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P04570 (SCP2_BRALA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sarcoplasmic calcium-binding proteins II, V, VI, and VII

Short name=SCP II
Short name=SCP V
Short name=SCP VI
Short name=SCP VII
OrganismBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Taxonomic identifier7740 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Like parvalbumins, SCP's seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution.

Miscellaneous

The sarcoplasmic calcium-binding proteins are abundant in the muscle of arthropods, mollusks, annelids, and protochordates.

This protein has three functional calcium-binding sites; potential site 4 has lost affinity for calcium.

There are 7 different SCP's in amphioxus. The sequence shown here is that of SCP II.

Sequence similarities

Contains 4 EF-hand domains.

Ontologies

Keywords
   DomainRepeat
   LigandCalcium
Metal-binding
   Molecular functionMuscle protein
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Sarcoplasmic calcium-binding proteins II, V, VI, and VII
PRO_0000073633

Regions

Domain5 – 4137EF-hand 1
Domain57 – 9236EF-hand 2
Domain102 – 13736EF-hand 3
Domain138 – 17336EF-hand 4
Calcium binding19 – 30121
Calcium binding70 – 81122
Calcium binding115 – 126123

Natural variations

Natural variant251S → A in SCP V.
Natural variant281D → W in SCP V, VI and VII.
Natural variant291N → E in SCP VI.

Secondary structure

........................... 185
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P04570 [UniParc].

Last modified November 1, 1990. Version 2.
Checksum: 76E3307B55C7595B

FASTA18521,286
        10         20         30         40         50         60 
GLNDFQKQKI KFTFDFFLDM NHDGSIQDND FEDMMTRYKE VNKGSLSDAD YKSMQASLED 

        70         80         90        100        110        120 
EWRDLKGRAD INKDDVVSWE EYLAMWEKTI ATCKSVADLP AWCQNRIPFL FKGMDVSGDG 

       130        140        150        160        170        180 
IVDLEEFQNY CKNFQLQCAD VPAVYNVITD GGKVTFDLNR YKELYYRLLT SPAADAGNTL 


MGQKP 

« Hide

References

[1]"Amino acid sequence of two sarcoplasmic calcium-binding proteins from the protochordate amphioxus."
Takagi T., Konishi K., Cox J.A.
Biochemistry 25:3585-3592(1986)
Cited for: PROTEIN SEQUENCE.
[2]"Amino acid sequences of four isoforms of amphioxus sarcoplasmic calcium-binding proteins."
Takagi T., Cox J.A.
Eur. J. Biochem. 192:387-399(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"Primary structure of three minor isoforms of amphioxus sarcoplasmic calcium-binding proteins."
Takagi T., Valette-Talbi L., Cox J.A.
FEBS Lett. 302:159-160(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (SCP V TO VII).
[4]"Structure of a sarcoplasmic calcium-binding protein from amphioxus refined at 2.4-A resolution."
Cook W.J., Jeffrey L.C., Cox J.A., Vijay-Kumar S.
J. Mol. Biol. 229:461-471(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

Cross-references

Sequence databases

PIRS13183.
S21153.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2SASX-ray2.40A1-185[»]
ProteinModelPortalP04570.
SMRP04570. Positions 1-185.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG017781.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP04570.

Entry information

Entry nameSCP2_BRALA
AccessionPrimary (citable) accession number: P04570
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 1, 1990
Last modified: May 14, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references