Reviewed, UniProtKB/Swiss-Prot P04628 (WNT1_HUMAN)

Names and origin

Protein names

Recommended name:
    Proto-oncogene protein Wnt-1

Gene names

Name:	WNT1
Synonyms:	INT1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.
Subunit structure	Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3 By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Disease	Proto-oncogene
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway, calcium modulating pathway Inferred from electronic annotation. Source: InterPro cell fate specification Traceable author statement. Source: UniProtKB cell migration Traceable author statement. Source: UniProtKB establishment or maintenance of cell polarity Traceable author statement. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from direct assay. Source: UniProtKB response to wounding Inferred from expression pattern. Source: UniProtKB
Cellular component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	receptor binding Non-traceable author statement. Source: UniProtKB signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 370	343	Proto-oncogene protein Wnt-1		PRO_0000041405
Amino acid modifications
	Glycosylation	29	1	N-linked (GlcNAc...) Potential
	Glycosylation	316	1	N-linked (GlcNAc...) Potential
	Glycosylation	346	1	N-linked (GlcNAc...) Potential
	Glycosylation	359	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P04628-1 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: F7E8111DA12E173F	FASTA	370	40,982
	10 20 30 40 50 60 MGLWALLPGW VSATLLLALA ALPAALAANS SGRWWGIVNV ASSTNLLTDS KSLQLVLEPS 70 80 90 100 110 120 LQLLSRKQRR LIRQNPGILH SVSGGLQSAV RECKWQFRNR RWNCPTAPGP HLFGKIVNRG 130 140 150 160 170 180 CRETAFIFAI TSAGVTHSVA RSCSEGSIES CTCDYRRRGP GGPDWHWGGC SDNIDFGRLF 190 200 210 220 230 240 GREFVDSGEK GRDLRFLMNL HNNEAGRTTV FSEMRQECKC HGMSGSCTVR TCWMRLPTLR 250 260 270 280 290 300 AVGDVLRDRF DGASRVLYGN RGSNRASRAE LLRLEPEDPA HKPPSPHDLV YFEKSPNFCT 310 320 330 340 350 360 YSGRLGTAGT AGRACNSSSP ALDGCELLCC GRGHRTRTQR VTERCNCTFH WCCHVSCRNC 370 THTRVLHECL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences." van Ooyen A., Kwee V., Nusse R. EMBO J. 4:2905-2909(1985) [PubMed: 2998762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X03072 Genomic DNA. Translation: CAA26874.1. BT019429 mRNA. Translation: AAV38236.1. CH471111 Genomic DNA. Translation: EAW58030.1. BC074798 mRNA. Translation: AAH74798.1. BC074799 mRNA. Translation: AAH74799.1.
IPI	IPI00025074.
PIR	TVHUT1. A24674.
RefSeq	NP_005421.1.
UniGene	Hs.248164
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P04628.
Proteomic databases
PRIDE	P04628.
Genome annotation databases
Ensembl	ENST00000293549; ENSP00000293549; ENSG00000125084; Homo sapiens. [Genome view]
GeneID	7471.
KEGG	hsa:7471.
UCSC	uc001rsu.1. human.
Organism-specific databases
CTD	7471.
GeneCards	GC12P047658.
H-InvDB	HIX0036830.
HGNC	HGNC:12774. WNT1.
MIM	164820. gene.
PharmGKB	PA37376.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13532.
HOGENOM	HBG446188.
HOVERGEN	P04628.
InParanoid	P04628.
OMA	CRETAFV.
OrthoDB	EOG9N5ZGH.
PhylomeDB	P04628.
Enzyme and pathway databases
Pathway_Interaction_DB	wnt_canonical_pathway. Canonical Wnt signaling pathway. ps1pathway. Presenilin action in Notch and Wnt signaling.
Gene expression databases
ArrayExpress	P04628.
Bgee	P04628.
CleanEx	HS_WNT1.
Genevestigator	P04628.
GermOnline	ENSG00000125084. Homo sapiens.
Family and domain databases
InterPro	IPR009139. Wnt1. IPR005816. Wnt_grthfactor. IPR018161. Wnt_grthfactor_CS. IPR005817. Wnt_SF. [Graphical view]
PANTHER	PTHR12027. Wnt. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01841. WNT1PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	29264.
SOURCE	Search...

Entry information

Entry name

WNT1_HUMAN

Accession

Primary (citable) accession number: P04628
Secondary accession number(s): Q5U0N2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	January 19, 2010
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.