P04492 (E1BS_ADE12) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: E1B protein, small T-antigen Alternative name(s): E1B 19 kDa protein Short name=E1B-19K
Organism	Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)
Taxonomic identifier	28282 [NCBI]
Taxonomic lineage	Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus A
Virus host	Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Putative adenovirus Bcl-2 homolog that inhibits apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis. Without E1B 19K function, virus production is compromised because of premature death of host cell. Interacts with Bax protein in cell lysates By similarity.
Subcellular location	Host cell membrane By similarity. Host nucleus envelope By similarity. Host nucleus lamina By similarity. Note: Associated with the plasma and nuclear membranes, and with the insoluble nuclear lamina By similarity.
Sequence similarities	Belongs to the adenoviridae E1B 19 kDa protein family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Host cell membrane Host membrane Host nucleus Membrane
Developmental stage	Early protein
Gene Ontology (GO)
Biological process	anti-apoptosis Inferred from electronic annotation. Source: InterPro apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	host cell nuclear lamina Inferred from electronic annotation. Source: UniProtKB-SubCell host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lamin binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 163	163	E1B protein, small T-antigen		PRO_0000221714

Sequences

	Sequence		Length	Mass (Da)
	P04492 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 216BE9B40857DD54	FASTA	163	19,125
	10 20 30 40 50 60 MELETVLQSF QSVRQLLQYT SKNTSGFWRY LFGSTLSKVV NRVKEDYREE FENILADCPG 70 80 90 100 110 120 LLASLDLCYH LVFQEKVVRS LDFSSVGRTV ASIAFLATIL DKWSEKSHLS WDYMLDYMSM 130 140 150 160 QLWRAWLKRR VCIYSLARPL TMPPLPTLQE EKEEERNPAV VEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets." Bos J.L., Polder L.J., Bernards R., Schrier P.I., van den Elsen P.J., van der Eb A.J., van Ormondt H. Cell 27:121-131(1981) [PubMed: 7326748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotide sequence of the transforming early region E1b of adenovirus type 12 DNA: structure and gene organization, and comparison with those of adenovirus type 5 DNA." Kimura T., Sawada Y., Shinawawa M., Shimizu Y., Shiroki K., Shimojo H., Sugisaki H., Takanami M., Uemizu Y., Fujinaga K. Nucleic Acids Res. 9:6571-6589(1981) [PubMed: 6275367] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Structure and sequence analysis of the transforming region E1B of human adenovirus type 12." Kimura T. Sapporo Igaku Zasshi 52:253-267(1983) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis." Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W. J. Virol. 68:379-389(1994) [PubMed: 8254750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	V00004 Genomic DNA. Translation: CAA23406.1. V00004 Genomic DNA. Translation: CAA23405.1. V00004 Genomic DNA. Translation: CAA23403.1. V00004 Genomic DNA. Translation: CAA23404.1. M55003 Genomic DNA. Translation: AAA42498.1. X73487 Genomic DNA. Translation: CAA51878.1.
PIR	ERAD21. A03816.
RefSeq	NP_040911.1. NC_001460.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-379N.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1460854.
Phylogenomic databases
ProtClustDB	CLSP2513884.
Family and domain databases
InterPro	IPR002924. Adenovir_t-Ag_E1B_19kDa. IPR002475. Bcl2-like_apoptosis. [Graphical view]
Pfam	PF01691. Adeno_E1B_19K. 1 hit. [Graphical view]
PROSITE	PS50062. BCL2_FAMILY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E1BS_ADE12

Accession

Primary (citable) accession number: P04492

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	May 3, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program