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P04570

- SCP2_BRALA

UniProt

P04570 - SCP2_BRALA

Protein

Sarcoplasmic calcium-binding proteins II, V, VI, and VII

Gene
N/A
Organism
Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Like parvalbumins, SCP's seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi19 – 30121Add
    BLAST
    Calcium bindingi70 – 81122Add
    BLAST
    Calcium bindingi115 – 126123Add
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sarcoplasmic calcium-binding proteins II, V, VI, and VII
    Short name:
    SCP II
    Short name:
    SCP V
    Short name:
    SCP VI
    Short name:
    SCP VII
    OrganismiBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
    Taxonomic identifieri7740 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Sarcoplasmic calcium-binding proteins II, V, VI, and VIIPRO_0000073633Add
    BLAST

    Structurei

    Secondary structure

    1
    185
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 1714
    Beta strandi23 – 264
    Helixi28 – 4215
    Helixi43 – 453
    Helixi48 – 6922
    Helixi79 – 9113
    Helixi96 – 983
    Helixi103 – 11412
    Beta strandi118 – 1203
    Helixi124 – 1307
    Helixi141 – 1499
    Turni150 – 1534
    Helixi158 – 17013
    Helixi176 – 1816

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2SASX-ray2.40A1-185[»]
    ProteinModelPortaliP04570.
    SMRiP04570. Positions 1-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP04570.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 4137EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini57 – 9236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini102 – 13736EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 17336EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG017781.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P04570-1 [UniParc]FASTAAdd to Basket

    « Hide

    GLNDFQKQKI KFTFDFFLDM NHDGSIQDND FEDMMTRYKE VNKGSLSDAD    50
    YKSMQASLED EWRDLKGRAD INKDDVVSWE EYLAMWEKTI ATCKSVADLP 100
    AWCQNRIPFL FKGMDVSGDG IVDLEEFQNY CKNFQLQCAD VPAVYNVITD 150
    GGKVTFDLNR YKELYYRLLT SPAADAGNTL MGQKP 185
    Length:185
    Mass (Da):21,286
    Last modified:November 1, 1990 - v2
    Checksum:i76E3307B55C7595B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251S → A in SCP V.
    Natural varianti28 – 281D → W in SCP V, VI and VII.
    Natural varianti29 – 291N → E in SCP VI.

    Sequence databases

    PIRiS13183.
    S21153.

    Cross-referencesi

    Sequence databases

    PIRi S13183.
    S21153.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2SAS X-ray 2.40 A 1-185 [» ]
    ProteinModelPortali P04570.
    SMRi P04570. Positions 1-185.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG017781.

    Miscellaneous databases

    EvolutionaryTracei P04570.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequence of two sarcoplasmic calcium-binding proteins from the protochordate amphioxus."
      Takagi T., Konishi K., Cox J.A.
      Biochemistry 25:3585-3592(1986)
      Cited for: PROTEIN SEQUENCE.
    2. "Amino acid sequences of four isoforms of amphioxus sarcoplasmic calcium-binding proteins."
      Takagi T., Cox J.A.
      Eur. J. Biochem. 192:387-399(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "Primary structure of three minor isoforms of amphioxus sarcoplasmic calcium-binding proteins."
      Takagi T., Valette-Talbi L., Cox J.A.
      FEBS Lett. 302:159-160(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE (SCP V TO VII).
    4. "Structure of a sarcoplasmic calcium-binding protein from amphioxus refined at 2.4-A resolution."
      Cook W.J., Jeffrey L.C., Cox J.A., Vijay-Kumar S.
      J. Mol. Biol. 229:461-471(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

    Entry informationi

    Entry nameiSCP2_BRALA
    AccessioniPrimary (citable) accession number: P04570
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The sarcoplasmic calcium-binding proteins are abundant in the muscle of arthropods, mollusks, annelids, and protochordates.
    This protein has three functional calcium-binding sites; potential site 4 has lost affinity for calcium.
    There are 7 different SCP's in amphioxus. The sequence shown here is that of SCP II.

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3