Reviewed,
UniProtKB/Swiss-Prot P04451 (RL23_YEAST)
Last modified
December 15, 2009.
Version 92.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 60S ribosomal protein L23 Alternative name(s): L17a YL32 | |||||||||||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | |||||||||||||||
| Taxonomic identifier | 4932 [NCBI] | |||||||||||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 137 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subunit structure | Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Ref.7 |
| Subcellular location | Cytoplasm By similarity. |
| Post-translational modification | Methylated by RKM1 at 2 different sites, but it is unclear which are the 2 methylated residues among Lys-40, Lys-106 and/or Lys-110. Ref.8 |
| Miscellaneous | There are 2 genes for L23 in yeast. |
| Sequence similarities | Belongs to the ribosomal protein L14P family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Ribonucleoprotein Ribosomal protein |
| PTM | Acetylation Methylation Phosphoprotein |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | response to drug Inferred from mutant phenotype. Source: SGD translation Ref.7Traceable author statement. Source: SGD |
| Cellular component | cytosolic large ribosomal subunit Ref.7 Traceable author statement. Source: SGD |
| Molecular function | structural constituent of ribosome Ref.7 Traceable author statement. Source: SGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | ||||||
| Chain | 2 – 137 | 136 | 60S ribosomal protein L23 | PRO_0000128630 | |||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylserine Ref.8 | ||||||
| Modified residue | 40 | 1 | N6,N6-dimethyllysine; by RKM1 Probable | ||||||
| Modified residue | 106 | 1 | N6,N6-dimethyllysine; by RKM1 Probable | ||||||
| Modified residue | 110 | 1 | N6,N6-dimethyllysine; by RKM1 Probable | ||||||
| Modified residue | 112 | 1 | Phosphoserine Ref.9 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Structural comparison of yeast ribosomal protein genes." Leer R.J., van Raamsdonk-Duin M.M.C., Hagendoorn M.J.M., Mager W.H., Planta R.J. Nucleic Acids Res. 12:6685-6700(1984) [PubMed: 6091033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (RPL23A). |
| [2] | "Sequence, map position and genome organization of the RPL17B gene, encoding ribosomal protein L17b in Saccharomyces cerevisiae." Berroteran R.W., Hampsey M. Yeast 11:761-766(1995) [PubMed: 7668045] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (RPL23B). |
| [3] | Erratum Berroteran R.W., Hampsey M. Yeast 12:91-91(1996) |
| [4] | "Sequence analysis of a 78.6 kb segment of the left end of Saccharomyces cerevisiae chromosome II." Obermaier B., Gassenhuber J., Piravandi E., Domdey H. Yeast 11:1103-1112(1995) [PubMed: 7502586] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (RPL23A). Strain: ATCC 204508 / S288c. |
| [5] | "Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. Kleine K.EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (RPL23A). Strain: ATCC 204508 / S288c. |
| [6] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. Davis R.W.Nature 387:78-81(1997) [PubMed: 9169868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (RPL23B). Strain: ATCC 204511 / S288c / AB972. |
| [7] | "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae." Planta R.J., Mager W.H. Yeast 14:471-477(1998) [PubMed: 9559554] [Abstract] Cited for: NOMENCLATURE, SUBUNIT. |
| [8] | "A novel SET domain methyltransferase modifies ribosomal protein Rpl23ab in yeast." Porras-Yakushi T.R., Whitelegge J.P., Miranda T.B., Clarke S. J. Biol. Chem. 280:34590-34598(2005) [PubMed: 16096273] [Abstract] Cited for: ACETYLATION AT SER-2, METHYLATION AT LYS-40; LYS-106 AND LYS-110. |
| [9] | "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed: 17287358] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112, MASS SPECTROMETRY. |
| [10] | "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions." Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J. Cell 107:373-386(2001) [PubMed: 11701127] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 7-137, ELECTRON MICROSCOPY. |
| [11] | "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation." Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J. EMBO J. 23:1008-1019(2004) [PubMed: 14976550] [Abstract] Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| X01694 Genomic DNA. Translation: CAA25841.1. U15653 Genomic DNA. Translation: AAA61906.1. X79489 Genomic DNA. Translation: CAA56018.1. Z35848 Genomic DNA. Translation: CAA84908.1. U18916 Genomic DNA. Translation: AAC03215.1. | |||||||||||||||||||
| PIR | R5BY17. A02792. | ||||||||||||||||||
| RefSeq | NP_009466.1. NP_011042.1. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| DIP | DIP-5601N. | ||||||||||||||||||
| IntAct | P04451. 48 interactions. | ||||||||||||||||||
| STRING | P04451. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | P04451. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | YBL087C; YBL087C; YBL087C; Saccharomyces cerevisiae. [Genome view] YER117W; YER117W; YER117W; Saccharomyces cerevisiae. [Genome view] | ||||||||||||||||||
| GeneID | 852191. 856853. | ||||||||||||||||||
| KEGG | sce:YBL087C. sce:YER117W. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CYGD | YBL087c. YER117w. | ||||||||||||||||||
| SGD | S000000183. RPL23A. S000000919. RPL23B. | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOGENOM | HBG594899. | ||||||||||||||||||
| OMA | TPEMRKQ. | ||||||||||||||||||
| OrthoDB | EOG9MPK6S. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | P04451. | ||||||||||||||||||
| Genevestigator | P04451. | ||||||||||||||||||
| GermOnline | YBL087C. Saccharomyces cerevisiae. YER117W. Saccharomyces cerevisiae. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR019972. Ribosomal_L14_CS. IPR000218. Ribosomal_L14b/L23e. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:2.40.150.20. Ribosomal_L14. 1 hit. | ||||||||||||||||||
| PANTHER | PTHR11761. Ribosomal_L14. 1 hit. | ||||||||||||||||||
| Pfam | PF00238. Ribosomal_L14. 1 hit. [Graphical view] | ||||||||||||||||||
| PROSITE | PS00049. RIBOSOMAL_L14. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 970670. | ||||||||||||||||||
Entry information
| Entry name | RL23_YEAST | ||||||||
| Accession | Primary (citable) accession number: P04451 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| Ribosomal proteins Ribosomal proteins families and list of entries |
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome II Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names |
| Yeast chromosome V Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names |

Clusters with


