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P04732

- MT1E_HUMAN

UniProt

P04732 - MT1E_HUMAN

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Protein
Metallothionein-1E
Gene
MT1E
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Divalent metal cation; cluster B
Metal bindingi7 – 71Divalent metal cation; cluster B
Metal bindingi13 – 131Divalent metal cation; cluster B
Metal bindingi15 – 151Divalent metal cation; cluster B
Metal bindingi19 – 191Divalent metal cation; cluster B
Metal bindingi21 – 211Divalent metal cation; cluster B
Metal bindingi24 – 241Divalent metal cation; cluster B
Metal bindingi26 – 261Divalent metal cation; cluster B
Metal bindingi29 – 291Divalent metal cation; cluster B
Metal bindingi33 – 331Divalent metal cation; cluster A
Metal bindingi34 – 341Divalent metal cation; cluster A
Metal bindingi36 – 361Divalent metal cation; cluster A
Metal bindingi37 – 371Divalent metal cation; cluster A
Metal bindingi41 – 411Divalent metal cation; cluster A
Metal bindingi44 – 441Divalent metal cation; cluster A
Metal bindingi48 – 481Divalent metal cation; cluster A
Metal bindingi50 – 501Divalent metal cation; cluster A
Metal bindingi57 – 571Divalent metal cation; cluster A
Metal bindingi59 – 591Divalent metal cation; cluster A
Metal bindingi60 – 601Divalent metal cation; cluster A

GO - Molecular functioni

  1. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cellular response to cadmium ion Source: UniProtKB
  2. cellular response to zinc ion Source: UniProtKB
  3. negative regulation of growth Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1E
Short name:
MT-1E
Alternative name(s):
Metallothionein-IE
Short name:
MT-IE
Gene namesi
Name:MT1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:7397. MT1E.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6161Metallothionein-1E
PRO_0000197236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP04732.
PaxDbiP04732.
PRIDEiP04732.

Expressioni

Gene expression databases

ArrayExpressiP04732.
BgeeiP04732.
CleanExiHS_MT1E.
GenevestigatoriP04732.

Organism-specific databases

HPAiHPA041152.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi110599. 1 interaction.
STRINGi9606.ENSP00000307706.

Structurei

3D structure databases

ProteinModelPortaliP04732.
SMRiP04732. Positions 1-61.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929Beta
Add
BLAST
Regioni30 – 6132Alpha
Add
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG138665.
HOGENOMiHOG000236262.
KOiK14739.
OMAiQVIRFAC.
OrthoDBiEOG7PZS1X.
PhylomeDBiP04732.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P04732-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDPNCSCATG GSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCVC   50
KGASEKCSCC A 61
Length:61
Mass (Da):6,014
Last modified:August 13, 1987 - v1
Checksum:i8E0A7C54F623A1D2
GO
Isoform 2 (identifier: P04732-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-61: CCSCCPVGCAKCAQGCVCKGASEKCSCCA → ECGAISRNLG...WVLSSSQACY

Show »
Length:127
Mass (Da):13,863
Checksum:iA2D0802B85A161B6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei33 – 6129CCSCC…CSCCA → ECGAISRNLGLWLRLGGNSR LALSASFWGTGLSLPSLPVS FPLQAFCPKFRWGRTAFFSW DTNPNCTPYGFRTELCQTKK SILWVWVLSSSQACY in isoform 2.
VSP_041603Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10942 Genomic DNA. Translation: AAA59587.1.
AF495759 mRNA. Translation: AAM15968.1.
AF348996 mRNA. Translation: AAO32956.2.
AC026461 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82872.1.
CH471092 Genomic DNA. Translation: EAW82874.1.
BC009699 mRNA. Translation: AAH09699.1.
BC062734 mRNA. Translation: AAH62734.1.
BC131609 mRNA. Translation: AAI31610.1.
S68949 mRNA. Translation: AAB30082.1.
CCDSiCCDS10764.2. [P04732-1]
PIRiA22634. SMHU1E.
RefSeqiNP_783316.2. NM_175617.3. [P04732-1]
XP_005256013.1. XM_005255956.2. [P04732-2]
UniGeneiHs.744893.

Genome annotation databases

EnsembliENST00000306061; ENSP00000307706; ENSG00000169715. [P04732-1]
ENST00000330439; ENSP00000328137; ENSG00000169715. [P04732-2]
GeneIDi4493.
KEGGihsa:4493.
UCSCiuc002ejl.3. human. [P04732-1]
uc002ejm.3. human. [P04732-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10942 Genomic DNA. Translation: AAA59587.1 .
AF495759 mRNA. Translation: AAM15968.1 .
AF348996 mRNA. Translation: AAO32956.2 .
AC026461 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82872.1 .
CH471092 Genomic DNA. Translation: EAW82874.1 .
BC009699 mRNA. Translation: AAH09699.1 .
BC062734 mRNA. Translation: AAH62734.1 .
BC131609 mRNA. Translation: AAI31610.1 .
S68949 mRNA. Translation: AAB30082.1 .
CCDSi CCDS10764.2. [P04732-1 ]
PIRi A22634. SMHU1E.
RefSeqi NP_783316.2. NM_175617.3. [P04732-1 ]
XP_005256013.1. XM_005255956.2. [P04732-2 ]
UniGenei Hs.744893.

3D structure databases

ProteinModelPortali P04732.
SMRi P04732. Positions 1-61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110599. 1 interaction.
STRINGi 9606.ENSP00000307706.

Proteomic databases

MaxQBi P04732.
PaxDbi P04732.
PRIDEi P04732.

Protocols and materials databases

DNASUi 4493.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306061 ; ENSP00000307706 ; ENSG00000169715 . [P04732-1 ]
ENST00000330439 ; ENSP00000328137 ; ENSG00000169715 . [P04732-2 ]
GeneIDi 4493.
KEGGi hsa:4493.
UCSCi uc002ejl.3. human. [P04732-1 ]
uc002ejm.3. human. [P04732-2 ]

Organism-specific databases

CTDi 4493.
GeneCardsi GC16P056659.
H-InvDB HIX0040616.
HGNCi HGNC:7397. MT1E.
HPAi HPA041152.
MIMi 156351. gene.
neXtProti NX_P04732.
PharmGKBi PA31202.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG138665.
HOGENOMi HOG000236262.
KOi K14739.
OMAi QVIRFAC.
OrthoDBi EOG7PZS1X.
PhylomeDBi P04732.
TreeFami TF336054.

Miscellaneous databases

GeneWikii MT1E.
GenomeRNAii 4493.
NextBioi 17375.
PROi P04732.
SOURCEi Search...

Gene expression databases

ArrayExpressi P04732.
Bgeei P04732.
CleanExi HS_MT1E.
Genevestigatori P04732.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of two human metallothionein-I isoform genes and a related pseudogene."
    Schmidt C.J., Jubier M.-F., Hamer D.H.
    J. Biol. Chem. 260:7731-7737(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1).
  2. Cited for: PROTEIN SEQUENCE (ISOFORM 1), ACETYLATION AT MET-1.
    Tissue: Liver.
  3. Guo J.H., Huang X.H., Yu L.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Liver.
  4. Yu L.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  8. "Induction by zinc of specific metallothionein isoforms in human monocytes."
    Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M.
    Eur. J. Biochem. 220:105-110(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-31 (ISOFORM 1/2).

Entry informationi

Entry nameiMT1E_HUMAN
AccessioniPrimary (citable) accession number: P04732
Secondary accession number(s): A2RRF7, Q86YX4, Q8TD51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 9, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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