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P04518 (RDRP_CARMV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase

EC=2.7.7.48
Alternative name(s):
Protein p88

Cleaved into the following chain:

  1. Protein p28
Gene names
ORF Names:ORF1
OrganismCarnation mottle virus (CarMV)
Taxonomic identifier11986 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeCarmovirus
Virus hostBegonia [TaxID: 3681]
Dianthus barbatus [TaxID: 278075]
Dianthus caryophyllus (Carnation) (Clove pink) [TaxID: 3570]
Dianthus chinensis [TaxID: 118431]
Dianthus superbus [TaxID: 288950]
Malus domestica (Apple) (Pyrus malus) [TaxID: 3750]
Saponaria officinalis (Common soapwort) (Lychnis saponaria) [TaxID: 3572]

Protein attributes

Sequence length763 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existencePredicted

General annotation (Comments)

Function

RNA-dependent RNA polymerase that plays an essential role in the virus replication Probable.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Miscellaneous

Readthrough of the terminator UAG occurs at position 246.

Sequence similarities

Contains 1 RdRp catalytic domain.

Sequence caution

The sequence CAA26726.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 763763RNA-directed RNA polymerase
PRO_0000222895
Chain1 – 245245Protein p28
PRO_0000398299

Regions

Domain466 – 579114RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P04518 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: 197256D8B4B61A38

FASTA76385,776
        10         20         30         40         50         60 
MGLPSLLVEG VIGCTLVGGL VAVGSAALAV RATIGVVEFN RECVRGARRI VSSGGRCLVV 

        70         80         90        100        110        120 
QSPYGNPNQG LIRGEDEEID NVEESTPVEL TPLIEVKAEV DGKEVVVSKK RVVNRHLRQR 

       130        140        150        160        170        180 
FVRSIAIEAK NHFGGDISPS KANYLSVSKF LTGKCKERHV VPAHTRDCVS AAMVLVFTPD 

       190        200        210        220        230        240 
VHEIRMMAGL ASDAAYGIKI AMASILNRKG WCWRLMVNPL DRARWWEMWC VVNGFDSNKP 

       250        260        270        280        290        300 
VTFPKXGGLF YLNGVETKIR RGGHPSVIEV DGQCPLKERK LYVQNAITTG YEYRVHNHSY 

       310        320        330        340        350        360 
ANLRRGLLER VFYVERNKEL VSCPQPEPGS FKEMGYLRRR FHRVCGNHTR ISANDLVDCY 

       370        380        390        400        410        420 
QGRKRTIYEN AAASLLDRAI ERKDGDLKTF IKAEKFNVNL KSDPAPRVIQ PRSPRYNVEL 

       430        440        450        460        470        480 
GRYLKKYEHH AYKALDKIWG GPTVMKGYTT EEVAQHIWSA WNQFQTPVAI GFDMSRFDQH 

       490        500        510        520        530        540 
VSVAALEFEH SCYLACFEGD AHLANLLKMQ LVNHGVGFAS NGMLRYTKEG CRMSGDMNTA 

       550        560        570        580        590        600 
LGNCLLACLI TKHLMKIRSR LINNGDDCVL ICERTDIDYV VSNLTTGWSR FGFNCIAEEP 

       610        620        630        640        650        660 
VYEMEKIRFC QMAPVFDGAG WLMVRDPLVS MSKDSHSLVH WNNETNAKQW LKSVGMCGLR 

       670        680        690        700        710        720 
IAGGVPVVQE FYQKYVETAG NVRENKNITE KSSSGFFMMA DRAKRGYSAV SEVCRFSFYQ 

       730        740        750        760 
AFGITPDQQI ALEGEIRSLT INTNVGPQCE AADSLWILNR KYQ 

« Hide

References

[1]"Nucleotide sequence and genome organization of carnation mottle virus RNA."
Guilley H., Carrington J.C., Balazs E., Jonard G., Richards K., Morris T.J.
Nucleic Acids Res. 13:6663-6677(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02986 Genomic RNA. Translation: CAA26726.1. Sequence problems.
PIRRRVECV. A04208.

3D structure databases

ProteinModelPortalP04518.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_CARMV
AccessionPrimary (citable) accession number: P04518
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families