P04560 (UTS2A_CYPCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Prepro-urotensin II-alpha Cleaved into the following 2 chains: Urophysin alpha Urotensin II-alpha Short name=U-II-alpha Short name=UII-alpha
Organism	Cyprinus carpio (Common carp)
Taxonomic identifier	7962 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Cyprinus

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Urotensin is found in the teleost caudal neurosecretory system. It has a suggested role in osmoregulation and as a corticotropin-releasing factor. The non-hormonal portion of this precursor may be a urotensin binding protein, urophysin.
Subcellular location	Secreted.
Sequence similarities	Belongs to the urotensin-2 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	regulation of blood pressure Inferred from electronic annotation. Source: InterPro regulation of vasodilation Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21
	Chain	22 – 106	85	Urophysin alpha Potential		PRO_0000036335
	Propeptide	109 – 111	3	Potential		PRO_0000036336
	Peptide	114 – 125	12	Urotensin II-alpha Ref.2		PRO_0000036337
Amino acid modifications
	Disulfide bond	119 ↔ 124

Sequences

	Sequence		Length	Mass (Da)
	P04560 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 1FB6F86CA6B3A5AF	FASTA	125	13,840
	10 20 30 40 50 60 MMCNLLLSFS VLLLSCTHLV AHPVTDTADM TYSGPDSVEE AGGVSPDDFA VSDLNDLLQR 70 80 90 100 110 120 AAVVEYSPLL SRENIKVPGQ IPKEALRELL LEKPYRLIPP SGLWGSRRQF RKRGGGADCF WKYCV

References

[1]	"Cloning and sequence analysis of cDNAs encoding precursors of urotensin II-alpha and -gamma." Ohsako S., Ishida I., Ichikawa T., Deguchi T. J. Neurosci. 6:2730-2735(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Munekata E., Ohtaki T., Ichikawa T., McMaster D., Lederis K. (In) Rich D.H., Gross E. (eds.); Proceedings of the 7th American peptide symposium, pp.69-72, Pierce Chemical Co., Rockford Il. (1981) Cited for: PROTEIN SEQUENCE OF 114-125.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M14084 mRNA. Translation: AAA49215.1.
PIR	I50498.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG098597.
Family and domain databases
InterPro	IPR001483. Urotensin_II. [Graphical view]
Pfam	PF02083. Urotensin_II. 1 hit. [Graphical view]
PROSITE	PS00984. UROTENSIN_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UTS2A_CYPCA

Accession

Primary (citable) accession number: P04560

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	January 1, 1988
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program