Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P04761 (ACM1_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Muscarinic acetylcholine receptor M1
Gene names
Name:CHRM1
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Subunit structure

Interacts with GPRASP2 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 460460Muscarinic acetylcholine receptor M1
PRO_0000069018

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4723Helical; Name=1; By similarity
Topological domain48 – 6114Cytoplasmic Potential
Transmembrane62 – 8221Helical; Name=2; By similarity
Topological domain83 – 9917Extracellular Potential
Transmembrane100 – 12122Helical; Name=3; By similarity
Topological domain122 – 14120Cytoplasmic Potential
Transmembrane142 – 16423Helical; Name=4; By similarity
Topological domain165 – 18622Extracellular Potential
Transmembrane187 – 20923Helical; Name=5; By similarity
Topological domain210 – 366157Cytoplasmic Potential
Transmembrane367 – 38721Helical; Name=6; By similarity
Topological domain388 – 40114Extracellular Potential
Transmembrane402 – 42120Helical; Name=7; By similarity
Topological domain422 – 46039Cytoplasmic Potential

Amino acid modifications

Modified residue4281Phosphothreonine Potential
Modified residue4511Phosphoserine Potential
Modified residue4551Phosphothreonine Potential
Modified residue4571Phosphoserine Potential
Glycosylation21N-linked (GlcNAc...) Probable
Glycosylation121N-linked (GlcNAc...) Probable
Disulfide bond98 ↔ 178 By similarity

Sequences

Sequence LengthMass (Da)Tools
P04761 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: C025C70EA43BC2AD

FASTA46051,419
        10         20         30         40         50         60 
MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF KVNTELKTVN 

        70         80         90        100        110        120 
NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL WLALDYVASN ASVMNLLLIS 

       130        140        150        160        170        180 
FDRYFSVTRP LSYRAKRTPR RAALMIGLAW LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI 

       190        200        210        220        230        240 
QFLSQPIITF GTAMAAFYLP VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS 

       250        260        270        280        290        300 
SERSQPGAEG SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 

       310        320        330        340        350        360 
VIKMPMVDPE AQAPAKQPPR SSPNTVKRPT RKGRERAGKG QKPRGKEQLA KRKTFSLVKE 

       370        380        390        400        410        420 
KKAARTLSAI LLAFIVTWTP YNIMVLVSTF CKDCVPETLW ELGYWLCYVN STINPMCYAL 

       430        440        450        460 
CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG SVHRTPSRQC 

« Hide

References

[1]"Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor."
Kubo T., Fukuda K., Mikami A., Maeda A., Takahashi H., Mishina M., Haga T., Haga K., Ichiyama A., Kangawa K., Kojima M., Matsuo H., Hirose T., Numa S.
Nature 323:411-416(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04413 mRNA. Translation: CAA28003.1.
PIRA24325.
RefSeqNP_999199.1. NM_214034.1.
UniGeneSsc.129.

3D structure databases

ProteinModelPortalP04761.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000028226; ENSSSCP00000026844; ENSSSCG00000024545.
GeneID397099.
KEGGssc:397099.

Organism-specific databases

CTD1128.

Phylogenomic databases

GeneTreeENSGT00690000101881.
HOVERGENHBG105720.
KOK04129.
OMARCCRTPR.
OrthoDBEOG7V49Z7.
TreeFamTF320495.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002228. Musac_Ach_M1_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PANTHERPTHR24249:SF59. PTHR24249:SF59. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00538. MUSCRINICM1R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACM1_PIG
AccessionPrimary (citable) accession number: P04761
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries