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Protein

Thyroid hormone receptor alpha

Gene

THRA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei226Thyroid hormoneBy similarity1
Binding sitei275Thyroid hormone; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi51 – 125Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri51 – 71NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri89 – 113NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor alpha
Alternative name(s):
Nuclear receptor subfamily 1 group A member 1
Gene namesi
Name:THRA
Synonyms:NR1A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534311 – 408Thyroid hormone receptor alphaAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12Phosphoserine; by CK21 Publication1
Modified residuei28Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP04625.

PTM databases

iPTMnetiP04625.

Interactioni

Subunit structurei

Probably interacts with SFPQ.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SFPQP23246-12EBI-286261,EBI-355463From a different organism.

Protein-protein interaction databases

DIPiDIP-32625N.
IntActiP04625. 4 interactors.
STRINGi9031.ENSGALP00000000351.

Chemistry databases

BindingDBiP04625.

Structurei

Secondary structure

1408
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni148 – 152Combined sources5
Helixi161 – 176Combined sources16
Beta strandi177 – 179Combined sources3
Turni183 – 186Combined sources4
Helixi210 – 233Combined sources24
Helixi235 – 238Combined sources4
Helixi244 – 262Combined sources19
Turni267 – 270Combined sources4
Beta strandi271 – 274Combined sources4
Turni275 – 277Combined sources3
Beta strandi278 – 280Combined sources3
Helixi282 – 287Combined sources6
Turni288 – 292Combined sources5
Helixi293 – 303Combined sources11
Turni304 – 308Combined sources5
Helixi311 – 322Combined sources12
Beta strandi327 – 329Combined sources3
Helixi334 – 354Combined sources21
Helixi361 – 366Combined sources6
Helixi368 – 389Combined sources22
Helixi397 – 403Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UVVX-ray2.95A148-408[»]
ProteinModelPortaliP04625.
SMRiP04625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 50ModulatingAdd BLAST50
Regioni168 – 408Ligand-bindingAdd BLAST241

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri51 – 71NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri89 – 113NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOVERGENiHBG005606.
InParanoidiP04625.
KOiK05547.
PhylomeDBiP04625.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQKPSTLDP LSEPEDTRWL DGKRKRKSSQ CLVKSSMSGY IPSYLDKDEQ
60 70 80 90 100
CVVCGDKATG YHYRCITCEG CKGFFRRTIQ KNLHPTYSCK YDGCCVIDKI
110 120 130 140 150
TRNQCQLCRF KKCISVGMAM DLVLDDSKRV AKRKLIEENR ERRRKEEMIK
160 170 180 190 200
SLQHRPSPSA EEWELIHVVT EAHRSTNAQG SHWKQKRKFL PEDIGQSPMA
210 220 230 240 250
SMPDGDKVDL EAFSEFTKII TPAITRVVDF AKKLPMFSEL PCEDQIILLK
260 270 280 290 300
GCCMEIMSLR AAVRYDPESE TLTLSGEMAV KREQLKNGGL GVVSDAIFDL
310 320 330 340 350
GKSLSAFNLD DTEVALLQAV LLMSSDRTGL ICVDKIEKCQ ETYLLAFEHY
360 370 380 390 400
INYRKHNIPH FWPKLLMKVT DLRMIGACHA SRFLHMKVEC PTELFPPLFL

EVFEDQEV
Length:408
Mass (Da):46,757
Last modified:August 13, 1987 - v1
Checksum:iAA7DB6B73322BAA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04854 Genomic DNA. Translation: CAA28545.1.
Y00987 mRNA. Translation: CAA68792.1.
PIRiA25236. TVCHVR.
RefSeqiNP_990644.1. NM_205313.1.
UniGeneiGga.609.
Gga.725.

Genome annotation databases

GeneIDi396251.
KEGGigga:396251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04854 Genomic DNA. Translation: CAA28545.1.
Y00987 mRNA. Translation: CAA68792.1.
PIRiA25236. TVCHVR.
RefSeqiNP_990644.1. NM_205313.1.
UniGeneiGga.609.
Gga.725.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UVVX-ray2.95A148-408[»]
ProteinModelPortaliP04625.
SMRiP04625.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-32625N.
IntActiP04625. 4 interactors.
STRINGi9031.ENSGALP00000000351.

Chemistry databases

BindingDBiP04625.

PTM databases

iPTMnetiP04625.

Proteomic databases

PaxDbiP04625.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396251.
KEGGigga:396251.

Organism-specific databases

CTDi7067.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOVERGENiHBG005606.
InParanoidiP04625.
KOiK05547.
PhylomeDBiP04625.

Miscellaneous databases

PROiP04625.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHA_CHICK
AccessioniPrimary (citable) accession number: P04625
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.