Reviewed,
UniProtKB/Swiss-Prot P04731 (MT1A_HUMAN)
Last modified
January 19, 2010.
Version 95.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Metallothionein-1A Short name=MT-1A Alternative name(s): Metallothionein-IA Short name=MT-IA | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 61 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. |
| Subunit structure | Monomer. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Ligand | Cadmium Copper Metal-binding Metal-thiolate cluster Zinc |
| PTM | Acetylation |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Non-traceable author statement. Source: UniProtKB |
| Molecular function | cadmium ion binding Non-traceable author statement. Source: UniProtKB copper ion bindingNon-traceable author statement. Source: UniProtKB zinc ion bindingNon-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 61 | 61 | Metallothionein-1A | PRO_0000197234 | |||||
Regions | |||||||||
| Region | 1 – 29 | 29 | Beta | ||||||
| Region | 30 – 61 | 32 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 5 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 7 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 13 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 15 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 19 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 21 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 24 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 26 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 29 | 1 | Divalent metal cation; cluster B | ||||||
| Metal binding | 33 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 34 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 36 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 37 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 41 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 44 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 48 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 50 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 57 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 59 | 1 | Divalent metal cation; cluster A | ||||||
| Metal binding | 60 | 1 | Divalent metal cation; cluster A | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 27 | 1 | T → N: dbSNP rs11640851. Ref.1 Ref.4 | VAR_060727 | |||||
| Natural variant | 51 | 1 | K → R: dbSNP rs8052394. | VAR_059436 | |||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids." Richards R.I., Heguy A., Karin M. Cell 37:263-272(1984) [PubMed: 6327055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-27. |
| [2] | "Cloning of a novel member of the MT gene family - MT1S." Wang J., Zheng L., Yu L. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. Pennacchio L.A.Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-27. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | K01383 Genomic DNA. Translation: AAA59586.1. AY028617 mRNA. Translation: AAK26162.1. AF348995 mRNA. Translation: AAO32955.1. AC026461 Genomic DNA. No translation available. BC029475 mRNA. Translation: AAH29475.1. |
| IPI | IPI00025460. |
| PIR | SMHU1A. A24502. |
| RefSeq | NP_005937.2. |
| UniGene | Hs.655199 |
3D structure databases | |
| SMR | P04731. Positions 1-61. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P04731. |
PTM databases | |
| PhosphoSite | P04731. |
Genome annotation databases | |
| Ensembl | ENST00000290705; ENSP00000290705; ENSG00000205362; Homo sapiens. [Genome view] ENST00000443255; ENSP00000401456; ENSG00000205362; Homo sapiens. [Genome view] |
| GeneID | 4489. |
| KEGG | hsa:4489. |
Organism-specific databases | |
| CTD | 4489. |
| GeneCards | GC16P055230. |
| H-InvDB | HIX0021628. |
| HGNC | HGNC:7393. MT1A. |
| HPA | CAB002161. CAB013056. |
| MIM | 156350. gene. |
| PharmGKB | PA142672108. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG21851. |
| HOVERGEN | P04731. |
| InParanoid | P04731. |
Gene expression databases | |
| CleanEx | HS_MT1A. |
| Genevestigator | P04731. |
Family and domain databases | |
| InterPro | IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | MT1A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P04731 Secondary accession number(s): Q86YX5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| Metallothioneins Classification of metallothioneins and list of entries |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


