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P04761

- ACM1_PIG

UniProt

P04761 - ACM1_PIG

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Protein

Muscarinic acetylcholine receptor M1

Gene

CHRM1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

GO - Molecular functioni

  1. G-protein coupled acetylcholine receptor activity Source: InterPro

GO - Biological processi

  1. cognition Source: InterPro
  2. positive regulation of ion transport Source: Ensembl
  3. regulation of locomotion Source: Ensembl
  4. saliva secretion Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_206828. Muscarinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M1
Gene namesi
Name:CHRM1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of plasma membrane Source: InterPro
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Muscarinic acetylcholine receptor M1PRO_0000069018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Curated
Glycosylationi12 – 121N-linked (GlcNAc...)Curated
Disulfide bondi98 ↔ 178PROSITE-ProRule annotation
Modified residuei428 – 4281PhosphothreonineSequence Analysis
Modified residuei451 – 4511PhosphoserineSequence Analysis
Modified residuei455 – 4551PhosphothreonineSequence Analysis
Modified residuei457 – 4571PhosphoserineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Interacts with GPRASP2.By similarity

Structurei

3D structure databases

ProteinModelPortaliP04761.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Topological domaini48 – 6114CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini83 – 9917ExtracellularSequence AnalysisAdd
BLAST
Topological domaini122 – 14120CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini165 – 18622ExtracellularSequence AnalysisAdd
BLAST
Topological domaini210 – 366157CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini388 – 40114ExtracellularSequence AnalysisAdd
BLAST
Topological domaini422 – 46039CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4723Helical; Name=1By similarityAdd
BLAST
Transmembranei62 – 8221Helical; Name=2By similarityAdd
BLAST
Transmembranei100 – 12122Helical; Name=3By similarityAdd
BLAST
Transmembranei142 – 16423Helical; Name=4By similarityAdd
BLAST
Transmembranei187 – 20923Helical; Name=5By similarityAdd
BLAST
Transmembranei367 – 38721Helical; Name=6By similarityAdd
BLAST
Transmembranei402 – 42120Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119165.
HOVERGENiHBG105720.
InParanoidiP04761.
KOiK04129.
OMAiRCCRTPR.
OrthoDBiEOG7V49Z7.
TreeFamiTF320495.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002228. Musac_Ach_M1_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00538. MUSCRINICM1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04761 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF
60 70 80 90 100
KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL
110 120 130 140 150
WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW
160 170 180 190 200
LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP
210 220 230 240 250
VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG
260 270 280 290 300
SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV
310 320 330 340 350
VIKMPMVDPE AQAPAKQPPR SSPNTVKRPT RKGRERAGKG QKPRGKEQLA
360 370 380 390 400
KRKTFSLVKE KKAARTLSAI LLAFIVTWTP YNIMVLVSTF CKDCVPETLW
410 420 430 440 450
ELGYWLCYVN STINPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG
460
SVHRTPSRQC
Length:460
Mass (Da):51,419
Last modified:August 13, 1987 - v1
Checksum:iC025C70EA43BC2AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04413 mRNA. Translation: CAA28003.1.
PIRiA24325.
RefSeqiNP_999199.1. NM_214034.1.
UniGeneiSsc.129.

Genome annotation databases

EnsembliENSSSCT00000028226; ENSSSCP00000026844; ENSSSCG00000024545.
GeneIDi397099.
KEGGissc:397099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04413 mRNA. Translation: CAA28003.1 .
PIRi A24325.
RefSeqi NP_999199.1. NM_214034.1.
UniGenei Ssc.129.

3D structure databases

ProteinModelPortali P04761.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000028226 ; ENSSSCP00000026844 ; ENSSSCG00000024545 .
GeneIDi 397099.
KEGGi ssc:397099.

Organism-specific databases

CTDi 1128.

Phylogenomic databases

GeneTreei ENSGT00760000119165.
HOVERGENi HBG105720.
InParanoidi P04761.
KOi K04129.
OMAi RCCRTPR.
OrthoDBi EOG7V49Z7.
TreeFami TF320495.

Enzyme and pathway databases

Reactomei REACT_206828. Muscarinic acetylcholine receptors.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002228. Musac_Ach_M1_rcpt.
IPR000995. Musac_Ach_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00538. MUSCRINICM1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor."
    Kubo T., Fukuda K., Mikami A., Maeda A., Takahashi H., Mishina M., Haga T., Haga K., Ichiyama A., Kangawa K., Kojima M., Matsuo H., Hirose T., Numa S.
    Nature 323:411-416(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiACM1_PIG
AccessioniPrimary (citable) accession number: P04761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3