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Protein

Gastric triacylglycerol lipase

Gene

Lipf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei171 – 1711NucleophileBy similarity
Active sitei342 – 3421Charge relay systemPROSITE-ProRule annotation
Active sitei371 – 3711Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  • lipase activity Source: RGD
  • malate dehydrogenase activity Source: MGI
  • triglyceride lipase activity Source: UniProtKB-EC

GO - Biological processi

  • digestion Source: RGD
  • lipid catabolic process Source: UniProtKB-KW
  • malate metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Protein family/group databases

ESTHERiratno-1lipg. Acidic_Lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric triacylglycerol lipase (EC:3.1.1.3)
Short name:
GL
Short name:
Gastric lipase
Alternative name(s):
Lingual lipase
Gene namesi
Name:Lipf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi708441. Lipf.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 395377Gastric triacylglycerol lipasePRO_0000017768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis
Disulfide bondi245 ↔ 254By similarity
Glycosylationi270 – 2701N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04634.
PRIDEiP04634.

Expressioni

Tissue specificityi

Secreted by the serous (von Ebner's) glands at the back of the rat tongue.

Gene expression databases

GenevisibleiP04634. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027969.

Structurei

3D structure databases

ProteinModelPortaliP04634.
SMRiP04634. Positions 20-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOGENOMiHOG000240694.
HOVERGENiHBG006265.
InParanoidiP04634.
KOiK14452.
OMAiDVYLGHN.
OrthoDBiEOG71RXJN.
PhylomeDBiP04634.
TreeFamiTF315485.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLLITSVI STFGGAHGLF GKLGPGNPEA NMNISQMITY WGYPCQEYEV
60 70 80 90 100
VTEDGYILGV YRIPHGKNNS ENIGKRPVVY LQHGLIASAT NWIANLPNNS
110 120 130 140 150
LAFMLADAGY DVWLGNSRGN TWSRKNVYYS PDSVEFWAFS FDEMAKYDLP
160 170 180 190 200
ATINFIVQKT GQEKIHYVGH SQGTTIGFIA FSTNPTLAKK IKTFYALAPV
210 220 230 240 250
ATVKYTQSPL KKISFIPTFL FKLMFGKKMF LPHTYFDDFL GTEVCSREVL
260 270 280 290 300
DLLCSNTLFI FCGFDKKNLN VSRFDVYLGH NPAGTSVQDF LHWAQLVRSG
310 320 330 340 350
KFQAFNWGSP SQNMLHYNQK TPPEYDVSAM TVPVAVWNGG NDILADPQDV
360 370 380 390
AMLLPKLSNL LFHKEILAYN HLDFIWAMDA PQEVYNEMIS MMAED
Length:395
Mass (Da):44,588
Last modified:August 13, 1987 - v1
Checksum:iE601854A923522EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02309 mRNA. Translation: CAA26179.1.
PIRiA23045. LIRTT.
RefSeqiNP_059037.1. NM_017341.2.
UniGeneiRn.11192.

Genome annotation databases

EnsembliENSRNOT00000027969; ENSRNOP00000027969; ENSRNOG00000019448.
GeneIDi50682.
KEGGirno:50682.
UCSCiRGD:708441. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02309 mRNA. Translation: CAA26179.1.
PIRiA23045. LIRTT.
RefSeqiNP_059037.1. NM_017341.2.
UniGeneiRn.11192.

3D structure databases

ProteinModelPortaliP04634.
SMRiP04634. Positions 20-395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027969.

Protein family/group databases

ESTHERiratno-1lipg. Acidic_Lipase.

Proteomic databases

PaxDbiP04634.
PRIDEiP04634.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027969; ENSRNOP00000027969; ENSRNOG00000019448.
GeneIDi50682.
KEGGirno:50682.
UCSCiRGD:708441. rat.

Organism-specific databases

CTDi8513.
RGDi708441. Lipf.

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOGENOMiHOG000240694.
HOVERGENiHBG006265.
InParanoidiP04634.
KOiK14452.
OMAiDVYLGHN.
OrthoDBiEOG71RXJN.
PhylomeDBiP04634.
TreeFamiTF315485.

Miscellaneous databases

PROiP04634.

Gene expression databases

GenevisibleiP04634. RN.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-50.

Entry informationi

Entry nameiLIPG_RAT
AccessioniPrimary (citable) accession number: P04634
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 6, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.