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Reviewed, UniProtKB/Swiss-Prot P04707 (ADH2_MAIZE)

Last modified September 22, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 2
    EC=1.1.1.1
Gene names
Name: ADH2
OrganismZea mays (Maize)
Taxonomic identifier4577 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACCAD clade › Panicoideae › Andropogoneae › Zea

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Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Miscellaneous

In maize there are two isozymes.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Alcohol dehydrogenase 2
PRO_0000160705

Regions

Nucleotide binding202 – 2076NAD By similarity
Nucleotide binding295 – 2973NAD By similarity

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding691Zinc 1; catalytic By similarity
Metal binding991Zinc 2 By similarity
Metal binding1021Zinc 2 By similarity
Metal binding1051Zinc 2 By similarity
Metal binding1131Zinc 2 By similarity
Metal binding1771Zinc 1; catalytic By similarity
Binding site2261NAD By similarity
Binding site2311NAD By similarity
Binding site3721NAD By similarity

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Sequences

Sequence LengthMass (Da)Tools
P04707-1 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: BC09E47DD5EA894F

FASTA37941,054
        10         20         30         40         50         60 
MATAGKVIKC RAAVTWEAGK PLSIEEVEVA PPQAMEVRIK ILYTALCHTD VYFWEAKGQT 

        70         80         90        100        110        120 
PVFPRILGHE AGGIVESVGE GVTDVAPGDH VLPVFTGECK ECAHCKSEES NMCDLLRINV 

       130        140        150        160        170        180 
DRGVMIGDGK SRFTISGQPI FHFVGTSTFS EYTVIHVGCL AKINPEAPLD KVCILSCGIS 

       190        200        210        220        230        240 
TGLGATLNVA KPAKGSTVAI FGLGAVGLAA MEGARLAGAS RIIGVDINPA KYEQAKKFGC 

       250        260        270        280        290        300 
TEFVNPKDHD KPVQEVLIEL TNGGVDRSVE CTGNVNAMIS AFECVHDGWG VAVLVGVPHK 

       310        320        330        340        350        360 
DDQFKTHPMN FLSEKTLKGT FFGNYKPRTD LPNVVEMYMK KELELEKFIT HSVPFSEINT 

       370 
AFDLMLKGES LRCIMRMED

« Hide

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References

[1]"Molecular analysis of the alcohol dehydrogenase 2 (Adh2) gene of maize."
Dennis E.S., Sachs M.M., Gerlach W.L., Finnegan E.J., Peacock W.J.
Nucleic Acids Res. 13:727-743(1985) [PubMed: 2987807] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

X01965 mRNA. Translation: CAA26001.1.
PIRA23084.
RefSeqNP_001105410.1.
UniGeneZm.2859

3D structure databases

HSSPHSSP built from PDB template 1M6H based on UniProtKB P11766.
ModBaseSearch...

Genome annotation databases

GeneID542364.

Organism-specific databases

GrameneP04707.
MaizeGDB13844.

Enzyme and pathway databases

BRENDA1.1.1.1. 289.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADH2_MAIZE
AccessionPrimary (citable) accession number: P04707
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 22, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents