P04758 (ACHB_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylcholine receptor subunit beta

Gene names

Name:

CHRNB1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subunit structure	Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ion channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	behavioral response to nicotine Inferred from sequence or structural similarity. Source: UniProtKB cation transport Inferred from sequence or structural similarity. Source: UniProtKB muscle contraction Inferred from sequence or structural similarity. Source: UniProtKB muscle fiber development Inferred from sequence or structural similarity. Source: UniProtKB neuromuscular synaptic transmission Inferred from sequence or structural similarity. Source: UniProtKB postsynaptic membrane organization Inferred from sequence or structural similarity. Source: UniProtKB regulation of membrane potential Inferred from electronic annotation. Source: Compara signal transduction Inferred from sequence or structural similarity. Source: UniProtKB synaptic transmission, cholinergic Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	acetylcholine-gated channel complex Inferred from sequence or structural similarity. Source: UniProtKB cell junction Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	acetylcholine binding Inferred from electronic annotation. Source: Compara acetylcholine receptor activity Inferred from electronic annotation. Source: Compara acetylcholine-activated cation-selective channel activity Inferred from electronic annotation. Source: Compara channel activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 505	481	Acetylcholine receptor subunit beta		PRO_0000000314
Regions
	Topological domain	25 – 245	221	Extracellular Potential
	Transmembrane	246 – 270	25	Helical; Potential
	Transmembrane	278 – 295	18	Helical; Potential
	Transmembrane	312 – 333	22	Helical; Potential
	Topological domain	334 – 473	140	Cytoplasmic Potential
	Transmembrane	474 – 492	19	Helical; Potential
Amino acid modifications
	Modified residue	394	1	Phosphotyrosine; by Tyr-kinases By similarity
	Glycosylation	165	1	N-linked (GlcNAc...) Potential
	Disulfide bond	152 ↔ 166		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P04758 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: B003D552A6701ECC	FASTA	505	57,352
	10 20 30 40 50 60 MTPGALLLLL LGVLGAHLAP GARGSEAEGR LREKLFSGYD STVRPAREVG DRVWVSIGLT 70 80 90 100 110 120 LAQLISLNEK DEEMSTKVYL DLEWTDYRLS WDPEEHEGID SLRISAESVW LPDVVLLNNN 130 140 150 160 170 180 DGNFDVALDI NVVVSSDGSM RWQPPGIYRS SCSIQVTYFP FDWQNCTMVF SSYSYDSSEV 190 200 210 220 230 240 SLQTGLSPEG QERQEVYIHE GTFIENGQWE IIHKPSRLIQ PSVDPRGGGE GRREEVTFYL 250 260 270 280 290 300 IIRRKPLFYL VNVIAPCILI TLLAIFVFYL PPDAGEKMGL SIFALLTLTV FLLLLADKVP 310 320 330 340 350 360 ETSLSVPIII KYLMFTMVLV TFSVILSVVV LNLHHRSPHT HQMPLWVRQI FIHKLPLYLG 370 380 390 400 410 420 LKRPKPERDQ MQEPPSIAPR DSPGSGWGRG TDEYFIRKPP NDFLFPKPNR FQPELSAPDL 430 440 450 460 470 480 RRFIDGPNRA VGLPPELREV VSSISYIARQ LQEQEDHDVL KEDWQFVAMV VDRLFLWTFI 490 500 IFTSVGTLVI FLDATYHLPP ADPFP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure of beta subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence." Tanabe T., Noda M., Furutani Y., Takai T., Takahashi H., Tanaka K., Hirose T., Inayama S., Numa S. Eur. J. Biochem. 144:11-17(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X00962 mRNA. Translation: CAA25475.1. BC147876 mRNA. Translation: AAI47877.1.
IPI	IPI00691448.
PIR	S07227.
RefSeq	NP_776941.1. NM_174516.2.
UniGene	Bt.5107.
3D structure databases
ProteinModelPortal	P04758.
SMR	P04758. Positions 25-342.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000025624; ENSBTAP00000025624; ENSBTAG00000019242.
GeneID	282179.
KEGG	bta:282179.
Organism-specific databases
CTD	1140.
Phylogenomic databases
eggNOG	NOG243276.
GeneTree	ENSGT00620000087691.
HOGENOM	HOG000006757.
HOVERGEN	HBG003756.
InParanoid	P04758.
KO	K04812.
OMA	FIDGPNR.
OrthoDB	EOG4DFPNC.
Family and domain databases
Gene3D	2.70.170.10. 1 hit.
InterPro	IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. IPR002394. Nicotinic_acetylcholine_rcpt. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR00254. NICOTINICR. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806008.

Entry information

Entry name

ACHB_BOVIN

Accession

Primary (citable) accession number: P04758
Secondary accession number(s): A6QL86

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	April 3, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program