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Protein

ADP,ATP carrier protein 1

Gene

AAC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861NucleotideBy similarity

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: SGD
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • aerobic respiration Source: SGD
  • heme biosynthetic process Source: SGD
  • heme transport Source: SGD
  • mitochondrial transport Source: SGD
  • protein targeting to mitochondrion Source: Reactome
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32761-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.
R-SCE-422356. Regulation of insulin secretion.

Protein family/group databases

TCDBi2.A.29.1.3. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 1
Alternative name(s):
ADP/ATP translocase 1
Adenine nucleotide translocator 1
Short name:
ANT 1
Gene namesi
Name:AAC1
Ordered Locus Names:YMR056C
ORF Names:YM9796.09C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR056C.
SGDiS000004660. AAC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 4435Helical; Name=1By similarityAdd
BLAST
Transmembranei81 – 10525Helical; Name=2By similarityAdd
BLAST
Transmembranei114 – 14835Helical; Name=3By similarityAdd
BLAST
Transmembranei183 – 21028Helical; Name=4By similarityAdd
BLAST
Transmembranei215 – 24935Helical; Name=5By similarityAdd
BLAST
Transmembranei278 – 30326Helical; Name=6By similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309ADP,ATP carrier protein 1PRO_0000090593Add
BLAST

Proteomic databases

MaxQBiP04710.
PRIDEiP04710.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi35232. 29 interactions.
DIPiDIP-2551N.
IntActiP04710. 3 interactions.
MINTiMINT-426683.

Structurei

3D structure databases

ProteinModelPortaliP04710.
SMRiP04710. Positions 11-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10494Solcar 1Add
BLAST
Repeati116 – 20893Solcar 2Add
BLAST
Repeati216 – 30287Solcar 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi243 – 2486Substrate recognitionBy similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
InParanoidiP04710.
KOiK05863.
OMAiIYDTAKX.
OrthoDBiEOG7NCVDV.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHTETQTQQ SHFGVDFLMG GVSAAIAKTG AAPIERVKLL MQNQEEMLKQ
60 70 80 90 100
GSLDTRYKGI LDCFKRTATH EGIVSFWRGN TANVLRYFPT QALNFAFKDK
110 120 130 140 150
IKSLLSYDRE RDGYAKWFAG NLFSGGAAGG LSLLFVYSLD YARTRLAADA
160 170 180 190 200
RGSKSTSQRQ FNGLLDVYKK TLKTDGLLGL YRGFVPSVLG IIVYRGLYFG
210 220 230 240 250
LYDSFKPVLL TGALEGSFVA SFLLGWVITM GASTASYPLD TVRRRMMMTS
260 270 280 290 300
GQTIKYDGAL DCLRKIVQKE GAYSLFKGCG ANIFRGVAAA GVISLYDQLQ

LIMFGKKFK
Length:309
Mass (Da):34,121
Last modified:August 13, 1987 - v1
Checksum:iBEC8999DFBB1CA51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12514 Genomic DNA. Translation: AAA97486.1.
Z49703 Genomic DNA. Translation: CAA89766.1.
M64706 Genomic DNA. Translation: AAA16884.1.
BK006946 Genomic DNA. Translation: DAA09955.1.
PIRiA24849.
RefSeqiNP_013772.1. NM_001182554.1.

Genome annotation databases

EnsemblFungiiYMR056C; YMR056C; YMR056C.
GeneIDi855078.
KEGGisce:YMR056C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12514 Genomic DNA. Translation: AAA97486.1.
Z49703 Genomic DNA. Translation: CAA89766.1.
M64706 Genomic DNA. Translation: AAA16884.1.
BK006946 Genomic DNA. Translation: DAA09955.1.
PIRiA24849.
RefSeqiNP_013772.1. NM_001182554.1.

3D structure databases

ProteinModelPortaliP04710.
SMRiP04710. Positions 11-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35232. 29 interactions.
DIPiDIP-2551N.
IntActiP04710. 3 interactions.
MINTiMINT-426683.

Protein family/group databases

TCDBi2.A.29.1.3. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBiP04710.
PRIDEiP04710.

Protocols and materials databases

DNASUi855078.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR056C; YMR056C; YMR056C.
GeneIDi855078.
KEGGisce:YMR056C.

Organism-specific databases

EuPathDBiFungiDB:YMR056C.
SGDiS000004660. AAC1.

Phylogenomic databases

GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
InParanoidiP04710.
KOiK05863.
OMAiIYDTAKX.
OrthoDBiEOG7NCVDV.

Enzyme and pathway databases

BioCyciYEAST:G3O-32761-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.
R-SCE-422356. Regulation of insulin secretion.

Miscellaneous databases

PROiP04710.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences required for delivery and localization of the ADP/ATP translocator to the mitochondrial inner membrane."
    Adrian G.S., McCammon M.T., Montgomery D.L., Douglas M.G.
    Mol. Cell. Biol. 6:626-634(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function."
    Hoyt M.A., Totis L., Roberts B.T.
    Cell 66:507-517(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 265-309.
    Strain: ATCC 204508 / S288c.
  5. "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
    Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
    Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.

Entry informationi

Entry nameiADT1_YEAST
AccessioniPrimary (citable) accession number: P04710
Secondary accession number(s): D6VZN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 6, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.