Reviewed, UniProtKB/Swiss-Prot P04637 (P53_HUMAN)

Names and origin

Protein names

Recommended name:
    Cellular tumor antigen p53
Alternative name(s):
    Tumor suppressor p53
    Phosphoprotein p53
    Antigen NY-CO-13

Gene names

Name:	TP53
Synonyms:	P53

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Ref.50
Cofactor	Binds 1 zinc ion per subunit.
Subunit structure	Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 By similarity. Binds DNA as a homotetramer. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. In vitro, the interaction of TP53 with cancer-associated/HPV (E6) viral proteins leads to ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This complex formation requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and P53DINP1. Interacts with WWOX. May interact with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity By similarity. Interacts with ARMC10, BANP, CDKN2AIP and E4F1. Interacts with YWHAZ; the interaction enhances P53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus).
Subcellular location	Cytoplasm. Nucleus. Endoplasmic reticulum. Note: Interaction with BANP promotes nuclear localization. Ref.36 Ref.53 Ref.59
Domain	The nuclear export signal acts as a transcriptional repression domain. Ref.35
Post-translational modification	Acetylated. Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 By similarity. Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated degradation. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated on Ser-15 upon ultraviolet irradiation; which is enhanced by interaction with BANP. Dephosphorylated by PP2A. SV40 small T antigen inhibits the dephosphorylation by the AC form of PP2A. Ref.53 Ref.24 Ref.26 Ref.32 Ref.37 Ref.38 Ref.42 Ref.43 Ref.51 Ref.55 Ref.61 Ref.64 Ref.65 May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line. Ref.28 Ubiquitinated by SYVN1, which leads to proteasomal degradation. Ref.59 Monomethylated at Lys-372 by SETD7, leading to stabilize it and increase transcriptional activation. Monomethylated at Lys-370 by SMYD2, leading to decrease DNA-binding activity and subsequent transcriptional regulation activity. Lys-372 monomethylation prevents the interaction with SMYD2 and subsequenct monomethylation at Lys-370. Ref.52 Ref.57 Ref.58 Sumoylated by SUMO1. Ref.36 Ref.29 Demethylation of di-methylated Lys-370 by KDM1/LSD1 prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation.
Involvement in disease	TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or inactivated in about 60% of cancers. Defects in TP53 are involved in esophageal squamous cell carcinoma (ESCC) [MIM:133239]. ESCC is a tumor of the esophagus. Defects in TP53 are a cause of Li-Fraumeni syndrome (LFS) [MIM:151623]. LFS is an autosomal dominant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed (Ref.101 and Ref.104) and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers. Ref.80 Ref.81 Ref.82 Ref.83 Ref.84 Ref.103 Ref.105 Ref.110 Ref.111 Defects in TP53 may be associated with nasopharyngeal carcinoma [MIM:161550]; also known as nasopharyngeal cancer. Defects in TP53 are found in Barrett metaplasia; also known as Barrett esophagus. It is a condition in which the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium. The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease and predisposes to the development of esophageal adenocarcinoma. Defects in TP53 are involved in head and neck squamous cell carcinomas (HNSCC) [MIM:275355]. Defects in TP53 are involved in oral squamous cell carcinoma (OSCC). Cigarette smoke is a prime mutagenic agent in cancer of the aerodigestive tract. Defects in TP53 are a cause of lung cancer [MIM:211980]. Defects in TP53 are a cause of choroid plexus papilloma [MIM:260500]. Choroid plexus papilloma is a slow-growing benign tumor of the choroid plexus that often invades the leptomeninges. In children it is usually in a lateral ventricle but in adults it is more often in the fourth ventricle. Hydrocephalus is common, either from obstruction or from tumor secretion of cerebrospinal fluid. If it undergoes malignant transformation it is called a choroid plexus carcinoma. Primary choroid plexus tumors are rare and usually occur in early childhood. Ref.114 Defects in TP53 are a cause of one form of hereditary adrenocortical carcinoma (ADCC) [MIM:202300]. ADCC is a rare childhood tumor, representing about 0.4% of childhood tumors, with a high incidence of associated tumors. ADCC occurs with increased frequency in patients with the Beckwith-Wiedemann syndrome [MIM:130650] and is a component tumor in Li-Fraumeni syndrome [MIM:151623]. Ref.113
Sequence similarities	Belongs to the p53 family.

Ontologies

Keywords
Biological process	Apoptosis Cell cycle Host-virus interaction Transcription Transcription regulation
Cellular component	Cytoplasm Endoplasmic reticulum Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Li-Fraumeni syndrome Tumor suppressor
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Acetylation Glycoprotein Isopeptide bond Methylation Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis Inferred from direct assay. Source: MGI ER overload response Inferred from direct assay. Source: MGI RNA-protein covalent cross-linking Inferred from electronic annotation. Source: UniProtKB-KW activation of caspase activity by cytochrome c Inferred from direct assay. Source: UniProtKB base-excision repair Traceable author statement. Source: UniProtKB cell aging Inferred from mutant phenotype. Source: UniProtKB cell cycle arrest Traceable author statement. Source: UniProtKB cellular response to glucose starvation Inferred from direct assay. Source: MGI interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell cycle Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell growth Inferred from mutant phenotype. Source: UniProtKB negative regulation of helicase activity Traceable author statement. Source: UniProtKB nucleotide-excision repair Inferred from mutant phenotype. Source: UniProtKB positive regulation of specific transcription from RNA polymerase II promoter Ref.34 Inferred from direct assay. Source: UniProtKB protein tetramerization Traceable author statement. Source: UniProtKB regulation of mitochondrial membrane permeability Traceable author statement. Source: UniProtKB response to tumor cell Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	PML body Inferred from direct assay. Source: UniProtKB endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell insoluble fraction Inferred from direct assay. Source: UniProtKB mitochondrion Inferred from direct assay. Source: UniProtKB nuclear matrix Inferred from direct assay. Source: UniProtKB nucleolus Inferred from direct assay. Source: UniProtKB
Molecular function	ATP binding Inferred from direct assay. Source: UniProtKB DNA strand annealing activity Inferred from direct assay. Source: UniProtKB chaperone binding Inferred from physical interaction. Source: UniProtKB chromatin binding Inferred from direct assay. Source: MGI copper ion binding Inferred from direct assay. Source: UniProtKB enzyme binding Inferred from physical interaction. Source: UniProtKB protein N-terminus binding Inferred from physical interaction. Source: UniProtKB protein heterodimerization activity Inferred from physical interaction. Source: UniProtKB transcription factor activity Inferred from direct assay. Source: UniProtKB zinc ion binding Traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	P03070	3	EBI-366083,EBI-617698	From a different organism.
	Q9PST7	2	EBI-366083,EBI-1782562	From a different organism.
ATR	Q13535	1	EBI-366083,EBI-968983
BARD1	Q99728	1	EBI-366083,EBI-473181
Bard1	O70445	1	EBI-366083,EBI-1790207	From a different organism.
BCL2L1	Q07817-1	2	EBI-366083,EBI-287195
BMX	P51813	1	EBI-366083,EBI-696657
BTBD2	Q9BX70	1	EBI-366083,EBI-710091
CABLES1	Q8TDN4	1	EBI-366083,EBI-604615
Cables1	Q9ESJ1	1	EBI-366083,EBI-604411	From a different organism.
CEBPB	P17676	3	EBI-366083,EBI-969696
CREBBP	Q92793	3	EBI-366083,EBI-81215
Crebbp	P45481	2	EBI-366083,EBI-296306	From a different organism.
CSE1L	P55060	4	EBI-366083,EBI-286709
CUL7	Q14999	1	EBI-366083,EBI-308606
CUL9	Q8IWT3	1	EBI-366083,EBI-311123
DAXX	Q9UER7	3	EBI-366083,EBI-77321
EP300	Q09472	3	EBI-366083,EBI-447295
FBXO11	Q86XK2	3	EBI-366083,EBI-1047804
GNL3	Q9BVP2	1	EBI-366083,EBI-641642
HDAC1	Q13547	1	EBI-366083,EBI-301834
HIPK1	Q86Z02	1	EBI-366083,EBI-692891
HMGB1	P09429	1	EBI-366083,EBI-389432
HNRNPUL1	Q9BUJ2	6	EBI-366083,EBI-1018153
HTATIP	Q92993	1	EBI-366083,EBI-399080
HTT	P42858	2	EBI-366083,EBI-466029
HUWE1	Q7Z6Z7	2	EBI-366083,EBI-625934
JMY	Q8N9B5	1	EBI-366083,EBI-866435
MAPK11	Q15759	1	EBI-366083,EBI-298304
MAPK11	Q15759-2	1	EBI-366083,EBI-303766
MAPKAPK5	Q8IW41	1	EBI-366083,EBI-1201460
MDM2	Q00987	7	EBI-366083,EBI-389668
mdm2	P56273	1	EBI-366083,EBI-541233	From a different organism.
MDM4	O15151	2	EBI-366083,EBI-398437
NFYA	P23511	2	EBI-366083,EBI-389739
NPM1	P06748	3	EBI-366083,EBI-78579
NPM1	P06748-1	1	EBI-366083,EBI-354150
PARP1	P09874	1	EBI-366083,EBI-355676
PBK	Q96KB5	2	EBI-366083,EBI-536853
PIAS1	O75925	1	EBI-366083,EBI-629434
PIAS4	Q8N2W9	1	EBI-366083,EBI-473160
PML	P29590	1	EBI-366083,EBI-295890
PPP1CC	P36873-1	2	EBI-366083,EBI-356289
PTK2	Q05397	6	EBI-366083,EBI-702142
RAD51	Q06609	1	EBI-366083,EBI-297202
RPA1	P27694	1	EBI-366083,EBI-621389
RPS27A	P62988	1	EBI-366083,EBI-413034
Rps27a	P62991	1	EBI-366083,EBI-413074	From a different organism.
SETD7	Q8WTS6	3	EBI-366083,EBI-1268586
SIN3A	Q96ST3	2	EBI-366083,EBI-347218
TBP	P20226	1	EBI-366083,EBI-355371
TP53BP2	Q13625	1	EBI-366083,EBI-77642
UBE3A	Q05086	1	EBI-366083,EBI-954357
USP7	Q93009	4	EBI-366083,EBI-302474
WRN	Q14191	2	EBI-366083,EBI-368417
XRCC6	P12956	1	EBI-366083,EBI-353208
ZNF385A	Q96PM9	1	EBI-366083,EBI-1539778

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P04637-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P04637-2)

Also known as: I9RET;

The sequence of this isoform differs from the canonical sequence as follows:
     332-341: IRGRERFEMF → DGTSFQKENC
     342-393: Missing.

Note: Seems to be non-functional. Expressed in quiescent lymphocytes.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Cellular tumor antigen p53		PRO_0000185703
Regions
	DNA binding	102 – 292	191
	Region	1 – 83	83	Interaction with HRMT1L2
	Region	1 – 44	44	Transcription activation (acidic)
	Region	66 – 110	45	Interaction with WWOX
	Region	100 – 370	271	Interaction with HIPK1 By similarity
	Region	116 – 292	177	Interaction with AXIN1 By similarity
	Region	241 – 248	8	Interacts with the 53BP2 SH3 domain
	Region	256 – 294	39	Interaction with E4F1
	Region	300 – 393	94	Interaction with CARM1
	Region	319 – 360	42	Interaction with HIPK2
	Region	325 – 356	32	Oligomerization
	Region	359 – 363	5	Interaction with USP7
	Region	368 – 387	20	Basic (repression of DNA-binding)
	Motif	305 – 321	17	Bipartite nuclear localization signal
	Motif	339 – 350	12	Nuclear export signal
	Motif	370 – 372	3	[KR]-[STA]-K motif
Sites
	Metal binding	176	1	Zinc
	Metal binding	179	1	Zinc
	Metal binding	238	1	Zinc
	Metal binding	242	1	Zinc
Amino acid modifications
	Modified residue	9	1	Phosphoserine; by HIPK4 Ref.61
	Modified residue	15	1	Phosphoserine; by PRPK Ref.53
	Modified residue	18	1	Phosphothreonine; by VRK1 Ref.32
	Modified residue	46	1	Phosphoserine; by HIPK2 Ref.42 Ref.43
	Modified residue	55	1	Phosphothreonine; by TAF1 Ref.51
	Modified residue	99	1	Phosphoserine Ref.65
	Modified residue	305	1	N6-acetyllysine Ref.45
	Modified residue	315	1	Phosphoserine; by CDC2 Ref.64
	Modified residue	370	1	N6-methyllysine Ref.57
	Modified residue	372	1	N6-methyllysine Ref.52 Ref.58
	Modified residue	373	1	N6-acetyllysine Ref.30
	Modified residue	382	1	N6-acetyllysine Ref.30 Ref.34
	Modified residue	392	1	Phosphoserine; by CK2 Ref.38 Ref.55
	Cross-link	386		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) Ref.36 Ref.29
Natural variations
	Alternative sequence	332 – 341	10	IRGRERFEMF → DGTSFQKENC in isoform 2.		VSP_006535
	Alternative sequence	342 – 393	52	Missing in isoform 2.		VSP_006536
	Natural variant	5	1	Q → H in a sporadic cancer; somatic mutation.		VAR_044543
	Natural variant	6	1	S → L in a sporadic cancer; somatic mutation.		VAR_044544
	Natural variant	7	1	D → H in a sporadic cancer; somatic mutation.		VAR_005851
	Natural variant	8	1	P → S in a sporadic cancer; somatic mutation.		VAR_044545
	Natural variant	10	1	V → I in a sporadic cancer; somatic mutation.		VAR_044546
	Natural variant	11	1	E → K in sporadic cancers; somatic mutation.		VAR_044547
	Natural variant	11	1	E → Q in sporadic cancers; somatic mutation.		VAR_044548
	Natural variant	15	1	S → R in a sporadic cancer; somatic mutation.		VAR_044549
	Natural variant	16	1	Q → L in a sporadic cancer; somatic mutation.		VAR_044550
	Natural variant	17	1	E → D in a sporadic cancer; somatic mutation.		VAR_044551
	Natural variant	24	1	K → N in a sporadic cancer; somatic mutation.		VAR_044552
	Natural variant	28	1	E → A in a sporadic cancer; somatic mutation.		VAR_044553
	Natural variant	29 – 30	2	NN → KD in a sporadic cancer; somatic mutation.		VAR_047158
	Natural variant	31	1	V → I in sporadic cancers; somatic mutation.		VAR_044554
	Natural variant	33	1	S → T in a sporadic cancer; somatic mutation.		VAR_044555
	Natural variant	34	1	P → L in a sporadic cancer; somatic mutation.		VAR_044556
	Natural variant	35	1	L → F in sporadic cancers; somatic mutation.		VAR_005852
	Natural variant	36	1	P → L in a sporadic cancer; somatic mutation.		VAR_044557
	Natural variant	37	1	S → P in a sporadic cancer; somatic mutation.		VAR_044558
	Natural variant	37	1	S → T in a sporadic cancer; somatic mutation.		VAR_044559
	Natural variant	39	1	A → P in a sporadic cancer; somatic mutation.		VAR_044560
	Natural variant	39	1	A → V in a sporadic cancer; somatic mutation.		VAR_044561
	Natural variant	42	1	D → Y in a sporadic cancer; somatic mutation.		VAR_044562
	Natural variant	43	1	L → S in a sporadic cancer; somatic mutation.		VAR_005853
	Natural variant	44	1	M → I in a sporadic cancer; somatic mutation.		VAR_044563
	Natural variant	44	1	M → T in a sporadic cancer; somatic mutation.		VAR_044564
	Natural variant	44	1	M → V in a sporadic cancer; somatic mutation.		VAR_044565
	Natural variant	45	1	L → M in a sporadic cancer; somatic mutation.		VAR_044566
	Natural variant	46	1	S → F in sporadic cancers; somatic mutation.		VAR_044567
	Natural variant	46	1	S → P in sporadic cancers; somatic mutation.		VAR_044568
	Natural variant	47	1	P → L in sporadic cancers; somatic mutation.		VAR_044569
	Natural variant	47	1	P → S: dbSNP rs1800371. Ref.12		VAR_014632
	Natural variant	48	1	D → G in a sporadic cancer; somatic mutation.		VAR_044570
	Natural variant	49	1	D → H in sporadic cancers; somatic mutation.		VAR_044571
	Natural variant	49	1	D → N in a sporadic cancer; somatic mutation.		VAR_044572
	Natural variant	49	1	D → Y in sporadic cancers; somatic mutation.		VAR_044573
	Natural variant	52	1	Q → H in a sporadic cancer; somatic mutation.		VAR_044574
	Natural variant	53	1	W → C in sporadic cancers; somatic mutation.		VAR_005854
	Natural variant	53	1	W → G in a sporadic cancer; somatic mutation.		VAR_044575
	Natural variant	54	1	F → L in a sporadic cancer; somatic mutation.		VAR_044576
	Natural variant	54	1	F → Y in a sporadic cancer; somatic mutation.		VAR_044577
	Natural variant	56	1	E → K in sporadic cancers; somatic mutation.		VAR_044578
	Natural variant	56	1	E → V in a sporadic cancer; somatic mutation.		VAR_044579
	Natural variant	58	1	P → Q in a sporadic cancer; somatic mutation.		VAR_044580
	Natural variant	58	1	P → T in a sporadic cancer; somatic mutation.		VAR_044581
	Natural variant	59	1	G → C in sporadic cancers; somatic mutation.		VAR_044582
	Natural variant	59	1	G → D in sporadic cancers; somatic mutation.		VAR_044583
	Natural variant	59	1	G → N in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045783
	Natural variant	60	1	P → L in sporadic cancers; somatic mutation.		VAR_044584
	Natural variant	60	1	P → Q in a sporadic cancer; somatic mutation.		VAR_044585
	Natural variant	60	1	P → S in a sporadic cancer; somatic mutation.		VAR_005855
	Natural variant	61	1	D → G in sporadic cancers; somatic mutation.		VAR_044586
	Natural variant	61	1	D → N in sporadic cancers; somatic mutation.		VAR_044587
	Natural variant	62	1	E → D in a sporadic cancer; somatic mutation.		VAR_044588
	Natural variant	63	1	A → T in a sporadic cancer; somatic mutation.		VAR_044589
	Natural variant	63	1	A → V in a sporadic cancer; somatic mutation.		VAR_044590
	Natural variant	65	1	R → T in a sporadic cancer; somatic mutation.		VAR_044591
	Natural variant	66	1	M → I in a sporadic cancer; somatic mutation.		VAR_044592
	Natural variant	66	1	M → R in a sporadic cancer; somatic mutation.		VAR_044593
	Natural variant	67	1	P → L in sporadic cancers; somatic mutation.		VAR_044594
	Natural variant	67	1	P → R in a sporadic cancer; somatic mutation.		VAR_044595
	Natural variant	67	1	P → S in sporadic cancers; somatic mutation.		VAR_044596
	Natural variant	68	1	E → G in sporadic cancers; somatic mutation.		VAR_044597
	Natural variant	68	1	E → Q in a sporadic cancer; somatic mutation.		VAR_044598
	Natural variant	69	1	A → D in a sporadic cancer; somatic mutation.		VAR_044599
	Natural variant	69	1	A → G in sporadic cancers; somatic mutation.		VAR_044600
	Natural variant	69	1	A → T in a sporadic cancer; somatic mutation.		VAR_044601
	Natural variant	69	1	A → V in a sporadic cancer; somatic mutation.		VAR_044602
	Natural variant	70	1	A → T in a sporadic cancer; somatic mutation.		VAR_044603
	Natural variant	71	1	P → T in a sporadic cancer; somatic mutation.		VAR_044604
	Natural variant	72	1	R → C in sporadic cancers; somatic mutation.		VAR_045784
	Natural variant	72	1	R → G in sporadic cancers; somatic mutation.		VAR_045785
	Natural variant	72	1	R → H in sporadic cancers; somatic mutation.		VAR_045786
	Natural variant	72	1	R → L in a sporadic cancer; somatic mutation.		VAR_045787
	Natural variant	72	1	R → P: dbSNP rs1042522. Ref.79		VAR_005856
	Natural variant	73	1	V → E in a sporadic cancer; somatic mutation.		VAR_044605
	Natural variant	73	1	V → L in sporadic cancers; somatic mutation.		VAR_044606
	Natural variant	73	1	V → M in sporadic cancers; somatic mutation.		VAR_044607
	Natural variant	74	1	A → T in a sporadic cancer; somatic mutation.		VAR_044608
	Natural variant	75	1	P → L in sporadic cancers; somatic mutation.		VAR_044609
	Natural variant	75	1	P → R in sporadic cancers; somatic mutation.		VAR_044610
	Natural variant	75	1	P → S in a sporadic cancer; somatic mutation.		VAR_044611
	Natural variant	76	1	A → G in a sporadic cancer; somatic mutation.		VAR_044612
	Natural variant	76	1	A → T in a sporadic cancer; somatic mutation.		VAR_044613
	Natural variant	77	1	P → A in sporadic cancers; somatic mutation.		VAR_044614
	Natural variant	78	1	A → V in sporadic cancers; somatic mutation.		VAR_044615
	Natural variant	79	1	A → G in a sporadic cancer; somatic mutation.		VAR_044616
	Natural variant	79	1	A → T in a sporadic cancer; somatic mutation.		VAR_005857
	Natural variant	79	1	A → V in sporadic cancers; somatic mutation.		VAR_044617
	Natural variant	80	1	P → L in a sporadic cancer; somatic mutation.		VAR_044618
	Natural variant	80	1	P → S in a sporadic cancer; somatic mutation.		VAR_044619
	Natural variant	81	1	T → I in sporadic cancers; somatic mutation.		VAR_044620
	Natural variant	82	1	P → L in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_044621
	Natural variant	82	1	P → S in sporadic cancers; somatic mutation.		VAR_044622
	Natural variant	83	1	A → E in a sporadic cancer; somatic mutation.		VAR_044623
	Natural variant	83	1	A → V in sporadic cancers; somatic mutation.		VAR_044624
	Natural variant	84	1	A → G in sporadic cancers; somatic mutation.		VAR_044625
	Natural variant	84	1	A → V in sporadic cancers; somatic mutation.		VAR_044626
	Natural variant	85	1	P → L in sporadic cancers; somatic mutation.		VAR_044627
	Natural variant	85	1	P → S in sporadic cancers; somatic mutation.		VAR_044628
	Natural variant	86	1	A → V in a sporadic cancer; somatic mutation.		VAR_044629
	Natural variant	87	1	P → Q in sporadic cancers; somatic mutation.		VAR_005858
	Natural variant	88	1	A → T in a sporadic cancer; somatic mutation.		VAR_044630
	Natural variant	88	1	A → V in sporadic cancers; somatic mutation.		VAR_044631
	Natural variant	89	1	P → L in sporadic cancers; somatic mutation.		VAR_044632
	Natural variant	89	1	P → S in sporadic cancers; somatic mutation.		VAR_044633
	Natural variant	90	1	S → F in sporadic cancers; somatic mutation.		VAR_044634
	Natural variant	90	1	S → Y in a sporadic cancer; somatic mutation.		VAR_044635
	Natural variant	91	1	W → C in a sporadic cancer; somatic mutation.		VAR_044636
	Natural variant	92	1	P → A in a sporadic cancer; somatic mutation.		VAR_044637
	Natural variant	92	1	P → L in a sporadic cancer; somatic mutation.		VAR_044638
	Natural variant	92	1	P → S in a sporadic cancer; somatic mutation.		VAR_044639
	Natural variant	93	1	L → M in a sporadic cancer; somatic mutation.		VAR_044640
	Natural variant	93	1	L → P in a sporadic cancer; somatic mutation.		VAR_044641
	Natural variant	94	1	S → L in sporadic cancers; somatic mutation.		VAR_044642
	Natural variant	94	1	S → T in sporadic cancers; somatic mutation.		VAR_005859
	Natural variant	95	1	S → F in sporadic cancers; somatic mutation.		VAR_044643
	Natural variant	95	1	S → T in a sporadic cancer; somatic mutation.		VAR_044644
	Natural variant	96	1	S → C in a sporadic cancer; somatic mutation.		VAR_044645
	Natural variant	96	1	S → F in sporadic cancers; somatic mutation.		VAR_044646
	Natural variant	96	1	S → P in a sporadic cancer; somatic mutation.		VAR_044647
	Natural variant	97	1	V → A in a sporadic cancer; somatic mutation.		VAR_044648
	Natural variant	97	1	V → F in a sporadic cancer; somatic mutation.		VAR_044649
	Natural variant	97	1	V → I in familial cancer not matching LFS; germline mutation and in a sporadic cancer; somatic mutation.		VAR_044650
	Natural variant	98	1	P → L in sporadic cancers; somatic mutation.		VAR_044651
	Natural variant	98	1	P → S in sporadic cancers; somatic mutation.		VAR_044652
	Natural variant	99	1	S → F in sporadic cancers; somatic mutation.		VAR_044653
	Natural variant	99	1	S → P in a sporadic cancer; somatic mutation.		VAR_044654
	Natural variant	100	1	Q → R in a sporadic cancer; somatic mutation.		VAR_044655
	Natural variant	101	1	K → N in a sporadic cancer; somatic mutation.		VAR_044656
	Natural variant	101	1	K → R in sporadic cancers; somatic mutation.		VAR_044657
	Natural variant	102	1	T → I in sporadic cancers; somatic mutation.		VAR_044658
	Natural variant	104	1	Q → H in sporadic cancers; somatic mutation.		VAR_044659
	Natural variant	104	1	Q → L in a sporadic cancer; somatic mutation.		VAR_044660
	Natural variant	105	1	G → C in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_044661
	Natural variant	105	1	G → D in sporadic cancers; somatic mutation.		VAR_044662
	Natural variant	105	1	G → R in sporadic cancers; somatic mutation.		VAR_044663
	Natural variant	105	1	G → S in a sporadic cancer; somatic mutation.		VAR_044664
	Natural variant	105	1	G → V in sporadic cancers; somatic mutation.		VAR_044665
	Natural variant	106	1	S → G in a sporadic cancer; somatic mutation.		VAR_044666
	Natural variant	106	1	S → R in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_044667
	Natural variant	107	1	Y → C in a sporadic cancer; somatic mutation.		VAR_044668
	Natural variant	107	1	Y → D in sporadic cancers; somatic mutation.		VAR_044669
	Natural variant	107	1	Y → H in a sporadic cancer; somatic mutation.		VAR_044670
	Natural variant	108	1	G → D in a sporadic cancer; somatic mutation.		VAR_044671
	Natural variant	108	1	G → S in sporadic cancers; somatic mutation.		VAR_044672
	Natural variant	109	1	F → C in sporadic cancers; somatic mutation.		VAR_044673
	Natural variant	109	1	F → L in a sporadic cancer; somatic mutation.		VAR_044674
	Natural variant	109	1	F → S in sporadic cancers; somatic mutation.		VAR_044675
	Natural variant	110	1	R → C in sporadic cancers; somatic mutation.		VAR_005860
	Natural variant	110	1	R → G in a sporadic cancer; somatic mutation.		VAR_044676
	Natural variant	110	1	R → H in sporadic cancers; somatic mutation.		VAR_044677
	Natural variant	110	1	R → L in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation. Ref.116		VAR_005861
	Natural variant	110	1	R → P in sporadic cancers; somatic mutation.		VAR_005862
	Natural variant	110	1	R → S in a sporadic cancer; somatic mutation.		VAR_044678
	Natural variant	111	1	L → M in a sporadic cancer; somatic mutation.		VAR_044679
	Natural variant	111	1	L → P in sporadic cancers; somatic mutation.		VAR_044680
	Natural variant	111	1	L → Q in sporadic cancers; somatic mutation.		VAR_044681
	Natural variant	111	1	L → R in sporadic cancers; somatic mutation.		VAR_044682
	Natural variant	112	1	G → D in sporadic cancers; somatic mutation.		VAR_044683
	Natural variant	112	1	G → S in sporadic cancers; somatic mutation.		VAR_044684
	Natural variant	113	1	F → C in sporadic cancers; somatic mutation.		VAR_005863
	Natural variant	113	1	F → G in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045788
	Natural variant	113	1	F → I in a sporadic cancer; somatic mutation.		VAR_044685
	Natural variant	113	1	F → L in sporadic cancers; somatic mutation.		VAR_044686
	Natural variant	113	1	F → S in sporadic cancers; somatic mutation.		VAR_044687
	Natural variant	113	1	F → V in sporadic cancers; somatic mutation.		VAR_033033
	Natural variant	115	1	H → Y in sporadic cancers; somatic mutation.		VAR_044688
	Natural variant	116	1	S → C in sporadic cancers; somatic mutation.		VAR_044689
	Natural variant	116	1	S → F in a sporadic cancer; somatic mutation.		VAR_044690
	Natural variant	116	1	S → P in a sporadic cancer; somatic mutation.		VAR_044691
	Natural variant	117	1	G → E in sporadic cancers; somatic mutation.		VAR_044692
	Natural variant	117	1	G → R in sporadic cancers; somatic mutation.		VAR_044693
	Natural variant	118	1	T → A in a sporadic cancer; somatic mutation.		VAR_044694
	Natural variant	118	1	T → I in sporadic cancers; somatic mutation.		VAR_044695
	Natural variant	118	1	T → R in a sporadic cancer; somatic mutation.		VAR_044696
	Natural variant	119	1	A → D in a sporadic cancer; somatic mutation.		VAR_044697
	Natural variant	119	1	A → T in a sporadic cancer; somatic mutation.		VAR_044698
	Natural variant	120	1	K → E in sporadic cancers; somatic mutation.		VAR_044699
	Natural variant	120	1	K → M in sporadic cancers; somatic mutation.		VAR_044700
	Natural variant	120	1	K → Q in a sporadic cancer; somatic mutation.		VAR_044701
	Natural variant	120	1	K → R in sporadic cancers; somatic mutation.		VAR_044702
	Natural variant	121	1	S → F in sporadic cancers; somatic mutation.		VAR_044703
	Natural variant	122	1	V → L in a sporadic cancer; somatic mutation.		VAR_044704
	Natural variant	123	1	T → I in a sporadic cancer; somatic mutation.		VAR_044705
	Natural variant	123	1	T → N in a sporadic cancer; somatic mutation.		VAR_044706
	Natural variant	124	1	C → G in a sporadic cancer; somatic mutation.		VAR_044707
	Natural variant	124	1	C → R in sporadic cancers; somatic mutation.		VAR_044708
	Natural variant	124	1	C → S in sporadic cancers; somatic mutation.		VAR_044709
	Natural variant	124	1	C → W in a sporadic cancer; somatic mutation.		VAR_044710
	Natural variant	124	1	C → Y in a sporadic cancer; somatic mutation.		VAR_044711
	Natural variant	125	1	T → A in a sporadic cancer; somatic mutation.		VAR_044712
	Natural variant	125	1	T → K in sporadic cancers; somatic mutation.		VAR_044713
	Natural variant	125	1	T → M in sporadic cancers; somatic mutation.		VAR_005864
	Natural variant	125	1	T → P in a sporadic cancer; somatic mutation.		VAR_044714
	Natural variant	125	1	T → R in sporadic cancers; somatic mutation.		VAR_044715
	Natural variant	126	1	Y → C in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_044716
	Natural variant	126	1	Y → D in sporadic cancers; somatic mutation.		VAR_005865
	Natural variant	126	1	Y → F in a sporadic cancer; somatic mutation.		VAR_044717
	Natural variant	126	1	Y → G in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045789
	Natural variant	126	1	Y → H in sporadic cancers; somatic mutation.		VAR_044718
	Natural variant	126	1	Y → N in sporadic cancers; somatic mutation.		VAR_005866
	Natural variant	126	1	Y → S in sporadic cancers; somatic mutation.		VAR_044719
	Natural variant	127	1	S → C in a sporadic cancer; somatic mutation.		VAR_044720
	Natural variant	127	1	S → F in sporadic cancers; somatic mutation.		VAR_005867
	Natural variant	127	1	S → P in sporadic cancers; somatic mutation.		VAR_044721
	Natural variant	127	1	S → T in sporadic cancers; somatic mutation.		VAR_044722
	Natural variant	127	1	S → Y in sporadic cancers; somatic mutation.		VAR_044723
	Natural variant	128	1	P → A in sporadic cancers; somatic mutation.		VAR_044724
	Natural variant	128	1	P → L in sporadic cancers; somatic mutation.		VAR_044725
	Natural variant	128	1	P → R in sporadic cancers; somatic mutation.		VAR_044726
	Natural variant	128	1	P → S in sporadic cancers; somatic mutation.		VAR_005868
	Natural variant	129	1	A → D in sporadic cancers; somatic mutation.		VAR_005869
	Natural variant	129	1	A → G in a sporadic cancer; somatic mutation.		VAR_044727
	Natural variant	129	1	A → T in sporadic cancers; somatic mutation.		VAR_044728
	Natural variant	129	1	A → V in sporadic cancers; somatic mutation.		VAR_044729
	Natural variant	130	1	L → F in sporadic cancers; somatic mutation.		VAR_044730
	Natural variant	130	1	L → H in sporadic cancers; somatic mutation.		VAR_044731
	Natural variant	130	1	L → I in a sporadic cancer; somatic mutation.		VAR_044732
	Natural variant	130	1	L → P in sporadic cancers; somatic mutation.		VAR_044733
	Natural variant	130	1	L → R in sporadic cancers; somatic mutation.		VAR_005870
	Natural variant	130	1	L → V in sporadic cancers; somatic mutation.		VAR_044734
	Natural variant	131	1	N → D in a sporadic cancer; somatic mutation.		VAR_044735
	Natural variant	131	1	N → H in sporadic cancers; somatic mutation.		VAR_044736
	Natural variant	131	1	N → I in sporadic cancers; somatic mutation.		VAR_044737
	Natural variant	131	1	N → K in sporadic cancers; somatic mutation.		VAR_005872
	Natural variant	131	1	N → S in sporadic cancers; somatic mutation.		VAR_005871
	Natural variant	131	1	N → T in a sporadic cancer; somatic mutation.		VAR_044738
	Natural variant	131	1	N → Y in sporadic cancers; somatic mutation.		VAR_044739
	Natural variant	132 – 133	2	KM → NL in a sporadic cancer; somatic mutation.		VAR_047159
	Natural variant	132	1	K → E in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_044740
	Natural variant	132	1	K → L in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045790
	Natural variant	132	1	K → M in sporadic cancers; somatic mutation.		VAR_005873
	Natural variant	132	1	K → N in sporadic cancers; somatic mutation.		VAR_044741
	Natural variant	132	1	K → Q in sporadic cancers; somatic mutation.		VAR_005874
	Natural variant	132	1	K → R in sporadic cancers; somatic mutation.		VAR_044742
	Natural variant	132	1	K → T in sporadic cancers; somatic mutation.		VAR_044743
	Natural variant	132	1	K → W in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045791
	Natural variant	133	1	M → I in sporadic cancers; somatic mutation.		VAR_044744
	Natural variant	133	1	M → K in sporadic cancers; somatic mutation.		VAR_044745
	Natural variant	133	1	M → L in sporadic cancers; somatic mutation.		VAR_044746
	Natural variant	133	1	M → R in LFS; germline mutation and in sporadic cancers; somatic mutation. Ref.80		VAR_044747
	Natural variant	133	1	M → T in LFS; germline mutation and in sporadic cancers; somatic mutation. Ref.80		VAR_005875
	Natural variant	133	1	M → V in sporadic cancers; somatic mutation.		VAR_044748
	Natural variant	134	1	F → C in sporadic cancers; somatic mutation.		VAR_044749
	Natural variant	134	1	F → I in sporadic cancers; somatic mutation.		VAR_044750
	Natural variant	134	1	F → L in sporadic cancers; somatic mutation.		VAR_036504
	Natural variant	134	1	F → S in sporadic cancers; somatic mutation.		VAR_044751
	Natural variant	134	1	F → V in sporadic cancers; somatic mutation.		VAR_044752
	Natural variant	135	1	C → F in sporadic cancers; somatic mutation.		VAR_005877
	Natural variant	135	1	C → G in sporadic cancers; somatic mutation.		VAR_044753
	Natural variant	135	1	C → R in sporadic cancers; somatic mutation.		VAR_044754
	Natural variant	135	1	C → S in sporadic cancers; somatic mutation.		VAR_005876
	Natural variant	135	1	C → T in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045792
	Natural variant	135	1	C → W in sporadic cancers; somatic mutation.		VAR_044755
	Natural variant	135	1	C → Y in sporadic cancers; somatic mutation.		VAR_044756
	Natural variant	136	1	Q → E in sporadic cancers; somatic mutation.		VAR_005878
	Natural variant	136	1	Q → H in sporadic cancers; somatic mutation.		VAR_044757
	Natural variant	136	1	Q → K in a sporadic cancer; somatic mutation.		VAR_005879
	Natural variant	136	1	Q → P in sporadic cancers; somatic mutation.		VAR_044758
	Natural variant	136	1	Q → R in sporadic cancers; somatic mutation.		VAR_044759
	Natural variant	137	1	L → M in sporadic cancers; somatic mutation.		VAR_044760
	Natural variant	137	1	L → P in sporadic cancers; somatic mutation.		VAR_044761
	Natural variant	137	1	L → Q in sporadic cancers; somatic mutation.		VAR_005880
	Natural variant	137	1	L → V in sporadic cancers; somatic mutation.		VAR_044762
	Natural variant	138	1	A → D in sporadic cancers; somatic mutation.		VAR_044763
	Natural variant	138	1	A → P in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_005881
	Natural variant	138	1	A → S in LFS; germline mutation.		VAR_044764
	Natural variant	138	1	A → T in sporadic cancers; somatic mutation.		VAR_044765
	Natural variant	138	1	A → V in sporadic cancers; somatic mutation.		VAR_033034
	Natural variant	139	1	K → E in sporadic cancers; somatic mutation.		VAR_044766
	Natural variant	139	1	K → N in sporadic cancers; somatic mutation.		VAR_005882
	Natural variant	139	1	K → Q in sporadic cancers; somatic mutation.		VAR_044767
	Natural variant	139	1	K → R in sporadic cancers; somatic mutation.		VAR_044768
	Natural variant	139	1	K → T in sporadic cancers; somatic mutation.		VAR_044769
	Natural variant	140	1	T → A in sporadic cancers; somatic mutation.		VAR_044770
	Natural variant	140	1	T → I in sporadic cancers; somatic mutation.		VAR_044771
	Natural variant	140	1	T → N in a sporadic cancer; somatic mutation.		VAR_044772
	Natural variant	140	1	T → P in a sporadic cancer; somatic mutation.		VAR_044773
	Natural variant	140	1	T → S in sporadic cancers; somatic mutation.		VAR_044774
	Natural variant	141	1	C → A in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045793
	Natural variant	141	1	C → F in sporadic cancers; somatic mutation.		VAR_005885
	Natural variant	141	1	C → G in sporadic cancers; somatic mutation.		VAR_005884
	Natural variant	141	1	C → R in sporadic cancers; somatic mutation.		VAR_044775
	Natural variant	141	1	C → S in sporadic cancers; somatic mutation.		VAR_044776
	Natural variant	141	1	C → W in sporadic cancers; somatic mutation.		VAR_044777
	Natural variant	141	1	C → Y in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_005886
	Natural variant	142	1	P → A in sporadic cancers; somatic mutation.		VAR_044778
	Natural variant	142	1	P → F in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions.		VAR_045794
	Natural variant	142	1	P → H in sporadic cancers; somatic mutation.		VAR_044779
	Natural variant	142	1	P → L in sporadic cancers; somatic mutation.		VAR_044780
	Natural variant	142	1	P → R in a sporadic cancer; somatic mutation.		VAR_044781
	Natural variant	142	1	P → S in sporadic cancers; somatic mutation.		VAR_044782
	Natural variant	142	1	P → T in sporadic cancers; somatic mutation.		VAR_044783
	Natural variant	143	1	V → A in sporadic cancers; somatic mutation; strong DNA binding ability at 32.5 degrees Celsius; strong reduction of transcriptional activity at 37.5 degrees Celsius.		VAR_005887
	Natural variant	143	1	V → E in sporadic cancers; somatic mutation.		VAR_044784
	Natural variant	143	1	V → G in sporadic cancers; somatic mutation.		VAR_044785
	Natural variant	143	1	V → L in sporadic cancers; somatic mutation.		VAR_044786
	Natural variant	143	1	V → M in sporadic cancers; somatic mutation.		VAR_044787
	Natural variant	144	1	Q → H in sporadic cancers; somatic mutation.		VAR_044788
	Natural variant	144	1	Q → K in sporadic cancers; somatic mutation.		VAR_044789
	Natural variant	144	1	Q → L in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_044790
	Natural variant	144	1	Q → P in sporadic cancers; somatic mutation.		VAR_005888
	Natural variant	144	1	Q → R in sporadic cancers; somatic mutation.		VAR_044791
	Natural variant	145	1	L → M in sporadic cancers; somatic mutation.		VAR_044792
	Natural variant	145	1	L → P in sporadic cancers; somatic mutation.		VAR_005889
	Natural variant	145	1	L → Q in sporadic cancers; somatic mutation.		VAR_005890
	Natural variant	145	1	L → R in sporadic cancers; somatic mutation.		VAR_044793
	Natural variant	145	1	L → V in sporadic cancers; somatic mutation.		VAR_044794
	Natural variant	146	1	W → C in a sporadic cancer; somatic mutation.		VAR_044795
	Natural variant	146	1	W → G in sporadic cancers; somatic mutation.		VAR_044796
	Natural variant	146	1	W → L in sporadic cancers; somatic mutation.		VAR_044797
	Natural variant	146	1	W → R in sporadic cancers; somatic mutation.		VAR_044798
	Natural variant	146	1	W → S in sporadic cancers; somatic mutation.		VAR_044799
	Natural variant	147	1	V → A in sporadic cancers; somatic mutation.		VAR_044800
	Natural variant	147	1	V → D in sporadic cancers; somatic mutation.		VAR_005891
	Natural variant	147	1	V → E in sporadic cancers; somatic mutation.		VAR_044801
	Natural variant	147	1	V → F in a sporadic cancer; somatic mutation.		VAR_044802
	Natural variant	147	1	V → G in sporadic cancers; somatic mutation.		VAR_005892
	Natural variant	147	1	V → I in sporadic cancers; somatic mutation.		VAR_044803
	Natural variant	148	1	D → A in a sporadic cancer; somatic mutation.		VAR_044804
	Natural variant	148	1	D → E in sporadic cancers; somatic mutation.		VAR_044805
	Natural variant	148	1	D → G in a sporadic cancer; somatic mutation.		VAR_044806
	Natural variant	148	1	D → N in sporadic cancers; somatic mutation.		VAR_044807
	Natural variant	148	1	D → V in sporadic cancers; somatic mutation.		VAR_044808
	Natural variant	148	1	D → Y in sporadic cancers; somatic mutation.		VAR_044809
	Natural variant	149	1	S → F in sporadic cancers; somatic mutation.		VAR_044810
	Natural variant	149	1	S → P in sporadic cancers; somatic mutation.		VAR_005893
	Natural variant	149	1	S → T in sporadic cancers; somatic mutation.		VAR_044811
	Natural variant	150	1	T → A in a sporadic cancer; somatic mutation.		VAR_044812
	Natural variant	150	1	T → I in sporadic cancers; somatic mutation.		VAR_044813
	Natural variant	150	1	T → K in sporadic cancers; somatic mutation.		VAR_044814
	Natural variant	150	1	T → N in a sporadic cancer; somatic mutation.		VAR_044815
	Natural variant	150	1	T → P in a sporadic cancer; somatic mutation.		VAR_044816
	Natural variant	150	1	T → R in a sporadic cancer; somatic mutation.		VAR_044817
	Natural variant	151	1	P → A in sporadic cancers; somatic mutation.		VAR_005894
	Natural variant	151	1	P → H in sporadic cancers; somatic mutation.		VAR_044818
	Natural variant	151	1	P → L in sporadic cancers; somatic mutation.		VAR_044819
	Natural variant	151	1	P → R in sporadic cancers; somatic mutation.		VAR_044820
	Natural variant	151	1	P → S in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_005895
	Natural variant	151	1	P → T in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_005896
	Natural variant	152	1	P → A in sporadic cancers; somatic mutation.		VAR_044821
	Natural variant	152	1	P → L in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_005897
	Natural variant	152	1	P → Q in sporadic cancers; somatic mutation.		VAR_044822
	Natural variant	152	1	P → R in sporadic cancers; somatic mutation.		VAR_044823
	Natural variant	152	1	P → S in sporadic cancers; somatic mutation.		VAR_005898
	Natural variant	152	1	P → T in sporadic cancers; somatic mutation.		VAR_044824
	Natural variant	153	1	P → A in sporadic cancers; somatic mutation.		VAR_044825
	Natural variant	153	1	P → F in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045795
	Natural variant	153	1	P → H in a sporadic cancer; somatic mutation.		VAR_044826
	Natural variant	153	1	P → L in sporadic cancers; somatic mutation.		VAR_044827
	Natural variant	153	1	P → R in a sporadic cancer; somatic mutation.		VAR_044828
	Natural variant	153	1	P → S in sporadic cancers; somatic mutation.		VAR_044829
	Natural variant	153	1	P → T in sporadic cancers; somatic mutation.		VAR_005899
	Natural variant	154	1	G → A in sporadic cancers; somatic mutation.		VAR_044830
	Natural variant	154	1	G → C in a sporadic cancer; somatic mutation.		VAR_044831
	Natural variant	154	1	G → D in sporadic cancers; somatic mutation.		VAR_044832
	Natural variant	154	1	G → I in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions.		VAR_045796
	Natural variant	154	1	G → S in sporadic cancers; somatic mutation.		VAR_044833
	Natural variant	154	1	G → V in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation. Ref.87		VAR_005900
	Natural variant	155	1	T → A in sporadic cancers; somatic mutation.		VAR_005901
	Natural variant	155	1	T → I in sporadic cancers; somatic mutation.		VAR_044834
	Natural variant	155	1	T → M in a sporadic cancer; somatic mutation.		VAR_044835
	Natural variant	155	1	T → N in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_044836
	Natural variant	155	1	T → P in sporadic cancers; somatic mutation.		VAR_044837
	Natural variant	155	1	T → S in sporadic cancers; somatic mutation.		VAR_044838
	Natural variant	156	1	R → C in sporadic cancers; somatic mutation.		VAR_044839
	Natural variant	156	1	R → G in sporadic cancers; somatic mutation.		VAR_044840
	Natural variant	156	1	R → H in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_044841
	Natural variant	156	1	R → L in sporadic cancers; somatic mutation.		VAR_044842
	Natural variant	156	1	R → P in sporadic cancers; somatic mutation.		VAR_005902
	Natural variant	156	1	R → S in sporadic cancers; somatic mutation.		VAR_044843
	Natural variant	157	1	V → A in sporadic cancers; somatic mutation.		VAR_044844
	Natural variant	157	1	V → D in sporadic cancers; somatic mutation.		VAR_005903
	Natural variant	157	1	V → F in sporadic cancers; somatic mutation.		VAR_005904
	Natural variant	157	1	V → G in sporadic cancers; somatic mutation.		VAR_044845
	Natural variant	157	1	V → I in sporadic cancers; somatic mutation.		VAR_012977
	Natural variant	157	1	V → L in sporadic cancers; somatic mutation.		VAR_044846
	Natural variant	158	1	R → C in sporadic cancers; somatic mutation.		VAR_005905
	Natural variant	158	1	R → F in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045797
	Natural variant	158	1	R → G in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_005906
	Natural variant	158	1	R → H in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_005907
	Natural variant	158	1	R → L in sporadic cancers; somatic mutation.		VAR_044847
	Natural variant	158	1	R → P in sporadic cancers; somatic mutation.		VAR_044848
	Natural variant	158	1	R → Q in a sporadic cancer; somatic mutation.		VAR_044849
	Natural variant	158	1	R → S in sporadic cancers; somatic mutation.		VAR_044850
	Natural variant	158	1	R → Y in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045798
	Natural variant	159	1	A → D in sporadic cancers; somatic mutation.		VAR_044851
	Natural variant	159	1	A → F in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045799
	Natural variant	159	1	A → G in sporadic cancers; somatic mutation.		VAR_044852
	Natural variant	159	1	A → P in sporadic cancers; somatic mutation.		VAR_044853
	Natural variant	159	1	A → S in sporadic cancers; somatic mutation.		VAR_044854
	Natural variant	159	1	A → T in sporadic cancers; somatic mutation.		VAR_044855
	Natural variant	159	1	A → V in sporadic cancers; somatic mutation.		VAR_044856
	Natural variant	160 – 161	2	MA → IP in a sporadic cancer; somatic mutation.		VAR_047160
	Natural variant	160 – 161	2	MA → IS in sporadic cancers; somatic mutation.		VAR_047161
	Natural variant	160 – 161	2	MA → IT in a sporadic cancer; somatic mutation.		VAR_047162
	Natural variant	160	1	M → I in sporadic cancers; somatic mutation.		VAR_005908
	Natural variant	160	1	M → K in sporadic cancers; somatic mutation.		VAR_044857
	Natural variant	160	1	M → T in a sporadic cancer; somatic mutation.		VAR_044858
	Natural variant	160	1	M → V in sporadic cancers; somatic mutation.		VAR_044859
	Natural variant	161	1	A → D in sporadic cancers; somatic mutation.		VAR_044860
	Natural variant	161	1	A → F in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.		VAR_045800
	Natural variant	161	1	A → G in sporadic cancers; somatic mutation.		VAR_044861
	Natural variant	161	1	A → P in sporadic cancers; somatic mutation.		VAR_044862
	Natural variant	161	1	A → S in sporadic cancers; somatic mutation.		VAR_005909
	Natural variant	161	1	A → T in sporadic cancers; somatic mutation.		VAR_044863
	Natural variant	161	1	A → V in sporadic cancers; somatic mutation.		VAR_044864
	Natural variant	162	1	I → F in sporadic cancers; somatic mutation.		VAR_044865
	Natural variant	162	1	I → M in sporadic cancers; somatic mutation.		VAR_044866
	Natural variant	162	1	I → N in a breast cancer with no family history; germline mutation and in sporadic cancers; somatic mutation.		VAR_044867
	Natural variant	162	1	I → S in sporadic cancers; somatic mutation.		VAR_005910
	Natural variant	162	1	I → T in sporadic cancers; somatic mutation.		VAR_044868
	Natural variant	162	1	I → V in sporadic cancers; somatic mutation.		VAR_005911
	Natural variant	163	1	Y → C in LFS; germline mutation and in sporadic cancers; somatic mutation.		VAR_033035
	Natural variant	163	1	Y → D in sporadic cancers; somatic mutation.		VAR_044869
	Natural variant	163	1	Y → F in a sporadic cancer; somatic mutation.		VAR_044870
	Natural variant	163	1	Y → H in sporadic cancers; somatic mutation.		VAR_005912
	Natural variant	163	1	Y → N in sporadic cancers; somatic mutation.		VAR_044871
	Natural variant	163	1	Y → S in sporadic cancers; somatic mutation.		VAR_044872
	Natural variant	164	1	K → E in sporadic cancers; somatic mutation.		VAR_044873
	Natural variant	164	1	K → M in sporadic cancers; somatic mutation.		VAR_044874
	Natural variant	164	1	K → N in sporadic cancers; somatic mutation.		VAR_005913
	Natural variant	164	1	K → Q in sporadic cancers; somatic mutation.		VAR_005914
	Natural variant	164	1	K → R in sporadic cancers; somatic mutation.		VAR_044875
	Natural variant	164	1	K → T in sporadic cancers; somatic mutation.		VAR_044876
	Natural variant	165	1	Q → E in sporadic cancers; somatic mutation.		VAR_044877
	Natural variant	165	1	Q → H in a sporadic cancer; somatic mutation.		VAR_044878
	Natural variant	165	1	Q → L in sporadic cancers; somatic mutation.		VAR_005915
	Natural variant	165	1	Q → P in sporadic cancers; somatic mutation.		VAR_044879
	Natural variant	165	1	Q → R in sporadic cancers; somatic mutation.		VAR_005916
	Natural variant	166	1	S → A in sporadic cancers; somatic mutation.		VAR_044880
	Natural variant	166	1	S → G in a sporadic cancer; somatic mutation.		VAR_044881
	Natural variant	166	1	S → L in sporadic cancers; somatic mutation.