Reviewed, UniProtKB/Swiss-Prot P04498 (DNB2_ADE12)

Names and origin

Protein names

Recommended name:
    Early E2A DNA-binding protein

Gene names

Name:

DBP

Organism

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

Taxonomic identifier

28282 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus A

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	484 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Binds cooperatively single-stranded DNA in a sequence-independent manner. Involved in DNA-replication, regulation of mRNA formation, and host-range specificity. Zinc is required for DNA binding.
Subcellular location	Host nucleus. Note: Accumulates in infected cells.
Sequence similarities	Belongs to the adenoviridae E2A DNA-binding protein family.

Ontologies

Keywords
Cellular component	Host nucleus
Developmental stage	Early protein
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: InterPro
Cellular component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 484	484	Early E2A DNA-binding protein		PRO_0000221681
Regions
	Zinc finger	228 – 241	14	Potential
Amino acid modifications
	Modified residue	150	1	Phosphotyrosine Probable

Sequences

	Sequence		Length	Mass (Da)
	P04498-1 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 60FE0378977C71F5	FASTA	484	54,999
	10 20 30 40 50 60 MASNQHSQRE RTPDRSAQPP PPKMGRYFLD SESEEELEAV PLPPKKKVKK SMAAIPLSPE 70 80 90 100 110 120 SAEEEEAEPP RAVLGVMGFS MPPVRIMHHA DGSQSFQKME TRQVHVLKAS AQNSDENEKN 130 140 150 160 170 180 VVVVRNPASQ PLVSAWEKGM EAMAMLMEKY HVDHDERATF RFLPDQGSVY KKICTTWLNE 190 200 210 220 230 240 EKRGLQLTFS SQKTFQELMG RFLQGYMQAY AGVQQNSWEP TGCCVWEHKC TEREGELRCL 250 260 270 280 290 300 HGMEMVRKEH LVEMDVTSES GQRALKENPS KAKVAQNRWG RNVVQIKNDD ARCCFHDVGC 310 320 330 340 350 360 GNNSFSGKSC GLFYSEGMKA QIAFRQIEAF MLADYPHMRH GQKRLLMPVR CECLNKQDGL 370 380 390 400 410 420 PRMGRQLCKI TPFNLSNVDN IDINEVTDPG ALASIKYPCL LVFQCANPVY RNARGNAGPN 430 440 450 460 470 480 CDFKISAPDV MGALQLVRQL WGENFDGSPP RLVIPEFKWH QRLQYRNISL PTNHGDCREE PFDF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and function of adenovirus DNA binding protein: comparison of the amino acid sequences of the Ad5 and Ad12 proteins derived from the nucleotide sequence of the corresponding genes." Kruijer W., van Schaik F.M.A., Speijer J.G., Sussenbach J.S. Virology 128:140-153(1983) [PubMed: 6308889] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis." Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W. J. Virol. 68:379-389(1994) [PubMed: 8254750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	V01483 Genomic DNA. Translation: CAA24732.1. X73487 Genomic DNA. Translation: CAA51893.1.
PIR	ERAD12. A03835.
RefSeq	NP_040926.1.
3D structure databases
HSSP	HSSP built from PDB template 1ADU based on UniProtKB P03265.
ModBase	Search...
Genome annotation databases
GeneID	1460850.
Family and domain databases
InterPro	IPR005376. Early_E2A_DNA/Zn-bd. IPR003176. Vir_DNA_bd. [Graphical view]
Gene3D	G3DSA:3.90.148.10. E2A_DNA_Zn_bd. 1 hit.
Pfam	PF02236. Viral_DNA_bi. 1 hit. PF03728. Viral_DNA_Zn_bi. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNB2_ADE12

Accession

Primary (citable) accession number: P04498

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	November 3, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)