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P04531 (DNMK_BPT4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxynucleotide monophosphate kinase

Short name=DNK
Short name=dNMP kinase
EC=2.7.4.13
Alternative name(s):
Gp1
Gene names
Name:1
OrganismEnterobacteria phage T4 (Bacteriophage T4) [Reference proteome]
Taxonomic identifier10665 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
Virus hostEscherichia coli [TaxID: 562]

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts on dGMP, dTMP and 5-hydroxymethyl-dCMP while excluding dCMP and dAMP.

Catalytic activity

ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the dNMP kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Deoxynucleotide monophosphate kinase
PRO_0000164948

Secondary structure

........................................ 241
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P04531 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 61AD2375CC94BDE8

FASTA24127,329
        10         20         30         40         50         60 
MKLIFLSGVK RSGKDTTADF IMSNYSAVKY QLAGPIKDAL AYAWGVFAAN TDYPCLTRKE 

        70         80         90        100        110        120 
FEGIDYDRET NLNLTKLEVI TIMEQAFCYL NGKSPIKGVF VFDDEGKESV NFVAFNKITD 

       130        140        150        160        170        180 
VINNIEDQWS VRRLMQALGT DLIVNNFDRM YWVKLFALDY LDKFNSGYDY YIVPDTRQDH 

       190        200        210        220        230        240 
EMDAARAMGA TVIHVVRPGQ KSNDTHITEA GLPIRDGDLV ITNDGSLEEL FSKIKNTLKV 


L 

« Hide

References

« Hide 'large scale' references
[1]"Sequence organization and control of transcription in the bacteriophage T4 tRNA region."
Broida J., Abelson J.
J. Mol. Biol. 185:545-563(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Bacteriophage T4 genome."
Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.
Microbiol. Mol. Biol. Rev. 67:86-156(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Nucleotide sequence of the bacteriophage T4 gene 57 and a deduced amino acid sequence."
Herrmann R.
Nucleic Acids Res. 10:1105-1112(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 148-241.
[4]"Sequencing, cloning and overexpression of genes of bacteriophage T4 between map positions 74.325 and 77.184."
Koch T., Lamm N., Rueger W.
Nucleic Acids Res. 17:4392-4392(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
[5]"Crystal structure of bacteriophage T4 deoxynucleotide kinase with its substrates dGMP and ATP."
Teplyakov A., Sebastiao P., Obmolova G., Perrakis A., Brush G.S., Bessman M.J., Wilson K.S.
EMBO J. 15:3487-3497(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X03016 Genomic DNA. Translation: CAA26800.1.
AF158101 Genomic DNA. Translation: AAD42414.1.
X14845 Genomic DNA. Translation: CAA32953.1.
PIRKIBPD4. C92919.
RefSeqNP_049752.1. NC_000866.4.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1DEKX-ray2.00A/B1-241[»]
1DELX-ray2.20A/B1-241[»]
ProteinModelPortalP04531.
SMRP04531. Positions 1-241.
ModBaseSearch...
MobiDBSearch...

Chemistry

DrugBankDB00131. Adenosine monophosphate.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1258557.

Family and domain databases

Gene3D1.10.238.70. 1 hit.
3.40.50.300. 1 hit.
InterProIPR023191. DNMP_kinase_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP04531.

Entry information

Entry nameDNMK_BPT4
AccessionPrimary (citable) accession number: P04531
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references