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Protein

60S ribosomal protein L35a

Gene

Rpl35a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the proliferation and viability of hematopoietic cells (By similarity). Plays a role in 60S ribosomal subunit formation (By similarity). The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, tRNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L35a
Gene namesi
Name:Rpl35a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 1, Chromosome 12, Chromosome 5, Chromosome 6

Organism-specific databases

RGDi628793. Rpl35a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928001 – 11060S ribosomal protein L35aAdd BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8N6-acetyllysineBy similarity1
Modified residuei63N6-acetyllysine; alternateBy similarity1
Modified residuei63N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP04646.
PRIDEiP04646.

PTM databases

iPTMnetiP04646.
PhosphoSitePlusiP04646.

Expressioni

Gene expression databases

BgeeiENSRNOG00000031641.
GenevisibleiP04646. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055825.

Structurei

3D structure databases

ProteinModelPortaliP04646.
SMRiP04646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L35Ae family.Curated

Phylogenomic databases

eggNOGiKOG0887. Eukaryota.
COG2451. LUCA.
GeneTreeiENSGT00390000016972.
HOGENOMiHOG000195636.
HOVERGENiHBG054581.
InParanoidiP04646.
KOiK02917.
OMAiNTRTEVD.
OrthoDBiEOG091G112U.
PhylomeDBiP04646.
TreeFamiTF300104.

Family and domain databases

InterProiIPR001780. Ribosomal_L35A.
IPR018266. Ribosomal_L35Ae_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR10902. PTHR10902. 1 hit.
PfamiPF01247. Ribosomal_L35Ae. 1 hit.
[Graphical view]
ProDomiPD012670. Ribosomal_L35Ae. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS01105. RIBOSOMAL_L35AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRLWCKAI FAGYKRGLRN QREHTALLKI EGVYARDETE FYLGKRCAYV
60 70 80 90 100
YKAKNNTVTP GGKPNKTRVI WGKVTRAHGN SGMVRAKFRS NLPAKAIGHR
110
IRVMLYPSRI
Length:110
Mass (Da):12,554
Last modified:August 13, 1987 - v1
Checksum:i126B5E77E75F29F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03475 mRNA. Translation: CAA27193.1.
BC061557 mRNA. Translation: AAH61557.1.
PIRiA25404. R5RT5A.
RefSeqiNP_067087.1. NM_021264.3.
XP_002727941.1. XM_002727895.5.
XP_002727942.1. XM_002727896.5.
XP_003752544.1. XM_003752496.4.
XP_003752545.1. XM_003752497.4.
XP_017445766.1. XM_017590277.1.
XP_017453659.1. XM_017598170.1.
XP_017453972.1. XM_017598483.1.
XP_017459744.1. XM_017604255.1.
XP_017459850.1. XM_017604361.1.
UniGeneiRn.156479.
Rn.201355.
Rn.2812.

Genome annotation databases

EnsembliENSRNOT00000040261; ENSRNOP00000040611; ENSRNOG00000032303.
ENSRNOT00000042285; ENSRNOP00000041209; ENSRNOG00000031641.
ENSRNOT00000043508; ENSRNOP00000049054; ENSRNOG00000032348.
ENSRNOT00000050438; ENSRNOP00000039099; ENSRNOG00000049536.
ENSRNOT00000050968; ENSRNOP00000051188; ENSRNOG00000047557.
GeneIDi100359498.
103690996.
108349682.
57809.
KEGGirno:100359498.
rno:57809.
UCSCiRGD:628793. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03475 mRNA. Translation: CAA27193.1.
BC061557 mRNA. Translation: AAH61557.1.
PIRiA25404. R5RT5A.
RefSeqiNP_067087.1. NM_021264.3.
XP_002727941.1. XM_002727895.5.
XP_002727942.1. XM_002727896.5.
XP_003752544.1. XM_003752496.4.
XP_003752545.1. XM_003752497.4.
XP_017445766.1. XM_017590277.1.
XP_017453659.1. XM_017598170.1.
XP_017453972.1. XM_017598483.1.
XP_017459744.1. XM_017604255.1.
XP_017459850.1. XM_017604361.1.
UniGeneiRn.156479.
Rn.201355.
Rn.2812.

3D structure databases

ProteinModelPortaliP04646.
SMRiP04646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055825.

PTM databases

iPTMnetiP04646.
PhosphoSitePlusiP04646.

Proteomic databases

PaxDbiP04646.
PRIDEiP04646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000040261; ENSRNOP00000040611; ENSRNOG00000032303.
ENSRNOT00000042285; ENSRNOP00000041209; ENSRNOG00000031641.
ENSRNOT00000043508; ENSRNOP00000049054; ENSRNOG00000032348.
ENSRNOT00000050438; ENSRNOP00000039099; ENSRNOG00000049536.
ENSRNOT00000050968; ENSRNOP00000051188; ENSRNOG00000047557.
GeneIDi100359498.
103690996.
108349682.
57809.
KEGGirno:100359498.
rno:57809.
UCSCiRGD:628793. rat.

Organism-specific databases

CTDi6165.
RGDi628793. Rpl35a.

Phylogenomic databases

eggNOGiKOG0887. Eukaryota.
COG2451. LUCA.
GeneTreeiENSGT00390000016972.
HOGENOMiHOG000195636.
HOVERGENiHBG054581.
InParanoidiP04646.
KOiK02917.
OMAiNTRTEVD.
OrthoDBiEOG091G112U.
PhylomeDBiP04646.
TreeFamiTF300104.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP04646.

Gene expression databases

BgeeiENSRNOG00000031641.
GenevisibleiP04646. RN.

Family and domain databases

InterProiIPR001780. Ribosomal_L35A.
IPR018266. Ribosomal_L35Ae_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR10902. PTHR10902. 1 hit.
PfamiPF01247. Ribosomal_L35Ae. 1 hit.
[Graphical view]
ProDomiPD012670. Ribosomal_L35Ae. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS01105. RIBOSOMAL_L35AE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL35A_RAT
AccessioniPrimary (citable) accession number: P04646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.