Reviewed, UniProtKB/Swiss-Prot P04564 (GAST_CAPHI)

Names and origin

Protein names

Recommended name:
    Gastrin
Cleaved into the following 2 chains:
    1- Recommended name:
            Big gastrin
        Alternative name(s):
            Gastrin-34
              Short name=G34
    2- Recommended name:
            Gastrin

Gene names

Name:	GAST
Synonyms:	GAS

Organism

Capra hircus (Goat)

Taxonomic identifier

9925 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Capra

Protein attributes

Sequence length	34 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Subcellular location	Secreted.
Sequence similarities	Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Pyrrolidone carboxylic acid Sulfation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 34	34	Big gastrin Ref.1		PRO_0000010617
	Peptide	18 – 34	17	Gastrin Ref.1		PRO_0000010618
Amino acid modifications
	Modified residue	1	1	Pyrrolidone carboxylic acid Ref.1
	Modified residue	18	1	Pyrrolidone carboxylic acid Ref.1
	Modified residue	29	1	Sulfotyrosine Ref.1
	Modified residue	34	1	Phenylalanine amide Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P04564-1 [UniParc]. Last modified February 1, 1994. Version 3. Checksum: 67501111E76D0CF4	FASTA	34	3,903
	10 20 30 QLGLQDPPHM VADLSKKQGP WVEEEEAAYG WMDF

References

[1]	"Sequences of gastrins purified from a single antrum of dog and of goat." Bonato C., Eng J., Hulmes J.D., Miedel M., Pan Y.-C.E., Yalow R.S. Peptides 7:689-693(1986) [PubMed: 3763441] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Gastric mucosa.

Cross-references

Sequence databases
PIR	JS0426.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P04564.
Family and domain databases
InterPro	IPR001651. Gastrin. IPR013152. Gastrin/cholecystokinin_CS. [Graphical view]
Pfam	PF00918. Gastrin. 1 hit. [Graphical view]
PROSITE	PS00259. GASTRIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAST_CAPHI

Accession

Primary (citable) accession number: P04564

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	February 1, 1994
Last modified:	June 16, 2009
This is version 54 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)