P04710 (ADT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADP,ATP carrier protein 1

Alternative name(s):
ADP/ATP translocase 1
Adenine nucleotide translocator 1
Short name=ANT 1

Gene names

Name:	AAC1
Ordered Locus Names:	YMR056C
ORF Names:	YM9796.09C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.
Subunit structure	Homodimer.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Miscellaneous	The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.
Sequence similarities	Belongs to the mitochondrial carrier family. Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from genetic interaction. Source: SGD heme transport Inferred from mutant phenotype. Source: SGD mitochondrial transport Inferred from genetic interaction. Source: SGD
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Traceable author statement. Source: SGD
Molecular function	ATP:ADP antiporter activity Inferred from direct assay. Source: SGD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	ADP,ATP carrier protein 1		PRO_0000090593
Regions
	Transmembrane	10 – 44	35	Helical; Name=1; By similarity
	Transmembrane	81 – 105	25	Helical; Name=2; By similarity
	Transmembrane	114 – 148	35	Helical; Name=3; By similarity
	Transmembrane	183 – 210	28	Helical; Name=4; By similarity
	Transmembrane	215 – 249	35	Helical; Name=5; By similarity
	Transmembrane	278 – 303	26	Helical; Name=6; By similarity
	Repeat	11 – 104	94	Solcar 1
	Repeat	116 – 208	93	Solcar 2
	Repeat	216 – 302	87	Solcar 3
	Motif	243 – 248	6	Substrate recognition By similarity
Sites
	Binding site	86	1	Nucleotide By similarity

Sequences

	Sequence		Length	Mass (Da)
	P04710 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: BEC8999DFBB1CA51	FASTA	309	34,121
	10 20 30 40 50 60 MSHTETQTQQ SHFGVDFLMG GVSAAIAKTG AAPIERVKLL MQNQEEMLKQ GSLDTRYKGI 70 80 90 100 110 120 LDCFKRTATH EGIVSFWRGN TANVLRYFPT QALNFAFKDK IKSLLSYDRE RDGYAKWFAG 130 140 150 160 170 180 NLFSGGAAGG LSLLFVYSLD YARTRLAADA RGSKSTSQRQ FNGLLDVYKK TLKTDGLLGL 190 200 210 220 230 240 YRGFVPSVLG IIVYRGLYFG LYDSFKPVLL TGALEGSFVA SFLLGWVITM GASTASYPLD 250 260 270 280 290 300 TVRRRMMMTS GQTIKYDGAL DCLRKIVQKE GAYSLFKGCG ANIFRGVAAA GVISLYDQLQ LIMFGKKFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequences required for delivery and localization of the ADP/ATP translocator to the mitochondrial inner membrane." Adrian G.S., McCammon M.T., Montgomery D.L., Douglas M.G. Mol. Cell. Biol. 6:626-634(1986) [PubMed: 3023860] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function." Hoyt M.A., Totis L., Roberts B.T. Cell 66:507-517(1991) [PubMed: 1651171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 265-309. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M12514 Genomic DNA. Translation: AAA97486.1. Z49703 Genomic DNA. Translation: CAA89766.1. M64706 Genomic DNA. Translation: AAA16884.1. BK006946 Genomic DNA. Translation: DAA09955.1.
PIR	A24849.
RefSeq	NP_013772.1. NM_001182554.1.
3D structure databases
ProteinModelPortal	P04710.
SMR	P04710. Positions 9-299.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2551N.
IntAct	P04710. 3 interactions.
MINT	MINT-426683.
STRING	P04710.
Protein family/group databases
TCDB	2.A.29.1.3. mitochondrial carrier (MC) family.
Proteomic databases
PeptideAtlas	P04710.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR056C; YMR056C; YMR056C.
GeneID	855078.
KEGG	sce:YMR056C.
NMPDR	fig|4932.3.peg.4819.
Organism-specific databases
CYGD	YMR056c.
SGD	S000004660. AAC1.
Phylogenomic databases
eggNOG	fuNOG06875.
GeneTree	EFGT00050000002383.
HOGENOM	HBG610399.
OMA	DCLAKIF.
OrthoDB	EOG4RV613.
Gene expression databases
ArrayExpress	P04710.
Genevestigator	P04710.
GermOnline	YMR056C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002113. Aden_trnslctor. IPR002067. Mit_carrier. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Gene3D	G3DSA:1.50.40.10. G3DSA:1.50.40.10. 1 hit.
KO	K05863.
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00927. ADPTRNSLCASE. PR00926. MITOCARRIER.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	978360.

Entry information

Entry name

ADT1_YEAST

Accession

Primary (citable) accession number: P04710
Secondary accession number(s): D6VZN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	December 14, 2011
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program