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Protein

Mitochondrial brown fat uncoupling protein 1

Gene

Ucp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

GO - Molecular functioni

  • oxidative phosphorylation uncoupler activity Source: RGD

GO - Biological processi

  • cellular response to dehydroepiandrosterone Source: RGD
  • cellular response to hormone stimulus Source: RGD
  • generation of precursor metabolites and energy Source: RGD
  • mitochondrial transport Source: RGD
  • positive regulation of multicellular organismal metabolic process Source: RGD
  • proton transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-167826. The fatty acid cycling model.
R-RNO-167827. The proton buffering model.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial brown fat uncoupling protein 1
Short name:
UCP 1
Alternative name(s):
Solute carrier family 25 member 7
Thermogenin
Gene namesi
Name:Ucp1
Synonyms:Slc25a7, Ucp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi3931. Ucp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3222Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei74 – 9623Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei117 – 13317Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei179 – 19517Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei213 – 23220Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei267 – 28923Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: RGD
  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 307306Mitochondrial brown fat uncoupling protein 1PRO_0000090662Add
BLAST

Proteomic databases

PaxDbiP04633.
PRIDEiP04633.

PTM databases

iPTMnetiP04633.
PhosphoSiteiP04633.

Expressioni

Tissue specificityi

Brown adipose tissue.

Gene expression databases

GenevisibleiP04633. RN.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.

Protein-protein interaction databases

BioGridi246975. 1 interaction.
STRINGi10116.ENSRNOP00000004900.

Structurei

3D structure databases

ProteinModelPortaliP04633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10292Solcar 1Add
BLAST
Repeati111 – 20191Solcar 2Add
BLAST
Repeati210 – 29586Solcar 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni274 – 29623Purine nucleotide bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP04633.
KOiK08769.
OMAiPCHLLSA.
OrthoDBiEOG793B7Z.
PhylomeDBiP04633.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04633-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSTTSEVQ PTMGVKIFSA GVSACLADII TFPLDTAKVR LQIQGEGQAS
60 70 80 90 100
STIRYKGVLG TITTLAKTEG LPKLYSGLPA GIQRQISFAS LRIGLYDTVQ
110 120 130 140 150
EYFSSGRETP ASLGSKISAG LMTGGVAVFI GQPTEVVKVR MQAQSHLHGI
160 170 180 190 200
KPRYTGTYNA YRVIATTESL STLWKGTTPN LMRNVIINCT ELVTYDLMKG
210 220 230 240 250
ALVNHHILAD DVPCHLLSAL VAGFCTTLLA SPVDVVKTRF INSLPGQYPS
260 270 280 290 300
VPSCAMTMYT KEGPAAFFKG FAPSFLRLGS WNVIMFVCFE QLKKELMKSR

QTVDCTT
Length:307
Mass (Da):33,212
Last modified:January 23, 2007 - v2
Checksum:i0B69CEFD3BE6F543
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11814 mRNA. Translation: AAA19671.1.
X03894 mRNA. Translation: CAA27531.1.
BC088156 mRNA. Translation: AAH88156.1.
X12925 Genomic DNA. Translation: CAA31392.1.
PIRiA26294.
RefSeqiNP_036814.1. NM_012682.2.
UniGeneiRn.10281.

Genome annotation databases

EnsembliENSRNOT00000004900; ENSRNOP00000004900; ENSRNOG00000003580.
GeneIDi24860.
KEGGirno:24860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11814 mRNA. Translation: AAA19671.1.
X03894 mRNA. Translation: CAA27531.1.
BC088156 mRNA. Translation: AAH88156.1.
X12925 Genomic DNA. Translation: CAA31392.1.
PIRiA26294.
RefSeqiNP_036814.1. NM_012682.2.
UniGeneiRn.10281.

3D structure databases

ProteinModelPortaliP04633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246975. 1 interaction.
STRINGi10116.ENSRNOP00000004900.

PTM databases

iPTMnetiP04633.
PhosphoSiteiP04633.

Proteomic databases

PaxDbiP04633.
PRIDEiP04633.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004900; ENSRNOP00000004900; ENSRNOG00000003580.
GeneIDi24860.
KEGGirno:24860.

Organism-specific databases

CTDi7350.
RGDi3931. Ucp1.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP04633.
KOiK08769.
OMAiPCHLLSA.
OrthoDBiEOG793B7Z.
PhylomeDBiP04633.
TreeFamiTF323211.

Enzyme and pathway databases

ReactomeiR-RNO-167826. The fatty acid cycling model.
R-RNO-167827. The proton buffering model.

Miscellaneous databases

NextBioi604664.
PROiP04633.

Gene expression databases

GenevisibleiP04633. RN.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein."
    Bouillaud F., Weissenbach J., Ricquier D.
    J. Biol. Chem. 261:1487-1490(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete nucleotide and derived amino acid sequence of cDNA encoding the mitochondrial uncoupling protein of rat brown adipose tissue: lack of a mitochondrial targeting presequence."
    Ridley R.G., Patel H.V., Gerber G.E., Morton R.C., Freeman K.B.
    Nucleic Acids Res. 14:4025-4035(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The gene for rat uncoupling protein: complete sequence, structure of primary transcript and evolutionary relationship between exons."
    Bouillaud F., Raimbault S., Ricquier D.
    Biochem. Biophys. Res. Commun. 157:783-792(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  5. "Immunological detection of cDNA clones encoding the uncoupling protein of brown adipose tissue: evidence for an antigenic determinant within the C-terminal eleven amino acids."
    Ridley R.G., Patel H.V., Parfett C.L., Olynyk K.A., Reichling S., Freeman K.B.
    Biosci. Rep. 6:87-94(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 254-307.
  6. "The topology of the brown adipose tissue mitochondrial uncoupling protein determined with antibodies against its antigenic sites revealed by a library of fusion proteins."
    Miroux B., Frossard V., Raimbault S., Ricquier D., Bouillaud F.
    EMBO J. 12:3739-3745(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.

Entry informationi

Entry nameiUCP1_RAT
AccessioniPrimary (citable) accession number: P04633
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.