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Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Carnation mottle virus (CarMV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p88
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiCarnation mottle virus (CarMV)
Taxonomic identifieri11986 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeCarmovirus
Virus hostiBegonia [TaxID: 3681]
Dianthus barbatus [TaxID: 278075]
Dianthus caryophyllus (Carnation) (Clove pink) [TaxID: 3570]
Dianthus chinensis [TaxID: 118431]
Dianthus superbus [TaxID: 288950]
Malus domestica (Apple) (Pyrus malus) [TaxID: 3750]
Saponaria officinalis (Common soapwort) (Lychnis saponaria) [TaxID: 3572]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763RNA-directed RNA polymerasePRO_0000222895Add
BLAST
Chaini1 – 245245Protein p28PRO_0000398299Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP04518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini466 – 579114RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04518-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLPSLLVEG VIGCTLVGGL VAVGSAALAV RATIGVVEFN RECVRGARRI
60 70 80 90 100
VSSGGRCLVV QSPYGNPNQG LIRGEDEEID NVEESTPVEL TPLIEVKAEV
110 120 130 140 150
DGKEVVVSKK RVVNRHLRQR FVRSIAIEAK NHFGGDISPS KANYLSVSKF
160 170 180 190 200
LTGKCKERHV VPAHTRDCVS AAMVLVFTPD VHEIRMMAGL ASDAAYGIKI
210 220 230 240 250
AMASILNRKG WCWRLMVNPL DRARWWEMWC VVNGFDSNKP VTFPKXGGLF
260 270 280 290 300
YLNGVETKIR RGGHPSVIEV DGQCPLKERK LYVQNAITTG YEYRVHNHSY
310 320 330 340 350
ANLRRGLLER VFYVERNKEL VSCPQPEPGS FKEMGYLRRR FHRVCGNHTR
360 370 380 390 400
ISANDLVDCY QGRKRTIYEN AAASLLDRAI ERKDGDLKTF IKAEKFNVNL
410 420 430 440 450
KSDPAPRVIQ PRSPRYNVEL GRYLKKYEHH AYKALDKIWG GPTVMKGYTT
460 470 480 490 500
EEVAQHIWSA WNQFQTPVAI GFDMSRFDQH VSVAALEFEH SCYLACFEGD
510 520 530 540 550
AHLANLLKMQ LVNHGVGFAS NGMLRYTKEG CRMSGDMNTA LGNCLLACLI
560 570 580 590 600
TKHLMKIRSR LINNGDDCVL ICERTDIDYV VSNLTTGWSR FGFNCIAEEP
610 620 630 640 650
VYEMEKIRFC QMAPVFDGAG WLMVRDPLVS MSKDSHSLVH WNNETNAKQW
660 670 680 690 700
LKSVGMCGLR IAGGVPVVQE FYQKYVETAG NVRENKNITE KSSSGFFMMA
710 720 730 740 750
DRAKRGYSAV SEVCRFSFYQ AFGITPDQQI ALEGEIRSLT INTNVGPQCE
760
AADSLWILNR KYQ
Length:763
Mass (Da):85,776
Last modified:October 5, 2010 - v2
Checksum:i197256D8B4B61A38
GO

Sequence cautioni

The sequence CAA26726.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02986 Genomic RNA. Translation: CAA26726.1. Sequence problems.
PIRiA04208. RRVECV.
RefSeqiYP_009032645.1. NC_001265.2.
YP_009032646.1. NC_001265.2.

Genome annotation databases

GeneIDi1724754.
1724755.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02986 Genomic RNA. Translation: CAA26726.1. Sequence problems.
PIRiA04208. RRVECV.
RefSeqiYP_009032645.1. NC_001265.2.
YP_009032646.1. NC_001265.2.

3D structure databases

ProteinModelPortaliP04518.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1724754.
1724755.

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence and genome organization of carnation mottle virus RNA."
    Guilley H., Carrington J.C., Balazs E., Jonard G., Richards K., Morris T.J.
    Nucleic Acids Res. 13:6663-6677(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_CARMV
AccessioniPrimary (citable) accession number: P04518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 246.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.