Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP,ATP carrier protein 1

Gene

AAC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86ADPBy similarity1
Binding sitei98ADPBy similarity1
Binding sitei243ADPBy similarity1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: SGD

GO - Biological processi

  • aerobic respiration Source: SGD
  • heme biosynthetic process Source: SGD
  • heme transport Source: SGD
  • mitochondrial transport Source: SGD
  • regulation of mitochondrial membrane permeability Source: GO_Central

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-32761-MONOMER

Protein family/group databases

TCDBi2.A.29.1.3 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 1
Alternative name(s):
ADP/ATP translocase 1
Adenine nucleotide translocator 1
Short name:
ANT 1
Gene namesi
Name:AAC1
Ordered Locus Names:YMR056C
ORF Names:YM9796.09C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR056C
SGDiS000004660 AAC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 40Helical; Name=1By similarityAdd BLAST28
Transmembranei81 – 105Helical; Name=2By similarityAdd BLAST25
Transmembranei114 – 134Helical; Name=3By similarityAdd BLAST21
Transmembranei184 – 205Helical; Name=4By similarityAdd BLAST22
Transmembranei219 – 239Helical; Name=5By similarityAdd BLAST21
Transmembranei279 – 299Helical; Name=6By similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000905931 – 309ADP,ATP carrier protein 1Add BLAST309

Proteomic databases

MaxQBiP04710
PaxDbiP04710
PRIDEiP04710

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi35232, 40 interactors
DIPiDIP-2551N
IntActiP04710, 5 interactors
MINTiP04710
STRINGi4932.YMR056C

Structurei

3D structure databases

ProteinModelPortaliP04710
SMRiP04710
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 104Solcar 1Add BLAST94
Repeati116 – 208Solcar 2Add BLAST93
Repeati216 – 302Solcar 3Add BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni243 – 248Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi243 – 248Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00910000145765
HOGENOMiHOG000165727
InParanoidiP04710
KOiK05863
OMAiGFFSYWR
OrthoDBiEOG092C3PSA

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P04710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHTETQTQQ SHFGVDFLMG GVSAAIAKTG AAPIERVKLL MQNQEEMLKQ
60 70 80 90 100
GSLDTRYKGI LDCFKRTATH EGIVSFWRGN TANVLRYFPT QALNFAFKDK
110 120 130 140 150
IKSLLSYDRE RDGYAKWFAG NLFSGGAAGG LSLLFVYSLD YARTRLAADA
160 170 180 190 200
RGSKSTSQRQ FNGLLDVYKK TLKTDGLLGL YRGFVPSVLG IIVYRGLYFG
210 220 230 240 250
LYDSFKPVLL TGALEGSFVA SFLLGWVITM GASTASYPLD TVRRRMMMTS
260 270 280 290 300
GQTIKYDGAL DCLRKIVQKE GAYSLFKGCG ANIFRGVAAA GVISLYDQLQ

LIMFGKKFK
Length:309
Mass (Da):34,121
Last modified:August 13, 1987 - v1
Checksum:iBEC8999DFBB1CA51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12514 Genomic DNA Translation: AAA97486.1
Z49703 Genomic DNA Translation: CAA89766.1
M64706 Genomic DNA Translation: AAA16884.1
BK006946 Genomic DNA Translation: DAA09955.1
PIRiA24849
RefSeqiNP_013772.1, NM_001182554.1

Genome annotation databases

EnsemblFungiiYMR056C; YMR056C; YMR056C
GeneIDi855078
KEGGisce:YMR056C

Similar proteinsi

Entry informationi

Entry nameiADT1_YEAST
AccessioniPrimary (citable) accession number: P04710
Secondary accession number(s): D6VZN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 23, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health