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Protein

Gastrin

Gene

Gast

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

GO - Molecular functioni

  • hormone activity Source: RGD

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: RGD
  • response to food Source: GO_Central
  • signal transduction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-881907. Gastrin-CREB signalling pathway via PKC and MAPK.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin
Cleaved into the following 2 chains:
Alternative name(s):
Gastrin-34
Short name:
G34
Gene namesi
Name:Gast
Synonyms:Gas
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2662. Gast.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121CuratedAdd
BLAST
Propeptidei22 – 5837PRO_0000010648Add
BLAST
Peptidei59 – 9234Big gastrinPRO_0000010649Add
BLAST
Peptidei76 – 9217GastrinPRO_0000010650Add
BLAST
Propeptidei96 – 1049PRO_0000010651

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 591Pyrrolidone carboxylic acidBy similarity
Modified residuei76 – 761Pyrrolidone carboxylic acidBy similarity
Modified residuei87 – 871Sulfotyrosine1 Publication
Modified residuei92 – 921Phenylalanine amide1 Publication
Modified residuei96 – 961Phosphoserine1 Publication
Modified residuei103 – 1031Sulfotyrosine1 Publication

Post-translational modificationi

Sulfation on Tyr-87 enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins and between tissues (By similarity).By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiP04563.
PRIDEiP04563.

PTM databases

iPTMnetiP04563.
PhosphoSiteiP04563.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014740.
GenevisibleiP04563. RN.

Interactioni

GO - Molecular functioni

  • hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019863.

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ZA. Eukaryota.
ENOG4111D7Y. LUCA.
GeneTreeiENSGT00390000014792.
HOGENOMiHOG000073533.
HOVERGENiHBG097593.
InParanoidiP04563.
KOiK13768.
OMAiKKQGPWM.
OrthoDBiEOG091G147Z.
PhylomeDBiP04563.
TreeFamiTF336994.

Family and domain databases

InterProiIPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLCVCMLV LVLALATFSE ASWKPRSQLQ DASSGPRTNG ALEQHQLEKL
60 70 80 90 100
GPASHHRRQL GPQGPQHFIA DLSKKQRPPM EEEEEAYGWM DFGRRSAEEE

DQYN
Length:104
Mass (Da):11,832
Last modified:November 1, 1990 - v2
Checksum:i973FD06276BF1E21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38653 mRNA. Translation: AAA41919.1.
M25459 mRNA. Translation: AAA41195.1.
PIRiA40910.
RefSeqiNP_036981.1. NM_012849.1.
UniGeneiRn.9754.

Genome annotation databases

EnsembliENSRNOT00000019863; ENSRNOP00000019863; ENSRNOG00000014740.
GeneIDi25320.
KEGGirno:25320.
UCSCiRGD:2662. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38653 mRNA. Translation: AAA41919.1.
M25459 mRNA. Translation: AAA41195.1.
PIRiA40910.
RefSeqiNP_036981.1. NM_012849.1.
UniGeneiRn.9754.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019863.

PTM databases

iPTMnetiP04563.
PhosphoSiteiP04563.

Proteomic databases

PaxDbiP04563.
PRIDEiP04563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019863; ENSRNOP00000019863; ENSRNOG00000014740.
GeneIDi25320.
KEGGirno:25320.
UCSCiRGD:2662. rat.

Organism-specific databases

CTDi2520.
RGDi2662. Gast.

Phylogenomic databases

eggNOGiENOG410J1ZA. Eukaryota.
ENOG4111D7Y. LUCA.
GeneTreeiENSGT00390000014792.
HOGENOMiHOG000073533.
HOVERGENiHBG097593.
InParanoidiP04563.
KOiK13768.
OMAiKKQGPWM.
OrthoDBiEOG091G147Z.
PhylomeDBiP04563.
TreeFamiTF336994.

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-881907. Gastrin-CREB signalling pathway via PKC and MAPK.

Miscellaneous databases

PROiP04563.

Gene expression databases

BgeeiENSRNOG00000014740.
GenevisibleiP04563. RN.

Family and domain databases

InterProiIPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAST_RAT
AccessioniPrimary (citable) accession number: P04563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.