Reviewed,
UniProtKB/Swiss-Prot P04495 (DPOL_ADE05)
Last modified
January 19, 2010.
Version 59.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: DNA polymerase EC=2.7.7.7 | ||
| Gene names |
| ||
| Organism | Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) | ||
| Taxonomic identifier | 28285 [NCBI] | ||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus | ||
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 1056 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
| Miscellaneous | This DNA polymerase requires a protein as a primer. |
| Sequence similarities | Belongs to the DNA polymerase type-B family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA replication |
| Ligand | DNA-binding |
| Molecular function | DNA-directed DNA polymerase Nucleotidyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | DNA-dependent DNA replication Inferred from electronic annotation. Source: InterPro |
| Molecular function | 3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA bindingInferred from electronic annotation. Source: UniProtKB-KW DNA-directed DNA polymerase activityInferred from electronic annotation. Source: UniProtKB-KW nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 1056 | 1056 | DNA polymerase | PRO_0000046494 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The nucleotide sequence of fragment HindIII-C of human adenovirus type 5 DNA (map positions 17.1-31.7)." Dekker B.M.M., van Ormondt H. Gene 27:115-120(1984) [PubMed: 6325298] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2." Chroboczek J., Bieber F., Jacrot B. Virology 186:280-285(1992) [PubMed: 1727603] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X02996 Genomic DNA. Translation: CAA26749.1. M73260 Genomic DNA. No translation available. |
| PIR | DJAD51. A00712. |
3D structure databases | |
| SMR | P04495. Positions 271-943. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.7.7.7. 291661. |
Family and domain databases | |
| InterPro | IPR006172. DNA-dir_DNA_pol_B. IPR014382. DNA-dir_DNA_pol_B_adenovir. IPR006134. DNA-dir_DNA_pol_B_cons-reg. IPR017966. DNA-dir_DNA_pol_B_cons_reg2. IPR017964. DNA-dir_DNA_pol_B_CS. IPR004868. DNA-dir_DNA_pol_B_mt/vir. IPR012337. PolynucTfrase_RNaseH_fold. [Graphical view] |
| Pfam | PF00136. DNA_pol_B. 1 hit. PF03175. DNA_pol_B_2. 1 hit. [Graphical view] |
| PIRSF | PIRSF000788. DPol_ADV. 1 hit. |
| PRINTS | PR00106. DNAPOLB. |
| SMART | SM00486. POLBc. 1 hit. [Graphical view] |
| PROSITE | PS00116. DNA_POLYMERASE_B. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DPOL_ADE05 | ||||||||
| Accession | Primary (citable) accession number: P04495 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||
