Reviewed, UniProtKB/Swiss-Prot P04732 (MT1E_HUMAN)

Names and origin

Protein names

Recommended name:
    Metallothionein-1E
      Short name=MT-1E
Alternative name(s):
    Metallothionein-IE
      Short name=MT-IE

Gene names

Name:

MT1E

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subunit structure	Monomer.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Cadmium Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	cytoplasm Non-traceable author statement. Source: UniProtKB
Molecular function	cadmium ion binding Non-traceable author statement. Source: UniProtKB copper ion binding Non-traceable author statement. Source: UniProtKB zinc ion binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 61	61	Metallothionein-1E		PRO_0000197236
Regions
	Region	1 – 29	29	Beta
	Region	30 – 61	32	Alpha
Sites
	Metal binding	5	1	Cluster B
	Metal binding	7	1	Cluster B
	Metal binding	13	1	Cluster B
	Metal binding	15	1	Cluster B
	Metal binding	19	1	Cluster B
	Metal binding	21	1	Cluster B
	Metal binding	24	1	Cluster B
	Metal binding	26	1	Cluster B
	Metal binding	29	1	Cluster B
	Metal binding	33	1	Cluster A
	Metal binding	34	1	Cluster A
	Metal binding	36	1	Cluster A
	Metal binding	37	1	Cluster A
	Metal binding	41	1	Cluster A
	Metal binding	44	1	Cluster A
	Metal binding	48	1	Cluster A
	Metal binding	50	1	Cluster A
	Metal binding	57	1	Cluster A
	Metal binding	59	1	Cluster A
	Metal binding	60	1	Cluster A
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P04732-1 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 8E0A7C54F623A1D2	FASTA	61	6,014
	10 20 30 40 50 60 MDPNCSCATG GSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCVC KGASEKCSCC A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of two human metallothionein-I isoform genes and a related pseudogene." Schmidt C.J., Jubier M.-F., Hamer D.H. J. Biol. Chem. 260:7731-7737(1985) [PubMed: 2581970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Amino acid sequence determination." Hunziker P.E. Methods Enzymol. 205:421-426(1991) [PubMed: 1779803] [Abstract] Cited for: PROTEIN SEQUENCE, ACETYLATION AT MET-1. Tissue: Liver.
[3]	Yu L. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	"Induction by zinc of specific metallothionein isoforms in human monocytes." Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M. Eur. J. Biochem. 220:105-110(1994) [PubMed: 8119276] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M10942 Genomic DNA. Translation: AAA59587.1. AF348996 mRNA. Translation: AAO32956.2. CH471092 Genomic DNA. Translation: EAW82872.1. BC009699 mRNA. Translation: AAH09699.1. BC062734 mRNA. Translation: AAH62734.1. BC131609 mRNA. Translation: AAI31610.1. S68949 mRNA. Translation: AAB30082.1.
IPI	IPI00025461.
PIR	SMHU1E. A22634.
RefSeq	NP_783316.2.
UniGene	Hs.534330
3D structure databases
SMR	P04732. Positions 1-61.
ModBase	Search...
Protein-protein interaction databases
STRING	P04732.
Proteomic databases
PRIDE	P04732.
Genome annotation databases
Ensembl	ENST00000306061; ENSP00000307706; ENSG00000169715; Homo sapiens. [Genome view]
GeneID	4493.
KEGG	hsa:4493.
UCSC	uc002ejl.1. human.
Organism-specific databases
CTD	4493.
GeneCards	GC16P055216.
H-InvDB	HIX0013056. HIX0058763.
HGNC	HGNC:7397. MT1E.
MIM	156351. gene.
PharmGKB	PA31202.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P04732.
OMA	NCNCANG.
OrthoDB	EOG91ZHW5.
Gene expression databases
ArrayExpress	P04732.
Bgee	P04732.
CleanEx	HS_MT1E.
Genevestigator	P04732.
GermOnline	ENSG00000169715. Homo sapiens.
Family and domain databases
InterPro	IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	17375.
SOURCE	Search...

Entry information

Entry name

MT1E_HUMAN

Accession

Primary (citable) accession number: P04732
Secondary accession number(s): A2RRF7, Q86YX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	November 24, 2009
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.