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P04505

- GP_BUNYW

UniProt

P04505 - GP_BUNYW

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Protein

Envelope glycoprotein

Gene
GP
Organism
Bunyamwera virus (BUNV)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei477 – 4782Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. modulation by virus of host morphology or physiology Source: InterPro
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiBunyamwera virus (BUNV)
Taxonomic identifieri35304 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
Homo sapiens (Human) [TaxID: 9606]
ProteomesiUP000002476: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs.2 Publications
Chain Glycoprotein G2 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction
Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region.2 Publications
Chain Non-structural protein NSm : Host Golgi apparatus membrane; Multi-pass membrane protein Reviewed prediction 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 203187Lumenal Reviewed predictionAdd
BLAST
Transmembranei204 – 22421Helical; Reviewed predictionAdd
BLAST
Topological domaini225 – 30884Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei309 – 32921Helical; Reviewed predictionAdd
BLAST
Topological domaini330 – 36940Lumenal Reviewed predictionAdd
BLAST
Transmembranei370 – 39021Helical; Reviewed predictionAdd
BLAST
Topological domaini391 – 45666Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei457 – 47721Helical; Reviewed predictionAdd
BLAST
Topological domaini478 – 1387910Lumenal Reviewed predictionAdd
BLAST
Transmembranei1388 – 140821Helical; Reviewed predictionAdd
BLAST
Topological domaini1409 – 143325Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. host cell Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Add
BLAST
Chaini17 – 14331417Envelope glycoproteinPRO_0000036798Add
BLAST
Chaini17 – 302286Glycoprotein G2 By similarityPRO_0000036799Add
BLAST
Chaini303 – 477175Non-structural protein NSm By similarityPRO_0000036800Add
BLAST
Chaini478 – 1433956Glycoprotein G1 By similarityPRO_0000036801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi624 – 6241N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1169 – 11691N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Protein-protein interaction databases

DIPiDIP-404N.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04505-1 [UniParc]FASTAAdd to Basket

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MRILILLLAV TQLAVSSPVI TRCFHGGQLI AERKSQTSIS EFCIKDDVSM     50
LKSEIVYTKN DTGIFGHSKV FRHWTITDWK ACNPVVTAGG SINVIEVDKN 100
LNLVTRNYVC TGDCTITVDR KNAQIIFQTD KLNHFEVTGT TISTGWFKSK 150
ASVTLDRTCE HIKVSCGKKT LQFHACFKQH MSCVRFLHRS ILPGSMAISI 200
CQNIELIIIT ILALCIFIIM IILTKTYICY VLIPVFMPIA FAYGWAYNRS 250
CKKCTCCGLA YHPFTNCGSY CVCGSKFETS DRMRMHRESG LCQGFKSLRV 300
ARRLCKSKGS SLIISILLSV LILSFVTPIE GTLTNYPTDQ KYTLDEIADV 350
LQAKTHEDST KYYIILYTSL FGAGLTIIFA GVALGLTIIL EVLTKINVIF 400
CNECNMYHSK KSIKYVGDFT NKCGFCTCGL LEDPEGVVVH KAKKSCTYSY 450
QINWVRGIMI FVAFLFVIQN TIIMVAAEED CWKNEELKED CVGPLIAPKD 500
CTDKDHKTYL SEASLLATAK KITQVDAENV EILGKTMESA IRVIERQKTY 550
HRMHLLEAVF LNKHCDYYKM FEHNSGYSQV KWRMMIKTQH FDICALQANS 600
PFCAQCIADN SCAQGSWEFD THMNSTYSSK VDNFKHDFSL FLRIFEAAFP 650
GTAYVHLLTN IKEKKPYQAV SMIEKIKKKF PNNKLLIGYL DFGKYLLGLS 700
HASTYELQQR QLDKLYQPTE LTRSGGQQTS LANSVVGQAT KECKKYKDVS 750
CLSPRFGIPL EDLISCCDQP NYNIYKKPKK VYKAHDKEET WCINDQHCLV 800
DFVPAEADTV EKLKPMKCWL VDPGKNDDVY SIAIKTCRVV DKGVCTVNSQ 850
KWNIIKCDSG PLYYSDHIPG EDTGNDIGHY CVSAGCKTDR YPINPDVVTD 900
CVWEFTSRKS QYIGKISMQS LEDYEKALTD RLTHTLETYS FAPLENLPHI 950
KPVYKYITAQ GVENSDGIEG AFITASIPAA GGTSIGYNVR SKDGFPLLDL 1000
IVFVKSAVIK STYNHIYDTG PTISINTKHD EHCTGQCPSN IEHEANWLTF 1050
SQERTSRWGC EEFGCLAVNT GCVFGSCQDV IRPETKVYRK AVDEVVILTV 1100
CITYPGHTFC TEINAIEPKI TEEIELQFKT VDTKTLPYIV AVNNHKLYSG 1150
QINDLGTFGQ MCGNVQKTNS SILGTGTPKF DYTCHGASRK DIIVRRCYNN 1200
NFDSCKLLKE ETQLIFNDDH DTITVYNTNH LIGELAIKLI LGDIQYKLFT 1250
ETLDLQIDAK CVGCPDCFES YSCNFQIVSN IDTICSLEGP CDTFHNRISI 1300
KAMQQNYAVK LSCQKDPRPS GTFKICNREY TVVFHTVAKD DKIEINVGDQ 1350
TSFIKEKDDR CKTWLCRVRD EGISVIFEPI KAFFGSYFSI FFYIIVVVVV 1400
GFLIIYIFMP MFMKLKEVLK ANEKLYLQEI KQK 1433
Length:1,433
Mass (Da):162,078
Last modified:August 13, 1987 - v1
Checksum:iCD61ABDE782018E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11852 Genomic RNA. Translation: AAA42777.1.
PIRiA04101. GNVUBW.
RefSeqiNP_047212.1. NC_001926.1.

Genome annotation databases

GeneIDi2648216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11852 Genomic RNA. Translation: AAA42777.1 .
PIRi A04101. GNVUBW.
RefSeqi NP_047212.1. NC_001926.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-404N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2648216.

Family and domain databases

InterProi IPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view ]
Pfami PF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view ]
PIRSFi PIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the Bunyamwera virus M RNA segment: conservation of structural features in the Bunyavirus glycoprotein gene product."
    Lees J.F., Pringle C.R., Elliott R.M.
    Virology 148:1-14(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Localization of Bunyamwera bunyavirus G1 glycoprotein to the Golgi requires association with G2 but not with NSm."
    Lappin D.F., Nakitare G.W., Palfreyman J.W., Elliott R.M.
    J. Gen. Virol. 75:3441-3451(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "Mapping the Golgi targeting and retention signal of Bunyamwera virus glycoproteins."
    Shi X., Lappin D.F., Elliott R.M.
    J. Virol. 78:10793-10802(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. "Requirement of the N-terminal region of orthobunyavirus nonstructural protein NSm for virus assembly and morphogenesis."
    Shi X., Kohl A., Leonard V.H., Li P., McLees A., Elliott R.M.
    J. Virol. 80:8089-8099(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.

Entry informationi

Entry nameiGP_BUNYW
AccessioniPrimary (citable) accession number: P04505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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