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P04570

- SCP2_BRALA

UniProt

P04570 - SCP2_BRALA

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Protein

Sarcoplasmic calcium-binding proteins II, V, VI, and VII

Gene
N/A
Organism
Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Like parvalbumins, SCP's seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi19 – 30121Add
BLAST
Calcium bindingi70 – 81122Add
BLAST
Calcium bindingi115 – 126123Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcoplasmic calcium-binding proteins II, V, VI, and VII
Short name:
SCP II
Short name:
SCP V
Short name:
SCP VI
Short name:
SCP VII
OrganismiBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Taxonomic identifieri7740 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Sarcoplasmic calcium-binding proteins II, V, VI, and VIIPRO_0000073633Add
BLAST

Structurei

Secondary structure

1
185
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1714
Beta strandi23 – 264
Helixi28 – 4215
Helixi43 – 453
Helixi48 – 6922
Helixi79 – 9113
Helixi96 – 983
Helixi103 – 11412
Beta strandi118 – 1203
Helixi124 – 1307
Helixi141 – 1499
Turni150 – 1534
Helixi158 – 17013
Helixi176 – 1816

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2SASX-ray2.40A1-185[»]
ProteinModelPortaliP04570.
SMRiP04570. Positions 1-185.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04570.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 4137EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini57 – 9236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini102 – 13736EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 17336EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG017781.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04570-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GLNDFQKQKI KFTFDFFLDM NHDGSIQDND FEDMMTRYKE VNKGSLSDAD
60 70 80 90 100
YKSMQASLED EWRDLKGRAD INKDDVVSWE EYLAMWEKTI ATCKSVADLP
110 120 130 140 150
AWCQNRIPFL FKGMDVSGDG IVDLEEFQNY CKNFQLQCAD VPAVYNVITD
160 170 180
GGKVTFDLNR YKELYYRLLT SPAADAGNTL MGQKP
Length:185
Mass (Da):21,286
Last modified:November 1, 1990 - v2
Checksum:i76E3307B55C7595B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251S → A in SCP V.
Natural varianti28 – 281D → W in SCP V, VI and VII.
Natural varianti29 – 291N → E in SCP VI.

Sequence databases

PIRiS13183.
S21153.

Cross-referencesi

Sequence databases

PIRi S13183.
S21153.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2SAS X-ray 2.40 A 1-185 [» ]
ProteinModelPortali P04570.
SMRi P04570. Positions 1-185.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG017781.

Miscellaneous databases

EvolutionaryTracei P04570.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of two sarcoplasmic calcium-binding proteins from the protochordate amphioxus."
    Takagi T., Konishi K., Cox J.A.
    Biochemistry 25:3585-3592(1986)
    Cited for: PROTEIN SEQUENCE.
  2. "Amino acid sequences of four isoforms of amphioxus sarcoplasmic calcium-binding proteins."
    Takagi T., Cox J.A.
    Eur. J. Biochem. 192:387-399(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Primary structure of three minor isoforms of amphioxus sarcoplasmic calcium-binding proteins."
    Takagi T., Valette-Talbi L., Cox J.A.
    FEBS Lett. 302:159-160(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (SCP V TO VII).
  4. "Structure of a sarcoplasmic calcium-binding protein from amphioxus refined at 2.4-A resolution."
    Cook W.J., Jeffrey L.C., Cox J.A., Vijay-Kumar S.
    J. Mol. Biol. 229:461-471(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

Entry informationi

Entry nameiSCP2_BRALA
AccessioniPrimary (citable) accession number: P04570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 1, 1990
Last modified: October 1, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The sarcoplasmic calcium-binding proteins are abundant in the muscle of arthropods, mollusks, annelids, and protochordates.
This protein has three functional calcium-binding sites; potential site 4 has lost affinity for calcium.
There are 7 different SCP's in amphioxus. The sequence shown here is that of SCP II.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3