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P04638

- APOA2_RAT

UniProt

P04638 - APOA2_RAT

Protein

Apolipoprotein A-II

Gene

Apoa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

    GO - Molecular functioni

    1. cholesterol binding Source: Ensembl
    2. cholesterol transporter activity Source: RGD
    3. high-density lipoprotein particle binding Source: Ensembl
    4. lipase inhibitor activity Source: Ensembl
    5. phosphatidylcholine binding Source: Ensembl
    6. phosphatidylcholine-sterol O-acyltransferase activator activity Source: Ensembl
    7. protein heterodimerization activity Source: UniProtKB

    GO - Biological processi

    1. acute inflammatory response Source: RGD
    2. cholesterol efflux Source: Ensembl
    3. cholesterol homeostasis Source: Ensembl
    4. cholesterol metabolic process Source: Ensembl
    5. cholesterol transport Source: RGD
    6. diacylglycerol catabolic process Source: Ensembl
    7. high-density lipoprotein particle assembly Source: Ensembl
    8. high-density lipoprotein particle clearance Source: Ensembl
    9. high-density lipoprotein particle remodeling Source: Ensembl
    10. lipoprotein metabolic process Source: Ensembl
    11. low-density lipoprotein particle remodeling Source: Ensembl
    12. negative regulation of cholesterol import Source: Ensembl
    13. negative regulation of cholesterol transporter activity Source: Ensembl
    14. negative regulation of cytokine secretion involved in immune response Source: Ensembl
    15. negative regulation of lipase activity Source: Ensembl
    16. negative regulation of lipid catabolic process Source: Ensembl
    17. negative regulation of very-low-density lipoprotein particle remodeling Source: Ensembl
    18. organ regeneration Source: RGD
    19. peptidyl-methionine modification Source: Ensembl
    20. phosphatidylcholine biosynthetic process Source: Ensembl
    21. phospholipid catabolic process Source: Ensembl
    22. phospholipid efflux Source: Ensembl
    23. positive regulation of cholesterol esterification Source: Ensembl
    24. positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
    25. positive regulation of lipid catabolic process Source: Ensembl
    26. protein folding Source: Ensembl
    27. protein oxidation Source: Ensembl
    28. regulation of intestinal cholesterol absorption Source: Ensembl
    29. regulation of protein stability Source: Ensembl
    30. response to drug Source: RGD
    31. response to estrogen Source: RGD
    32. response to glucocorticoid Source: RGD
    33. response to glucose Source: Ensembl
    34. reverse cholesterol transport Source: Ensembl
    35. triglyceride-rich lipoprotein particle remodeling Source: Ensembl

    Keywords - Biological processi

    Lipid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196408. PPARA activates gene expression.
    REACT_199015. Retinoid metabolism and transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein A-II
    Short name:
    Apo-AII
    Short name:
    ApoA-II
    Alternative name(s):
    Apolipoprotein A2
    Cleaved into the following chain:
    Proapolipoprotein A-II
    Short name:
    ProapoA-II
    Gene namesi
    Name:Apoa2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi2131. Apoa2.

    Subcellular locationi

    GO - Cellular componenti

    1. chylomicron Source: Ensembl
    2. spherical high-density lipoprotein particle Source: Ensembl
    3. very-low-density lipoprotein particle Source: Ensembl

    Keywords - Cellular componenti

    HDL, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Chaini19 – 10284Proapolipoprotein A-IIPRO_0000425360Add
    BLAST
    Chaini24 – 10279Apolipoprotein A-IIPRO_0000002012Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acid; in Apolipoprotein A-IIBy similarity
    Modified residuei49 – 491Methionine sulfoxideBy similarity

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Oxidation, Phosphoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    PaxDbiP04638.
    PRIDEiP04638.

    PTM databases

    PhosphoSiteiP04638.

    Expressioni

    Tissue specificityi

    Plasma.

    Gene expression databases

    GenevestigatoriP04638.

    Interactioni

    Subunit structurei

    Monomer. Interacts with APOA1BP and NDRG1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004662.

    Structurei

    3D structure databases

    ProteinModelPortaliP04638.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the apolipoprotein A2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40617.
    GeneTreeiENSGT00390000003306.
    HOGENOMiHOG000033999.
    HOVERGENiHBG050544.
    InParanoidiP04638.
    KOiK08758.
    OMAiAYFEKTQ.
    OrthoDBiEOG7G4QHG.
    PhylomeDBiP04638.
    TreeFamiTF338165.

    Family and domain databases

    InterProiIPR006801. ApoA-II.
    [Graphical view]
    PANTHERiPTHR11027. PTHR11027. 1 hit.
    PfamiPF04711. ApoA-II. 1 hit.
    [Graphical view]
    ProDomiPD010397. ApoA-II. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04638-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLAMVALL VTICSLEGAL VRRQAAETDV QTLFSQYLQS LTDYGKDLME    50
    KAQPSEIQNQ AKAYFQNAQE RLTPFVQRTG TNLMDFLSRL MSPEEKPAPA 100
    AK 102
    Length:102
    Mass (Da):11,439
    Last modified:August 13, 1987 - v1
    Checksum:i94A29508DFE7A813
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03468 mRNA. Translation: CAA27185.1.
    M28615 mRNA. Translation: AAA40750.1.
    PIRiA24846.
    RefSeqiNP_037244.1. NM_013112.1.
    XP_006250300.1. XM_006250238.1.
    XP_006250301.1. XM_006250239.1.
    UniGeneiRn.89304.

    Genome annotation databases

    EnsembliENSRNOT00000004662; ENSRNOP00000004662; ENSRNOG00000003500.
    GeneIDi25649.
    KEGGirno:25649.
    UCSCiRGD:2131. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03468 mRNA. Translation: CAA27185.1 .
    M28615 mRNA. Translation: AAA40750.1 .
    PIRi A24846.
    RefSeqi NP_037244.1. NM_013112.1.
    XP_006250300.1. XM_006250238.1.
    XP_006250301.1. XM_006250239.1.
    UniGenei Rn.89304.

    3D structure databases

    ProteinModelPortali P04638.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004662.

    PTM databases

    PhosphoSitei P04638.

    Proteomic databases

    PaxDbi P04638.
    PRIDEi P04638.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004662 ; ENSRNOP00000004662 ; ENSRNOG00000003500 .
    GeneIDi 25649.
    KEGGi rno:25649.
    UCSCi RGD:2131. rat.

    Organism-specific databases

    CTDi 336.
    RGDi 2131. Apoa2.

    Phylogenomic databases

    eggNOGi NOG40617.
    GeneTreei ENSGT00390000003306.
    HOGENOMi HOG000033999.
    HOVERGENi HBG050544.
    InParanoidi P04638.
    KOi K08758.
    OMAi AYFEKTQ.
    OrthoDBi EOG7G4QHG.
    PhylomeDBi P04638.
    TreeFami TF338165.

    Enzyme and pathway databases

    Reactomei REACT_196408. PPARA activates gene expression.
    REACT_199015. Retinoid metabolism and transport.

    Miscellaneous databases

    NextBioi 607515.
    PROi P04638.

    Gene expression databases

    Genevestigatori P04638.

    Family and domain databases

    InterProi IPR006801. ApoA-II.
    [Graphical view ]
    PANTHERi PTHR11027. PTHR11027. 1 hit.
    Pfami PF04711. ApoA-II. 1 hit.
    [Graphical view ]
    ProDomi PD010397. ApoA-II. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and evolution of the apolipoprotein multigene family."
      Luo C.-C., Li W.-H., Moore M.N., Chan L.
      J. Mol. Biol. 187:325-340(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Amino acid sequence of rat apolipoprotein A-II deduced from the nucleotide sequence of cloned cDNA."
      Nagashima M., Morris G., Howlett G., Fidge N., Schreiber G.
      J. Lipid Res. 27:706-712(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-102.

    Entry informationi

    Entry nameiAPOA2_RAT
    AccessioniPrimary (citable) accession number: P04638
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3