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Protein

Alpha-S2-casein

Gene

CSN1S2

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S2-casein
Gene namesi
Name:CSN1S2
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei1241. Ovi a 8.
2963. Ovi a 10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515By similarityAdd
BLAST
Chaini16 – 223208Alpha-S2-caseinPRO_0000004469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei24 – 241PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei72 – 721PhosphoserineBy similarity
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei74 – 741PhosphoserineBy similarity
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei159 – 1591PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP04654.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati77 – 14165Add
BLAST
Repeati159 – 22365Add
BLAST

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG005244.

Family and domain databases

InterProiIPR011175. Alpha-s2_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 2 hits.
[Graphical view]
PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFIFTCLL AVALAKHKME HVSSSEEPIN ISQEIYKQEK NMAIHPRKEK
60 70 80 90 100
LCTTSCEEVV RNADEEEYSI RSSSEESAEV APEEVKITVD DKHYQKALNE
110 120 130 140 150
INQFYQKFPQ YLQYLYQGPI VLNPWDQVKR NAGPFTPTVN REQLSTSEEN
160 170 180 190 200
SKKTIDMEST EVFTKKTKLT EEEKNRLNFL KKISQYYQKF AWPQYLKTVD
210 220
QHQKAMKPWT QPKTNAIPYV RYL
Length:223
Mass (Da):26,332
Last modified:August 13, 1987 - v1
Checksum:i67212935E27426D7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941Y → T no nucleotide entry (PubMed:1935959).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641D → N.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03238 mRNA. Translation: CAA26983.1.
PIRiA25070. KASHS2.
RefSeqiNP_001009363.1. NM_001009363.1.
UniGeneiOar.426.

Genome annotation databases

GeneIDi443383.
KEGGioas:443383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03238 mRNA. Translation: CAA26983.1.
PIRiA25070. KASHS2.
RefSeqiNP_001009363.1. NM_001009363.1.
UniGeneiOar.426.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1241. Ovi a 8.
2963. Ovi a 10.

Proteomic databases

PRIDEiP04654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443383.
KEGGioas:443383.

Organism-specific databases

CTDi100327035.

Phylogenomic databases

HOVERGENiHBG005244.

Family and domain databases

InterProiIPR011175. Alpha-s2_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 2 hits.
[Graphical view]
PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASA2_SHEEP
AccessioniPrimary (citable) accession number: P04654
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 14, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.