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Protein

Apolipoprotein A-II

Gene

Apoa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-174800. Chylomicron-mediated lipid transport.
R-RNO-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-II
Short name:
Apo-AII
Short name:
ApoA-II
Alternative name(s):
Apolipoprotein A2
Cleaved into the following chain:
Proapolipoprotein A-II
Short name:
ProapoA-II
Gene namesi
Name:Apoa2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2131. Apoa2.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000042536019 – 102Proapolipoprotein A-IIAdd BLAST84
ChainiPRO_000000201224 – 102Apolipoprotein A-IIBy similarityAdd BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acid; in Apolipoprotein A-IIBy similarity1
Modified residuei49Methionine sulfoxideBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Oxidation, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP04638.
PRIDEiP04638.

PTM databases

iPTMnetiP04638.
PhosphoSitePlusiP04638.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSRNOG00000003500.
GenevisibleiP04638. RN.

Interactioni

Subunit structurei

Monomer. Interacts with APOA1BP and NDRG1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004662.

Structurei

3D structure databases

ProteinModelPortaliP04638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3V8. Eukaryota.
ENOG4111552. LUCA.
GeneTreeiENSGT00390000003306.
HOGENOMiHOG000033999.
HOVERGENiHBG050544.
InParanoidiP04638.
KOiK08758.
OMAiAYFEKTQ.
OrthoDBiEOG091G0Z27.
PhylomeDBiP04638.
TreeFamiTF338165.

Family and domain databases

InterProiIPR006801. ApoA-II.
[Graphical view]
PANTHERiPTHR11027. PTHR11027. 1 hit.
ProDomiPD010397. ApoA-II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF82936. SSF82936. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLAMVALL VTICSLEGAL VRRQAAETDV QTLFSQYLQS LTDYGKDLME
60 70 80 90 100
KAQPSEIQNQ AKAYFQNAQE RLTPFVQRTG TNLMDFLSRL MSPEEKPAPA

AK
Length:102
Mass (Da):11,439
Last modified:August 13, 1987 - v1
Checksum:i94A29508DFE7A813
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03468 mRNA. Translation: CAA27185.1.
M28615 mRNA. Translation: AAA40750.1.
PIRiA24846.
RefSeqiNP_037244.1. NM_013112.1.
XP_006250300.1. XM_006250238.2.
XP_006250301.1. XM_006250239.2.
UniGeneiRn.89304.

Genome annotation databases

EnsembliENSRNOT00000004662; ENSRNOP00000004662; ENSRNOG00000003500.
GeneIDi25649.
KEGGirno:25649.
UCSCiRGD:2131. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03468 mRNA. Translation: CAA27185.1.
M28615 mRNA. Translation: AAA40750.1.
PIRiA24846.
RefSeqiNP_037244.1. NM_013112.1.
XP_006250300.1. XM_006250238.2.
XP_006250301.1. XM_006250239.2.
UniGeneiRn.89304.

3D structure databases

ProteinModelPortaliP04638.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004662.

PTM databases

iPTMnetiP04638.
PhosphoSitePlusiP04638.

Proteomic databases

PaxDbiP04638.
PRIDEiP04638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004662; ENSRNOP00000004662; ENSRNOG00000003500.
GeneIDi25649.
KEGGirno:25649.
UCSCiRGD:2131. rat.

Organism-specific databases

CTDi336.
RGDi2131. Apoa2.

Phylogenomic databases

eggNOGiENOG410J3V8. Eukaryota.
ENOG4111552. LUCA.
GeneTreeiENSGT00390000003306.
HOGENOMiHOG000033999.
HOVERGENiHBG050544.
InParanoidiP04638.
KOiK08758.
OMAiAYFEKTQ.
OrthoDBiEOG091G0Z27.
PhylomeDBiP04638.
TreeFamiTF338165.

Enzyme and pathway databases

ReactomeiR-RNO-174800. Chylomicron-mediated lipid transport.
R-RNO-975634. Retinoid metabolism and transport.

Miscellaneous databases

PROiP04638.

Gene expression databases

BgeeiENSRNOG00000003500.
GenevisibleiP04638. RN.

Family and domain databases

InterProiIPR006801. ApoA-II.
[Graphical view]
PANTHERiPTHR11027. PTHR11027. 1 hit.
ProDomiPD010397. ApoA-II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF82936. SSF82936. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPOA2_RAT
AccessioniPrimary (citable) accession number: P04638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.