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Protein

Sarcoplasmic calcium-binding proteins II, V, VI, and VII

Gene
N/A
Organism
Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Like parvalbumins, SCP's seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi19 – 301Add BLAST12
Calcium bindingi70 – 812Add BLAST12
Calcium bindingi115 – 1263Add BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcoplasmic calcium-binding proteins II, V, VI, and VII
Short name:
SCP II
Short name:
SCP V
Short name:
SCP VI
Short name:
SCP VII
OrganismiBranchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum)
Taxonomic identifieri7740 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000736331 – 185Sarcoplasmic calcium-binding proteins II, V, VI, and VIIAdd BLAST185

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 17Combined sources14
Beta strandi23 – 26Combined sources4
Helixi28 – 42Combined sources15
Helixi43 – 45Combined sources3
Helixi48 – 69Combined sources22
Helixi79 – 91Combined sources13
Helixi96 – 98Combined sources3
Helixi103 – 114Combined sources12
Beta strandi118 – 120Combined sources3
Helixi124 – 130Combined sources7
Helixi141 – 149Combined sources9
Turni150 – 153Combined sources4
Helixi158 – 170Combined sources13
Helixi176 – 181Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2SASX-ray2.40A1-185[»]
ProteinModelPortaliP04570.
SMRiP04570.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04570.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 41EF-hand 1PROSITE-ProRule annotationAdd BLAST37
Domaini57 – 92EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini102 – 137EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini138 – 173EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG017781.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13833. EF-hand_8. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GLNDFQKQKI KFTFDFFLDM NHDGSIQDND FEDMMTRYKE VNKGSLSDAD
60 70 80 90 100
YKSMQASLED EWRDLKGRAD INKDDVVSWE EYLAMWEKTI ATCKSVADLP
110 120 130 140 150
AWCQNRIPFL FKGMDVSGDG IVDLEEFQNY CKNFQLQCAD VPAVYNVITD
160 170 180
GGKVTFDLNR YKELYYRLLT SPAADAGNTL MGQKP
Length:185
Mass (Da):21,286
Last modified:November 1, 1990 - v2
Checksum:i76E3307B55C7595B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti25S → A in SCP V. 1
Natural varianti28D → W in SCP V, VI and VII. 1
Natural varianti29N → E in SCP VI. 1

Sequence databases

PIRiS13183.
S21153.

Cross-referencesi

Sequence databases

PIRiS13183.
S21153.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2SASX-ray2.40A1-185[»]
ProteinModelPortaliP04570.
SMRiP04570.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG017781.

Miscellaneous databases

EvolutionaryTraceiP04570.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13833. EF-hand_8. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCP2_BRALA
AccessioniPrimary (citable) accession number: P04570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The sarcoplasmic calcium-binding proteins are abundant in the muscle of arthropods, mollusks, annelids, and protochordates.
This protein has three functional calcium-binding sites; potential site 4 has lost affinity for calcium.
There are 7 different SCP's in amphioxus. The sequence shown here is that of SCP II.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.