei

Homooctamer.

Protein-protein interaction databases

STRINGi224911.blr4169.

Structurei

3D structure databases

ProteinModelPortaliP04772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000061500.
InParanoidiP04772.
KOiK01915.
OrthoDBiEOG6K3ZXS.
PhylomeDBiP04772.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04772-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKYKLEYIW LDGYTPTPNL RGKTQIKEFA SFPTLEQLPL WGFDGSSTQQ
60 70 80 90 100
AEGHSSDCVL KPVAVFPDAA RTNGVLVMCE VMMPDGKTPH ASNKRATILD
110 120 130 140 150
DAGAWFGFEQ EYFFYKDGRP LGFPTSGYPA PQGPYYTGVG FSNVGDVARK
160 170 180 190 200
IVEEHLDLCL AAGINHEGIN AEVAKGQWEF QIFGKGSKKA ADEMWMARYL
210 220 230 240 250
MLRLTEKYGI DIEFHCKPLG DTDWNGSGMH ANFSTEYMRT VGGKEYFEAL
260 270 280 290 300
MAAFDKNLMD HIAVYGPDND KRLTGKHETA PWNKFSYGVA DRGASIRVPH
310 320 330 340
SFVNNGYKGY LEDRRPNSQG DPYQIASQIL KTISSVPTEK KAVA
Length:344
Mass (Da):38,366
Last modified:February 28, 2003 - v2
Checksum:i5462522D03DC51B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 382QL → HV in CAA27779. 1 PublicationCurated
Sequence conflicti326 – 34419ASQIL…KKAVA → VRRS in CAA27779. 1 PublicationCuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04187 Genomic DNA. Translation: CAA27779.1.
BA000040 Genomic DNA. Translation: BAC49434.1.
PIRiA24155. AJZJQ2.
RefSeqiNP_770809.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC49434; BAC49434; BAC49434.
GeneIDi1054220.
KEGGibja:blr4169.
PATRICi21191856. VBIBraJap65052_4184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04187 Genomic DNA. Translation: CAA27779.1 .
BA000040 Genomic DNA. Translation: BAC49434.1 .
PIRi A24155. AJZJQ2.
RefSeqi NP_770809.1. NC_004463.1.

3D structure databases

ProteinModelPortali P04772.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.blr4169.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC49434 ; BAC49434 ; BAC49434 .
GeneIDi 1054220.
KEGGi bja:blr4169.
PATRICi 21191856. VBIBraJap65052_4184.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000061500.
InParanoidi P04772.
KOi K01915.
OrthoDBi EOG6K3ZXS.
PhylomeDBi P04772.

Enzyme and pathway databases

BioCyci BJAP224911:GJEJ-4195-MONOMER.
RETL1328306-WGS:GSTH-3150-MONOMER.

Family and domain databases

Gene3Di 3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Apparent eukaryotic origin of glutamine synthetase II from the bacterium Bradyrhizobium japonicum."
    Carlson T.A., Chelm B.K.
    Nature 322:568-570(1986)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiGLNA2_BRADU
AccessioniPrimary (citable) accession number: P04772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 28, 2003
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Two forms of glutamine synthetase (GSI and GSII) can be found in this nitrogen fixing bacteria, GSI is a typical prokaryotic glutamine synthetase whereas GSII is similar to the eukaryotic enzyme.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3