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Protein

Osteocalcin

Gene

Bglap

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi66Calcium 3By similarity1
Metal bindingi70Calcium 2By similarity1
Metal bindingi73Calcium 1By similarity1
Metal bindingi73Calcium 2By similarity1
Metal bindingi79Calcium 1By similarity1

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • structural constituent of bone Source: RGD

GO - Biological processi

  • aging Source: RGD
  • biomineral tissue development Source: UniProtKB-KW
  • bone development Source: RGD
  • cell aging Source: RGD
  • cellular response to growth factor stimulus Source: RGD
  • cellular response to vitamin D Source: RGD
  • odontogenesis Source: RGD
  • ossification Source: RGD
  • osteoblast development Source: RGD
  • osteoblast differentiation Source: RGD
  • regulation of bone mineralization Source: InterPro
  • response to activity Source: RGD
  • response to drug Source: RGD
  • response to estrogen Source: RGD
  • response to ethanol Source: RGD
  • response to glucocorticoid Source: RGD
  • response to gravity Source: RGD
  • response to hydroxyisoflavone Source: RGD
  • response to inorganic substance Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to nutrient levels Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to testosterone Source: RGD
  • response to vitamin K Source: RGD
  • response to zinc ion Source: RGD
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-159740. Gamma-carboxylation of protein precursors.
R-RNO-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-RNO-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:Bglap
Synonyms:Bglap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2206. Bglap.

Subcellular locationi

GO - Cellular componenti

  • cell projection Source: RGD
  • cytoplasm Source: RGD
  • dendrite Source: RGD
  • extracellular region Source: MGI
  • extracellular space Source: RGD
  • Golgi apparatus Source: RGD
  • membrane-bounded vesicle Source: RGD
  • perikaryon Source: RGD
  • rough endoplasmic reticulum Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23CuratedAdd BLAST23
PropeptideiPRO_000001109224 – 49CuratedAdd BLAST26
ChainiPRO_000001109350 – 99OsteocalcinAdd BLAST50

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58Hydroxyproline1 Publication1
Modified residuei664-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei704-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Disulfide bondi72 ↔ 78PROSITE-ProRule annotation
Modified residuei734-carboxyglutamatePROSITE-ProRule annotationBy similarity1

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Proteomic databases

PaxDbiP04640.
PRIDEiP04640.

Expressioni

Gene expression databases

GenevisibleiP04640. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026530.

Structurei

3D structure databases

ProteinModelPortaliP04640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 96GlaPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
InParanoidiP04640.
OMAiNCDELAD.
OrthoDBiEOG091G13UG.
PhylomeDBiP04640.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLSLLTLL ALTAFCLSDL AGAKPSDSES DKAFMSKQEG SKVVNRLRRY
60 70 80 90
LNNGLGAPAP YPDPLEPHRE VCELNPNCDE LADHIGFQDA YKRIYGTTV
Length:99
Mass (Da):10,927
Last modified:August 13, 1987 - v1
Checksum:i7F18F1866D4E4388
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04141 mRNA. Translation: CAA27761.1.
M11777 mRNA. Translation: AAA40816.1.
M23637 Genomic DNA. Translation: AAA41761.1.
M25490 Genomic DNA. Translation: AAA53280.1.
J04500 Genomic DNA. Translation: AAA41764.1.
PIRiA31856. GERT.
RefSeqiNP_038200.1. NM_013414.1.
XP_006232656.1. XM_006232594.3.
UniGeneiRn.9722.

Genome annotation databases

EnsembliENSRNOT00000026530; ENSRNOP00000026530; ENSRNOG00000019607.
GeneIDi25295.
KEGGirno:25295.
UCSCiRGD:2206. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04141 mRNA. Translation: CAA27761.1.
M11777 mRNA. Translation: AAA40816.1.
M23637 Genomic DNA. Translation: AAA41761.1.
M25490 Genomic DNA. Translation: AAA53280.1.
J04500 Genomic DNA. Translation: AAA41764.1.
PIRiA31856. GERT.
RefSeqiNP_038200.1. NM_013414.1.
XP_006232656.1. XM_006232594.3.
UniGeneiRn.9722.

3D structure databases

ProteinModelPortaliP04640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026530.

Proteomic databases

PaxDbiP04640.
PRIDEiP04640.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026530; ENSRNOP00000026530; ENSRNOG00000019607.
GeneIDi25295.
KEGGirno:25295.
UCSCiRGD:2206. rat.

Organism-specific databases

CTDi632.
RGDi2206. Bglap.

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
InParanoidiP04640.
OMAiNCDELAD.
OrthoDBiEOG091G13UG.
PhylomeDBiP04640.
TreeFamiTF330920.

Enzyme and pathway databases

ReactomeiR-RNO-159740. Gamma-carboxylation of protein precursors.
R-RNO-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-RNO-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Miscellaneous databases

PROiP04640.

Gene expression databases

GenevisibleiP04640. RN.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSTCN_RAT
AccessioniPrimary (citable) accession number: P04640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.