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Protein

Calbindin

Gene

CALB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 351Add BLAST12
Calcium bindingi111 – 1222Add BLAST12
Calcium bindingi155 – 1663Add BLAST12
Calcium bindingi199 – 2104Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Calbindin
Alternative name(s):
Calbindin D28
D-28K
Vitamin D-dependent calcium-binding protein, avian-type
Gene namesi
Name:CALB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:26700 CALB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000734712 – 261CalbindinAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP04467
PeptideAtlasiP04467
PRIDEiP04467

PTM databases

iPTMnetiP04467

Expressioni

Gene expression databases

BgeeiENSBTAG00000015924

Interactioni

Subunit structurei

Interacts with RANBP9.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021174

Structurei

3D structure databases

ProteinModelPortaliP04467
SMRiP04467
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 46EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini47 – 82EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini98 – 133EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini142 – 177EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini186 – 221EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini226 – 251EF-hand 6PROSITE-ProRule annotationAdd BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 7Interaction with RANBP9By similarity6

Domaini

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Sequence similaritiesi

Belongs to the calbindin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000013118
HOGENOMiHOG000231866
HOVERGENiHBG000855
InParanoidiP04467
KOiK14757
OMAiMQTWRKY
OrthoDBiEOG091G0GNH
TreeFamiTF325083

Family and domain databases

InterProiView protein in InterPro
IPR029634 Calbindin
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR19972:SF3 PTHR19972:SF3, 1 hit
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA
60 70 80 90 100
GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC
110 120 130 140 150
EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM
160 170 180 190 200
LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGVKMCGKE FNKAFELYDQ
210 220 230 240 250
DGNGYIDENE LDALLKDLCE KNKQDLDINN IPTYKKSIMA LSDGGKLYRT
260
DLALILSAGD N
Length:261
Mass (Da):29,964
Last modified:January 23, 2007 - v3
Checksum:i847CD14BD7431E03
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67Q → E AA sequence (PubMed:3754823).Curated1
Sequence conflicti203N → D AA sequence (PubMed:3754823).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC116125 mRNA Translation: AAI16126.1
PIRiA03071 KLBOB
RefSeqiNP_001069663.1, NM_001076195.1
UniGeneiBt.41062

Genome annotation databases

EnsembliENSBTAT00000021174; ENSBTAP00000021174; ENSBTAG00000015924
GeneIDi539930
KEGGibta:539930

Similar proteinsi

Entry informationi

Entry nameiCALB1_BOVIN
AccessioniPrimary (citable) accession number: P04467
Secondary accession number(s): Q1LZA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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