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Protein

Sperm protamine P1

Gene

PRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

GO - Molecular functioni

  1. DNA binding Source: ProtInc

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. chromosome condensation Source: UniProtKB-KW
  3. DNA packaging Source: ProtInc
  4. multicellular organismal development Source: UniProtKB-KW
  5. spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, DNA condensation, Spermatogenesis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm protamine P1
Alternative name(s):
Cysteine-rich protamine
Gene namesi
Name:PRM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:9447. PRM1.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: ProtInc
  2. nucleosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33792.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 5150Sperm protamine P1PRO_0000191482Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi6 – 6InterchainBy similarity
Disulfide bondi39 – 39Interchain (with C-39)By similarity
Disulfide bondi40 ↔ 48By similarity

Post-translational modificationi

Phosphorylated by SRPK1.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP04553.

PTM databases

PhosphoSiteiP04553.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiP04553.
CleanExiHS_PRM1.
ExpressionAtlasiP04553. baseline and differential.
GenevestigatoriP04553.

Organism-specific databases

HPAiHPA055150.

Interactioni

Subunit structurei

Cross-linked by interchain disulfide bonds around the DNA-helix.

Protein-protein interaction databases

BioGridi111604. 1 interaction.
STRINGi9606.ENSP00000310515.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AWRmodel-A1-51[»]
ProteinModelPortaliP04553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protamine P1 family.Curated

Phylogenomic databases

HOVERGENiHBG081661.
OMAiRRAMRCC.

Family and domain databases

InterProiIPR000221. Protamine_P1.
[Graphical view]
PfamiPF00260. Protamine_P1. 1 hit.
[Graphical view]
PROSITEiPS00048. PROTAMINE_P1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARYRCCRSQ SRSRYYRQRQ RSRRRRRRSC QTRRRAMRCC RPRYRPRCRR

H
Length:51
Mass (Da):6,823
Last modified:January 23, 2007 - v2
Checksum:i4A5C6A92C713C33D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46940 Genomic DNA. Translation: CAA87065.1.
M60331 Genomic DNA. Translation: AAA63249.1.
M29706 Genomic DNA. Translation: AAA60191.1.
Y00443 mRNA. Translation: CAA68499.1.
U15422 Genomic DNA. Translation: AAC50486.1.
S68144 Genomic DNA. Translation: AAB29321.2.
AF215707 Genomic DNA. Translation: AAF34620.1.
BT006746 mRNA. Translation: AAP35392.1.
BC003673 mRNA. Translation: AAH03673.1.
CCDSiCCDS10547.1.
PIRiA38515. HSHUP1.
RefSeqiNP_002752.1. NM_002761.2.
UniGeneiHs.2909.

Genome annotation databases

EnsembliENST00000312511; ENSP00000310515; ENSG00000175646.
GeneIDi5619.
KEGGihsa:5619.
UCSCiuc002dav.3. human.

Polymorphism databases

DMDMi123691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46940 Genomic DNA. Translation: CAA87065.1.
M60331 Genomic DNA. Translation: AAA63249.1.
M29706 Genomic DNA. Translation: AAA60191.1.
Y00443 mRNA. Translation: CAA68499.1.
U15422 Genomic DNA. Translation: AAC50486.1.
S68144 Genomic DNA. Translation: AAB29321.2.
AF215707 Genomic DNA. Translation: AAF34620.1.
BT006746 mRNA. Translation: AAP35392.1.
BC003673 mRNA. Translation: AAH03673.1.
CCDSiCCDS10547.1.
PIRiA38515. HSHUP1.
RefSeqiNP_002752.1. NM_002761.2.
UniGeneiHs.2909.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AWRmodel-A1-51[»]
ProteinModelPortaliP04553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111604. 1 interaction.
STRINGi9606.ENSP00000310515.

PTM databases

PhosphoSiteiP04553.

Polymorphism databases

DMDMi123691.

Proteomic databases

PRIDEiP04553.

Protocols and materials databases

DNASUi5619.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312511; ENSP00000310515; ENSG00000175646.
GeneIDi5619.
KEGGihsa:5619.
UCSCiuc002dav.3. human.

Organism-specific databases

CTDi5619.
GeneCardsiGC16M011374.
H-InvDBHIX0012816.
HGNCiHGNC:9447. PRM1.
HPAiHPA055150.
MIMi182880. gene.
neXtProtiNX_P04553.
PharmGKBiPA33792.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG081661.
OMAiRRAMRCC.

Miscellaneous databases

GenomeRNAii5619.
NextBioi21836.
PROiP04553.
SOURCEiSearch...

Gene expression databases

BgeeiP04553.
CleanExiHS_PRM1.
ExpressionAtlasiP04553. baseline and differential.
GenevestigatoriP04553.

Family and domain databases

InterProiIPR000221. Protamine_P1.
[Graphical view]
PfamiPF00260. Protamine_P1. 1 hit.
[Graphical view]
PROSITEiPS00048. PROTAMINE_P1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered."
    Domenjoud L., Nussbaum G., Adham I.M., Greeske G., Engel W.
    Genomics 8:127-133(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Chromosomal localization and structure of the human P1 protamine gene."
    Krawetz S.A., Herfort M.H., Hamerton J.L., Pon R.T., Dixon G.H.
    Genomics 5:639-645(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of a human protamine 1 cDNA."
    Lee C.-H., Hoyer-Fender S., Engel W.
    Nucleic Acids Res. 15:7639-7639(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Characterization of a human locus in transition."
    Nelson J.E., Krawetz S.A.
    J. Biol. Chem. 269:31067-31073(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Direct sequencing of the human protamine P1 gene and application in forensic medicine."
    Queralt R., de Fabregues-Boixar O., Adroer R., Gene M., Gomez-Catalan J., Huguet E., Oliva R.
    J. Forensic Sci. 38:1491-1501(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Rapid evolution of male reproductive genes in the descent of man."
    Wyckoff G.J., Wang W., Wu C.-I.
    Nature 403:304-309(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  9. "The amino acid sequence of human sperm protamine P1."
    McKay D.J., Renaux B.S., Dixon G.H.
    Biosci. Rep. 5:383-391(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-51.
  10. "Isolation and amino-acid sequence analysis of human sperm protamines P1 and P2. Occurrence of two forms of protamine P2."
    Ammer H., Henschen A., Lee C.-H.
    Biol. Chem. Hoppe-Seyler 367:515-522(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-51.
  11. "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1."
    Papoutsopoulou S., Nikolakaki E., Chalepakis G., Kruft V., Chevaillier P., Giannakouros T.
    Nucleic Acids Res. 27:2972-2980(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY SRPK1.

Entry informationi

Entry nameiHSP1_HUMAN
AccessioniPrimary (citable) accession number: P04553
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.