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Protein

Metallothionein-1A

Gene

MT1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi15Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

GO - Biological processi

  • cellular response to cadmium ion Source: UniProtKB
  • cellular response to zinc ion Source: UniProtKB
  • negative regulation of growth Source: UniProtKB
  • response to metal ion Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125157-MONOMER.
ReactomeiR-HSA-5661231. Metallothioneins bind metals.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1A
Short name:
MT-1A
Alternative name(s):
Metallothionein-IA
Short name:
MT-IA
Gene namesi
Name:MT1A
Synonyms:MT1S
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7393. MT1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi4489.
OpenTargetsiENSG00000205362.
PharmGKBiPA31198.

Chemistry databases

DrugBankiDB00958. Carboplatin.
DB00515. Cisplatin.
DB00526. Oxaliplatin.

Polymorphism and mutation databases

BioMutaiMT1A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972341 – 61Metallothionein-1AAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei58PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP04731.
PaxDbiP04731.
PeptideAtlasiP04731.
PRIDEiP04731.

PTM databases

PhosphoSitePlusiP04731.

Expressioni

Gene expression databases

BgeeiENSG00000205362.
CleanExiHS_MT1A.

Organism-specific databases

HPAiCAB002161.
CAB013056.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
GPR50Q135853EBI-8045030,EBI-8550965
TP53P046373EBI-8045030,EBI-366083

Protein-protein interaction databases

BioGridi110595. 1 interactor.
IntActiP04731. 4 interactors.
MINTiMINT-1781424.
STRINGi9606.ENSP00000290705.

Structurei

3D structure databases

ProteinModelPortaliP04731.
SMRiP04731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JFS1. Eukaryota.
ENOG41113QR. LUCA.
GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
HOVERGENiHBG009063.
InParanoidiP04731.
KOiK14739.
OMAiCKGASEN.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCATG GSCTCTGSCK CKECKCTSCK KSCCSCCPMS CAKCAQGCIC
60
KGASEKCSCC A
Length:61
Mass (Da):6,120
Last modified:November 24, 2009 - v2
Checksum:i8FBA7C54EE8B6A13
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06072727T → N.2 PublicationsCorresponds to variant rs11640851dbSNPEnsembl.1
Natural variantiVAR_05943651K → R.Corresponds to variant rs8052394dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01383 Genomic DNA. Translation: AAA59586.1.
AY028617 mRNA. Translation: AAK26162.1.
AF348995 mRNA. Translation: AAO32955.1.
AC026461 Genomic DNA. No translation available.
BC029475 mRNA. Translation: AAH29475.1.
CCDSiCCDS32454.1.
PIRiA24502. SMHU1A.
RefSeqiNP_005937.2. NM_005946.2.
UniGeneiHs.655199.

Genome annotation databases

EnsembliENST00000290705; ENSP00000290705; ENSG00000205362.
GeneIDi4489.
KEGGihsa:4489.
UCSCiuc002ejq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01383 Genomic DNA. Translation: AAA59586.1.
AY028617 mRNA. Translation: AAK26162.1.
AF348995 mRNA. Translation: AAO32955.1.
AC026461 Genomic DNA. No translation available.
BC029475 mRNA. Translation: AAH29475.1.
CCDSiCCDS32454.1.
PIRiA24502. SMHU1A.
RefSeqiNP_005937.2. NM_005946.2.
UniGeneiHs.655199.

3D structure databases

ProteinModelPortaliP04731.
SMRiP04731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110595. 1 interactor.
IntActiP04731. 4 interactors.
MINTiMINT-1781424.
STRINGi9606.ENSP00000290705.

Chemistry databases

DrugBankiDB00958. Carboplatin.
DB00515. Cisplatin.
DB00526. Oxaliplatin.

PTM databases

PhosphoSitePlusiP04731.

Polymorphism and mutation databases

BioMutaiMT1A.

Proteomic databases

MaxQBiP04731.
PaxDbiP04731.
PeptideAtlasiP04731.
PRIDEiP04731.

Protocols and materials databases

DNASUi4489.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290705; ENSP00000290705; ENSG00000205362.
GeneIDi4489.
KEGGihsa:4489.
UCSCiuc002ejq.5. human.

Organism-specific databases

CTDi4489.
DisGeNETi4489.
GeneCardsiMT1A.
H-InvDBHIX0021628.
HGNCiHGNC:7393. MT1A.
HPAiCAB002161.
CAB013056.
MIMi156350. gene.
neXtProtiNX_P04731.
OpenTargetsiENSG00000205362.
PharmGKBiPA31198.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFS1. Eukaryota.
ENOG41113QR. LUCA.
GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
HOVERGENiHBG009063.
InParanoidiP04731.
KOiK14739.
OMAiCKGASEN.
TreeFamiTF336054.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125157-MONOMER.
ReactomeiR-HSA-5661231. Metallothioneins bind metals.

Miscellaneous databases

ChiTaRSiMT1A. human.
GeneWikiiMetallothionein_1A.
GenomeRNAii4489.
PROiP04731.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205362.
CleanExiHS_MT1A.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMT1A_HUMAN
AccessioniPrimary (citable) accession number: P04731
Secondary accession number(s): Q86YX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Metallothioneins
    Classification of metallothioneins and list of entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.