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P04638

- APOA2_RAT

UniProt

P04638 - APOA2_RAT

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Protein

Apolipoprotein A-II

Gene

Apoa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

GO - Molecular functioni

  1. cholesterol binding Source: Ensembl
  2. cholesterol transporter activity Source: RGD
  3. high-density lipoprotein particle binding Source: Ensembl
  4. lipase inhibitor activity Source: Ensembl
  5. phosphatidylcholine binding Source: Ensembl
  6. phosphatidylcholine-sterol O-acyltransferase activator activity Source: Ensembl
  7. protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  1. acute inflammatory response Source: RGD
  2. cholesterol efflux Source: Ensembl
  3. cholesterol homeostasis Source: Ensembl
  4. cholesterol metabolic process Source: Ensembl
  5. cholesterol transport Source: RGD
  6. diacylglycerol catabolic process Source: Ensembl
  7. high-density lipoprotein particle assembly Source: Ensembl
  8. high-density lipoprotein particle clearance Source: Ensembl
  9. high-density lipoprotein particle remodeling Source: Ensembl
  10. lipoprotein metabolic process Source: Ensembl
  11. low-density lipoprotein particle remodeling Source: Ensembl
  12. negative regulation of cholesterol import Source: Ensembl
  13. negative regulation of cholesterol transporter activity Source: Ensembl
  14. negative regulation of cytokine secretion involved in immune response Source: Ensembl
  15. negative regulation of lipase activity Source: Ensembl
  16. negative regulation of lipid catabolic process Source: Ensembl
  17. negative regulation of very-low-density lipoprotein particle remodeling Source: Ensembl
  18. organ regeneration Source: RGD
  19. peptidyl-methionine modification Source: Ensembl
  20. phosphatidylcholine biosynthetic process Source: Ensembl
  21. phospholipid catabolic process Source: Ensembl
  22. phospholipid efflux Source: Ensembl
  23. positive regulation of cholesterol esterification Source: Ensembl
  24. positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
  25. positive regulation of lipid catabolic process Source: Ensembl
  26. protein folding Source: Ensembl
  27. protein oxidation Source: Ensembl
  28. regulation of intestinal cholesterol absorption Source: Ensembl
  29. regulation of protein stability Source: Ensembl
  30. response to drug Source: RGD
  31. response to estrogen Source: RGD
  32. response to glucocorticoid Source: RGD
  33. response to glucose Source: Ensembl
  34. reverse cholesterol transport Source: Ensembl
  35. triglyceride-rich lipoprotein particle remodeling Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_196408. PPARA activates gene expression.
REACT_199015. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-II
Short name:
Apo-AII
Short name:
ApoA-II
Alternative name(s):
Apolipoprotein A2
Cleaved into the following chain:
Proapolipoprotein A-II
Short name:
ProapoA-II
Gene namesi
Name:Apoa2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi2131. Apoa2.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: Ensembl
  2. chylomicron Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. spherical high-density lipoprotein particle Source: Ensembl
  5. very-low-density lipoprotein particle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 10284Proapolipoprotein A-IIPRO_0000425360Add
BLAST
Chaini24 – 10279Apolipoprotein A-IIPRO_0000002012Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid; in Apolipoprotein A-IIBy similarity
Modified residuei49 – 491Methionine sulfoxideBy similarity

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Oxidation, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP04638.
PRIDEiP04638.

PTM databases

PhosphoSiteiP04638.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

GenevestigatoriP04638.

Interactioni

Subunit structurei

Monomer. Interacts with APOA1BP and NDRG1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004662.

Structurei

3D structure databases

ProteinModelPortaliP04638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40617.
GeneTreeiENSGT00390000003306.
HOGENOMiHOG000033999.
HOVERGENiHBG050544.
InParanoidiP04638.
KOiK08758.
OMAiAYFEKTQ.
OrthoDBiEOG7G4QHG.
PhylomeDBiP04638.
TreeFamiTF338165.

Family and domain databases

InterProiIPR006801. ApoA-II.
[Graphical view]
PANTHERiPTHR11027. PTHR11027. 1 hit.
PfamiPF04711. ApoA-II. 1 hit.
[Graphical view]
ProDomiPD010397. ApoA-II. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04638-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLAMVALL VTICSLEGAL VRRQAAETDV QTLFSQYLQS LTDYGKDLME
60 70 80 90 100
KAQPSEIQNQ AKAYFQNAQE RLTPFVQRTG TNLMDFLSRL MSPEEKPAPA

AK
Length:102
Mass (Da):11,439
Last modified:August 13, 1987 - v1
Checksum:i94A29508DFE7A813
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03468 mRNA. Translation: CAA27185.1.
M28615 mRNA. Translation: AAA40750.1.
PIRiA24846.
RefSeqiNP_037244.1. NM_013112.1.
XP_006250300.1. XM_006250238.2.
XP_006250301.1. XM_006250239.2.
UniGeneiRn.89304.

Genome annotation databases

EnsembliENSRNOT00000004662; ENSRNOP00000004662; ENSRNOG00000003500.
GeneIDi25649.
KEGGirno:25649.
UCSCiRGD:2131. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03468 mRNA. Translation: CAA27185.1 .
M28615 mRNA. Translation: AAA40750.1 .
PIRi A24846.
RefSeqi NP_037244.1. NM_013112.1.
XP_006250300.1. XM_006250238.2.
XP_006250301.1. XM_006250239.2.
UniGenei Rn.89304.

3D structure databases

ProteinModelPortali P04638.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000004662.

PTM databases

PhosphoSitei P04638.

Proteomic databases

PaxDbi P04638.
PRIDEi P04638.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004662 ; ENSRNOP00000004662 ; ENSRNOG00000003500 .
GeneIDi 25649.
KEGGi rno:25649.
UCSCi RGD:2131. rat.

Organism-specific databases

CTDi 336.
RGDi 2131. Apoa2.

Phylogenomic databases

eggNOGi NOG40617.
GeneTreei ENSGT00390000003306.
HOGENOMi HOG000033999.
HOVERGENi HBG050544.
InParanoidi P04638.
KOi K08758.
OMAi AYFEKTQ.
OrthoDBi EOG7G4QHG.
PhylomeDBi P04638.
TreeFami TF338165.

Enzyme and pathway databases

Reactomei REACT_196408. PPARA activates gene expression.
REACT_199015. Retinoid metabolism and transport.

Miscellaneous databases

NextBioi 607515.
PROi P04638.

Gene expression databases

Genevestigatori P04638.

Family and domain databases

InterProi IPR006801. ApoA-II.
[Graphical view ]
PANTHERi PTHR11027. PTHR11027. 1 hit.
Pfami PF04711. ApoA-II. 1 hit.
[Graphical view ]
ProDomi PD010397. ApoA-II. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Structure and evolution of the apolipoprotein multigene family."
    Luo C.-C., Li W.-H., Moore M.N., Chan L.
    J. Mol. Biol. 187:325-340(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Amino acid sequence of rat apolipoprotein A-II deduced from the nucleotide sequence of cloned cDNA."
    Nagashima M., Morris G., Howlett G., Fidge N., Schreiber G.
    J. Lipid Res. 27:706-712(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-102.

Entry informationi

Entry nameiAPOA2_RAT
AccessioniPrimary (citable) accession number: P04638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3