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P04505

- GP_BUNYW

UniProt

P04505 - GP_BUNYW

Protein

Envelope glycoprotein

Gene

GP

Organism
Bunyamwera virus (BUNV)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei477 – 4782Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. modulation by virus of host morphology or physiology Source: InterPro
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:GP
    OrganismiBunyamwera virus (BUNV)
    Taxonomic identifieri35304 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiAedes aegypti (Yellowfever mosquito) (Culex aegypti) [TaxID: 7159]
    Homo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000002476: Genome

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs.
    Chain Glycoprotein G2 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated
    Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region.

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Add
    BLAST
    Chaini17 – 14331417Envelope glycoproteinPRO_0000036798Add
    BLAST
    Chaini17 – 302286Glycoprotein G2By similarityPRO_0000036799Add
    BLAST
    Chaini303 – 477175Non-structural protein NSmBy similarityPRO_0000036800Add
    BLAST
    Chaini478 – 1433956Glycoprotein G1By similarityPRO_0000036801Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi624 – 6241N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1169 – 11691N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Protein-protein interaction databases

    DIPiDIP-404N.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 203187LumenalSequence AnalysisAdd
    BLAST
    Topological domaini225 – 30884CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini330 – 36940LumenalSequence AnalysisAdd
    BLAST
    Topological domaini391 – 45666CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini478 – 1387910LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1409 – 143325CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei309 – 32921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei370 – 39021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei457 – 47721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1388 – 140821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR005167. Bunya_G1.
    IPR005168. Bunya_G2.
    IPR026400. Bunya_nonstruc_pro_NSm.
    IPR014413. M_poly_OrthobunV.
    [Graphical view]
    PfamiPF03557. Bunya_G1. 1 hit.
    PF03563. Bunya_G2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
    TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04505-1 [UniParc]FASTAAdd to Basket

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    MRILILLLAV TQLAVSSPVI TRCFHGGQLI AERKSQTSIS EFCIKDDVSM     50
    LKSEIVYTKN DTGIFGHSKV FRHWTITDWK ACNPVVTAGG SINVIEVDKN 100
    LNLVTRNYVC TGDCTITVDR KNAQIIFQTD KLNHFEVTGT TISTGWFKSK 150
    ASVTLDRTCE HIKVSCGKKT LQFHACFKQH MSCVRFLHRS ILPGSMAISI 200
    CQNIELIIIT ILALCIFIIM IILTKTYICY VLIPVFMPIA FAYGWAYNRS 250
    CKKCTCCGLA YHPFTNCGSY CVCGSKFETS DRMRMHRESG LCQGFKSLRV 300
    ARRLCKSKGS SLIISILLSV LILSFVTPIE GTLTNYPTDQ KYTLDEIADV 350
    LQAKTHEDST KYYIILYTSL FGAGLTIIFA GVALGLTIIL EVLTKINVIF 400
    CNECNMYHSK KSIKYVGDFT NKCGFCTCGL LEDPEGVVVH KAKKSCTYSY 450
    QINWVRGIMI FVAFLFVIQN TIIMVAAEED CWKNEELKED CVGPLIAPKD 500
    CTDKDHKTYL SEASLLATAK KITQVDAENV EILGKTMESA IRVIERQKTY 550
    HRMHLLEAVF LNKHCDYYKM FEHNSGYSQV KWRMMIKTQH FDICALQANS 600
    PFCAQCIADN SCAQGSWEFD THMNSTYSSK VDNFKHDFSL FLRIFEAAFP 650
    GTAYVHLLTN IKEKKPYQAV SMIEKIKKKF PNNKLLIGYL DFGKYLLGLS 700
    HASTYELQQR QLDKLYQPTE LTRSGGQQTS LANSVVGQAT KECKKYKDVS 750
    CLSPRFGIPL EDLISCCDQP NYNIYKKPKK VYKAHDKEET WCINDQHCLV 800
    DFVPAEADTV EKLKPMKCWL VDPGKNDDVY SIAIKTCRVV DKGVCTVNSQ 850
    KWNIIKCDSG PLYYSDHIPG EDTGNDIGHY CVSAGCKTDR YPINPDVVTD 900
    CVWEFTSRKS QYIGKISMQS LEDYEKALTD RLTHTLETYS FAPLENLPHI 950
    KPVYKYITAQ GVENSDGIEG AFITASIPAA GGTSIGYNVR SKDGFPLLDL 1000
    IVFVKSAVIK STYNHIYDTG PTISINTKHD EHCTGQCPSN IEHEANWLTF 1050
    SQERTSRWGC EEFGCLAVNT GCVFGSCQDV IRPETKVYRK AVDEVVILTV 1100
    CITYPGHTFC TEINAIEPKI TEEIELQFKT VDTKTLPYIV AVNNHKLYSG 1150
    QINDLGTFGQ MCGNVQKTNS SILGTGTPKF DYTCHGASRK DIIVRRCYNN 1200
    NFDSCKLLKE ETQLIFNDDH DTITVYNTNH LIGELAIKLI LGDIQYKLFT 1250
    ETLDLQIDAK CVGCPDCFES YSCNFQIVSN IDTICSLEGP CDTFHNRISI 1300
    KAMQQNYAVK LSCQKDPRPS GTFKICNREY TVVFHTVAKD DKIEINVGDQ 1350
    TSFIKEKDDR CKTWLCRVRD EGISVIFEPI KAFFGSYFSI FFYIIVVVVV 1400
    GFLIIYIFMP MFMKLKEVLK ANEKLYLQEI KQK 1433
    Length:1,433
    Mass (Da):162,078
    Last modified:August 13, 1987 - v1
    Checksum:iCD61ABDE782018E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11852 Genomic RNA. Translation: AAA42777.1.
    PIRiA04101. GNVUBW.
    RefSeqiNP_047212.1. NC_001926.1.

    Genome annotation databases

    GeneIDi2648216.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11852 Genomic RNA. Translation: AAA42777.1 .
    PIRi A04101. GNVUBW.
    RefSeqi NP_047212.1. NC_001926.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-404N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2648216.

    Family and domain databases

    InterProi IPR005167. Bunya_G1.
    IPR005168. Bunya_G2.
    IPR026400. Bunya_nonstruc_pro_NSm.
    IPR014413. M_poly_OrthobunV.
    [Graphical view ]
    Pfami PF03557. Bunya_G1. 1 hit.
    PF03563. Bunya_G2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003944. M_poly_OrthobunV. 1 hit.
    TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the Bunyamwera virus M RNA segment: conservation of structural features in the Bunyavirus glycoprotein gene product."
      Lees J.F., Pringle C.R., Elliott R.M.
      Virology 148:1-14(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Localization of Bunyamwera bunyavirus G1 glycoprotein to the Golgi requires association with G2 but not with NSm."
      Lappin D.F., Nakitare G.W., Palfreyman J.W., Elliott R.M.
      J. Gen. Virol. 75:3441-3451(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    3. "Mapping the Golgi targeting and retention signal of Bunyamwera virus glycoproteins."
      Shi X., Lappin D.F., Elliott R.M.
      J. Virol. 78:10793-10802(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    4. "Requirement of the N-terminal region of orthobunyavirus nonstructural protein NSm for virus assembly and morphogenesis."
      Shi X., Kohl A., Leonard V.H., Li P., McLees A., Elliott R.M.
      J. Virol. 80:8089-8099(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY.

    Entry informationi

    Entry nameiGP_BUNYW
    AccessioniPrimary (citable) accession number: P04505
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3