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P04731

- MT1A_HUMAN

UniProt

P04731 - MT1A_HUMAN

Protein

Metallothionein-1A

Gene

MT1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi5 – 51Divalent metal cation; cluster B
    Metal bindingi7 – 71Divalent metal cation; cluster B
    Metal bindingi13 – 131Divalent metal cation; cluster B
    Metal bindingi15 – 151Divalent metal cation; cluster B
    Metal bindingi19 – 191Divalent metal cation; cluster B
    Metal bindingi21 – 211Divalent metal cation; cluster B
    Metal bindingi24 – 241Divalent metal cation; cluster B
    Metal bindingi26 – 261Divalent metal cation; cluster B
    Metal bindingi29 – 291Divalent metal cation; cluster B
    Metal bindingi33 – 331Divalent metal cation; cluster A
    Metal bindingi34 – 341Divalent metal cation; cluster A
    Metal bindingi36 – 361Divalent metal cation; cluster A
    Metal bindingi37 – 371Divalent metal cation; cluster A
    Metal bindingi41 – 411Divalent metal cation; cluster A
    Metal bindingi44 – 441Divalent metal cation; cluster A
    Metal bindingi48 – 481Divalent metal cation; cluster A
    Metal bindingi50 – 501Divalent metal cation; cluster A
    Metal bindingi57 – 571Divalent metal cation; cluster A
    Metal bindingi59 – 591Divalent metal cation; cluster A
    Metal bindingi60 – 601Divalent metal cation; cluster A

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to cadmium ion Source: UniProtKB
    2. cellular response to zinc ion Source: UniProtKB
    3. negative regulation of growth Source: UniProtKB

    Keywords - Ligandi

    Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-1A
    Short name:
    MT-1A
    Alternative name(s):
    Metallothionein-IA
    Short name:
    MT-IA
    Gene namesi
    Name:MT1A
    Synonyms:MT1S
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:7393. MT1A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. perinuclear region of cytoplasm Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31198.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6161Metallothionein-1APRO_0000197234Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP04731.
    PRIDEiP04731.

    PTM databases

    PhosphoSiteiP04731.

    Expressioni

    Gene expression databases

    BgeeiP04731.
    CleanExiHS_MT1A.
    GenevestigatoriP04731.

    Organism-specific databases

    HPAiCAB002161.
    CAB013056.

    Interactioni

    Subunit structurei

    Monomer.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GPR50Q135853EBI-8045030,EBI-8550965
    TP53P046373EBI-8045030,EBI-366083

    Protein-protein interaction databases

    BioGridi110595. 2 interactions.
    IntActiP04731. 4 interactions.
    MINTiMINT-1781424.
    STRINGi9606.ENSP00000290705.

    Structurei

    3D structure databases

    ProteinModelPortaliP04731.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929BetaAdd
    BLAST
    Regioni30 – 6132AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG138665.
    HOGENOMiHOG000236262.
    HOVERGENiHBG009063.
    InParanoidiP04731.
    OMAiTNINGHN.
    TreeFamiTF336054.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P04731-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPNCSCATG GSCTCTGSCK CKECKCTSCK KSCCSCCPMS CAKCAQGCIC   50
    KGASEKCSCC A 61
    Length:61
    Mass (Da):6,120
    Last modified:November 24, 2009 - v2
    Checksum:i8FBA7C54EE8B6A13
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271T → N.2 Publications
    Corresponds to variant rs11640851 [ dbSNP | Ensembl ].
    VAR_060727
    Natural varianti51 – 511K → R.
    Corresponds to variant rs8052394 [ dbSNP | Ensembl ].
    VAR_059436

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01383 Genomic DNA. Translation: AAA59586.1.
    AY028617 mRNA. Translation: AAK26162.1.
    AF348995 mRNA. Translation: AAO32955.1.
    AC026461 Genomic DNA. No translation available.
    BC029475 mRNA. Translation: AAH29475.1.
    CCDSiCCDS32454.1.
    PIRiA24502. SMHU1A.
    RefSeqiNP_005937.2. NM_005946.2.
    UniGeneiHs.655199.

    Genome annotation databases

    EnsembliENST00000290705; ENSP00000290705; ENSG00000205362.
    GeneIDi4489.
    KEGGihsa:4489.
    UCSCiuc002ejq.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01383 Genomic DNA. Translation: AAA59586.1 .
    AY028617 mRNA. Translation: AAK26162.1 .
    AF348995 mRNA. Translation: AAO32955.1 .
    AC026461 Genomic DNA. No translation available.
    BC029475 mRNA. Translation: AAH29475.1 .
    CCDSi CCDS32454.1.
    PIRi A24502. SMHU1A.
    RefSeqi NP_005937.2. NM_005946.2.
    UniGenei Hs.655199.

    3D structure databases

    ProteinModelPortali P04731.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110595. 2 interactions.
    IntActi P04731. 4 interactions.
    MINTi MINT-1781424.
    STRINGi 9606.ENSP00000290705.

    PTM databases

    PhosphoSitei P04731.

    Proteomic databases

    PaxDbi P04731.
    PRIDEi P04731.

    Protocols and materials databases

    DNASUi 4489.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000290705 ; ENSP00000290705 ; ENSG00000205362 .
    GeneIDi 4489.
    KEGGi hsa:4489.
    UCSCi uc002ejq.3. human.

    Organism-specific databases

    CTDi 4489.
    GeneCardsi GC16P056672.
    H-InvDB HIX0021628.
    HGNCi HGNC:7393. MT1A.
    HPAi CAB002161.
    CAB013056.
    MIMi 156350. gene.
    neXtProti NX_P04731.
    PharmGKBi PA31198.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG138665.
    HOGENOMi HOG000236262.
    HOVERGENi HBG009063.
    InParanoidi P04731.
    OMAi TNINGHN.
    TreeFami TF336054.

    Miscellaneous databases

    ChiTaRSi MT1A. human.
    GeneWikii Metallothionein_1A.
    GenomeRNAii 4489.
    NextBioi 17367.
    PROi P04731.
    SOURCEi Search...

    Gene expression databases

    Bgeei P04731.
    CleanExi HS_MT1A.
    Genevestigatori P04731.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids."
      Richards R.I., Heguy A., Karin M.
      Cell 37:263-272(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-27.
    2. "Cloning of a novel member of the MT gene family - MT1S."
      Wang J., Zheng L., Yu L.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-27.
      Tissue: Liver.

    Entry informationi

    Entry nameiMT1A_HUMAN
    AccessioniPrimary (citable) accession number: P04731
    Secondary accession number(s): Q86YX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Metallothioneins
      Classification of metallothioneins and list of entries
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3