Reviewed,
UniProtKB/Swiss-Prot P04732 (MT1E_HUMAN)
Last modified
November 24, 2009.
Version 97.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Metallothionein-1E Short name=MT-1E Alternative name(s): Metallothionein-IE Short name=MT-IE | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 61 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. |
| Subunit structure | Monomer. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Cadmium Copper Metal-binding Metal-thiolate cluster Zinc |
| PTM | Acetylation |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Non-traceable author statement. Source: UniProtKB |
| Molecular function | cadmium ion binding Non-traceable author statement. Source: UniProtKB copper ion bindingNon-traceable author statement. Source: UniProtKB zinc ion bindingNon-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 61 | 61 | Metallothionein-1E | PRO_0000197236 | |||||
Regions | |||||||||
| Region | 1 – 29 | 29 | Beta | ||||||
| Region | 30 – 61 | 32 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 5 | 1 | Cluster B | ||||||
| Metal binding | 7 | 1 | Cluster B | ||||||
| Metal binding | 13 | 1 | Cluster B | ||||||
| Metal binding | 15 | 1 | Cluster B | ||||||
| Metal binding | 19 | 1 | Cluster B | ||||||
| Metal binding | 21 | 1 | Cluster B | ||||||
| Metal binding | 24 | 1 | Cluster B | ||||||
| Metal binding | 26 | 1 | Cluster B | ||||||
| Metal binding | 29 | 1 | Cluster B | ||||||
| Metal binding | 33 | 1 | Cluster A | ||||||
| Metal binding | 34 | 1 | Cluster A | ||||||
| Metal binding | 36 | 1 | Cluster A | ||||||
| Metal binding | 37 | 1 | Cluster A | ||||||
| Metal binding | 41 | 1 | Cluster A | ||||||
| Metal binding | 44 | 1 | Cluster A | ||||||
| Metal binding | 48 | 1 | Cluster A | ||||||
| Metal binding | 50 | 1 | Cluster A | ||||||
| Metal binding | 57 | 1 | Cluster A | ||||||
| Metal binding | 59 | 1 | Cluster A | ||||||
| Metal binding | 60 | 1 | Cluster A | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine Ref.2 | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Structure and expression of two human metallothionein-I isoform genes and a related pseudogene." Schmidt C.J., Jubier M.-F., Hamer D.H. J. Biol. Chem. 260:7731-7737(1985) [PubMed: 2581970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Amino acid sequence determination." Hunziker P.E. Methods Enzymol. 205:421-426(1991) [PubMed: 1779803] [Abstract] Cited for: PROTEIN SEQUENCE, ACETYLATION AT MET-1. Tissue: Liver. |
| [3] | Yu L. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [6] | "Induction by zinc of specific metallothionein isoforms in human monocytes." Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M. Eur. J. Biochem. 220:105-110(1994) [PubMed: 8119276] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M10942 Genomic DNA. Translation: AAA59587.1. AF348996 mRNA. Translation: AAO32956.2. CH471092 Genomic DNA. Translation: EAW82872.1. BC009699 mRNA. Translation: AAH09699.1. BC062734 mRNA. Translation: AAH62734.1. BC131609 mRNA. Translation: AAI31610.1. S68949 mRNA. Translation: AAB30082.1. | |
| IPI | IPI00025461. |
| PIR | SMHU1E. A22634. |
| RefSeq | NP_783316.2. |
| UniGene | Hs.534330 |
3D structure databases | |
| SMR | P04732. Positions 1-61. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P04732. |
Proteomic databases | |
| PRIDE | P04732. |
Genome annotation databases | |
| Ensembl | ENST00000306061; ENSP00000307706; ENSG00000169715; Homo sapiens. [Genome view] |
| GeneID | 4493. |
| KEGG | hsa:4493. |
| UCSC | uc002ejl.1. human. |
Organism-specific databases | |
| CTD | 4493. |
| GeneCards | GC16P055216. |
| H-InvDB | HIX0013056. HIX0058763. |
| HGNC | HGNC:7397. MT1E. |
| MIM | 156351. gene. |
| PharmGKB | PA31202. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P04732. |
| OMA | NCNCANG. |
| OrthoDB | EOG91ZHW5. |
Gene expression databases | |
| ArrayExpress | P04732. |
| Bgee | P04732. |
| CleanEx | HS_MT1E. |
| Genevestigator | P04732. |
| GermOnline | ENSG00000169715. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 17375. |
| SOURCE | Search... |
Entry information
| Entry name | MT1E_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P04732 Secondary accession number(s): A2RRF7, Q86YX4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Metallothioneins Classification of metallothioneins and list of entries |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


