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Protein

Tubulin beta-1/beta-2 chain

Gene

TUBB1

more
Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Miscellaneous

The 2 beta-tubulin genes of Chlamydomonas (beta-1 and beta-2) encode the same protein.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi140 – 146GTPSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta-1/beta-2 chain
Alternative name(s):
Beta-tubulin
Gene namesi
Name:TUBB1
AND
Name:TUBB2
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000483351 – 443Tubulin beta-1/beta-2 chainAdd BLAST443

Proteomic databases

PRIDEiP04690.
ProMEXiP04690.

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Structurei

3D structure databases

ProteinModelPortaliP04690.
SMRiP04690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1375. Eukaryota.
COG5023. LUCA.
KOiK07375.
OMAiDEMEGEC.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiView protein in InterPro
IPR013838. Beta-tubulin_BS.
IPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR037103. Tubulin/FtsZ_C_sf.
IPR036525. Tubulin/FtsZ_GTPase_sf.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
PANTHERiPTHR11588. PTHR11588. 1 hit.
PTHR11588:SF256. PTHR11588:SF256. 1 hit.
PfamiView protein in Pfam
PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiView protein in PROSITE
PS00227. TUBULIN. 1 hit.
PS00228. TUBULIN_B_AUTOREG. 1 hit.

Sequencei

Sequence statusi: Complete.

P04690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREIVHIQGG QCGNQIGAKF WEVVSDEHGI DPTGTYHGDS DLQLERINVY
60 70 80 90 100
FNEATGGRYV PRAILMDLEP GTMDSVRSGP YGQIFRPDNF VFGQTGAGNN
110 120 130 140 150
WAKGHYTEGA ELIDSVLDVV RKEAESCDCL QGFQVCHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYP DRMMLTFSVV PSPKVSDTVV EPYNATLSVH QLVENADECM
210 220 230 240 250
VLDNEALYDI CFRTLKLTTP TFGDLNHLIS AVMSGITCCL RFPGQLNADL
260 270 280 290 300
RKLAVNLIPF PRLHFFMVGF TPLTSRGSQQ YRALTVPELT QQMWDAKNMM
310 320 330 340 350
CAADPRHGRY LTASALFRGR MSTKEVDEQM LNVQNKNSSY FVEWIPNNVK
360 370 380 390 400
SSVCDIPPKG LKMSATFIGN STAIQEMFKR VSEQFTAMFR RKAFLHWYTG
410 420 430 440
EGMDEMEFTE AESNMNDLVS EYQQYQDASA EEEGEFEGEE EEA
Length:443
Mass (Da):49,619
Last modified:August 13, 1987 - v1
Checksum:i5967934FCA8FDB8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10064 Genomic DNA. Translation: AAA33101.1.
K03281 Genomic DNA. Translation: AAA33102.1.
K01808 Genomic DNA. Translation: AAA33099.1.
K01809 Genomic DNA. Translation: AAA33100.1.
PIRiA29141. UBKM.
RefSeqiXP_001693997.1. XM_001693945.1.
XP_001694072.1. XM_001694020.1.
UniGeneiCre.13965.
Cre.14179.

Genome annotation databases

EnsemblPlantsiEDP02933; EDP02933; CHLREDRAFT_129868.
EDP03008; EDP03008; CHLREDRAFT_129876.
GeneIDi5719519.
5719644.
GrameneiEDP02933; EDP02933; CHLREDRAFT_129868.
EDP03008; EDP03008; CHLREDRAFT_129876.
KEGGicre:CHLREDRAFT_129868.
cre:CHLREDRAFT_129876.

Similar proteinsi

Entry informationi

Entry nameiTBB_CHLRE
AccessioniPrimary (citable) accession number: P04690
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: January 31, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families