Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P04553

- HSP1_HUMAN

UniProt

P04553 - HSP1_HUMAN

Protein

Sperm protamine P1

Gene

PRM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

    GO - Molecular functioni

    1. DNA binding Source: ProtInc

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. chromosome condensation Source: UniProtKB-KW
    3. DNA packaging Source: ProtInc
    4. multicellular organismal development Source: UniProtKB-KW
    5. spermatogenesis Source: ProtInc

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, DNA condensation, Spermatogenesis

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sperm protamine P1
    Alternative name(s):
    Cysteine-rich protamine
    Gene namesi
    Name:PRM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:9447. PRM1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: ProtInc
    2. nucleosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Chromosome, Nucleosome core, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33792.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 5150Sperm protamine P1PRO_0000191482Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi6 – 6InterchainBy similarity
    Disulfide bondi39 – 39Interchain (with C-39)By similarity
    Disulfide bondi40 ↔ 48By similarity

    Post-translational modificationi

    Phosphorylated by SRPK1.1 Publication

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PRIDEiP04553.

    PTM databases

    PhosphoSiteiP04553.

    Expressioni

    Tissue specificityi

    Testis.

    Gene expression databases

    ArrayExpressiP04553.
    BgeeiP04553.
    CleanExiHS_PRM1.
    GenevestigatoriP04553.

    Organism-specific databases

    HPAiHPA055150.

    Interactioni

    Subunit structurei

    Cross-linked by interchain disulfide bonds around the DNA-helix.

    Protein-protein interaction databases

    BioGridi111604. 1 interaction.
    STRINGi9606.ENSP00000310515.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2AWRmodel-A1-51[»]
    ProteinModelPortaliP04553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protamine P1 family.Curated

    Phylogenomic databases

    HOVERGENiHBG081661.
    OMAiARTVNNS.

    Family and domain databases

    InterProiIPR000221. Protamine_P1.
    [Graphical view]
    PfamiPF00260. Protamine_P1. 1 hit.
    [Graphical view]
    PROSITEiPS00048. PROTAMINE_P1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04553-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARYRCCRSQ SRSRYYRQRQ RSRRRRRRSC QTRRRAMRCC RPRYRPRCRR   50
    H 51
    Length:51
    Mass (Da):6,823
    Last modified:January 23, 2007 - v2
    Checksum:i4A5C6A92C713C33D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46940 Genomic DNA. Translation: CAA87065.1.
    M60331 Genomic DNA. Translation: AAA63249.1.
    M29706 Genomic DNA. Translation: AAA60191.1.
    Y00443 mRNA. Translation: CAA68499.1.
    U15422 Genomic DNA. Translation: AAC50486.1.
    S68144 Genomic DNA. Translation: AAB29321.2.
    AF215707 Genomic DNA. Translation: AAF34620.1.
    BT006746 mRNA. Translation: AAP35392.1.
    BC003673 mRNA. Translation: AAH03673.1.
    CCDSiCCDS10547.1.
    PIRiA38515. HSHUP1.
    RefSeqiNP_002752.1. NM_002761.2.
    UniGeneiHs.2909.

    Genome annotation databases

    EnsembliENST00000312511; ENSP00000310515; ENSG00000175646.
    GeneIDi5619.
    KEGGihsa:5619.
    UCSCiuc002dav.3. human.

    Polymorphism databases

    DMDMi123691.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46940 Genomic DNA. Translation: CAA87065.1 .
    M60331 Genomic DNA. Translation: AAA63249.1 .
    M29706 Genomic DNA. Translation: AAA60191.1 .
    Y00443 mRNA. Translation: CAA68499.1 .
    U15422 Genomic DNA. Translation: AAC50486.1 .
    S68144 Genomic DNA. Translation: AAB29321.2 .
    AF215707 Genomic DNA. Translation: AAF34620.1 .
    BT006746 mRNA. Translation: AAP35392.1 .
    BC003673 mRNA. Translation: AAH03673.1 .
    CCDSi CCDS10547.1.
    PIRi A38515. HSHUP1.
    RefSeqi NP_002752.1. NM_002761.2.
    UniGenei Hs.2909.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2AWR model - A 1-51 [» ]
    ProteinModelPortali P04553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111604. 1 interaction.
    STRINGi 9606.ENSP00000310515.

    PTM databases

    PhosphoSitei P04553.

    Polymorphism databases

    DMDMi 123691.

    Proteomic databases

    PRIDEi P04553.

    Protocols and materials databases

    DNASUi 5619.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312511 ; ENSP00000310515 ; ENSG00000175646 .
    GeneIDi 5619.
    KEGGi hsa:5619.
    UCSCi uc002dav.3. human.

    Organism-specific databases

    CTDi 5619.
    GeneCardsi GC16M011374.
    H-InvDB HIX0012816.
    HGNCi HGNC:9447. PRM1.
    HPAi HPA055150.
    MIMi 182880. gene.
    neXtProti NX_P04553.
    PharmGKBi PA33792.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG081661.
    OMAi ARTVNNS.

    Miscellaneous databases

    GenomeRNAii 5619.
    NextBioi 21836.
    PROi P04553.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P04553.
    Bgeei P04553.
    CleanExi HS_PRM1.
    Genevestigatori P04553.

    Family and domain databases

    InterProi IPR000221. Protamine_P1.
    [Graphical view ]
    Pfami PF00260. Protamine_P1. 1 hit.
    [Graphical view ]
    PROSITEi PS00048. PROTAMINE_P1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered."
      Domenjoud L., Nussbaum G., Adham I.M., Greeske G., Engel W.
      Genomics 8:127-133(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Chromosomal localization and structure of the human P1 protamine gene."
      Krawetz S.A., Herfort M.H., Hamerton J.L., Pon R.T., Dixon G.H.
      Genomics 5:639-645(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The nucleotide sequence of a human protamine 1 cDNA."
      Lee C.-H., Hoyer-Fender S., Engel W.
      Nucleic Acids Res. 15:7639-7639(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Characterization of a human locus in transition."
      Nelson J.E., Krawetz S.A.
      J. Biol. Chem. 269:31067-31073(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Direct sequencing of the human protamine P1 gene and application in forensic medicine."
      Queralt R., de Fabregues-Boixar O., Adroer R., Gene M., Gomez-Catalan J., Huguet E., Oliva R.
      J. Forensic Sci. 38:1491-1501(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Rapid evolution of male reproductive genes in the descent of man."
      Wyckoff G.J., Wang W., Wu C.-I.
      Nature 403:304-309(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    9. "The amino acid sequence of human sperm protamine P1."
      McKay D.J., Renaux B.S., Dixon G.H.
      Biosci. Rep. 5:383-391(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-51.
    10. "Isolation and amino-acid sequence analysis of human sperm protamines P1 and P2. Occurrence of two forms of protamine P2."
      Ammer H., Henschen A., Lee C.-H.
      Biol. Chem. Hoppe-Seyler 367:515-522(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-51.
    11. "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1."
      Papoutsopoulou S., Nikolakaki E., Chalepakis G., Kruft V., Chevaillier P., Giannakouros T.
      Nucleic Acids Res. 27:2972-2980(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY SRPK1.

    Entry informationi

    Entry nameiHSP1_HUMAN
    AccessioniPrimary (citable) accession number: P04553
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3