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Protein

60S ribosomal protein L39

Gene

RPL39

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31621-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L391 Publication
Alternative name(s):
L46
Large ribosomal subunit protein eL391 Publication
YL40
Gene namesi
Name:RPL391 Publication
Synonyms:RPL46, SPB2
Ordered Locus Names:YJL189W
ORF Names:J0360
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL189W
SGDiS000003725 RPL39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001270442 – 5160S ribosomal protein L39Add BLAST50

Proteomic databases

PaxDbiP04650
PRIDEiP04650
TopDownProteomicsiP04650

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). eL39 interacts with YIH1 (PubMed:22404850).1 Publication2 Publications

Protein-protein interaction databases

BioGridi33574, 37 interactors
DIPiDIP-4522N
IntActiP04650, 8 interactors
MINTiP04650
STRINGi4932.YJL189W

Structurei

Secondary structure

151
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 18Combined sources12
Helixi25 – 29Combined sources5
Turni44 – 46Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WW9electron microscopy8.60O1-51[»]
2WWAelectron microscopy8.90O1-51[»]
2WWBelectron microscopy6.48O1-51[»]
3J6Xelectron microscopy6.10791-51[»]
3J6Yelectron microscopy6.10791-51[»]
3J77electron microscopy6.20891-51[»]
3J78electron microscopy6.30891-51[»]
3JCTelectron microscopy3.08l1-51[»]
4U3MX-ray3.00O9/o92-51[»]
4U3NX-ray3.20O9/o92-51[»]
4U3UX-ray2.90O9/o92-51[»]
4U4NX-ray3.10O9/o92-51[»]
4U4OX-ray3.60O9/o92-51[»]
4U4QX-ray3.00O9/o92-51[»]
4U4RX-ray2.80O9/o92-51[»]
4U4UX-ray3.00O9/o92-51[»]
4U4YX-ray3.20O9/o92-51[»]
4U4ZX-ray3.10O9/o92-51[»]
4U50X-ray3.20O9/o92-51[»]
4U51X-ray3.20O9/o92-51[»]
4U52X-ray3.00O9/o92-51[»]
4U53X-ray3.30O9/o92-51[»]
4U55X-ray3.20O9/o92-51[»]
4U56X-ray3.45O9/o92-51[»]
4U6FX-ray3.10O9/o92-51[»]
4V6Ielectron microscopy8.80Bo1-51[»]
4V7Felectron microscopy8.70j1-51[»]
4V7RX-ray4.00Be/De1-51[»]
4V88X-ray3.00Bl/Dl1-51[»]
4V8Telectron microscopy8.10l1-51[»]
4V8Yelectron microscopy4.30Bl2-51[»]
4V8Zelectron microscopy6.60Bl2-51[»]
4V91electron microscopy3.70l1-51[»]
5APNelectron microscopy3.91l1-51[»]
5APOelectron microscopy3.41l1-51[»]
5DATX-ray3.15O9/o92-51[»]
5DC3X-ray3.25O9/o92-51[»]
5DGEX-ray3.45O9/o92-51[»]
5DGFX-ray3.30O9/o92-51[»]
5DGVX-ray3.10O9/o92-51[»]
5FCIX-ray3.40O9/o92-51[»]
5FCJX-ray3.10O9/o92-51[»]
5FL8electron microscopy9.50l1-51[»]
5GAKelectron microscopy3.88n1-51[»]
5H4Pelectron microscopy3.07l1-51[»]
5I4LX-ray3.10O9/o92-51[»]
5IT7electron microscopy3.60ll2-50[»]
5JCSelectron microscopy9.50l1-51[»]
5JUOelectron microscopy4.00QA1-51[»]
5JUPelectron microscopy3.50QA1-51[»]
5JUSelectron microscopy4.20QA1-51[»]
5JUTelectron microscopy4.00QA1-51[»]
5JUUelectron microscopy4.00QA1-51[»]
5LYBX-ray3.25O9/o92-51[»]
5M1Jelectron microscopy3.30l52-51[»]
5MC6electron microscopy3.80AL1-51[»]
5MEIX-ray3.50AM/DN2-51[»]
5NDGX-ray3.70O9/o92-51[»]
5NDVX-ray3.30O9/o92-51[»]
5NDWX-ray3.70O9/o92-51[»]
5OBMX-ray3.40O9/o92-51[»]
5ON6X-ray3.10AM/DN2-51[»]
5T62electron microscopy3.30y1-51[»]
5T6Relectron microscopy4.50y1-51[»]
5TBWX-ray3.00AM/DN2-51[»]
5TGAX-ray3.30O9/o92-51[»]
5TGMX-ray3.50O9/o92-51[»]
ProteinModelPortaliP04650
SMRiP04650
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04650

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000014814
HOGENOMiHOG000230627
InParanoidiP04650
KOiK02924
OrthoDBiEOG092C5TJL

Family and domain databases

Gene3Di1.10.1620.10, 1 hit
HAMAPiMF_00629 Ribosomal_L39e, 1 hit
InterProiView protein in InterPro
IPR000077 Ribosomal_L39
IPR020083 Ribosomal_L39_CS
IPR023626 Ribosomal_L39e_dom_sf
PANTHERiPTHR19970 PTHR19970, 1 hit
PfamiView protein in Pfam
PF00832 Ribosomal_L39, 1 hit
SUPFAMiSSF48662 SSF48662, 1 hit
PROSITEiView protein in PROSITE
PS00051 RIBOSOMAL_L39E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQKSFRIK QKMAKAKKQN RPLPQWIRLR TNNTIRYNAK RRNWRRTKMN

I
Length:51
Mass (Da):6,342
Last modified:January 23, 2007 - v3
Checksum:iFE518D8B3949C163
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01963 Genomic DNA Translation: CAA25999.1
Z49464 Genomic DNA Translation: CAA89483.1
BK006943 Genomic DNA Translation: DAA08618.1
PIRiB23082 R6BY46
RefSeqiNP_012346.1, NM_001181622.1

Genome annotation databases

EnsemblFungiiYJL189W; YJL189W; YJL189W
GeneIDi853250
KEGGisce:YJL189W

Similar proteinsi

Entry informationi

Entry nameiRL39_YEAST
AccessioniPrimary (citable) accession number: P04650
Secondary accession number(s): D6VW02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health