true1987-08-132023-05-0380NSP3_ROTBUNucleotide sequence of gene segment 9 encoding a nonstructural protein of UK bovine rotavirus.Ward C.W.Elleman T.C.Azad A.A.Dyall-Smith M.L.doi:10.1016/0042-6822(84)90292-71984Virology134249-253NUCLEOTIDE SEQUENCE [GENOMIC RNA]Different initiation.NSP3_rotavirusNonstructural RNA-binding proteinRotavirus non-structural protein NSP3, N-terminal domainROTA_A_NSP3ROTA_NSP3NSP3_N_rotavirusNSP3_sfRotavirus_NSP3Rota_NSP3NSP3 homodimerRotavirus nonstructural proteinsNon-structural protein 3NSP3NCVP4Non-structural RNA-binding protein 34NS34Plays an important role in stimulating the translation of viral mRNAs. These mRNAs are capped but not polyadenylated, instead terminating in a conserved sequence 'GACC' at the 3' that is recognized by NSP3, which competes with host PABPC1 for EIF4G1 binding. The interaction between NSP3 and host EIF4G1 stabilizes the EIF4E-EIF4G1 interaction, thereby facilitating the initiation of capped mRNA translation.Homodimer. Interacts (via the coiled-coil region) with host ZC3H7B (via LD motif). Interacts with host EIF4G1.Belongs to the rotavirus NSP3 family.Non-structural protein 3361531313RNA-binding149Dimerization150206Interaction with host ZC3H7B170234Interaction with host EIF4G12081662371987-08-1313615362b444ff895728ebffd5bdc4680af50bMLKMESTQQMASSIINTSFEAAVVAATSTLELMGIQYDYNEIYTRVKSKFDYVMDDSGVKNNLLGKAATIDQALNGKFGSVMRNKNWMTDSRTVAKLDEDVNKLRMMLSSKGIDQKMRVLNACFSVKRIPGKSSSVIKCTRLMKDKIERGAVEVDDSFVEEKMEVDTVDWKSRYDQLERRFESLKQRVNEKYTTWVQKAKKVNENMYSLQNVISQQQNQIADLQNYCSKLEADLQNKVGSLVSSVEWYLKSMELPDEVKTDIEQQLNSIDTISPINAIDDLEILIRNLIHDYDRTFLMFKGLLRQCNYEYAYEtrue