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P04518

- RDRP_CARMV

UniProt

P04518 - RDRP_CARMV

Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Carnation mottle virus (CarMV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p88
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF1
    OrganismiCarnation mottle virus (CarMV)
    Taxonomic identifieri11986 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeCarmovirus
    Virus hostiBegonia [TaxID: 3681]
    Dianthus barbatus [TaxID: 278075]
    Dianthus caryophyllus (Carnation) (Clove pink) [TaxID: 3570]
    Dianthus chinensis [TaxID: 118431]
    Dianthus superbus [TaxID: 288950]
    Malus domestica (Apple) (Pyrus malus) [TaxID: 3750]
    Saponaria officinalis (Common soapwort) (Lychnis saponaria) [TaxID: 3572]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 763763RNA-directed RNA polymerasePRO_0000222895Add
    BLAST
    Chaini1 – 245245Protein p28PRO_0000398299Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP04518.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini466 – 579114RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04518-1 [UniParc]FASTAAdd to Basket

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    MGLPSLLVEG VIGCTLVGGL VAVGSAALAV RATIGVVEFN RECVRGARRI    50
    VSSGGRCLVV QSPYGNPNQG LIRGEDEEID NVEESTPVEL TPLIEVKAEV 100
    DGKEVVVSKK RVVNRHLRQR FVRSIAIEAK NHFGGDISPS KANYLSVSKF 150
    LTGKCKERHV VPAHTRDCVS AAMVLVFTPD VHEIRMMAGL ASDAAYGIKI 200
    AMASILNRKG WCWRLMVNPL DRARWWEMWC VVNGFDSNKP VTFPKXGGLF 250
    YLNGVETKIR RGGHPSVIEV DGQCPLKERK LYVQNAITTG YEYRVHNHSY 300
    ANLRRGLLER VFYVERNKEL VSCPQPEPGS FKEMGYLRRR FHRVCGNHTR 350
    ISANDLVDCY QGRKRTIYEN AAASLLDRAI ERKDGDLKTF IKAEKFNVNL 400
    KSDPAPRVIQ PRSPRYNVEL GRYLKKYEHH AYKALDKIWG GPTVMKGYTT 450
    EEVAQHIWSA WNQFQTPVAI GFDMSRFDQH VSVAALEFEH SCYLACFEGD 500
    AHLANLLKMQ LVNHGVGFAS NGMLRYTKEG CRMSGDMNTA LGNCLLACLI 550
    TKHLMKIRSR LINNGDDCVL ICERTDIDYV VSNLTTGWSR FGFNCIAEEP 600
    VYEMEKIRFC QMAPVFDGAG WLMVRDPLVS MSKDSHSLVH WNNETNAKQW 650
    LKSVGMCGLR IAGGVPVVQE FYQKYVETAG NVRENKNITE KSSSGFFMMA 700
    DRAKRGYSAV SEVCRFSFYQ AFGITPDQQI ALEGEIRSLT INTNVGPQCE 750
    AADSLWILNR KYQ 763
    Length:763
    Mass (Da):85,776
    Last modified:October 5, 2010 - v2
    Checksum:i197256D8B4B61A38
    GO

    Sequence cautioni

    The sequence CAA26726.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02986 Genomic RNA. Translation: CAA26726.1. Sequence problems.
    PIRiA04208. RRVECV.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02986 Genomic RNA. Translation: CAA26726.1 . Sequence problems.
    PIRi A04208. RRVECV.

    3D structure databases

    ProteinModelPortali P04518.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and genome organization of carnation mottle virus RNA."
      Guilley H., Carrington J.C., Balazs E., Jonard G., Richards K., Morris T.J.
      Nucleic Acids Res. 13:6663-6677(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_CARMV
    AccessioniPrimary (citable) accession number: P04518
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 63 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 246.

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3