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Protein

Acetylcholine receptor subunit beta

Gene

CHRNB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit beta
Gene namesi
Name:CHRNB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 245221ExtracellularSequence analysisAdd
BLAST
Transmembranei246 – 27025HelicalSequence analysisAdd
BLAST
Transmembranei278 – 29518HelicalSequence analysisAdd
BLAST
Transmembranei312 – 33322HelicalSequence analysisAdd
BLAST
Topological domaini334 – 473140CytoplasmicSequence analysisAdd
BLAST
Transmembranei474 – 49219HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 505481Acetylcholine receptor subunit betaPRO_0000000314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi152 ↔ 166By similarity
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence analysis
Modified residuei394 – 3941Phosphotyrosine; by Tyr-kinasesBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP04758.

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025624.

Structurei

3D structure databases

ProteinModelPortaliP04758.
SMRiP04758. Positions 25-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006757.
HOVERGENiHBG003756.
InParanoidiP04758.
KOiK04812.
OMAiFIDGPNR.
OrthoDBiEOG70ZZN7.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPGALLLLL LGVLGAHLAP GARGSEAEGR LREKLFSGYD STVRPAREVG
60 70 80 90 100
DRVWVSIGLT LAQLISLNEK DEEMSTKVYL DLEWTDYRLS WDPEEHEGID
110 120 130 140 150
SLRISAESVW LPDVVLLNNN DGNFDVALDI NVVVSSDGSM RWQPPGIYRS
160 170 180 190 200
SCSIQVTYFP FDWQNCTMVF SSYSYDSSEV SLQTGLSPEG QERQEVYIHE
210 220 230 240 250
GTFIENGQWE IIHKPSRLIQ PSVDPRGGGE GRREEVTFYL IIRRKPLFYL
260 270 280 290 300
VNVIAPCILI TLLAIFVFYL PPDAGEKMGL SIFALLTLTV FLLLLADKVP
310 320 330 340 350
ETSLSVPIII KYLMFTMVLV TFSVILSVVV LNLHHRSPHT HQMPLWVRQI
360 370 380 390 400
FIHKLPLYLG LKRPKPERDQ MQEPPSIAPR DSPGSGWGRG TDEYFIRKPP
410 420 430 440 450
NDFLFPKPNR FQPELSAPDL RRFIDGPNRA VGLPPELREV VSSISYIARQ
460 470 480 490 500
LQEQEDHDVL KEDWQFVAMV VDRLFLWTFI IFTSVGTLVI FLDATYHLPP

ADPFP
Length:505
Mass (Da):57,352
Last modified:August 13, 1987 - v1
Checksum:iB003D552A6701ECC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00962 mRNA. Translation: CAA25475.1.
BC147876 mRNA. Translation: AAI47877.1.
PIRiS07227.
RefSeqiNP_776941.1. NM_174516.2.
XP_005220248.1. XM_005220191.3.
UniGeneiBt.5107.

Genome annotation databases

EnsembliENSBTAT00000025624; ENSBTAP00000025624; ENSBTAG00000019242.
GeneIDi282179.
KEGGibta:282179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00962 mRNA. Translation: CAA25475.1.
BC147876 mRNA. Translation: AAI47877.1.
PIRiS07227.
RefSeqiNP_776941.1. NM_174516.2.
XP_005220248.1. XM_005220191.3.
UniGeneiBt.5107.

3D structure databases

ProteinModelPortaliP04758.
SMRiP04758. Positions 25-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025624.

Proteomic databases

PaxDbiP04758.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000025624; ENSBTAP00000025624; ENSBTAG00000019242.
GeneIDi282179.
KEGGibta:282179.

Organism-specific databases

CTDi1140.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006757.
HOVERGENiHBG003756.
InParanoidiP04758.
KOiK04812.
OMAiFIDGPNR.
OrthoDBiEOG70ZZN7.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of beta subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence."
    Tanabe T., Noda M., Furutani Y., Takai T., Takahashi H., Tanaka K., Hirose T., Inayama S., Numa S.
    Eur. J. Biochem. 144:11-17(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiACHB_BOVIN
AccessioniPrimary (citable) accession number: P04758
Secondary accession number(s): A6QL86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.