Reviewed, UniProtKB/Swiss-Prot P04486 (ATIN_HHV1F)

Names and origin

Protein names

Recommended name:
    Alpha trans-inducing protein
Alternative name(s):
    Vmw65
    ICP25
    VP16 protein
    Alpha-TIF

Gene names

Name:

UL48

Organism

Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

Taxonomic identifier

10304 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'.
Sequence similarities	Belongs to the herpesviridae alpha trans-inducing protein family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Technical term	3D-structure
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Alpha trans-inducing protein		PRO_0000115799

Sequences

	Sequence		Length	Mass (Da)
	P04486-1 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 8DFF24AC1717A1C6	FASTA	479	53,054
	10 20 30 40 50 60 MDADGASPPP PRPAGGPKNT PAAPPLYATG RLSQAQLMPS PPMPVPPAAL FNRLLDDLGF 70 80 90 100 110 120 SAGPALCTML DTWNEDLFSA LPTNADLYRE CKFLSTLPSD VVEWGDAYVP ERAQIDIRAH 130 140 150 160 170 180 GDVAFPTLPA TRDGLGLYYE ALSRFFHAEL RAREESYRTV LANFCSALYR YLRASVRQLH 190 200 210 220 230 240 RQAHMRGRDR DLGEMLRATI ADRYYRETAR LARVLFLHLY LFLTREILWA AYAEQMMRPD 250 260 270 280 290 300 LFDCLCCDLE SWRQLAGLFQ PFMFVNGALT VRGVPIEARR LRELNHIREH LNLPLVRSAA 310 320 330 340 350 360 TEEPGAPLTT PPTLHGNQAR ASGYFMVLIR AKLDSYSSFT TSPSEAVMRE HAYSRARTKN 370 380 390 400 410 420 NYGSTIEGLL DLPDDDAPEE AGLAAPRLSF LPAGHTRRLS TAPPTDVSLG DELHLDGEDV 430 440 450 460 470 AMAHADALDD FDLDMLGDGD SPGPGFTPHD SAPYGALDMA DFEFEQMFTD ALGIDEYGG

References

[1]	"Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes." Pellett P.E., McKnight J.L.C., Jenkins F.J., Roizman B. Proc. Natl. Acad. Sci. U.S.A. 82:5870-5874(1985) [PubMed: 2994050] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

K03350 Genomic DNA. Translation: AAA45766.1.

PIR

IXBE1F. A03727.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2K2U	NMR	-	B	445-479	[»]

ModBase

Search...

Family and domain databases

InterPro

IPR003174. Alpha_TIF.
[Graphical view]

Gene3D

G3DSA:1.10.1290.10. Alpha_TIF. 1 hit.

Pfam

PF02232. Alpha_TIF. 1 hit.
[Graphical view]

SMART

SM00814. Alpha_TIF. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

ATIN_HHV1F

Accession

Primary (citable) accession number: P04486

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)