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Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Carnation mottle virus (CarMV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

Miscellaneous

Readthrough of the terminator UAG occurs at position 246.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandNucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p88
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiCarnation mottle virus (CarMV)
Taxonomic identifieri11986 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTombusviridaeAlphacarmovirus
Virus hostiBegonia [TaxID: 3681]
Dianthus barbatus [TaxID: 278075]
Dianthus caryophyllus (Carnation) (Clove pink) [TaxID: 3570]
Dianthus chinensis [TaxID: 118431]
Dianthus superbus [TaxID: 288950]
Malus domestica (Apple) (Pyrus malus) [TaxID: 3750]
Saponaria officinalis (Common soapwort) (Lychnis saponaria) [TaxID: 3572]
Proteomesi
  • UP000201784 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002228951 – 763RNA-directed RNA polymeraseAdd BLAST763
ChainiPRO_00003982991 – 245Protein p28Add BLAST245

Proteomic databases

PRIDEiP04518

Structurei

3D structure databases

ProteinModelPortaliP04518
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini466 – 579RdRp catalyticPROSITE-ProRule annotationAdd BLAST114

Family and domain databases

InterProiView protein in InterPro
IPR007094 RNA-dir_pol_PSvirus
IPR002166 RNA_pol_HCV
PfamiView protein in Pfam
PF00998 RdRP_3, 1 hit
PROSITEiView protein in PROSITE
PS50507 RDRP_SSRNA_POS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPSLLVEG VIGCTLVGGL VAVGSAALAV RATIGVVEFN RECVRGARRI
60 70 80 90 100
VSSGGRCLVV QSPYGNPNQG LIRGEDEEID NVEESTPVEL TPLIEVKAEV
110 120 130 140 150
DGKEVVVSKK RVVNRHLRQR FVRSIAIEAK NHFGGDISPS KANYLSVSKF
160 170 180 190 200
LTGKCKERHV VPAHTRDCVS AAMVLVFTPD VHEIRMMAGL ASDAAYGIKI
210 220 230 240 250
AMASILNRKG WCWRLMVNPL DRARWWEMWC VVNGFDSNKP VTFPKXGGLF
260 270 280 290 300
YLNGVETKIR RGGHPSVIEV DGQCPLKERK LYVQNAITTG YEYRVHNHSY
310 320 330 340 350
ANLRRGLLER VFYVERNKEL VSCPQPEPGS FKEMGYLRRR FHRVCGNHTR
360 370 380 390 400
ISANDLVDCY QGRKRTIYEN AAASLLDRAI ERKDGDLKTF IKAEKFNVNL
410 420 430 440 450
KSDPAPRVIQ PRSPRYNVEL GRYLKKYEHH AYKALDKIWG GPTVMKGYTT
460 470 480 490 500
EEVAQHIWSA WNQFQTPVAI GFDMSRFDQH VSVAALEFEH SCYLACFEGD
510 520 530 540 550
AHLANLLKMQ LVNHGVGFAS NGMLRYTKEG CRMSGDMNTA LGNCLLACLI
560 570 580 590 600
TKHLMKIRSR LINNGDDCVL ICERTDIDYV VSNLTTGWSR FGFNCIAEEP
610 620 630 640 650
VYEMEKIRFC QMAPVFDGAG WLMVRDPLVS MSKDSHSLVH WNNETNAKQW
660 670 680 690 700
LKSVGMCGLR IAGGVPVVQE FYQKYVETAG NVRENKNITE KSSSGFFMMA
710 720 730 740 750
DRAKRGYSAV SEVCRFSFYQ AFGITPDQQI ALEGEIRSLT INTNVGPQCE
760
AADSLWILNR KYQ
Length:763
Mass (Da):85,776
Last modified:October 5, 2010 - v2
Checksum:i197256D8B4B61A38
GO

Sequence cautioni

The sequence CAA26726 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02986 Genomic RNA Translation: CAA26726.1 Sequence problems.
PIRiA04208 RRVECV
RefSeqiYP_009032645.1, NC_001265.2
YP_009032646.1, NC_001265.2

Genome annotation databases

GeneIDi1724754
1724755
KEGGivg:1724754
vg:1724755

Keywords - Coding sequence diversityi

RNA suppression of termination

Similar proteinsi

Entry informationi

Entry nameiRDRP_CARMV
AccessioniPrimary (citable) accession number: P04518
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 5, 2010
Last modified: May 23, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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