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Protein

Sperm protamine P1

Gene

PRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

GO - Molecular functioni

  • DNA binding Source: ProtInc

GO - Biological processi

  • chromosome condensation Source: GO_Central
  • DNA packaging Source: ProtInc
  • multicellular organism development Source: UniProtKB-KW
  • nucleus organization Source: GO_Central
  • spermatid development Source: GO_Central
  • spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, DNA condensation, Spermatogenesis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175646-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protamine P1
Alternative name(s):
Cysteine-rich protamine
Gene namesi
Name:PRM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:9447. PRM1.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: ProtInc
  • nucleosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5619.
OpenTargetsiENSG00000175646.
PharmGKBiPA33792.

Polymorphism and mutation databases

BioMutaiPRM1.
DMDMi123691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001914822 – 51Sperm protamine P1Add BLAST50

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6InterchainBy similarity
Disulfide bondi39Interchain (with C-39)By similarity
Disulfide bondi40 ↔ 48By similarity

Post-translational modificationi

Phosphorylated by SRPK1.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP04553.
PRIDEiP04553.

PTM databases

iPTMnetiP04553.
PhosphoSitePlusiP04553.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSG00000175646.
CleanExiHS_PRM1.
ExpressionAtlasiP04553. baseline and differential.
GenevisibleiP04553. HS.

Organism-specific databases

HPAiHPA055150.

Interactioni

Subunit structurei

Cross-linked by interchain disulfide bonds around the DNA-helix.

Protein-protein interaction databases

BioGridi111604. 1 interactor.
STRINGi9606.ENSP00000310515.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AWRmodel-A1-51[»]
ProteinModelPortaliP04553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protamine P1 family.Curated

Phylogenomic databases

HOVERGENiHBG081661.
OMAiRRAMRCC.

Family and domain databases

InterProiIPR000221. Protamine_P1.
[Graphical view]
PfamiPF00260. Protamine_P1. 1 hit.
[Graphical view]
PROSITEiPS00048. PROTAMINE_P1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARYRCCRSQ SRSRYYRQRQ RSRRRRRRSC QTRRRAMRCC RPRYRPRCRR

H
Length:51
Mass (Da):6,823
Last modified:January 23, 2007 - v2
Checksum:i4A5C6A92C713C33D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46940 Genomic DNA. Translation: CAA87065.1.
M60331 Genomic DNA. Translation: AAA63249.1.
M29706 Genomic DNA. Translation: AAA60191.1.
Y00443 mRNA. Translation: CAA68499.1.
U15422 Genomic DNA. Translation: AAC50486.1.
S68144 Genomic DNA. Translation: AAB29321.2.
AF215707 Genomic DNA. Translation: AAF34620.1.
BT006746 mRNA. Translation: AAP35392.1.
BC003673 mRNA. Translation: AAH03673.1.
CCDSiCCDS10547.1.
PIRiA38515. HSHUP1.
RefSeqiNP_002752.1. NM_002761.2.
UniGeneiHs.2909.
Hs.60257.

Genome annotation databases

EnsembliENST00000312511; ENSP00000310515; ENSG00000175646.
GeneIDi5619.
KEGGihsa:5619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46940 Genomic DNA. Translation: CAA87065.1.
M60331 Genomic DNA. Translation: AAA63249.1.
M29706 Genomic DNA. Translation: AAA60191.1.
Y00443 mRNA. Translation: CAA68499.1.
U15422 Genomic DNA. Translation: AAC50486.1.
S68144 Genomic DNA. Translation: AAB29321.2.
AF215707 Genomic DNA. Translation: AAF34620.1.
BT006746 mRNA. Translation: AAP35392.1.
BC003673 mRNA. Translation: AAH03673.1.
CCDSiCCDS10547.1.
PIRiA38515. HSHUP1.
RefSeqiNP_002752.1. NM_002761.2.
UniGeneiHs.2909.
Hs.60257.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AWRmodel-A1-51[»]
ProteinModelPortaliP04553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111604. 1 interactor.
STRINGi9606.ENSP00000310515.

PTM databases

iPTMnetiP04553.
PhosphoSitePlusiP04553.

Polymorphism and mutation databases

BioMutaiPRM1.
DMDMi123691.

Proteomic databases

PaxDbiP04553.
PRIDEiP04553.

Protocols and materials databases

DNASUi5619.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312511; ENSP00000310515; ENSG00000175646.
GeneIDi5619.
KEGGihsa:5619.

Organism-specific databases

CTDi5619.
DisGeNETi5619.
GeneCardsiPRM1.
H-InvDBHIX0012816.
HGNCiHGNC:9447. PRM1.
HPAiHPA055150.
MIMi182880. gene.
neXtProtiNX_P04553.
OpenTargetsiENSG00000175646.
PharmGKBiPA33792.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG081661.
OMAiRRAMRCC.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175646-MONOMER.

Miscellaneous databases

GenomeRNAii5619.
PROiP04553.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175646.
CleanExiHS_PRM1.
ExpressionAtlasiP04553. baseline and differential.
GenevisibleiP04553. HS.

Family and domain databases

InterProiIPR000221. Protamine_P1.
[Graphical view]
PfamiPF00260. Protamine_P1. 1 hit.
[Graphical view]
PROSITEiPS00048. PROTAMINE_P1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP1_HUMAN
AccessioniPrimary (citable) accession number: P04553
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.