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Protein

Thyrotropin subunit beta

Gene

Tshb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Indispensable for the control of thyroid structure and metabolism.

GO - Molecular functioni

  • hormone activity Source: RGD

GO - Biological processi

  • response to calcium ion Source: RGD
  • response to estrogen Source: RGD
  • response to vitamin A Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-209822. Glycoprotein hormones.
R-RNO-209968. Thyroxine biosynthesis.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin subunit beta
Alternative name(s):
Thyroid-stimulating hormone subunit beta
Short name:
TSH-B
Short name:
TSH-beta
Thyrotropin beta chain
Gene namesi
Name:Tshb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3910. Tshb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 132112Thyrotropin subunit betaPRO_0000011754Add
BLAST
Propeptidei133 – 1386PRO_0000011755

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 72By similarity
Disulfide bondi36 ↔ 87By similarity
Disulfide bondi39 ↔ 125By similarity
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi47 ↔ 103By similarity
Disulfide bondi51 ↔ 105By similarity
Disulfide bondi108 ↔ 115By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04652.
PRIDEiP04652.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016793.
ExpressionAtlasiP04652. baseline.
GenevisibleiP04652. RN.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

  • hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022575.

Structurei

3D structure databases

ProteinModelPortaliP04652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXJG. Eukaryota.
ENOG410YSY0. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP04652.
KOiK05251.
OMAiTNYCTKP.
OrthoDBiEOG091G0XFH.
PhylomeDBiP04652.
TreeFamiTF332940.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAVVLFSVL FALACGQVSS FCIPTEYMMY VDRRECAYCL TINTTICAGY
60 70 80 90 100
CMTRDINGKL FLPKYALSQD VCTYRDFTYR TVEIPGCPHH VAPYFSYPVA
110 120 130
LSCKCGKCNT DYSDCTHEAV KTNYCTKPQT FYLGGFSG
Length:138
Mass (Da):15,505
Last modified:May 1, 2007 - v2
Checksum:iF8AD7F2426DAEE09
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161G → E in CAA25684 (PubMed:6086256).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01454 mRNA. Translation: CAA25684.1.
M10902 mRNA. Translation: AAA42301.1.
M13897 Genomic DNA. Translation: AAB59720.1.
M14450 Genomic DNA. Translation: AAA99238.1.
BC058488 mRNA. Translation: AAH58488.1.
D00578 mRNA. Translation: BAA00456.1.
PIRiA90954. TTRTB.
RefSeqiNP_037248.2. NM_013116.2.
UniGeneiRn.9966.

Genome annotation databases

EnsembliENSRNOT00000022575; ENSRNOP00000022575; ENSRNOG00000016793.
GeneIDi25653.
KEGGirno:25653.
UCSCiRGD:3910. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01454 mRNA. Translation: CAA25684.1.
M10902 mRNA. Translation: AAA42301.1.
M13897 Genomic DNA. Translation: AAB59720.1.
M14450 Genomic DNA. Translation: AAA99238.1.
BC058488 mRNA. Translation: AAH58488.1.
D00578 mRNA. Translation: BAA00456.1.
PIRiA90954. TTRTB.
RefSeqiNP_037248.2. NM_013116.2.
UniGeneiRn.9966.

3D structure databases

ProteinModelPortaliP04652.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022575.

Proteomic databases

PaxDbiP04652.
PRIDEiP04652.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022575; ENSRNOP00000022575; ENSRNOG00000016793.
GeneIDi25653.
KEGGirno:25653.
UCSCiRGD:3910. rat.

Organism-specific databases

CTDi7252.
RGDi3910. Tshb.

Phylogenomic databases

eggNOGiENOG410IXJG. Eukaryota.
ENOG410YSY0. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP04652.
KOiK05251.
OMAiTNYCTKP.
OrthoDBiEOG091G0XFH.
PhylomeDBiP04652.
TreeFamiTF332940.

Enzyme and pathway databases

ReactomeiR-RNO-209822. Glycoprotein hormones.
R-RNO-209968. Thyroxine biosynthesis.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP04652.

Gene expression databases

BgeeiENSRNOG00000016793.
ExpressionAtlasiP04652. baseline.
GenevisibleiP04652. RN.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSHB_RAT
AccessioniPrimary (citable) accession number: P04652
Secondary accession number(s): Q6GTA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: May 1, 2007
Last modified: September 7, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.