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Reviewed, UniProtKB/Swiss-Prot P04486 (ATIN_HHV1F)

Last modified June 16, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Alpha trans-inducing protein
Alternative name(s):
    Vmw65
    ICP25
    VP16 protein
    Alpha-TIF
Gene names
Name: UL48
OrganismHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifier10304 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'.

Sequence similarities

Belongs to the herpesviridae alpha trans-inducing protein family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   LigandDNA-binding
   Technical term3D-structure
Gene Ontology (GO)
   Biological processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Alpha trans-inducing protein
PRO_0000115799

Sequences

Sequence LengthMass (Da)Tools
P04486-1 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 8DFF24AC1717A1C6

FASTA47953,054
        10         20         30         40         50         60 
MDADGASPPP PRPAGGPKNT PAAPPLYATG RLSQAQLMPS PPMPVPPAAL FNRLLDDLGF 

        70         80         90        100        110        120 
SAGPALCTML DTWNEDLFSA LPTNADLYRE CKFLSTLPSD VVEWGDAYVP ERAQIDIRAH 

       130        140        150        160        170        180 
GDVAFPTLPA TRDGLGLYYE ALSRFFHAEL RAREESYRTV LANFCSALYR YLRASVRQLH 

       190        200        210        220        230        240 
RQAHMRGRDR DLGEMLRATI ADRYYRETAR LARVLFLHLY LFLTREILWA AYAEQMMRPD 

       250        260        270        280        290        300 
LFDCLCCDLE SWRQLAGLFQ PFMFVNGALT VRGVPIEARR LRELNHIREH LNLPLVRSAA 

       310        320        330        340        350        360 
TEEPGAPLTT PPTLHGNQAR ASGYFMVLIR AKLDSYSSFT TSPSEAVMRE HAYSRARTKN 

       370        380        390        400        410        420 
NYGSTIEGLL DLPDDDAPEE AGLAAPRLSF LPAGHTRRLS TAPPTDVSLG DELHLDGEDV 

       430        440        450        460        470 
AMAHADALDD FDLDMLGDGD SPGPGFTPHD SAPYGALDMA DFEFEQMFTD ALGIDEYGG 

« Hide

References

[1]"Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes."
Pellett P.E., McKnight J.L.C., Jenkins F.J., Roizman B.
Proc. Natl. Acad. Sci. U.S.A. 82:5870-5874(1985) [PubMed: 2994050] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

K03350 Genomic DNA. Translation: AAA45766.1.
PIRIXBE1F. A03727.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2K2UNMR-B445-479[»]
ModBaseSearch...

Family and domain databases

InterProIPR003174. Alpha_TIF.
[Graphical view]
Gene3DG3DSA:1.10.1290.10. Alpha_TIF. 1 hit.
PfamPF02232. Alpha_TIF. 1 hit.
[Graphical view]
SMARTSM00814. Alpha_TIF. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATIN_HHV1F
AccessionPrimary (citable) accession number: P04486
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents