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Protein

Kappa-casein

Gene

Csn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Gene namesi
Name:Csn3
Synonyms:Csn10, Csnk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi61990. Csn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2151. Rat n 8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 178157Kappa-caseinPRO_0000004504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 1201PhosphothreonineSequence analysis
Glycosylationi141 – 1411O-linked (GalNAc...)By similarity
Modified residuei145 – 1451PhosphothreonineSequence analysis
Glycosylationi146 – 1461O-linked (GalNAc...)By similarity
Glycosylationi152 – 1521O-linked (GalNAc...)By similarity
Modified residuei159 – 1591Phosphoserine; alternateBy similarity
Glycosylationi159 – 1591O-linked (GalNAc...); alternateBy similarity
Modified residuei165 – 1651PhosphothreonineSequence analysis
Glycosylationi174 – 1741O-linked (GalNAc...)By similarity
Modified residuei175 – 1751PhosphoserineBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei115 – 1162Cleavage; by chymosin/rennin

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP04468.

PTM databases

SwissPalmiP04468.

Miscellaneous databases

PMAP-CutDBP04468.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

GenevisibleiP04468. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002671.

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
GeneTreeiENSGT00390000009184.
HOGENOMiHOG000111309.
HOVERGENiHBG005246.
InParanoidiP04468.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG7MWH09.
PhylomeDBiP04468.
TreeFamiTF338369.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRNFIVVMN ILALTLPFLA AEVQNPDSNC REKNEVVYDV QRVLYTPVSS
60 70 80 90 100
VLNRNHYEPI YYHYRTSVPV SPYAYFPVGL KLLLLRSPAQ ILKWQPMPNF
110 120 130 140 150
PQPVGVPHPI PNPSFLAIPT NEKHDNTAIP ASNTIAPIVS TPVSTTESVV
160 170
NTVANTEAST VPISTPETAT VPVTSPAA
Length:178
Mass (Da):19,548
Last modified:August 13, 1987 - v1
Checksum:i0BC793AEFA8D7423
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02598 mRNA. Translation: AAA40880.1.
PIRiA03115. KKRT.
RefSeqiNP_113750.1. NM_031562.1.
UniGeneiRn.10746.

Genome annotation databases

EnsembliENSRNOT00000002671; ENSRNOP00000002671; ENSRNOG00000001951.
GeneIDi29188.
KEGGirno:29188.
UCSCiRGD:61990. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02598 mRNA. Translation: AAA40880.1.
PIRiA03115. KKRT.
RefSeqiNP_113750.1. NM_031562.1.
UniGeneiRn.10746.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002671.

Protein family/group databases

Allergomei2151. Rat n 8.

PTM databases

SwissPalmiP04468.

Proteomic databases

PaxDbiP04468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002671; ENSRNOP00000002671; ENSRNOG00000001951.
GeneIDi29188.
KEGGirno:29188.
UCSCiRGD:61990. rat.

Organism-specific databases

CTDi1448.
RGDi61990. Csn3.

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
GeneTreeiENSGT00390000009184.
HOGENOMiHOG000111309.
HOVERGENiHBG005246.
InParanoidiP04468.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG7MWH09.
PhylomeDBiP04468.
TreeFamiTF338369.

Miscellaneous databases

PMAP-CutDBP04468.
PROiP04468.

Gene expression databases

GenevisibleiP04468. RN.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Expression of kappa-casein in normal and neoplastic rat mammary gland is under the control of prolactin."
    Nakhasi H.L., Grantham F.H., Gullino P.M.
    J. Biol. Chem. 259:14894-14898(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCASK_RAT
AccessioniPrimary (citable) accession number: P04468
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.