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Protein

Fimbrial protein

Gene

pilA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • regulation of calcium-mediated signaling Source: PseudoCAP
  • single organismal cell-cell adhesion Source: PseudoCAP
  • type IV pilus-dependent motility Source: PseudoCAP
Complete GO annotation...

Protein family/group databases

TCDBi3.A.15.2.1. the outer membrane protein secreting main terminal branch (mtb) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Fimbrial protein
Alternative name(s):
Pilin
Gene namesi
Name:pilA
Synonyms:fimA
Ordered Locus Names:PA4525
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4525.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: CACAO
  • cytosol Source: CACAO
  • type IV pilus Source: PseudoCAP
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi11 – 111E → A: Decrease in methylation of F-7 and loss of pili assembly. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 66PRO_0000024178
Chaini7 – 149143Fimbrial proteinPRO_0000024179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71N-methylphenylalanine1 Publication
Disulfide bondi134 ↔ 147

Keywords - PTMi

Disulfide bond, Methylation

Proteomic databases

PaxDbiP04739.
PRIDEiP04739.

Interactioni

Subunit structurei

The pili are polar flexible filaments of about 5.4 nanometers diameter and 2.5 micrometers average length; they consist of only a single polypeptide chain arranged in a helical configuration of five subunits per turn in the assembled pilus.

Protein-protein interaction databases

STRINGi208964.PA4525.

Structurei

Secondary structure

1
149
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi140 – 1423Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PANNMR-A133-149[»]
1PAONMR-A133-149[»]
ProteinModelPortaliP04739.
SMRiP04739. Positions 7-147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04739.

Family & Domainsi

Sequence similaritiesi

Belongs to the N-Me-Phe pilin family.Curated

Phylogenomic databases

eggNOGiENOG4105X0D. Bacteria.
COG4969. LUCA.
HOGENOMiHOG000008197.
KOiK02650.
OMAiNSEDAGF.

Family and domain databases

InterProiIPR012902. N_methyl_site.
IPR001082. Pilin.
[Graphical view]
PfamiPF13633. N_methyl_3. 1 hit.
PF00114. Pilin. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02532. IV_pilin_GFxxxE. 1 hit.
PROSITEiPS00409. PROKAR_NTER_METHYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAQKGFTLI ELMIVVAIIG ILAAIAIPQY QNYVARSEGA SALATINPLK
60 70 80 90 100
TTVEESLSRG IAGSKIKIGT TASTATETYV GVEPDANKLG VIAVAIEDSG
110 120 130 140
AGDITFTFQT GTSSPKNATK VITLNRTADG VWACKSTQDP MFTPKGCDN
Length:149
Mass (Da):15,512
Last modified:August 13, 1987 - v1
Checksum:i98EC8A6F7B022214
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11323 Genomic DNA. Translation: AAA25954.1.
AE004091 Genomic DNA. Translation: AAG07913.1.
PIRiA25023.
RefSeqiNP_253215.1. NC_002516.2.
WP_003112842.1. NZ_ASJY01000735.1.

Genome annotation databases

EnsemblBacteriaiAAG07913; AAG07913; PA4525.
GeneIDi878423.
KEGGipae:PA4525.
PATRICi19843781. VBIPseAer58763_4736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11323 Genomic DNA. Translation: AAA25954.1.
AE004091 Genomic DNA. Translation: AAG07913.1.
PIRiA25023.
RefSeqiNP_253215.1. NC_002516.2.
WP_003112842.1. NZ_ASJY01000735.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PANNMR-A133-149[»]
1PAONMR-A133-149[»]
ProteinModelPortaliP04739.
SMRiP04739. Positions 7-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4525.

Protein family/group databases

TCDBi3.A.15.2.1. the outer membrane protein secreting main terminal branch (mtb) family.

Proteomic databases

PaxDbiP04739.
PRIDEiP04739.

Protocols and materials databases

DNASUi878423.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07913; AAG07913; PA4525.
GeneIDi878423.
KEGGipae:PA4525.
PATRICi19843781. VBIPseAer58763_4736.

Organism-specific databases

PseudoCAPiPA4525.

Phylogenomic databases

eggNOGiENOG4105X0D. Bacteria.
COG4969. LUCA.
HOGENOMiHOG000008197.
KOiK02650.
OMAiNSEDAGF.

Miscellaneous databases

EvolutionaryTraceiP04739.

Family and domain databases

InterProiIPR012902. N_methyl_site.
IPR001082. Pilin.
[Graphical view]
PfamiPF13633. N_methyl_3. 1 hit.
PF00114. Pilin. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02532. IV_pilin_GFxxxE. 1 hit.
PROSITEiPS00409. PROKAR_NTER_METHYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFMPO_PSEAE
AccessioniPrimary (citable) accession number: P04739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.