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P04761

- ACM1_PIG

UniProt

P04761 - ACM1_PIG

Protein

Muscarinic acetylcholine receptor M1

Gene

CHRM1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

    GO - Molecular functioni

    1. G-protein coupled acetylcholine receptor activity Source: InterPro

    GO - Biological processi

    1. cognition Source: InterPro
    2. positive regulation of ion transport Source: Ensembl
    3. regulation of locomotion Source: Ensembl
    4. saliva secretion Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_206828. Muscarinic acetylcholine receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Muscarinic acetylcholine receptor M1
    Gene namesi
    Name:CHRM1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of plasma membrane Source: InterPro
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460Muscarinic acetylcholine receptor M1PRO_0000069018Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Curated
    Glycosylationi12 – 121N-linked (GlcNAc...)Curated
    Disulfide bondi98 ↔ 178PROSITE-ProRule annotation
    Modified residuei428 – 4281PhosphothreonineSequence Analysis
    Modified residuei451 – 4511PhosphoserineSequence Analysis
    Modified residuei455 – 4551PhosphothreonineSequence Analysis
    Modified residuei457 – 4571PhosphoserineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with GPRASP2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP04761.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 6114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini83 – 9917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini165 – 18622ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 366157CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini388 – 40114ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini422 – 46039CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4723Helical; Name=1By similarityAdd
    BLAST
    Transmembranei62 – 8221Helical; Name=2By similarityAdd
    BLAST
    Transmembranei100 – 12122Helical; Name=3By similarityAdd
    BLAST
    Transmembranei142 – 16423Helical; Name=4By similarityAdd
    BLAST
    Transmembranei187 – 20923Helical; Name=5By similarityAdd
    BLAST
    Transmembranei367 – 38721Helical; Name=6By similarityAdd
    BLAST
    Transmembranei402 – 42120Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00690000101881.
    HOVERGENiHBG105720.
    KOiK04129.
    OMAiRCCRTPR.
    OrthoDBiEOG7V49Z7.
    TreeFamiTF320495.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002228. Musac_Ach_M1_rcpt.
    IPR000995. Musac_Ach_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00243. MUSCARINICR.
    PR00538. MUSCRINICM1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P04761-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF    50
    KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL 100
    WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW 150
    LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP 200
    VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG 250
    SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 300
    VIKMPMVDPE AQAPAKQPPR SSPNTVKRPT RKGRERAGKG QKPRGKEQLA 350
    KRKTFSLVKE KKAARTLSAI LLAFIVTWTP YNIMVLVSTF CKDCVPETLW 400
    ELGYWLCYVN STINPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG 450
    SVHRTPSRQC 460
    Length:460
    Mass (Da):51,419
    Last modified:August 13, 1987 - v1
    Checksum:iC025C70EA43BC2AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04413 mRNA. Translation: CAA28003.1.
    PIRiA24325.
    RefSeqiNP_999199.1. NM_214034.1.
    UniGeneiSsc.129.

    Genome annotation databases

    EnsembliENSSSCT00000028226; ENSSSCP00000026844; ENSSSCG00000024545.
    GeneIDi397099.
    KEGGissc:397099.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04413 mRNA. Translation: CAA28003.1 .
    PIRi A24325.
    RefSeqi NP_999199.1. NM_214034.1.
    UniGenei Ssc.129.

    3D structure databases

    ProteinModelPortali P04761.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000028226 ; ENSSSCP00000026844 ; ENSSSCG00000024545 .
    GeneIDi 397099.
    KEGGi ssc:397099.

    Organism-specific databases

    CTDi 1128.

    Phylogenomic databases

    GeneTreei ENSGT00690000101881.
    HOVERGENi HBG105720.
    KOi K04129.
    OMAi RCCRTPR.
    OrthoDBi EOG7V49Z7.
    TreeFami TF320495.

    Enzyme and pathway databases

    Reactomei REACT_206828. Muscarinic acetylcholine receptors.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002228. Musac_Ach_M1_rcpt.
    IPR000995. Musac_Ach_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00243. MUSCARINICR.
    PR00538. MUSCRINICM1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor."
      Kubo T., Fukuda K., Mikami A., Maeda A., Takahashi H., Mishina M., Haga T., Haga K., Ichiyama A., Kangawa K., Kojima M., Matsuo H., Hirose T., Numa S.
      Nature 323:411-416(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiACM1_PIG
    AccessioniPrimary (citable) accession number: P04761
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3