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P04485

- ICP22_HHV11

UniProt

P04485 - ICP22_HHV11

Protein

Transcriptional regulator ICP22

Gene

US1

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    Functions as a general transcriptional regulator of cellular and viral mRNAs mainly by mediating changes on the host RNA polymerase II. One change, which is UL13 independent, is the rapid loss of Pol II forms bearing Ser-2 phosphorylation. A second change, which is UL13 dependent, is the appearance of an intermediate form of Pol II that differs from the normal hypo- and hyperphosphorylated forms. These Pol II modifications immediately inhibit host genome transcription, leading to cell cycle deregulation and loss of efficient antiviral response.2 Publications

    GO - Biological processi

    1. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulator ICP22
    Alternative name(s):
    Immediate-early protein IE68
    Infected cell protein 22
    Short name:
    ICP22
    Gene namesi
    ORF Names:US1
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Host nucleus
    Note: Localizes in small nuclear bodies early in infection then moves to a more diffuse distribution in viral compartments as infecion progresses.

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi193 – 1931Y → A: Alteration of post-translational modifications. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Transcriptional regulator ICP22PRO_0000115837Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei193 – 1931Phosphotyrosine1 Publication

    Post-translational modificationi

    Tyrosine phosphorylated.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Keywords - Developmental stagei

    Early protein

    Interactioni

    Protein-protein interaction databases

    IntActiP04485. 1 interaction.
    MINTiMINT-6732597.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the herpesviridae ICP22 family.Curated

    Family and domain databases

    InterProiIPR003403. IE68.
    [Graphical view]
    PfamiPF02479. Herpes_IE68. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative promoter usage. Align

    Note: Additional isoforms seem to exist.

    Isoform ICP22 (identifier: P04485-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MADISPGAFA PCVKARRPAL RSPPLGTRKR KRPSRPLSSE SEVESDTALE    50
    SEVESETASD STESGDQDEA PRIGGRRAPR RLGGRFFLDM SAESTTGTET 100
    DASVSDDPDD TSDWSYDDIP PRPKRARVNL RLTSSPDRRD GVIFPKMGRV 150
    RSTRETQPRA PTPSAPSPNA MLRRSVRQAQ RRSSARWTPD LGYMRQCINQ 200
    LFRVLRVARD PHGSANRLRH LIRDCYLMGY CRARLAPRTW CRLLQVSGGT 250
    WGMHLRNTIR EVEARFDATA EPVCKLPCLE TRRYGPECDL SNLEIHLSAT 300
    SDDEISDATD LEAAGSDHTL ASQSDTEDAP SPVTLETPEP RGSLAVRLED 350
    EFGEFDWTPQ EGSQPWLSAV VADTSSVERP GPSDSGAGRA AEDRKCLDGC 400
    RKMRFSTACP YPCSDTFLRP 420
    Length:420
    Mass (Da):46,525
    Last modified:August 13, 1987 - v1
    Checksum:i94D56376545B1192
    GO
    Isoform US1.5 (identifier: P04485-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-146: Missing.

    Show »
    Length:274
    Mass (Da):30,580
    Checksum:i0C6802604B01100E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 146146Missing in isoform US1.5. CuratedVSP_025673Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32287.1.
    X02138 Genomic DNA. Translation: CAA26055.1.
    L00036 Genomic DNA. Translation: AAA96687.1.
    PIRiA03723. EDBE17.
    RefSeqiNP_044663.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703435.

    Keywords - Coding sequence diversityi

    Alternative promoter usage

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32287.1 .
    X02138 Genomic DNA. Translation: CAA26055.1 .
    L00036 Genomic DNA. Translation: AAA96687.1 .
    PIRi A03723. EDBE17.
    RefSeqi NP_044663.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P04485. 1 interaction.
    MINTi MINT-6732597.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703435.

    Family and domain databases

    InterProi IPR003403. IE68.
    [Graphical view ]
    Pfami PF02479. Herpes_IE68. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dolan A., Donald S., Rixon F.J.
      J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Mutation of the protein tyrosine kinase consensus site in the herpes simplex virus 1 alpha22 gene alters ICP22 posttranslational modification."
      O'Toole J.M., Aubert M., Kotsakis A., Blaho J.A.
      Virology 305:153-167(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-193, MUTAGENESIS OF TYR-193.
    4. "Herpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functions."
      Poon A.P., Roizman B.
      J. Virol. 79:8470-8479(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: ISOFORM US1.5.
    5. "The products of the herpes simplex virus type 1 immediate-early US1/US1.5 genes downregulate levels of S-phase-specific cyclins and facilitate virus replication in S-phase Vero cells."
      Orlando J.S., Astor T.L., Rundle S.A., Schaffer P.A.
      J. Virol. 80:4005-4016(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Herpes simplex virus immediate-early protein ICP22 triggers loss of serine 2-phosphorylated RNA polymerase II."
      Fraser K.A., Rice S.A.
      J. Virol. 81:5091-5101(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiICP22_HHV11
    AccessioniPrimary (citable) accession number: P04485
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    ICP22 and protein US1.5 mRNAs are transcribed from two different promoters on the US1 gene.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3