SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P04507

- SIGM1_REOVJ

UniProt

P04507 - SIGM1_REOVJ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Outer capsid protein sigma-1
Gene
S1
Organism
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis By similarity.

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. viral entry into host cell Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Outer capsid protein sigma-1
Short name:
Sigma1
Alternative name(s):
Cell attachment protein
Hemagglutinin
Gene namesi
Name:S1
OrganismiReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
Taxonomic identifieri10885 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000006370: Genome

Subcellular locationi

Virion By similarity
Note: Found in the outer capsid (36 copies) By similarity.

GO - Cellular componenti

  1. viral outer capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Outer capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Outer capsid protein sigma-1
PRO_0000040666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi237 – 2371N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi243 – 2431N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi297 – 2971N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi413 – 4131N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Undergoes dramatic conformational rearrangements during viral disassembly in the endocytic pathway By similarity.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotrimer. Interacts (via the head region) with human F11R By similarity.

Structurei

3D structure databases

ProteinModelPortaliP04507.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 317317Tail
Add
BLAST
Regioni318 – 462145Head
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili18 – 4932 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Family and domain databases

Gene3Di2.60.90.20. 1 hit.
InterProiIPR008982. Adenovirus_pIV-rel_att.
IPR027314. Sigma1_globular_dom.
IPR002592. Vir_attach_sigma1_reovir.
[Graphical view]
PfamiPF01664. Reo_sigma1. 1 hit.
[Graphical view]
SUPFAMiSSF49835. SSF49835. 1 hit.

Sequencei

Sequence statusi: Complete.

P04507-1 [UniParc]FASTAAdd to Basket

« Hide

MSDLVQLIRR EILLLTGNGE SANSKHEIEE IKKQIKDISA DVNRISNIVD    50
SIQGQLGGLS VRVSAIESGV SENGNRIDRL ERDVSGISAS VSGIDSRLSE 100
LGDRVNVAEQ RIGQLDTVTD NLLERASRLE TEVSAITNDL GSLNTRVTTE 150
LNDVRQTIAA IDTRLTTLET DAVTSVGQGL QKTGNSIKVI VGTGMWFDRN 200
NVLQLFLSNQ QKGLGFIDNG MVVKIDTQYF SFDSNGNITL NNNISGLPAR 250
TGSLEASRID VVAPPLVIQS TGSTRLLRLM YEAVDFVVTN NVLTLRNRSV 300
TPTFKFPLEL NSADNSVSIH RNYRIRLGQW SGQLEYHTPS LRWNAPVTVN 350
LMRVDDWLIL SFTRFSTSGI LASGKFVLNF VTGLSPGWAT GSTEPSTTTN 400
PLSTTFAAIQ FINGSSRVDA FRILGVAEWN AGELEITNHG GTYTAHTNVD 450
WAPMTIMYPC LG 462
Length:462
Mass (Da):50,466
Last modified:July 22, 2008 - v3
Checksum:i87383752835EEA8F
GO

Sequence cautioni

The sequence AAA66879.1 differs from that shown. Reason: Frameshift at positions 370 and 415.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471V → L in AAA47268. 1 Publication
Sequence conflicti207 – 2071L → V in AAA47251. 1 Publication
Sequence conflicti439 – 4391H → Y in AAA47251. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10261 Genomic RNA. Translation: AAA66879.1. Frameshift.
M32861 Genomic RNA. Translation: AAA47268.1.
M35964 Genomic RNA. Translation: AAA47251.1.
PIRiA04123. HMXRH2.
C34829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10261 Genomic RNA. Translation: AAA66879.1 . Frameshift.
M32861 Genomic RNA. Translation: AAA47268.1 .
M35964 Genomic RNA. Translation: AAA47251.1 .
PIRi A04123. HMXRH2.
C34829.

3D structure databases

ProteinModelPortali P04507.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.90.20. 1 hit.
InterProi IPR008982. Adenovirus_pIV-rel_att.
IPR027314. Sigma1_globular_dom.
IPR002592. Vir_attach_sigma1_reovir.
[Graphical view ]
Pfami PF01664. Reo_sigma1. 1 hit.
[Graphical view ]
SUPFAMi SSF49835. SSF49835. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequences of the S1 genes of the three serotypes of reovirus."
    Cashdollar L.W., Chmelo R.A., Wiener J.R., Joklik W.K.
    Proc. Natl. Acad. Sci. U.S.A. 82:24-28(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Identification of conserved domains in the cell attachment proteins of the three serotypes of reovirus."
    Duncan R., Horne D., Cashdollar L.W., Joklik W.K., Lee P.W.K.
    Virology 174:399-409(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Structure of the reovirus cell-attachment protein: a model for the domain organization of sigma 1."
    Nibert M.L., Dermody T.S., Fields B.N.
    J. Virol. 64:2976-2989(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiSIGM1_REOVJ
AccessioniPrimary (citable) accession number: P04507
Secondary accession number(s): Q85663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: July 22, 2008
Last modified: February 19, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi