P04722 (GDA2_WHEAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Alpha/beta-gliadin A-II Alternative name(s): Prolamin
Organism	Triticum aestivum (Wheat)
Taxonomic identifier	4565 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Pooideae › Triticeae › Triticum

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Gliadin is the major seed storage protein in wheat.
Post-translational modification	Substrate of transglutaminase By similarity.
Allergenic properties	Causes an allergic reaction in human. Is the cause of the celiac disease, also known as celiac sprue or gluten-sensitive enteropathy By similarity.
Miscellaneous	The alpha/beta-gliadins can be divided into 5 homology classes. Sequence divergence between the classes is due to single base substitutions and to duplications or deletions within or near direct repeats. There are more than a 100 copies of the gene for alpha/beta-gliadin per haploid genome.
Sequence similarities	Belongs to the gliadin/glutenin family.

Ontologies

Keywords
Disease	Allergen
Domain	Repeat Signal
Molecular function	Seed storage protein Storage protein
Gene Ontology (GO)
Molecular_function	nutrient reservoir activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20
	Chain	21 – 291	271	Alpha/beta-gliadin A-II		PRO_0000032269

Sequences

	Sequence		Length	Mass (Da)
	P04722 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 9B39F93B0825A2E0	FASTA	291	33,661
	10 20 30 40 50 60 MKTFPILALL AIVATTATTA VRVPVPQLQL QNPSQQQPQE QVPLVQEQQF QGQQQPFPPQ 70 80 90 100 110 120 QPYPQPQPFP SQQPYLQLQP FPQPQLPYPQ PQPFRPQQPY PQPQPQYSQP QQPISQQQQQ 130 140 150 160 170 180 QQQQQQQQQQ ILQQILQQQL IPCRDVVLQQ HNIAHGSSQV LQESTYQLVQ QLCCQQLWQI 190 200 210 220 230 240 PEQSRCQAIH NVVHAIILHQ QHHHHQQQQQ QQQQQPLSQV SFQQPQQQYP SGQGFFQPSQ 250 260 270 280 290 QNPQAQGSFQ PQQLPQFEEI RNLALQTLPA MCNVYIPPYC TIAPFGIFGT N

References

[1]	"Evolution and heterogeneity of the alpha-/beta-type and gamma-type gliadin DNA sequences." Okita T.W., Cheesbrough V., Reeves C.D. J. Biol. Chem. 260:8203-8213(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M10092 mRNA. Translation: AAA34276.1.
PIR	C22364. T06498.
UniGene	Ta.54206.
3D structure databases
ProteinModelPortal	P04722.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Gramene	P04722.
Family and domain databases
Gene3D	1.10.120.10. 2 hits.
InterPro	IPR016140. Bifunc_inhib/LTP/seed_store. IPR001954. Glia_glutenin. IPR001376. Gliadin. IPR013771. Trypsin/amylase_inhib. [Graphical view]
Pfam	PF00234. Tryp_alpha_amyl. 1 hit. [Graphical view]
PRINTS	PR00208. GLIADGLUTEN. PR00209. GLIADIN.
SMART	SM00499. AAI. 1 hit. [Graphical view]
SUPFAM	SSF47699. Bifunc_inhib/LTP/seed_store. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GDA2_WHEAT

Accession

Primary (citable) accession number: P04722

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program