P04650 (RL39_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L39

Alternative name(s):
L46
YL40

Gene names

Name:	RPL39
Synonyms:	RPL46, SPB2
Ordered Locus Names:	YJL189W
ORF Names:	J0360

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	51 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Ref.4
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ribosomal protein L39e family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytoplasmic translation Traceable author statement Ref.4. Source: SGD
Cellular_component	cytosolic large ribosomal subunit Traceable author statement Ref.4. Source: SGD
Molecular_function	structural constituent of ribosome Traceable author statement Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.5
	Chain	2 – 51	50	60S ribosomal protein L39		PRO_0000127044

Sequences

	Sequence		Length	Mass (Da)
	P04650 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: FE518D8B3949C163	FASTA	51	6,342
	10 20 30 40 50 MAAQKSFRIK QKMAKAKKQN RPLPQWIRLR TNNTIRYNAK RRNWRRTKMN I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genes for yeast ribosomal proteins S24 and L46 are adjacent and divergently transcribed." Leer R.J., van Raamsdonk-Duin M.M.C., Kraakman P., Mager W.H., Planta R.J. Nucleic Acids Res. 13:701-709(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae." Planta R.J., Mager W.H. Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE, SUBUNIT.
[5]	"The action of N-terminal acetyltransferases on yeast ribosomal proteins." Arnold R.J., Polevoda B., Reilly J.P., Sherman F. J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CLEAVAGE OF INITIATOR METHIONINE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X01963 Genomic DNA. Translation: CAA25999.1.
Z49464 Genomic DNA. Translation: CAA89483.1.
BK006943 Genomic DNA. Translation: DAA08618.1.

PIR

R6BY46. B23082.

RefSeq

NP_012346.1. NM_001181622.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WW9	electron microscopy	8.60	O	1-51	[»]
2WWA	electron microscopy	8.90	O	1-51	[»]
3IZS	electron microscopy	-	o	1-51	[»]
3O58	X-ray	4.00	e	1-51	[»]
3O5H	X-ray	4.00	e	1-51	[»]
3U5E	X-ray	3.00	l	1-51	[»]
3U5I	X-ray	3.00	l	1-51	[»]
4B6A	electron microscopy	8.10	l	1-51	[»]

ProteinModelPortal

P04650.

SMR

P04650. Positions 2-51.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-4522N.

IntAct

P04650. 3 interactions.

MINT

MINT-491659.

STRING

4932.YJL189W.

Proteomic databases

PaxDb

P04650.

PeptideAtlas

P04650.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YJL189W; YJL189W; YJL189W.

GeneID

853250.

KEGG

sce:YJL189W.

Organism-specific databases

SGD

S000003725. RPL39.

Phylogenomic databases

eggNOG

COG2167.

GeneTree

ENSGT00390000014814.

HOGENOM

HOG000230627.

KO

K02924.

OrthoDB

EOG41ZJMS.

Gene expression databases

Genevestigator

P04650.

GermOnline

YJL189W. Saccharomyces cerevisiae.

Family and domain databases

Gene3D

1.10.1620.10. 1 hit.

InterPro

IPR000077. Ribosomal_L39.
IPR020083. Ribosomal_L39_CS.
IPR023626. Ribosomal_L39e_dom.
[Graphical view]

PANTHER

PTHR19970. PTHR19970. 1 hit.

Pfam

PF00832. Ribosomal_L39. 1 hit.
[Graphical view]

SUPFAM

SSF48662. Ribosomal_L39. 1 hit.

PROSITE

PS00051. RIBOSOMAL_L39E. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P04650.

NextBio

973493.

Entry information

Entry name

RL39_YEAST

Accession

Primary (citable) accession number: P04650
Secondary accession number(s): D6VW02

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program