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P04525

- DPA5_BPT4

UniProt

P04525 - DPA5_BPT4

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Protein
DNA polymerase processivity component
Gene
45
Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Replisome sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase processivity component
Alternative name(s):
DNA polymerase accessory protein 45
Gp45
Gene namesi
Name:45
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
Virus hostiEscherichia coli [TaxID: 562]
ProteomesiUP000009087: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228DNA polymerase processivity component
PRO_0000149229Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1713
Beta strandi21 – 233
Beta strandi25 – 328
Beta strandi36 – 4813
Beta strandi52 – 554
Helixi57 – 648
Beta strandi72 – 754
Beta strandi79 – 846
Beta strandi86 – 927
Helixi97 – 993
Beta strandi113 – 1186
Helixi120 – 13213
Beta strandi137 – 1437
Beta strandi146 – 1527
Helixi154 – 1563
Beta strandi158 – 1603
Beta strandi165 – 1717
Beta strandi178 – 1836
Helixi184 – 1863
Beta strandi194 – 2018
Beta strandi204 – 2107
Beta strandi212 – 2198

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CZDX-ray2.45A/B/C1-228[»]
3U5ZX-ray3.50F/G/H/P/Q/R1-228[»]
3U60X-ray3.34F/G/H1-228[»]
3U61X-ray3.20F/G/H1-228[»]
ProteinModelPortaliP04525.
SMRiP04525. Positions 1-228.

Miscellaneous databases

EvolutionaryTraceiP04525.

Family & Domainsi

Family and domain databases

InterProiIPR004190. DNA_pol_proc_fac.
IPR015200. Gp45_slide_clamp_C.
[Graphical view]
PfamiPF02916. DNA_PPF. 1 hit.
PF09116. gp45-slide_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04525-1 [UniParc]FASTAAdd to Basket

« Hide

MKLSKDTTAL LKNFATINSG IMLKSGQFIM TRAVNGTTYA EANISDVIDF    50
DVAIYDLNGF LGILSLVNDD AEISQSEDGN IKIADARSTI FWPAADPSTV 100
VAPNKPIPFP VASAVTEIKA EDLQQLLRVS RGLQIDTIAI TVKEGKIVIN 150
GFNKVEDSAL TRVKYSLTLG DYDGENTFNF IINMANMKMQ PGNYKLLLWA 200
KGKQGAAKFE GEHANYVVAL EADSTHDF 228
Length:228
Mass (Da):24,858
Last modified:December 19, 2001 - v3
Checksum:i765DF4AAB76D005B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691Missing in CAA24777. 1 Publication
Sequence conflicti93 – 931P → R in CAA24777. 1 Publication
Sequence conflicti93 – 931P → R in CAA25340. 1 Publication
Sequence conflicti93 – 931P → R in AAC05393. 1 Publication
Sequence conflicti100 – 1001V → D in CAA24777. 1 Publication
Sequence conflicti129 – 1291V → L in CAA24777. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01535 Genomic DNA. Translation: CAA24777.1.
M10160 Genomic DNA. Translation: AAC05393.1.
X00769 Genomic DNA. Translation: CAA25340.1.
AF158101 Genomic DNA. Translation: AAD42470.1.
M15080 Genomic DNA. Translation: AAA32519.1.
PIRiA04301. IDBP44.
RefSeqiNP_049666.1. NC_000866.4.

Genome annotation databases

GeneIDi1258821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01535 Genomic DNA. Translation: CAA24777.1 .
M10160 Genomic DNA. Translation: AAC05393.1 .
X00769 Genomic DNA. Translation: CAA25340.1 .
AF158101 Genomic DNA. Translation: AAD42470.1 .
M15080 Genomic DNA. Translation: AAA32519.1 .
PIRi A04301. IDBP44.
RefSeqi NP_049666.1. NC_000866.4.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1CZD X-ray 2.45 A/B/C 1-228 [» ]
3U5Z X-ray 3.50 F/G/H/P/Q/R 1-228 [» ]
3U60 X-ray 3.34 F/G/H 1-228 [» ]
3U61 X-ray 3.20 F/G/H 1-228 [» ]
ProteinModelPortali P04525.
SMRi P04525. Positions 1-228.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1258821.

Miscellaneous databases

EvolutionaryTracei P04525.

Family and domain databases

InterProi IPR004190. DNA_pol_proc_fac.
IPR015200. Gp45_slide_clamp_C.
[Graphical view ]
Pfami PF02916. DNA_PPF. 1 hit.
PF09116. gp45-slide_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bacteriophage T4 gene 45. Sequences of the structural gene and its protein product."
    Spicer E.K., Noble J.A., Nossal N.G., Konigsberg W.H., Williams K.R.
    J. Biol. Chem. 257:8972-8979(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Spicer E.K.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 69; 100 AND 129.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Identification of two new bacteriophage T4 genes that may have roles in transcription and DNA replication."
    Hsu T., Wei R., Dawson M., Karam J.D.
    J. Virol. 61:366-374(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36.
  5. "Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage."
    Moarefi I., Jeruzalmi D., Turner J., O'Donnell M., Kuriyan J.
    J. Mol. Biol. 296:1215-1223(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS).

Entry informationi

Entry nameiDPA5_BPT4
AccessioniPrimary (citable) accession number: P04525
Secondary accession number(s): Q9T0Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: December 19, 2001
Last modified: May 14, 2014
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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