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Protein

Metallothionein-1A

Gene

MT1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Divalent metal cation; cluster B
Metal bindingi7 – 71Divalent metal cation; cluster B
Metal bindingi13 – 131Divalent metal cation; cluster B
Metal bindingi15 – 151Divalent metal cation; cluster B
Metal bindingi19 – 191Divalent metal cation; cluster B
Metal bindingi21 – 211Divalent metal cation; cluster B
Metal bindingi24 – 241Divalent metal cation; cluster B
Metal bindingi26 – 261Divalent metal cation; cluster B
Metal bindingi29 – 291Divalent metal cation; cluster B
Metal bindingi33 – 331Divalent metal cation; cluster A
Metal bindingi34 – 341Divalent metal cation; cluster A
Metal bindingi36 – 361Divalent metal cation; cluster A
Metal bindingi37 – 371Divalent metal cation; cluster A
Metal bindingi41 – 411Divalent metal cation; cluster A
Metal bindingi44 – 441Divalent metal cation; cluster A
Metal bindingi48 – 481Divalent metal cation; cluster A
Metal bindingi50 – 501Divalent metal cation; cluster A
Metal bindingi57 – 571Divalent metal cation; cluster A
Metal bindingi59 – 591Divalent metal cation; cluster A
Metal bindingi60 – 601Divalent metal cation; cluster A

GO - Molecular functioni

GO - Biological processi

  • cellular response to cadmium ion Source: UniProtKB
  • cellular response to zinc ion Source: UniProtKB
  • negative regulation of growth Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1A
Short name:
MT-1A
Alternative name(s):
Metallothionein-IA
Short name:
MT-IA
Gene namesi
Name:MT1A
Synonyms:MT1S
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7393. MT1A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31198.

Chemistry

DrugBankiDB00958. Carboplatin.
DB00515. Cisplatin.
DB00526. Oxaliplatin.

Polymorphism and mutation databases

BioMutaiMT1A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6161Metallothionein-1APRO_0000197234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei58 – 581PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP04731.
PRIDEiP04731.

PTM databases

PhosphoSiteiP04731.

Expressioni

Gene expression databases

BgeeiP04731.
CleanExiHS_MT1A.

Organism-specific databases

HPAiCAB002161.
CAB013056.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
GPR50Q135853EBI-8045030,EBI-8550965
TP53P046373EBI-8045030,EBI-366083

Protein-protein interaction databases

BioGridi110595. 2 interactions.
IntActiP04731. 4 interactions.
MINTiMINT-1781424.
STRINGi9606.ENSP00000290705.

Structurei

3D structure databases

ProteinModelPortaliP04731.
SMRiP04731. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929BetaAdd
BLAST
Regioni30 – 6132AlphaAdd
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG138665.
GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
HOVERGENiHBG009063.
InParanoidiP04731.
KOiK14739.
OMAiCKGASEN.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCATG GSCTCTGSCK CKECKCTSCK KSCCSCCPMS CAKCAQGCIC
60
KGASEKCSCC A
Length:61
Mass (Da):6,120
Last modified:November 24, 2009 - v2
Checksum:i8FBA7C54EE8B6A13
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271T → N.2 Publications
Corresponds to variant rs11640851 [ dbSNP | Ensembl ].
VAR_060727
Natural varianti51 – 511K → R.
Corresponds to variant rs8052394 [ dbSNP | Ensembl ].
VAR_059436

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01383 Genomic DNA. Translation: AAA59586.1.
AY028617 mRNA. Translation: AAK26162.1.
AF348995 mRNA. Translation: AAO32955.1.
AC026461 Genomic DNA. No translation available.
BC029475 mRNA. Translation: AAH29475.1.
CCDSiCCDS32454.1.
PIRiA24502. SMHU1A.
RefSeqiNP_005937.2. NM_005946.2.
UniGeneiHs.655199.

Genome annotation databases

EnsembliENST00000290705; ENSP00000290705; ENSG00000205362.
ENST00000622334; ENSP00000478425; ENSG00000205362.
GeneIDi4489.
KEGGihsa:4489.
UCSCiuc002ejq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01383 Genomic DNA. Translation: AAA59586.1.
AY028617 mRNA. Translation: AAK26162.1.
AF348995 mRNA. Translation: AAO32955.1.
AC026461 Genomic DNA. No translation available.
BC029475 mRNA. Translation: AAH29475.1.
CCDSiCCDS32454.1.
PIRiA24502. SMHU1A.
RefSeqiNP_005937.2. NM_005946.2.
UniGeneiHs.655199.

3D structure databases

ProteinModelPortaliP04731.
SMRiP04731. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110595. 2 interactions.
IntActiP04731. 4 interactions.
MINTiMINT-1781424.
STRINGi9606.ENSP00000290705.

Chemistry

DrugBankiDB00958. Carboplatin.
DB00515. Cisplatin.
DB00526. Oxaliplatin.

PTM databases

PhosphoSiteiP04731.

Polymorphism and mutation databases

BioMutaiMT1A.

Proteomic databases

PaxDbiP04731.
PRIDEiP04731.

Protocols and materials databases

DNASUi4489.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290705; ENSP00000290705; ENSG00000205362.
ENST00000622334; ENSP00000478425; ENSG00000205362.
GeneIDi4489.
KEGGihsa:4489.
UCSCiuc002ejq.3. human.

Organism-specific databases

CTDi4489.
GeneCardsiGC16P056672.
H-InvDBHIX0021628.
HGNCiHGNC:7393. MT1A.
HPAiCAB002161.
CAB013056.
MIMi156350. gene.
neXtProtiNX_P04731.
PharmGKBiPA31198.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG138665.
GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
HOVERGENiHBG009063.
InParanoidiP04731.
KOiK14739.
OMAiCKGASEN.
TreeFamiTF336054.

Miscellaneous databases

ChiTaRSiMT1A. human.
GeneWikiiMetallothionein_1A.
GenomeRNAii4489.
NextBioi17367.
PROiP04731.
SOURCEiSearch...

Gene expression databases

BgeeiP04731.
CleanExiHS_MT1A.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids."
    Richards R.I., Heguy A., Karin M.
    Cell 37:263-272(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-27.
  2. "Cloning of a novel member of the MT gene family - MT1S."
    Wang J., Zheng L., Yu L.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-27.
    Tissue: Liver.

Entry informationi

Entry nameiMT1A_HUMAN
AccessioniPrimary (citable) accession number: P04731
Secondary accession number(s): Q86YX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 24, 2009
Last modified: June 24, 2015
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Metallothioneins
    Classification of metallothioneins and list of entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.