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P04485

- ICP22_HHV11

UniProt

P04485 - ICP22_HHV11

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Protein

Transcriptional regulator ICP22

Gene

US1

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a general transcriptional regulator of cellular and viral mRNAs mainly by mediating changes on the host RNA polymerase II. One change, which is UL13 independent, is the rapid loss of Pol II forms bearing Ser-2 phosphorylation. A second change, which is UL13 dependent, is the appearance of an intermediate form of Pol II that differs from the normal hypo- and hyperphosphorylated forms. These Pol II modifications immediately inhibit host genome transcription, leading to cell cycle deregulation and loss of efficient antiviral response.2 Publications

GO - Biological processi

  1. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator ICP22
Alternative name(s):
Immediate-early protein IE68
Infected cell protein 22
Short name:
ICP22
Gene namesi
ORF Names:US1
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Host nucleus
Note: Localizes in small nuclear bodies early in infection then moves to a more diffuse distribution in viral compartments as infecion progresses.

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi193 – 1931Y → A: Alteration of post-translational modifications. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Transcriptional regulator ICP22PRO_0000115837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei193 – 1931Phosphotyrosine1 Publication

Post-translational modificationi

Tyrosine phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Protein-protein interaction databases

IntActiP04485. 1 interaction.
MINTiMINT-6732597.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae ICP22 family.Curated

Family and domain databases

InterProiIPR003403. IE68.
[Graphical view]
PfamiPF02479. Herpes_IE68. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Note: Additional isoforms seem to exist.

Isoform ICP22 (identifier: P04485-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADISPGAFA PCVKARRPAL RSPPLGTRKR KRPSRPLSSE SEVESDTALE
60 70 80 90 100
SEVESETASD STESGDQDEA PRIGGRRAPR RLGGRFFLDM SAESTTGTET
110 120 130 140 150
DASVSDDPDD TSDWSYDDIP PRPKRARVNL RLTSSPDRRD GVIFPKMGRV
160 170 180 190 200
RSTRETQPRA PTPSAPSPNA MLRRSVRQAQ RRSSARWTPD LGYMRQCINQ
210 220 230 240 250
LFRVLRVARD PHGSANRLRH LIRDCYLMGY CRARLAPRTW CRLLQVSGGT
260 270 280 290 300
WGMHLRNTIR EVEARFDATA EPVCKLPCLE TRRYGPECDL SNLEIHLSAT
310 320 330 340 350
SDDEISDATD LEAAGSDHTL ASQSDTEDAP SPVTLETPEP RGSLAVRLED
360 370 380 390 400
EFGEFDWTPQ EGSQPWLSAV VADTSSVERP GPSDSGAGRA AEDRKCLDGC
410 420
RKMRFSTACP YPCSDTFLRP
Length:420
Mass (Da):46,525
Last modified:August 13, 1987 - v1
Checksum:i94D56376545B1192
GO
Isoform US1.5 (identifier: P04485-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Show »
Length:274
Mass (Da):30,580
Checksum:i0C6802604B01100E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 146146Missing in isoform US1.5. CuratedVSP_025673Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32287.1.
X02138 Genomic DNA. Translation: CAA26055.1.
L00036 Genomic DNA. Translation: AAA96687.1.
PIRiA03723. EDBE17.
RefSeqiNP_044663.1. NC_001806.1.

Genome annotation databases

GeneIDi2703435.

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32287.1 .
X02138 Genomic DNA. Translation: CAA26055.1 .
L00036 Genomic DNA. Translation: AAA96687.1 .
PIRi A03723. EDBE17.
RefSeqi NP_044663.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P04485. 1 interaction.
MINTi MINT-6732597.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703435.

Family and domain databases

InterProi IPR003403. IE68.
[Graphical view ]
Pfami PF02479. Herpes_IE68. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dolan A., Donald S., Rixon F.J.
    J. Mol. Biol. 181:1-13(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Mutation of the protein tyrosine kinase consensus site in the herpes simplex virus 1 alpha22 gene alters ICP22 posttranslational modification."
    O'Toole J.M., Aubert M., Kotsakis A., Blaho J.A.
    Virology 305:153-167(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-193, MUTAGENESIS OF TYR-193.
  4. "Herpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functions."
    Poon A.P., Roizman B.
    J. Virol. 79:8470-8479(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ISOFORM US1.5.
  5. "The products of the herpes simplex virus type 1 immediate-early US1/US1.5 genes downregulate levels of S-phase-specific cyclins and facilitate virus replication in S-phase Vero cells."
    Orlando J.S., Astor T.L., Rundle S.A., Schaffer P.A.
    J. Virol. 80:4005-4016(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Herpes simplex virus immediate-early protein ICP22 triggers loss of serine 2-phosphorylated RNA polymerase II."
    Fraser K.A., Rice S.A.
    J. Virol. 81:5091-5101(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiICP22_HHV11
AccessioniPrimary (citable) accession number: P04485
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

ICP22 and protein US1.5 mRNAs are transcribed from two different promoters on the US1 gene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3