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Protein

Myosin regulatory light chain 2, skeletal muscle isoform

Gene

Mylpf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi38 – 4912Add
BLAST

GO - Molecular functioni

GO - Biological processi

  • immune response Source: RGD
  • muscle contraction Source: RGD
  • skeletal muscle tissue development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin regulatory light chain 2, skeletal muscle isoform
Alternative name(s):
DTNB
Fast skeletal myosin light chain 2
Short name:
G2
Short name:
MLC-2
Gene namesi
Name:Mylpf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3141. Mylpf.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 169168Myosin regulatory light chain 2, skeletal muscle isoformPRO_0000198743Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N,N,N-trimethylalanineBy similarity
Modified residuei15 – 151PhosphoserineBy similarity
Modified residuei16 – 161PhosphoserineBy similarity
Modified residuei25 – 251PhosphothreonineCombined sources
Modified residuei35 – 351PhosphothreonineCombined sources
Modified residuei75 – 751PhosphoserineCombined sources
Modified residuei101 – 1011PhosphothreonineCombined sources

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiP04466.
PRIDEiP04466.

PTM databases

iPTMnetiP04466.
PhosphoSiteiP04466.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017645.
GenevisibleiP04466. RN.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

IntActiP04466. 1 interaction.
STRINGi10116.ENSRNOP00000023944.

Structurei

3D structure databases

ProteinModelPortaliP04466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 6036EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini95 – 13036EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini131 – 16636EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0031. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP04466.
KOiK12758.
OMAiQCDRFSP.
OrthoDBiEOG091G0QF6.
PhylomeDBiP04466.
TreeFamiTF314218.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKAKRRA AAEGSSNVFS MFDQTQIQEF KEAFTVIDQN RDGIIDKEDL
60 70 80 90 100
RDTFAAMGRL NVKNEELDAM MKEASGPINF TVFLTMFGEK LKGADPEDVI
110 120 130 140 150
TGAFKVLDPE GKGTIKKQFL EELLTTQCDR FSQEEIKNMW AAFPPDVGGN
160
VDYKNICYVI THGDAKDQE
Length:169
Mass (Da):18,969
Last modified:January 23, 2007 - v2
Checksum:i22C0BEB268C0318A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00975 Genomic DNA. Translation: CAA25480.1.
J00754 mRNA. Translation: AAA41660.1.
PIRiA03041. MORTL2.
RefSeqiNP_036737.1. NM_012605.2.
UniGeneiRn.6534.

Genome annotation databases

EnsembliENSRNOT00000023944; ENSRNOP00000023944; ENSRNOG00000017645.
GeneIDi24584.
KEGGirno:24584.
UCSCiRGD:3141. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00975 Genomic DNA. Translation: CAA25480.1.
J00754 mRNA. Translation: AAA41660.1.
PIRiA03041. MORTL2.
RefSeqiNP_036737.1. NM_012605.2.
UniGeneiRn.6534.

3D structure databases

ProteinModelPortaliP04466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04466. 1 interaction.
STRINGi10116.ENSRNOP00000023944.

PTM databases

iPTMnetiP04466.
PhosphoSiteiP04466.

Proteomic databases

PaxDbiP04466.
PRIDEiP04466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023944; ENSRNOP00000023944; ENSRNOG00000017645.
GeneIDi24584.
KEGGirno:24584.
UCSCiRGD:3141. rat.

Organism-specific databases

CTDi29895.
RGDi3141. Mylpf.

Phylogenomic databases

eggNOGiKOG0031. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119196.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP04466.
KOiK12758.
OMAiQCDRFSP.
OrthoDBiEOG091G0QF6.
PhylomeDBiP04466.
TreeFamiTF314218.

Enzyme and pathway databases

ReactomeiR-RNO-445355. Smooth Muscle Contraction.

Miscellaneous databases

PROiP04466.

Gene expression databases

BgeeiENSRNOG00000017645.
GenevisibleiP04466. RN.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLRS_RAT
AccessioniPrimary (citable) accession number: P04466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This chain binds calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.