P04744 (PAPB_ECOLX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major pilu subunit operon regulatory protein PapB

Gene names

Name:

papB

Organism

Escherichia coli

Taxonomic identifier

562 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as both positive and negative regulator of pap transcription. Might positively regulate levels of papI and/or mbf. Its autoregulatory mode of action involves differential binding to separate sites.
Subcellular location	Cytoplasm.

Ontologies

Keywords
Biological process	Fimbrium biogenesis Transcription Transcription regulation
Cellular component	Cytoplasm
Molecular function	Activator Repressor
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 104	104	Major pilu subunit operon regulatory protein PapB		PRO_0000058230

Sequences

	Sequence		Length	Mass (Da)
	P04744 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 90CA7B9E72A63A22	FASTA	104	11,695
	10 20 30 40 50 60 MAHHEVISRS GNAFLLNIRE SVLLPGSMSE MHFFLLIGIS SIHSDRVILA MKDYLVGGHS 70 80 90 100 RKEVCEKYQM NNGYFSTTLG RLIRLNALAA RLAPYYTDES SAFD

References

[1]	"Transcriptional activation of a pap pilus virulence operon from uropathogenic Escherichia coli." Baga M., Goeransson M., Normark S., Uhlin B.E. EMBO J. 4:3887-3893(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 700336 / J96.
[2]	"Horizontal gene transfer of the Escherichia coli pap and prs pili operons as a mechanism for the development of tissue-specific adhesive properties." Marklund B.-I., Tennent J.M., Garcia E., Hamers A., Baga M., Lindberg F., Gaastra W., Normark S. Mol. Microbiol. 6:2225-2242(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 700336 / J96.
[3]	"Autoregulation and multiple DNA interactions by a transcriptional regulatory protein in E. coli pili biogenesis." Forsman K., Goeransson M., Uhlin B.E. EMBO J. 8:1271-1277(1989) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X03391 Genomic DNA. Translation: CAA27125.1. X61239 Genomic DNA. Translation: CAA43561.1. X55249 Genomic DNA. Translation: CAA38989.1. M63747 Genomic DNA. Translation: AAA24287.1.
PIR	RGECPB. B25121.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004356. Fim_regulat. [Graphical view]
Pfam	PF03333. PapB. 1 hit. [Graphical view]
PRINTS	PR01554. FIMREGULATRY.
ProtoNet	Search...

Entry information

Entry name

PAPB_ECOLX

Accession

Primary (citable) accession number: P04744

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program