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Protein

Metallothionein-A

Gene

MTA

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-A
Short name:
MTA
Gene namesi
Name:MTA
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
Proteomesi
  • UP000007110 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973471 – 64Metallothionein-AAdd BLAST64

Expressioni

Inductioni

By heavy metals.

Structurei

Secondary structure

164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 11Combined sources5
Beta strandi19 – 21Combined sources3
Helixi22 – 25Combined sources4
Beta strandi29 – 32Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QJKNMR-A2-37[»]
1QJLNMR-A37-64[»]
ProteinModelPortaliP04734.
SMRiP04734.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04734.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR017980. Metalthion_4_echinoid/annelid.
IPR001396. Metalthion_4_echinoidea.
IPR017854. Metalthion_dom.
PfamiView protein in Pfam
PF05522. Metallothio_6. 1 hit.
PRINTSiPR00873. MTECHINOIDEA.
SUPFAMiSSF57868. SSF57868. 2 hits.

Sequencei

Sequence statusi: Complete.

P04734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDVKCVCCK EGKECACFGQ DCCKTGECCK DGTCCGICTN AACKCANGCK
60
CGSGCSCTEG NCAC
Length:64
Mass (Da):6,445
Last modified:April 1, 1990 - v2
Checksum:i66F0AA7A4991E3E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10K → T in AAA30061 (PubMed:3860837).Curated1
Sequence conflicti24K → V in AAA30061 (PubMed:3860837).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30606 Genomic DNA. Translation: AAA30067.1.
K02464 mRNA. Translation: AAA30061.1.
PIRiA25775.
A33825.
RefSeqiNP_999742.1. NM_214577.1.
UniGeneiSpu.96.

Genome annotation databases

GeneIDi373380.
KEGGispu:373380.

Similar proteinsi

Entry informationi

Entry nameiMTA_STRPU
AccessioniPrimary (citable) accession number: P04734
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families