P04476 (HXB7B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-B7-B

Alternative name(s):
P52
XlHbox-2 B

Gene names

Name:	hoxb7-b
Synonyms:	hbox2-b

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Developmental stage	Maternally expressed in oocytes.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P04476-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P04476-2)

Also known as: Homeobox-less;

The sequence of this isoform differs from the canonical sequence as follows:
     135-146: GSDRKRGRQTYT → DPVMMKVSSKPL
     147-220: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Homeobox protein Hox-B7-B		PRO_0000200147
Regions
	DNA binding	138 – 197	60	Homeobox
	Motif	127 – 132	6	Antp-type hexapeptide
	Compositional bias	211 – 220	10	Glu-rich (acidic)
Natural variations
	Alternative sequence	135 – 146	12	GSDRK…RQTYT → DPVMMKVSSKPL in isoform 2.		VSP_002390
	Alternative sequence	147 – 220	74	Missing in isoform 2.		VSP_002391

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: 0C8E63B70BAC9E82	FASTA	220	25,115
	10 20 30 40 50 60 MSSLYYANAL FSKYPTATSV FPSGVFSEQT SCAFASSPQR SGYGNSPGGT FPAGSAAHGL 70 80 90 100 110 120 FSNGSSLHPQ SPAMYPSSYG LDAASFNMHC SPFEQNLSSL MCDPTKQNCT KAEQRDSELH 130 140 150 160 170 180 NEANLRIYPW MRSAGSDRKR GRQTYTRYQT LELEKEFHFN RYLTRRRRIE IAHTLCLTER 190 200 210 220 QIKIWFQNRR MKWKKENKAS SPSSNSQEKP ETEEEEEEEE
	Isoform 2 (Homeobox-less) [UniParc]. Checksum: CCE6B5047B358EAE	FASTA	146	15,740
	10 20 30 40 50 60 MSSLYYANAL FSKYPTATSV FPSGVFSEQT SCAFASSPQR SGYGNSPGGT FPAGSAAHGL 70 80 90 100 110 120 FSNGSSLHPQ SPAMYPSSYG LDAASFNMHC SPFEQNLSSL MCDPTKQNCT KAEQRDSELH 130 140 NEANLRIYPW MRSADPVMMK VSSKPL

References

[1]	"A Xenopus laevis gene encodes both homeobox-containing and homeobox-less transcripts." Wright C.V.E., Cho K.W.Y., Fritz A., Buerglin T.R., De Robertis E.M. EMBO J. 6:4083-4094(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Xenopus homeobox-containing cDNAs expressed in early development." Fritz A., De Robertis E.M. Nucleic Acids Res. 16:1453-1469(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 119-220.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X07102 mRNA. Translation: CAA30123.1. X06592 mRNA. Translation: CAA29814.1. X06593 mRNA. Translation: CAA29815.1.
PIR	S01063. S01064.
UniGene	Xl.1210.
3D structure databases
ProteinModelPortal	P04476.
SMR	P04476. Positions 138-198.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Xenbase	XB-GENE-6254051. hoxb7.
Phylogenomic databases
HOVERGEN	HBG016849.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXB7B_XENLA

Accession

Primary (citable) accession number: P04476
Secondary accession number(s): P09018

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	November 1, 1988
Last modified:	April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program