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Protein

Non-structural protein 1

Gene

1C

Organism
Human respiratory syncytial virus A (strain A2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in antagonizing the type I IFN-mediated antiviral response. Acts cooperatively with NS2 to repress activation and nuclear translocation of host IFN-regulatory factor IRF-3. Interacts with host MAVS and prevents the interaction with its upstream partner DDX58/RIG-I in the signaling pathway leading to interferon production. Mediates the proteasomal degradation of host STAT2 with elongin-cullin E3 ligase. Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth. Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication.5 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host MAVS by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1
Short name:
NS1
Alternative name(s):
Non-structural protein 1C
Gene namesi
Name:1C
Synonyms:NS1
OrganismiHuman respiratory syncytial virus A (strain A2)
Taxonomic identifieri11259 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaePneumovirinaePneumovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007678 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139Non-structural protein 1PRO_0000142783Add
BLAST

Interactioni

Subunit structurei

Homomultimerizes. Interacts with the matrix protein M. Interacts with host TCEB1 and CUL2. interacts with host MAVS; this interaction inhibits signaling pathway leading to interferon production.3 Publications

Protein-protein interaction databases

IntActiP04544. 220 interactions.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR005099. Pneumo_NS1.
[Graphical view]
PfamiPF03438. Pneumo_NS1. 1 hit.
[Graphical view]
ProDomiPD009407. Pneumo_NS1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P04544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNSLSMIK VRLQNLFDND EVALLKITCY TDKLIHLTNA LAKAVIHTIK
60 70 80 90 100
LNGIVFVHVI TSSDICPNNN IVVKSNFTTM PVLQNGGYIW EMMELTHCSQ
110 120 130
PNGLLDDNCE IKFSKKLSDS TMTNYMNQLS ELLGFDLNP
Length:139
Mass (Da):15,567
Last modified:August 13, 1987 - v1
Checksum:iEBCC69B09BC46B6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11486 Genomic RNA. Translation: AAB59850.1.
U50362 Genomic RNA. Translation: AAB86656.1.
U50363 Genomic RNA. Translation: AAB86668.1.
U39662 Genomic RNA. Translation: AAC57020.1.
U63644 Genomic RNA. Translation: AAC55962.1.
AF035006 Genomic RNA. Translation: AAC14894.1.
PIRiA94336. MNNZ1C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11486 Genomic RNA. Translation: AAB59850.1.
U50362 Genomic RNA. Translation: AAB86656.1.
U50363 Genomic RNA. Translation: AAB86668.1.
U39662 Genomic RNA. Translation: AAC57020.1.
U63644 Genomic RNA. Translation: AAC55962.1.
AF035006 Genomic RNA. Translation: AAC14894.1.
PIRiA94336. MNNZ1C.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04544. 220 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR005099. Pneumo_NS1.
[Graphical view]
PfamiPF03438. Pneumo_NS1. 1 hit.
[Graphical view]
ProDomiPD009407. Pneumo_NS1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiNS1_HRSVA
AccessioniPrimary (citable) accession number: P04544
Secondary accession number(s): Q77YB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 8, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.