P04491 (E1BL_ADE12) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: E1B protein, large T-antigen Alternative name(s): E1B 55 kDa protein Short name=E1B-55K
Organism	Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)
Taxonomic identifier	28282 [NCBI]
Taxonomic lineage	Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus A
Virus host	Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the adenoviridae E1B 55 kDa protein family.

Ontologies

Keywords
Developmental stage	Early protein
Gene Ontology (GO)
Biological process	response to external stimulus Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 482	482	E1B protein, large T-antigen		PRO_0000221727
Experimental info
	Sequence conflict	75 – 76	2	DS → ER in AAA42499. Ref.3
	Sequence conflict	191	1	I → E in AAA42499. Ref.3
	Sequence conflict	299 – 301	3	LIV → ILN in AAA42499. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P04491 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 359E8082B7EF3659	FASTA	482	53,936
	10 20 30 40 50 60 MEREIPPELG LHAGLHVNAA VEGMAEEEGL HLLAGAAFDH AAAADVARGE GGGAEPCGGG 70 80 90 100 110 120 EVNMEQQVQE GHVLDSGEGP SCADDRDKQE KKESLKEAAV LSRLTVNLMS RPRLETVYWQ 130 140 150 160 170 180 ELQDEFQRGD MHLQYKYSFE QLKTHWLEPW EDMECAIKAF AKLALRPDCS YRITKTVTIT 190 200 210 220 230 240 SCAYIIGNGA IVEVDTSDRV AFRCRMQGMG PGVVGLDGIT FINVRFAGDK FKGIMFEANT 250 260 270 280 290 300 CLVLHGVYFL NFSNICVESW NKVSARGCTF YGCWKGLVGR PKSKLSVKKC LFEKCVLALI 310 320 330 340 350 360 VEGDAHIRHN AASENACFVL LKGMAILKHN MVCGVSDQTM RRFVTCADGN CHTLKTVHIV 370 380 390 400 410 420 SHSRHCWPVC DHNMFMRCTI HLGLRRGMFR PSQCNFSHSN IMLEPEVFSR VCLNGVFDLS 430 440 450 460 470 480 VELCKVIRYN DDTRHRCRQC ECGSSHLELR PIVLNVTEEL RSDHLTLSCL RTDYESSDED DN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the transforming early region E1b of adenovirus type 12 DNA: structure and gene organization, and comparison with those of adenovirus type 5 DNA." Kimura T., Sawada Y., Shinawawa M., Shimizu Y., Shiroki K., Shimojo H., Sugisaki H., Takanami M., Uemizu Y., Fujinaga K. Nucleic Acids Res. 9:6571-6589(1981) [PubMed: 6275367] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets." Bos J.L., Polder L.J., Bernards R., Schrier P.I., van den Elsen P.J., van der Eb A.J., van Ormondt H. Cell 27:121-131(1981) [PubMed: 7326748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Structure and sequence analysis of the transforming region E1B of human adenovirus type 12." Kimura T. Sapporo Igaku Zasshi 52:253-267(1983) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis." Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W. J. Virol. 68:379-389(1994) [PubMed: 8254750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V00004 Genomic DNA. Translation: CAA23407.1. M55003 Genomic DNA. Translation: AAA42499.1. X73487 Genomic DNA. Translation: CAA51879.1.
PIR	ERAD24. A03812.
RefSeq	NP_040912.1. NC_001460.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P04491. 1 interaction.
MINT	MINT-2518710.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1460854.
Phylogenomic databases
ProtClustDB	CLSP2513873.
Family and domain databases
InterPro	IPR006717. Adeno_E1B_55K_N. IPR002612. Adeno_E1B_55kDa. [Graphical view]
Pfam	PF01696. Adeno_E1B_55K. 1 hit. PF04623. Adeno_E1B_55K_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E1BL_ADE12

Accession

Primary (citable) accession number: P04491
Secondary accession number(s): Q64837

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	September 21, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program