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Protein

DNA replication protein

Gene

69

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

May play a role in viral DNA replication. Found associated with a viral DNA origin of replication and with host membranes, may attach this origin to the bacterial envelope to initiate replication.1 Publication

GO - Biological processi

Keywordsi

Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication protein
Alternative name(s):
Gene product 69
Short name:
gp69
Gene namesi
Name:69
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000033241 – 392DNA replication proteinAdd BLAST392

Structurei

3D structure databases

ProteinModelPortaliP04523.
SMRiP04523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR000305. GIY-YIG_SF.
SMARTiView protein in SMART
SM00465. GIYc. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform Long (identifier: P04523-1) [UniParc]FASTAAdd to basket
Also known as: GP69

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHFNECAHL IEGVDKAQNE YWDILGDEKD PLQVMLDMQR FLQIRLANVR
60 70 80 90 100
EYCYHPDKLE TAGDVVSWMR EQKDCIDDEF RELLTSLGEM SRGEKEASAV
110 120 130 140 150
WKKWKARYIE AQEKRIDEMS PEDQLEIKFE LVDIFHFVLN MFVGLGMNAE
160 170 180 190 200
EIFKLYYLKN KHILNVKIMD IKQKFYRTYI VKVRTPKGVF WYAGKHESFI
210 220 230 240 250
VNPYNDKYPG SGKILWNIYR KYGFNYKIRW SKCHGSREKS YEVERELISA
260 270 280 290 300
LKRKHPDTCI NISPGGQGGE GRKWTEQQRL EHKLRLNNPE TKTRMKNSQR
310 320 330 340 350
IAQNRAERKA RQSEVMKKFY SNGGNKKISE GTSRAQRKAP HWHEPLKSEI
360 370 380 390
HELWVSLGKP ATGPVVKALK GKYDVTSSAL KNLIYLFRKE DV
Note: Expression of isoform Long is delayed since its middle promoter requires T4 coded proteins for activation.
Length:392
Mass (Da):46,179
Last modified:January 23, 2002 - v2
Checksum:i740AE210731D0161
GO
Isoform Short (identifier: P04523-2) [UniParc]FASTAAdd to basket
Also known as: GP69*

The sequence of this isoform differs from the canonical sequence as follows:
     1-168: Missing.

Note: Can be expressed immediately from an E.coli-like promoter.
Show »
Length:224
Mass (Da):26,216
Checksum:i2747F05B2B6D20BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti356S → F in CAA25661 (PubMed:6098451).Curated1
Sequence conflicti356S → F in CAA25662 (PubMed:6098451).Curated1
Sequence conflicti356S → F in AAA32556 (PubMed:6098451).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0186771 – 168Missing in isoform Short. CuratedAdd BLAST168

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01416 Genomic DNA. Translation: CAA25661.1.
X01416 Genomic DNA. Translation: CAA25662.1.
K03113 Genomic DNA. Translation: AAA32556.1.
AF158101 Genomic DNA. Translation: AAD42517.1.
M30001 Genomic DNA. Translation: AAB07792.1.
PIRiA04299. Z9BPT4.
T10133.
RefSeqiNP_049645.1. NC_000866.4. [P04523-2]

Genome annotation databases

GeneIDi1258803.
KEGGivg:1258803.

Keywords - Coding sequence diversityi

Alternative promoter usage

Similar proteinsi

Entry informationi

Entry nameiDNRE_BPT4
AccessioniPrimary (citable) accession number: P04523
Secondary accession number(s): Q94N08, Q96224
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2002
Last modified: March 15, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome