##gff-version 3 P04517 UniProtKB Chain 1 3054 . . . ID=PRO_0000420026;Note=Genome polyprotein P04517 UniProtKB Chain 1 304 . . . ID=PRO_0000040450;Note=P1 proteinase;Ontology_term=ECO:0000255;evidence=ECO:0000255 P04517 UniProtKB Chain 305 763 . . . ID=PRO_0000040451;Note=Helper component proteinase;Ontology_term=ECO:0000255;evidence=ECO:0000255 P04517 UniProtKB Chain 764 1110 . . . ID=PRO_0000040452;Note=Protein P3;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Chain 1111 1163 . . . ID=PRO_0000040453;Note=6 kDa protein 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Chain 1164 1796 . . . ID=PRO_0000040454;Note=Cytoplasmic inclusion protein P04517 UniProtKB Chain 1797 1849 . . . ID=PRO_0000040455;Note=6 kDa protein 2 P04517 UniProtKB Chain 1850 2037 . . . ID=PRO_0000040456;Note=Viral genome-linked protein;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Chain 2038 2279 . . . ID=PRO_0000040457;Note=Nuclear inclusion protein A;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Chain 2280 2791 . . . ID=PRO_0000040458;Note=Nuclear inclusion protein B P04517 UniProtKB Chain 2792 3054 . . . ID=PRO_0000040459;Note=Capsid protein P04517 UniProtKB Domain 163 304 . . . Note=Peptidase S30;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01219 P04517 UniProtKB Domain 641 763 . . . Note=Peptidase C6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01080 P04517 UniProtKB Domain 1234 1386 . . . Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 P04517 UniProtKB Domain 1401 1564 . . . Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542 P04517 UniProtKB Domain 2038 2255 . . . Note=Peptidase C4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00766 P04517 UniProtKB Domain 2521 2641 . . . Note=RdRp catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00539 P04517 UniProtKB Region 2798 2827 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P04517 UniProtKB Motif 358 361 . . . Note=Involved in interaction with stylet and aphid transmission P04517 UniProtKB Motif 615 617 . . . Note=Involved in virions binding and aphid transmission;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Motif 1336 1339 . . . Note=DECH box P04517 UniProtKB Motif 1889 1896 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P04517 UniProtKB Compositional bias 2799 2818 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P04517 UniProtKB Active site 214 214 . . . Note=For P1 proteinase activity;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01219,ECO:0000269|PubMed:1962435;Dbxref=PMID:1962435 P04517 UniProtKB Active site 223 223 . . . Note=For P1 proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01219 P04517 UniProtKB Active site 256 256 . . . Note=For P1 proteinase activity;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01219,ECO:0000269|PubMed:1962435;Dbxref=PMID:1962435 P04517 UniProtKB Active site 649 649 . . . Note=For helper component proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01080 P04517 UniProtKB Active site 722 722 . . . Note=For helper component proteinase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01080 P04517 UniProtKB Active site 2083 2083 . . . Note=For nuclear inclusion protein A activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2475971;Dbxref=PMID:2475971 P04517 UniProtKB Active site 2118 2118 . . . Note=For nuclear inclusion protein A activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2475971;Dbxref=PMID:2475971 P04517 UniProtKB Active site 2188 2188 . . . Note=For nuclear inclusion protein A activity;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2475971;Dbxref=PMID:2475971 P04517 UniProtKB Binding site 1247 1254 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 P04517 UniProtKB Site 304 305 . . . Note=Cleavage%3B by P1 proteinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01219 P04517 UniProtKB Site 763 764 . . . Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01080,ECO:0000269|PubMed:2656254;Dbxref=PMID:2656254 P04517 UniProtKB Site 1110 1111 . . . Note=Cleavage%3B by NIa-pro;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Site 1163 1164 . . . Note=Cleavage%3B by NIa-pro;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Site 1796 1797 . . . Note=Cleavage%3B by NIa-pro;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Site 1849 1850 . . . Note=Cleavage%3B by NIa-pro;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Site 2037 2038 . . . Note=Cleavage%3B by NIa-pro;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Site 2279 2280 . . . Note=Cleavage%3B by NIa-pro;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Site 2791 2792 . . . Note=Cleavage%3B by NIa-pro;Ontology_term=ECO:0000250;evidence=ECO:0000250 P04517 UniProtKB Modified residue 1911 1911 . . . Note=O-(5'-phospho-RNA)-tyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P09814 P04517 UniProtKB Disulfide bond 2167 2167 . . . Note=Interchain;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12377789,ECO:0000269|PubMed:15919091;Dbxref=PMID:12377789,PMID:15919091 P04517 UniProtKB Natural variant 1960 1960 . . . Note=In strain: CAA10. I->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18182024;Dbxref=PMID:18182024 P04517 UniProtKB Natural variant 1961 1961 . . . Note=In strain: CAA10. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18182024;Dbxref=PMID:18182024 P04517 UniProtKB Natural variant 1962 1962 . . . Note=In strain: CAA10. P->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18182024;Dbxref=PMID:18182024 P04517 UniProtKB Natural variant 1964 1964 . . . Note=In strain: CAA10. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18182024;Dbxref=PMID:18182024 P04517 UniProtKB Mutagenesis 214 214 . . . Note=Complete loss of proteolytic activity of P1 proteinase. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1962435;Dbxref=PMID:1962435 P04517 UniProtKB Mutagenesis 256 256 . . . Note=Complete loss of proteolytic activity of P1 proteinase. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1962435;Dbxref=PMID:1962435 P04517 UniProtKB Mutagenesis 314 314 . . . Note=Complete loss of aphid transmission. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9880030;Dbxref=PMID:9880030 P04517 UniProtKB Mutagenesis 358 358 . . . Note=Complete loss of interaction with stylet and aphid transmission%3B no effect on virion binding. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9880030;Dbxref=PMID:9880030 P04517 UniProtKB Mutagenesis 610 610 . . . Note=No effect on proteolytic activity of HC-pro. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 619 619 . . . Note=No effect on proteolytic activity of HC-pro. H->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 625 625 . . . Note=No effect on proteolytic activity of HC-pro. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 627 627 . . . Note=No effect on proteolytic activity of HC-pro. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 632 632 . . . Note=No effect on proteolytic activity of HC-pro. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 649 649 . . . Note=Complete loss of proteolytic activity of HC-pro. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 675 675 . . . Note=No effect on proteolytic activity of HC-pro. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 689 689 . . . Note=No effect on proteolytic activity of HC-pro. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 694 694 . . . Note=No effect on proteolytic activity of HC-pro. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 698 698 . . . Note=No effect on proteolytic activity of HC-pro. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 715 715 . . . Note=No effect on proteolytic activity of HC-pro. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 716 716 . . . Note=No effect on proteolytic activity of HC-pro. H->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 722 722 . . . Note=Complete loss of proteolytic activity of HC-pro. H->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 725 725 . . . Note=No effect on proteolytic activity of HC-pro. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 726 726 . . . Note=No effect on proteolytic activity of HC-pro. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 729 729 . . . Note=No effect on proteolytic activity of HC-pro. S->T P04517 UniProtKB Mutagenesis 735 735 . . . Note=No effect on proteolytic activity of HC-pro. H->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 743 743 . . . Note=No effect on proteolytic activity of HC-pro. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 755 755 . . . Note=No effect on proteolytic activity of HC-pro. S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2688301;Dbxref=PMID:2688301 P04517 UniProtKB Mutagenesis 2188 2188 . . . Note=Complete loss of NIa-pro activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12377789;Dbxref=PMID:12377789 P04517 UniProtKB Helix 2038 2040 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Helix 2049 2052 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2055 2062 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2065 2074 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2077 2080 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Helix 2082 2086 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2089 2096 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2099 2104 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Helix 2106 2108 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2109 2113 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2120 2123 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2145 2152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2154 2157 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2159 2162 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2169 2171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Turn 2172 2175 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2176 2179 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2191 2194 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Turn 2195 2197 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2200 2208 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2209 2211 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1Q31 P04517 UniProtKB Beta strand 2213 2218 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Helix 2223 2228 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Helix 2230 2232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2235 2238 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2243 2248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2251 2256 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM P04517 UniProtKB Beta strand 2276 2278 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1Q31 P04517 UniProtKB Beta strand 2788 2790 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1LVM