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P04553 (HSP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sperm protamine P1
Alternative name(s):
Cysteine-rich protamine
Gene names
Name:PRM1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length51 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

Subunit structure

Cross-linked by interchain disulfide bonds around the DNA-helix.

Subcellular location

Nucleus. Chromosome.

Tissue specificity

Testis.

Post-translational modification

Phosphorylated by SRPK1. Ref.11

Sequence similarities

Belongs to the protamine P1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.9 Ref.10
Chain2 – 5150Sperm protamine P1
PRO_0000191482

Amino acid modifications

Disulfide bond6Interchain By similarity
Disulfide bond39Interchain (with C-39) By similarity
Disulfide bond40 ↔ 48 By similarity

Sequences

Sequence LengthMass (Da)Tools
P04553 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 4A5C6A92C713C33D

FASTA516,823
        10         20         30         40         50 
MARYRCCRSQ SRSRYYRQRQ RSRRRRRRSC QTRRRAMRCC RPRYRPRCRR H 

« Hide

References

« Hide 'large scale' references
[1]"Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered."
Domenjoud L., Nussbaum G., Adham I.M., Greeske G., Engel W.
Genomics 8:127-133(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Chromosomal localization and structure of the human P1 protamine gene."
Krawetz S.A., Herfort M.H., Hamerton J.L., Pon R.T., Dixon G.H.
Genomics 5:639-645(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The nucleotide sequence of a human protamine 1 cDNA."
Lee C.-H., Hoyer-Fender S., Engel W.
Nucleic Acids Res. 15:7639-7639(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Characterization of a human locus in transition."
Nelson J.E., Krawetz S.A.
J. Biol. Chem. 269:31067-31073(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Direct sequencing of the human protamine P1 gene and application in forensic medicine."
Queralt R., de Fabregues-Boixar O., Adroer R., Gene M., Gomez-Catalan J., Huguet E., Oliva R.
J. Forensic Sci. 38:1491-1501(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Rapid evolution of male reproductive genes in the descent of man."
Wyckoff G.J., Wang W., Wu C.-I.
Nature 403:304-309(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[9]"The amino acid sequence of human sperm protamine P1."
McKay D.J., Renaux B.S., Dixon G.H.
Biosci. Rep. 5:383-391(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-51.
[10]"Isolation and amino-acid sequence analysis of human sperm protamines P1 and P2. Occurrence of two forms of protamine P2."
Ammer H., Henschen A., Lee C.-H.
Biol. Chem. Hoppe-Seyler 367:515-522(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-51.
[11]"SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1."
Papoutsopoulou S., Nikolakaki E., Chalepakis G., Kruft V., Chevaillier P., Giannakouros T.
Nucleic Acids Res. 27:2972-2980(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION BY SRPK1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46940 Genomic DNA. Translation: CAA87065.1.
M60331 Genomic DNA. Translation: AAA63249.1.
M29706 Genomic DNA. Translation: AAA60191.1.
Y00443 mRNA. Translation: CAA68499.1.
U15422 Genomic DNA. Translation: AAC50486.1.
S68144 Genomic DNA. Translation: AAB29321.2.
AF215707 Genomic DNA. Translation: AAF34620.1.
BT006746 mRNA. Translation: AAP35392.1.
BC003673 mRNA. Translation: AAH03673.1.
PIRHSHUP1. A38515.
RefSeqNP_002752.1. NM_002761.2.
UniGeneHs.2909.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2AWRmodel-A1-51[»]
ProteinModelPortalP04553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111604. 1 interaction.
STRING9606.ENSP00000310515.

PTM databases

PhosphoSiteP04553.

Polymorphism databases

DMDM123691.

Proteomic databases

PRIDEP04553.

Protocols and materials databases

DNASU5619.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312511; ENSP00000310515; ENSG00000175646.
GeneID5619.
KEGGhsa:5619.
UCSCuc002dav.3. human.

Organism-specific databases

CTD5619.
GeneCardsGC16M011374.
H-InvDBHIX0012816.
HGNCHGNC:9447. PRM1.
HPAHPA055150.
MIM182880. gene.
neXtProtNX_P04553.
PharmGKBPA33792.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG081661.
OMARRAMRCC.

Gene expression databases

ArrayExpressP04553.
BgeeP04553.
CleanExHS_PRM1.
GenevestigatorP04553.

Family and domain databases

InterProIPR000221. Protamine_P1.
[Graphical view]
PfamPF00260. Protamine_P1. 1 hit.
[Graphical view]
PROSITEPS00048. PROTAMINE_P1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi5619.
NextBio21836.
PROP04553.
SOURCESearch...

Entry information

Entry nameHSP1_HUMAN
AccessionPrimary (citable) accession number: P04553
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM