Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metallothionein-1E

Gene

MT1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi15Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

GO - Biological processi

  • cellular response to cadmium ion Source: UniProtKB
  • cellular response to zinc ion Source: UniProtKB
  • negative regulation of growth Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231. Metallothioneins bind metals.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1E
Short name:
MT-1E
Alternative name(s):
Metallothionein-IE
Short name:
MT-IE
Gene namesi
Name:MT1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7397. MT1E.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi4493.
OpenTargetsiENSG00000169715.
PharmGKBiPA31202.

Polymorphism and mutation databases

BioMutaiMT1E.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972361 – 61Metallothionein-1EAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP04732.
PaxDbiP04732.
PeptideAtlasiP04732.
PRIDEiP04732.
TopDownProteomicsiP04732-1. [P04732-1]

PTM databases

iPTMnetiP04732.
PhosphoSitePlusiP04732.

Expressioni

Gene expression databases

BgeeiENSG00000169715.
CleanExiHS_MT1E.
ExpressionAtlasiP04732. baseline and differential.
GenevisibleiP04732. HS.

Organism-specific databases

HPAiHPA041152.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi110599. 1 interactor.
IntActiP04732. 1 interactor.
STRINGi9606.ENSP00000307706.

Structurei

3D structure databases

ProteinModelPortaliP04732.
SMRiP04732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JFS1. Eukaryota.
ENOG41113QR. LUCA.
GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
InParanoidiP04732.
KOiK14739.
OMAiSCACKNC.
OrthoDBiEOG091G0ZHV.
PhylomeDBiP04732.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P04732-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPNCSCATG GSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCVC
60
KGASEKCSCC A
Length:61
Mass (Da):6,014
Last modified:August 13, 1987 - v1
Checksum:i8E0A7C54F623A1D2
GO
Isoform 2 (identifier: P04732-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-61: CCSCCPVGCAKCAQGCVCKGASEKCSCCA → ECGAISRNLG...WVLSSSQACY

Show »
Length:127
Mass (Da):13,863
Checksum:iA2D0802B85A161B6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04160333 – 61CCSCC…CSCCA → ECGAISRNLGLWLRLGGNSR LALSASFWGTGLSLPSLPVS FPLQAFCPKFRWGRTAFFSW DTNPNCTPYGFRTELCQTKK SILWVWVLSSSQACY in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10942 Genomic DNA. Translation: AAA59587.1.
AF495759 mRNA. Translation: AAM15968.1.
AF348996 mRNA. Translation: AAO32956.2.
AC026461 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82872.1.
CH471092 Genomic DNA. Translation: EAW82874.1.
BC009699 mRNA. Translation: AAH09699.1.
BC062734 mRNA. Translation: AAH62734.1.
BC131609 mRNA. Translation: AAI31610.1.
S68949 mRNA. Translation: AAB30082.1.
CCDSiCCDS10764.2. [P04732-1]
PIRiA22634. SMHU1E.
RefSeqiNP_783316.2. NM_175617.3. [P04732-1]
XP_005256013.1. XM_005255956.4. [P04732-2]
UniGeneiHs.744893.

Genome annotation databases

EnsembliENST00000306061; ENSP00000307706; ENSG00000169715. [P04732-1]
ENST00000330439; ENSP00000328137; ENSG00000169715. [P04732-2]
GeneIDi4493.
KEGGihsa:4493.
UCSCiuc002ejl.5. human. [P04732-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10942 Genomic DNA. Translation: AAA59587.1.
AF495759 mRNA. Translation: AAM15968.1.
AF348996 mRNA. Translation: AAO32956.2.
AC026461 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82872.1.
CH471092 Genomic DNA. Translation: EAW82874.1.
BC009699 mRNA. Translation: AAH09699.1.
BC062734 mRNA. Translation: AAH62734.1.
BC131609 mRNA. Translation: AAI31610.1.
S68949 mRNA. Translation: AAB30082.1.
CCDSiCCDS10764.2. [P04732-1]
PIRiA22634. SMHU1E.
RefSeqiNP_783316.2. NM_175617.3. [P04732-1]
XP_005256013.1. XM_005255956.4. [P04732-2]
UniGeneiHs.744893.

3D structure databases

ProteinModelPortaliP04732.
SMRiP04732.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110599. 1 interactor.
IntActiP04732. 1 interactor.
STRINGi9606.ENSP00000307706.

PTM databases

iPTMnetiP04732.
PhosphoSitePlusiP04732.

Polymorphism and mutation databases

BioMutaiMT1E.

Proteomic databases

MaxQBiP04732.
PaxDbiP04732.
PeptideAtlasiP04732.
PRIDEiP04732.
TopDownProteomicsiP04732-1. [P04732-1]

Protocols and materials databases

DNASUi4493.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306061; ENSP00000307706; ENSG00000169715. [P04732-1]
ENST00000330439; ENSP00000328137; ENSG00000169715. [P04732-2]
GeneIDi4493.
KEGGihsa:4493.
UCSCiuc002ejl.5. human. [P04732-1]

Organism-specific databases

CTDi4493.
DisGeNETi4493.
GeneCardsiMT1E.
H-InvDBHIX0040616.
HGNCiHGNC:7397. MT1E.
HPAiHPA041152.
MIMi156351. gene.
neXtProtiNX_P04732.
OpenTargetsiENSG00000169715.
PharmGKBiPA31202.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFS1. Eukaryota.
ENOG41113QR. LUCA.
GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
InParanoidiP04732.
KOiK14739.
OMAiSCACKNC.
OrthoDBiEOG091G0ZHV.
PhylomeDBiP04732.
TreeFamiTF336054.

Enzyme and pathway databases

ReactomeiR-HSA-5661231. Metallothioneins bind metals.

Miscellaneous databases

GeneWikiiMT1E.
GenomeRNAii4493.
PROiP04732.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169715.
CleanExiHS_MT1E.
ExpressionAtlasiP04732. baseline and differential.
GenevisibleiP04732. HS.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMT1E_HUMAN
AccessioniPrimary (citable) accession number: P04732
Secondary accession number(s): A2RRF7, Q86YX4, Q8TD51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.